Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr3 | 10183865 | . | T | A | CCDS2597.1:NM_000551.3:c.334Tac>Aac_NP_000542.1:p.112Y>N | Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 4wqo | 1 | P40337 | 100.0 | 4e-156 |
X-RAY |
2015-03-04 | TYR | A:132 | A:112 | 46.0 | 0.2 | E | -138.5 | 151.8 | 46.0 | 0.2 | 0.0 | ||||||
| 7q2j | 3 | P40337 | 94.25 | 1e-118 |
X-RAY |
2021-11-24 | TYR | C:96 | C:112 | 101.0 | 0.439 | E | -124.7 | 149.3 | 73.0 | 0.317 | 0.122 |
D:P61964:0.122 |
8KH HOH |
3.060 3.311 |
CE1 OH |
O4 O |
|
| 4b9k | 3 | P40337 | 95.32 | 3e-118 |
X-RAY |
2012-10-24 | TYR | C:70 | C:112 | 96.0 | 0.417 | E | -143.7 | 152.7 | 96.0 | 0.417 | 0.0 |
TG0 HOH |
3.584 3.409 |
CE1 CE2 |
O29 O |
||
| TYR | F:70 | F:112 | 95.0 | 0.413 | E | -144.0 | 151.8 | NA | NA | NA | |||||||||||||
| TYR | I:70 | I:112 | 95.0 | 0.413 | E | -136.9 | 151.1 | NA | NA | NA | |||||||||||||
| TYR | L:70 | L:112 | 97.0 | 0.422 | E | -142.8 | 151.8 | NA | NA | NA | |||||||||||||
| 1lqb | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2002-07-03 | TYR | C:61 | C:112 | 95.0 | 0.413 | E | -138.4 | 153.5 | 17.0 | 0.074 | 0.339 |
D:Q16665:0.339 |
HOH |
3.792 |
CG |
O |
|
| 3ztd | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2012-07-25 | TYR | C:61 | C:112 | 49.0 | 0.213 | E | -169.9 | 149.1 | 49.0 | 0.213 | 0.0 |
ZTD HOH |
3.038 4.692 |
CE2 CG |
OAT O |
||
| TYR | F:61 | F:112 | 48.0 | 0.209 | E | -159.2 | 153.9 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 47.0 | 0.204 | E | -148.4 | 144.8 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 41.0 | 0.178 | E | -143.9 | 144.8 | NA | NA | NA | |||||||||||||
| 4b95 | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2012-10-24 | TYR | C:61 | C:112 | 97.0 | 0.422 | E | -140.2 | 152.5 | 97.0 | 0.422 | 0.0 |
UCK HOH |
3.234 4.166 |
CE1 CG |
O25 O |
||
| TYR | F:61 | F:112 | 96.0 | 0.417 | E | -139.4 | 152.7 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 100.0 | 0.435 | E | -139.5 | 152.8 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 99.0 | 0.43 | E | -138.2 | 153.6 | NA | NA | NA | |||||||||||||
| 4bks | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2013-11-27 | TYR | C:61 | C:112 | 66.0 | 0.287 | E | -141.7 | 154.6 | 66.0 | 0.287 | 0.0 |
X6C HOH |
3.535 3.836 |
CE1 CE1 |
OAB O |
||
| TYR | F:61 | F:112 | 70.0 | 0.304 | E | -140.8 | 153.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 68.0 | 0.296 | E | -140.5 | 154.6 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 68.0 | 0.296 | E | -141.0 | 154.7 | NA | NA | NA | |||||||||||||
| 4bkt | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2013-11-27 | TYR | C:61 | C:112 | 95.0 | 0.413 | E | -137.8 | 153.3 | 95.0 | 0.413 | 0.0 |
QD0 HOH |
3.721 3.590 |
CE1 CZ |
O18 O |
||
| TYR | F:61 | F:112 | 94.0 | 0.409 | E | -137.8 | 149.7 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 95.0 | 0.413 | E | -138.4 | 152.3 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 95.0 | 0.413 | E | -138.0 | 151.2 | NA | NA | NA | |||||||||||||
| 4w9c | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 66.0 | 0.287 | E | -145.4 | 150.5 | 66.0 | 0.287 | 0.0 |
3JG HOH |
3.430 4.385 |
CE1 CG |
OAD O |
||
| TYR | F:61 | F:112 | 66.0 | 0.287 | E | -144.9 | 151.6 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 66.0 | 0.287 | E | -141.3 | 155.0 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 64.0 | 0.278 | E | -149.6 | 152.9 | NA | NA | NA | |||||||||||||
| 4w9d | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 68.0 | 0.296 | E | -145.0 | 152.8 | 68.0 | 0.296 | 0.0 |
3JK HOH |
3.465 4.388 |
CE1 CG |
OAE O |
||
| TYR | F:61 | F:112 | 67.0 | 0.291 | E | -141.7 | 155.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 70.0 | 0.304 | E | -144.7 | 153.4 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 66.0 | 0.287 | E | -145.1 | 154.4 | NA | NA | NA | |||||||||||||
| 4w9e | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 65.0 | 0.283 | E | -148.7 | 148.7 | 65.0 | 0.283 | 0.0 |
3JT HOH |
3.620 4.240 |
CE1 CB |
OAD O |
||
| TYR | F:61 | F:112 | 65.0 | 0.283 | E | -144.0 | 154.2 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 69.0 | 0.3 | E | -146.5 | 154.3 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 67.0 | 0.291 | E | -153.1 | 147.8 | NA | NA | NA | |||||||||||||
| 4w9f | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 65.0 | 0.283 | E | -143.3 | 156.8 | 65.0 | 0.283 | 0.0 |
3JU HOH |
3.583 3.166 |
CE1 CE1 |
OAE O |
||
| TYR | F:61 | F:112 | 66.0 | 0.287 | E | -143.0 | 152.0 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 69.0 | 0.3 | E | -144.8 | 156.0 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 68.0 | 0.296 | E | -143.5 | 152.3 | NA | NA | NA | |||||||||||||
| 4w9g | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 68.0 | 0.296 | E | -142.4 | 151.6 | 68.0 | 0.296 | 0.0 |
3JV HOH |
3.535 4.287 |
CE1 CB |
OAE O |
||
| TYR | F:61 | F:112 | 70.0 | 0.304 | E | -138.9 | 159.2 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 69.0 | 0.3 | E | -137.0 | 159.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 68.0 | 0.296 | E | -146.7 | 155.9 | NA | NA | NA | |||||||||||||
| 4w9h | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 47.0 | 0.204 | E | -144.6 | 151.4 | 47.0 | 0.204 | 0.0 |
3JF HOH |
3.320 2.705 |
CE1 OH |
OAH O |
||
| TYR | F:61 | F:112 | 47.0 | 0.204 | E | -146.9 | 149.9 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 46.0 | 0.2 | E | -144.2 | 153.4 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 48.0 | 0.209 | E | -147.3 | 149.0 | NA | NA | NA | |||||||||||||
| 4w9i | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 59.0 | 0.257 | E | -143.8 | 155.0 | 59.0 | 0.257 | 0.0 |
3JS HOH |
3.388 3.210 |
CE1 OH |
OAC O |
||
| TYR | F:61 | F:112 | 58.0 | 0.252 | E | -141.7 | 153.2 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 59.0 | 0.257 | E | -143.4 | 152.2 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 59.0 | 0.257 | E | -149.1 | 153.1 | NA | NA | NA | |||||||||||||
| 4w9j | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 38.0 | 0.165 | E | -148.8 | 153.9 | 38.0 | 0.165 | 0.0 |
3JH HOH |
3.410 4.078 |
CZ CZ |
CB O |
||
| TYR | F:61 | F:112 | 41.0 | 0.178 | E | -141.8 | 152.9 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 39.0 | 0.17 | E | -144.8 | 148.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 39.0 | 0.17 | E | -143.7 | 153.6 | NA | NA | NA | |||||||||||||
| 4w9k | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 33.0 | 0.143 | E | -140.8 | 158.5 | 33.0 | 0.143 | 0.0 |
3JO HOH |
3.476 4.138 |
CE1 CG |
C O |
||
| TYR | F:61 | F:112 | 36.0 | 0.157 | E | -139.4 | 156.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 33.0 | 0.143 | E | -142.6 | 149.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 35.0 | 0.152 | E | -140.1 | 154.2 | NA | NA | NA | |||||||||||||
| 4w9l | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2014-09-10 | TYR | C:61 | C:112 | 33.0 | 0.143 | E | -143.7 | 154.0 | 33.0 | 0.143 | 0.0 |
3JJ HOH |
2.924 4.371 |
OH CG |
CG2 O |
||
| TYR | F:61 | F:112 | 40.0 | 0.174 | E | -144.2 | 152.2 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 38.0 | 0.165 | E | -146.4 | 150.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 37.0 | 0.161 | E | -147.6 | 150.0 | NA | NA | NA | |||||||||||||
| 5lli | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2016-11-09 | TYR | C:61 | C:112 | 39.0 | 0.17 | E | -143.3 | 152.2 | 39.0 | 0.17 | 0.0 |
6Z3 HOH |
3.225 2.828 |
CZ OH |
CAQ O |
||
| TYR | F:61 | F:112 | 39.0 | 0.17 | E | -144.4 | 153.7 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 38.0 | 0.165 | E | -148.3 | 150.0 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 40.0 | 0.174 | E | -149.4 | 150.1 | NA | NA | NA | |||||||||||||
| 5nvv | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 45.0 | 0.196 | E | -141.8 | 150.7 | 45.0 | 0.196 | 0.0 |
9BT HOH |
3.535 2.892 |
CE1 OH |
CAW O |
||
| TYR | F:61 | F:112 | 47.0 | 0.204 | E | -146.1 | 151.9 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 39.0 | 0.17 | E | -143.8 | 153.4 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 43.0 | 0.187 | E | -144.7 | 153.1 | NA | NA | NA | |||||||||||||
| 5nvw | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 46.0 | 0.2 | E | -143.6 | 153.2 | 46.0 | 0.2 | 0.0 |
9BW HOH |
3.386 2.683 |
CE2 OH |
CAO O |
||
| TYR | F:61 | F:112 | 46.0 | 0.2 | E | -147.8 | 154.2 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 45.0 | 0.196 | E | -146.3 | 157.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 47.0 | 0.204 | E | -148.4 | 151.9 | NA | NA | NA | |||||||||||||
| 5nvx | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 40.0 | 0.174 | E | -146.5 | 152.0 | 40.0 | 0.174 | 0.0 |
4YY HOH |
3.304 2.700 |
CE2 OH |
CAP O |
||
| TYR | F:61 | F:112 | 41.0 | 0.178 | E | -145.7 | 152.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 39.0 | 0.17 | E | -147.2 | 156.3 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 42.0 | 0.183 | E | -150.7 | 149.8 | NA | NA | NA | |||||||||||||
| 5nvy | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 62.0 | 0.27 | E | -138.3 | 162.7 | 62.0 | 0.27 | 0.0 |
9B5 HOH |
3.403 4.099 |
CE1 CB |
OAD O |
||
| TYR | F:61 | F:112 | 56.0 | 0.243 | E | -133.6 | 157.4 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 55.0 | 0.239 | E | -139.6 | 153.6 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 56.0 | 0.243 | E | -142.5 | 156.3 | NA | NA | NA | |||||||||||||
| 5nvz | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 35.0 | 0.152 | E | -136.8 | 153.0 | 35.0 | 0.152 | 0.0 |
9BN HOH |
3.439 4.296 |
OH CB |
CAY O |
||
| TYR | F:61 | F:112 | 33.0 | 0.143 | E | -143.6 | 157.1 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 33.0 | 0.143 | E | -137.7 | 151.1 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 34.0 | 0.148 | E | -148.9 | 148.7 | NA | NA | NA | |||||||||||||
| 5nw0 | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 44.0 | 0.191 | E | -142.9 | 157.3 | 44.0 | 0.191 | 0.0 |
9BK HOH |
3.305 2.815 |
CZ OH |
CAQ O |
||
| TYR | F:61 | F:112 | 42.0 | 0.183 | E | -144.2 | 162.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 39.0 | 0.17 | E | -144.3 | 153.7 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 40.0 | 0.174 | E | -147.3 | 150.6 | NA | NA | NA | |||||||||||||
| 5nw1 | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 48.0 | 0.209 | E | -143.0 | 152.5 | 48.0 | 0.209 | 0.0 |
9BH HOH |
3.383 2.792 |
CE1 OH |
CAX O |
||
| TYR | F:61 | F:112 | 45.0 | 0.196 | E | -146.0 | 151.1 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 44.0 | 0.191 | E | -145.2 | 151.6 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 44.0 | 0.191 | E | -140.9 | 150.7 | NA | NA | NA | |||||||||||||
| 5nw2 | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-09-20 | TYR | C:61 | C:112 | 48.0 | 0.209 | E | -142.5 | 153.5 | 48.0 | 0.209 | 0.0 |
9B8 HOH |
3.240 2.841 |
CZ OH |
CAP O |
||
| TYR | F:61 | F:112 | 51.0 | 0.222 | E | -143.8 | 152.1 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 50.0 | 0.217 | E | -142.3 | 150.4 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 49.0 | 0.213 | E | -147.3 | 151.7 | NA | NA | NA | |||||||||||||
| 5t35 | 4 | P40337 | 99.38 | 4e-117 |
X-RAY |
2017-03-08 | TYR | D:61 | D:112 | 5.0 | 0.022 | E | -138.5 | 158.0 | 1.0 | 0.004 | 0.018 |
759 HOH |
3.208 2.666 |
OH OH |
CAO O |
||
| TYR | H:61 | H:112 | 5.0 | 0.022 | E | -137.6 | 158.4 | NA | NA | NA | |||||||||||||
| 6bvb | 1 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-08-01 | TYR | A:61 | V:112 | 97.0 | 0.422 | E | -152.2 | 155.7 | 22.0 | 0.096 | 0.326 |
D:None:0.326 |
HOH |
3.809 |
HB2 |
O |
|
| 6gfy | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-07-11 | TYR | C:61 | C:112 | 55.0 | 0.239 | E | -140.8 | 151.7 | 55.0 | 0.239 | 0.0 |
EXH HOH |
3.465 4.325 |
CE1 CB |
O O |
||
| TYR | F:61 | F:112 | 56.0 | 0.243 | E | -145.5 | 152.0 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 55.0 | 0.239 | E | -143.9 | 148.7 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 51.0 | 0.222 | E | -150.9 | 147.6 | NA | NA | NA | |||||||||||||
| 6gfz | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-07-11 | TYR | C:61 | C:112 | 51.0 | 0.222 | E | -145.1 | 151.9 | 51.0 | 0.222 | 0.0 |
EXE HOH |
3.366 2.919 |
CE1 OH |
CAV O |
||
| TYR | F:61 | F:112 | 52.0 | 0.226 | E | -138.1 | 155.9 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 49.0 | 0.213 | E | -143.8 | 156.5 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 50.0 | 0.217 | E | -146.0 | 150.9 | NA | NA | NA | |||||||||||||
| 6gmn | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-08-08 | TYR | C:61 | C:112 | 92.0 | 0.4 | E | -142.4 | 149.0 | 92.0 | 0.4 | 0.0 |
HOH |
3.605 |
CZ |
O |
||
| TYR | F:61 | F:112 | 93.0 | 0.404 | E | -143.1 | 149.7 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 94.0 | 0.409 | E | -142.5 | 150.0 | NA | NA | NA | |||||||||||||
| 6gmn | 5 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-08-08 | TYR | I:61 | I:112 | 95.0 | 0.413 | E | -142.6 | 150.1 | NA | NA | NA | ||||||
| 6gmq | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-08-22 | TYR | C:61 | C:112 | 102.0 | 0.443 | E | -141.2 | 150.5 | 102.0 | 0.443 | 0.0 |
HOH |
4.139 |
CG |
O |
||
| TYR | F:61 | F:112 | 90.0 | 0.391 | E | -140.6 | 153.3 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 90.0 | 0.391 | E | -142.5 | 153.1 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 97.0 | 0.422 | E | -142.5 | 147.9 | NA | NA | NA | |||||||||||||
| 6gmx | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2018-08-08 | TYR | C:61 | C:112 | 96.0 | 0.417 | E | -142.9 | 151.6 | 96.0 | 0.417 | 0.0 |
IPA HOH |
4.036 4.031 |
CD1 CB |
C2 O |
||
| TYR | F:61 | F:112 | 92.0 | 0.4 | E | -141.5 | 148.1 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 94.0 | 0.409 | E | -142.4 | 152.2 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 94.0 | 0.409 | E | -141.1 | 150.0 | NA | NA | NA | |||||||||||||
| 6hax | 2 | P40337 | 99.38 | 4e-117 |
X-RAY |
2019-06-12 | TYR | B:61 | B:112 | 81.0 | 0.352 | E | -135.6 | 153.6 | 31.0 | 0.135 | 0.217 |
A:P51531:0.217 |
EDO FWZ EDO HOH |
6.484 3.332 8.580 3.646 |
OH OH OH OH |
O2 F34 O2 O |
|
| TYR | F:61 | F:112 | 82.0 | 0.357 | E | -134.9 | 154.2 | NA | NA | NA | |||||||||||||
| 6hay | 2 | P40337 | 99.38 | 4e-117 |
X-RAY |
2019-06-12 | TYR | B:61 | B:112 | 80.0 | 0.348 | E | -141.9 | 158.4 | 29.0 | 0.126 | 0.222 |
A:P51531:0.222 |
FX8 EDO HOH |
3.099 8.588 3.332 |
OH CE1 OH |
F34 O1 O |
|
| TYR | F:61 | F:112 | 103.0 | 0.448 | E | -139.7 | 154.9 | NA | NA | NA | |||||||||||||
| 6sis | 4 | P40337 | 99.38 | 4e-117 |
X-RAY |
2019-12-04 | TYR | D:61 | D:112 | 94.0 | 0.409 | E | -130.2 | 165.8 | 78.0 | 0.339 | 0.07 |
A:O60885:0.07 |
LFE |
3.147 |
OH |
C65 |
|
| TYR | H:61 | H:112 | 91.0 | 0.396 | E | -130.2 | 165.8 | NA | NA | NA | |||||||||||||
| 7jto | 4 | P40337 | 99.38 | 4e-117 |
X-RAY |
2021-10-06 | TYR | D:61 | L:112 | 95.0 | 0.413 | E | -144.3 | 155.2 | 82.0 | 0.357 | 0.056 |
A:P61964:0.057 |
VKA EDO HOH |
3.343 8.191 2.060 |
CE2 CE2 OH |
O23 O1 O |
|
| 7jtp | 3 | P40337 | 99.38 | 4e-117 |
X-RAY |
2021-10-06 | TYR | C:61 | L:112 | 58.0 | 0.252 | E | -141.6 | 149.8 | 41.0 | 0.178 | 0.074 |
D:P61964:0.074 |
GOL X6M HOH |
8.364 2.629 2.677 |
CE1 OH OH |
O2 N4 O |
|
| 3zrc | 3 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-03-07 | TYR | C:62 | C:112 | 50.0 | 0.217 | E | -151.3 | 146.0 | 50.0 | 0.217 | 0.0 |
L8B |
3.636 |
CE1 |
NAQ |
||
| TYR | F:62 | F:112 | 47.0 | 0.204 | E | -157.4 | 154.6 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 54.0 | 0.235 | E | -159.1 | 158.0 | NA | NA | NA | |||||||||||||
| TYR | L:62 | L:112 | 46.0 | 0.2 | E | -157.3 | 137.4 | NA | NA | NA | |||||||||||||
| 3zrf | 3 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-03-07 | TYR | C:62 | C:112 | 89.0 | 0.387 | E | -154.2 | 138.2 | 89.0 | 0.387 | 0.0 | ||||||
| TYR | F:62 | F:112 | 87.0 | 0.378 | E | -142.7 | 155.7 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 101.0 | 0.439 | E | -160.1 | 157.6 | NA | NA | NA | |||||||||||||
| TYR | L:62 | L:112 | 94.0 | 0.409 | E | -157.8 | 133.6 | NA | NA | NA | |||||||||||||
| 3ztc | 3 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-07-25 | TYR | C:62 | C:112 | 49.0 | 0.213 | E | -151.7 | 150.3 | 49.0 | 0.213 | 0.0 |
TR0 HOH |
3.288 4.345 |
CE1 CG |
OAT O |
||
| TYR | F:62 | F:112 | 49.0 | 0.213 | E | -151.0 | 155.2 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 48.0 | 0.209 | E | -146.3 | 150.7 | NA | NA | NA | |||||||||||||
| TYR | L:62 | L:112 | 47.0 | 0.204 | E | -139.6 | 159.8 | NA | NA | NA | |||||||||||||
| 3zun | 3 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-07-25 | TYR | C:62 | C:112 | 45.0 | 0.196 | E | -152.3 | 161.9 | 45.0 | 0.196 | 0.0 |
ZUN HOH |
3.658 3.508 |
CE1 CZ |
OAT O |
||
| TYR | F:62 | F:112 | 45.0 | 0.196 | E | -149.3 | 162.8 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 46.0 | 0.2 | E | -148.3 | 155.0 | NA | NA | NA | |||||||||||||
| TYR | L:62 | L:112 | 43.0 | 0.187 | E | -141.4 | 162.1 | NA | NA | NA | |||||||||||||
| 4ajy | 4 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-11-14 | TYR | D:62 | V:112 | 93.0 | 0.404 | E | -141.9 | 154.7 | 18.0 | 0.078 | 0.326 |
C:Q16665:0.326 |
HOH |
2.641 |
OH |
O |
|
| 4awj | 3 | P40337 | 98.77 | 4e-117 |
X-RAY |
2012-11-14 | TYR | C:62 | C:112 | 100.0 | 0.435 | E | -137.2 | 155.3 | 100.0 | 0.435 | 0.0 |
V6F HOH |
3.490 3.700 |
CE1 CZ |
O12 O |
||
| TYR | F:62 | F:112 | 98.0 | 0.426 | E | -141.1 | 152.4 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 101.0 | 0.439 | E | -139.8 | 148.3 | NA | NA | NA | |||||||||||||
| TYR | L:62 | L:112 | 96.0 | 0.417 | E | -139.1 | 152.8 | NA | NA | NA | |||||||||||||
| 6gmr | 4 | P40337 | 98.77 | 4e-117 |
X-RAY |
2018-08-08 | TYR | D:62 | V:112 | 97.0 | 0.422 | E | -145.8 | 152.3 | 19.0 | 0.083 | 0.339 |
C:None:0.339 |
HOH |
2.413 |
OH |
O |
|
| 1lm8 | 3 | P40337 | 100.0 | 6e-117 |
X-RAY |
2002-06-12 | TYR | C:59 | V:112 | 95.0 | 0.413 | E | -139.7 | 152.3 | 19.0 | 0.083 | 0.33 |
D:Q16665:0.33 |
HOH |
2.680 |
OH |
O |
|
| 1vcb | 3 | P40337 | 100.0 | 6e-117 |
X-RAY |
1999-04-21 | TYR | C:59 | C:112 | 97.0 | 0.422 | E | -144.9 | 155.4 | 97.0 | 0.422 | 0.0 |
HOH |
3.319 |
CE2 |
O |
||
| TYR | F:59 | F:112 | 99.0 | 0.43 | E | -146.1 | 155.7 | NA | NA | NA | |||||||||||||
| TYR | I:59 | I:112 | 95.0 | 0.413 | E | -145.4 | 155.5 | NA | NA | NA | |||||||||||||
| TYR | L:59 | L:112 | 95.0 | 0.413 | E | -146.2 | 156.2 | NA | NA | NA | |||||||||||||
| 5n4w | 2 | P40337 | 100.0 | 6e-117 |
X-RAY |
2017-06-07 | TYR | B:59 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6gfx | 3 | P40337 | 100.0 | 6e-117 |
X-RAY |
2018-07-11 | TYR | C:59 | C:112 | 96.0 | 0.417 | E | -140.4 | 149.0 | 19.0 | 0.083 | 0.334 |
D:None:0.335 |
HOH |
2.645 |
OH |
O |
|
| 6i7q | 4 | P40337 | 100.0 | 6e-117 |
X-RAY |
2019-11-27 | TYR | D:59 | V:112 | 95.0 | 0.413 | E | -141.7 | 149.1 | 18.0 | 0.078 | 0.335 |
C:Q99814:0.335 |
HOH |
1.859 |
HH |
O |
|
| 6i7r | 4 | P40337 | 100.0 | 6e-117 |
X-RAY |
2019-11-27 | TYR | D:59 | V:112 | 93.0 | 0.404 | E | -147.4 | 145.4 | 17.0 | 0.074 | 0.33 |
C:Q99814:0.33 |
HOH |
2.694 |
OH |
O |
|
| 6r7f | 9 | P40337 | 100.0 | 6e-117 |
EM |
2019-08-28 | TYR | I:59 | V:112 | 50.0 | 0.217 | E | -133.9 | 157.2 | 50.0 | 0.217 | 0.0 | ||||||
| 7khh | 3 | P40337 | 100.0 | 6e-116 |
X-RAY |
2021-02-24 | TYR | C:74 | C:112 | 75.0 | 0.326 | E | -138.0 | 158.7 | 75.0 | 0.326 | 0.0 |
WEP HOH |
3.292 2.667 |
CE1 OH |
O25 O |
||
| 7cjb | 1 | P40337 | 100.0 | 8e-116 |
X-RAY |
2021-07-14 | TYR | A:62 | A:112 | 72.0 | 0.313 | E | -151.5 | 154.7 | 13.0 | 0.057 | 0.256 |
D:Q13546:0.257 |
|||||
| TYR | E:62 | E:112 | 71.0 | 0.309 | E | -154.7 | 154.5 | NA | NA | NA | |||||||||||||
| TYR | I:62 | I:112 | 71.0 | 0.309 | E | -151.9 | 154.3 | NA | NA | NA | |||||||||||||
| TYR | M:62 | M:112 | 75.0 | 0.326 | E | -152.9 | 154.4 | NA | NA | NA | |||||||||||||
| 6zhc | 1 | P40337 | 100.0 | 4e-113 |
X-RAY |
2020-08-05 | TYR | A:54 | AAA:112 | 91.0 | 0.396 | E | -145.9 | 147.6 | 86.0 | 0.374 | 0.022 |
D:Q07817:0.022 |
QL8 GOL IOD IOD HOH |
3.380 9.850 7.025 8.735 2.735 |
CZ O C CE1 OH |
C31 O1 I I O |
|
| 7pi4 | 1 | P40337 | 100.0 | 4e-113 |
X-RAY |
2021-09-29 | TYR | A:54 | AAA:112 | 93.0 | 0.404 | E | -144.2 | 148.7 | 68.0 | 0.296 | 0.108 |
D:Q05397:0.109 |
7QB PEG PEG HOH |
3.358 6.621 9.398 3.712 |
CE1 OH OH CZ |
O2 O4 C2 O |
|
| 6fmi | 3 | P40337 | 99.34 | 1e-109 |
X-RAY |
2018-04-11 | TYR | C:61 | C:112 | 58.0 | 0.252 | E | -135.7 | 158.4 | 58.0 | 0.252 | 0.0 |
DV2 HOH |
3.351 4.081 |
CE1 CB |
OAD O |
||
| TYR | F:61 | F:112 | 59.0 | 0.257 | E | -135.9 | 161.7 | NA | NA | NA | |||||||||||||
| 6fmj | 3 | P40337 | 99.34 | 1e-109 |
X-RAY |
2018-04-11 | TYR | C:61 | C:112 | 57.0 | 0.248 | E | -143.2 | 156.8 | 57.0 | 0.248 | 0.0 |
DV5 HOH |
3.434 2.903 |
CE1 OH |
OAD O |
||
| TYR | F:61 | F:112 | 57.0 | 0.248 | E | -139.1 | 156.1 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 56.0 | 0.243 | E | -137.3 | 153.0 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 56.0 | 0.243 | E | -143.3 | 155.2 | NA | NA | NA | |||||||||||||
| 6fmk | 3 | P40337 | 99.34 | 1e-109 |
X-RAY |
2018-04-11 | TYR | C:61 | C:112 | 103.0 | 0.448 | E | -139.7 | 160.9 | 103.0 | 0.448 | 0.0 |
DV8 HOH |
3.569 4.264 |
CE1 CB |
OAD O |
||
| TYR | F:61 | F:112 | 110.0 | 0.478 | E | -131.3 | 160.8 | NA | NA | NA | |||||||||||||
| TYR | I:61 | I:112 | 107.0 | 0.465 | E | -136.9 | 153.9 | NA | NA | NA | |||||||||||||
| TYR | L:61 | L:112 | 104.0 | 0.452 | E | -141.8 | 156.4 | NA | NA | NA | |||||||||||||
| 6hr2 | 2 | P40337 | 100.0 | 3e-108 |
X-RAY |
2019-06-12 | TYR | B:52 | B:112 | 77.0 | 0.335 | E | -139.4 | 161.0 | 32.0 | 0.139 | 0.196 |
A:P51532:0.196 |
FWZ DMS HOH |
2.400 8.386 3.027 |
HE1 HE1 HH |
H11 O O |
|
| TYR | F:52 | F:112 | 77.0 | 0.335 | E | -139.4 | 161.9 | NA | NA | NA | |||||||||||||
| 6r6h | 12 | P40337 | 100.0 | 3e-107 |
EM |
2019-08-28 | TYR | L:53 | V:112 | 64.0 | 0.278 | E | -112.2 | 116.0 | 64.0 | 0.278 | 0.0 | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p40337-f1 | 1 | P40337 | 100.0 | 2e-156 | TYR | A:112 | A:112 | 101.0 | 0.439 | E | -132.9 | 154.8 | |