Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10188231 . A C CCDS2597.1:NM_000551.3:c.374cAc>cCc_NP_000542.1:p.125H>P Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
 2015-03-04 HIS A:145 A:125 86.0 0.441 69.2 19.1 86.0 0.441 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
 2021-11-24 HIS C:109 C:125 82.0 0.421 55.5 15.8 82.0 0.421 0.0
4b9k 3 P40337 95.32 3e-118 X-RAY
 2012-10-24 HIS C:83 C:125 68.0 0.349 70.5 16.0 68.0 0.349 0.0 HOH
 3.804
 CG
 O
HIS F:83 F:125 73.0 0.374 71.4 15.2 NA NA NA
HIS I:83 I:125 81.0 0.415 71.8 14.4 NA NA NA
HIS L:83 L:125 79.0 0.405 72.6 13.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
 2002-07-03 HIS C:74 C:125 71.0 0.364 65.7 18.3 71.0 0.364 0.0 HOH
 2.996
 O
 O
3ztd 3 P40337 99.38 4e-117 X-RAY
 2012-07-25 HIS C:74 C:125 79.0 0.405 59.6 8.1 79.0 0.405 0.0
HIS F:74 F:125 84.0 0.431 68.6 7.7 NA NA NA
HIS I:74 I:125 80.0 0.41 81.0 -2.4 NA NA NA
HIS L:74 L:125 84.0 0.431 75.3 3.5 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
 2012-10-24 HIS C:74 C:125 75.0 0.385 70.3 15.4 75.0 0.385 0.0 HOH
 3.639
 CG
 O
HIS F:74 F:125 75.0 0.385 70.7 15.8 NA NA NA
HIS I:74 I:125 87.0 0.446 70.4 16.0 NA NA NA
HIS L:74 L:125 74.0 0.379 72.6 14.9 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
 2013-11-27 HIS C:74 C:125 79.0 0.405 72.0 14.8 79.0 0.405 0.0 ACT
HOH
 9.693
3.898
 N
CG
 CH3
O
HIS F:74 F:125 78.0 0.4 72.5 14.7 NA NA NA
HIS I:74 I:125 82.0 0.421 72.3 15.8 NA NA NA
HIS L:74 L:125 79.0 0.405 72.2 16.0 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
 2013-11-27 HIS C:74 C:125 79.0 0.405 70.1 15.9 79.0 0.405 0.0 HOH
 4.028
 CG
 O
HIS F:74 F:125 80.0 0.41 70.2 17.5 NA NA NA
HIS I:74 I:125 80.0 0.41 71.2 15.7 NA NA NA
HIS L:74 L:125 78.0 0.4 70.0 17.0 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 76.0 0.39 67.4 15.2 76.0 0.39 0.0 HOH
 4.862
 O
 O
HIS F:74 F:125 78.0 0.4 68.9 15.6 NA NA NA
HIS I:74 I:125 78.0 0.4 66.0 14.2 NA NA NA
HIS L:74 L:125 80.0 0.41 65.1 14.2 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 76.0 0.39 62.5 15.2 76.0 0.39 0.0 HOH
 5.079
 O
 O
HIS F:74 F:125 80.0 0.41 67.8 15.3 NA NA NA
HIS I:74 I:125 80.0 0.41 65.5 14.2 NA NA NA
HIS L:74 L:125 79.0 0.405 70.3 12.7 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 77.0 0.395 61.2 13.3 77.0 0.395 0.0 HOH
 6.137
 N
 O
HIS F:74 F:125 78.0 0.4 69.7 15.8 NA NA NA
HIS I:74 I:125 75.0 0.385 65.0 17.4 NA NA NA
HIS L:74 L:125 78.0 0.4 68.8 13.5 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 75.0 0.385 63.5 15.8 75.0 0.385 0.0 HOH
 4.990
 O
 O
HIS F:74 F:125 78.0 0.4 65.2 16.8 NA NA NA
HIS I:74 I:125 79.0 0.405 65.0 14.9 NA NA NA
HIS L:74 L:125 83.0 0.426 68.3 14.4 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 82.0 0.421 61.0 20.0 82.0 0.421 0.0 HOH
 6.188
 N
 O
HIS F:74 F:125 81.0 0.415 65.9 18.9 NA NA NA
HIS I:74 I:125 77.0 0.395 66.6 20.2 NA NA NA
HIS L:74 L:125 79.0 0.405 67.7 13.4 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 80.0 0.41 64.3 17.9 80.0 0.41 0.0 HOH
 5.011
 N
 O
HIS F:74 F:125 80.0 0.41 65.9 18.0 NA NA NA
HIS I:74 I:125 81.0 0.415 64.9 14.4 NA NA NA
HIS L:74 L:125 78.0 0.4 66.8 16.0 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 77.0 0.395 71.1 9.2 77.0 0.395 0.0 HOH
 5.076
 O
 O
HIS F:74 F:125 78.0 0.4 67.0 12.9 NA NA NA
HIS I:74 I:125 81.0 0.415 64.4 14.4 NA NA NA
HIS L:74 L:125 82.0 0.421 66.4 14.3 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 70.0 0.359 66.5 15.9 70.0 0.359 0.0 HOH
 4.956
 O
 O
HIS F:74 F:125 76.0 0.39 66.9 14.7 NA NA NA
HIS I:74 I:125 82.0 0.421 70.7 13.8 NA NA NA
HIS L:74 L:125 80.0 0.41 66.0 13.8 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 78.0 0.4 65.2 12.0 78.0 0.4 0.0 HOH
 4.773
 O
 O
HIS F:74 F:125 79.0 0.405 66.6 14.5 NA NA NA
HIS I:74 I:125 80.0 0.41 65.8 15.8 NA NA NA
HIS L:74 L:125 79.0 0.405 65.2 14.5 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:74 C:125 69.0 0.354 67.7 11.9 69.0 0.354 0.0 HOH
 4.773
 O
 O
HIS F:74 F:125 73.0 0.374 66.8 14.5 NA NA NA
HIS I:74 I:125 82.0 0.421 67.2 14.1 NA NA NA
HIS L:74 L:125 79.0 0.405 69.1 15.9 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
 2016-11-09 HIS C:74 C:125 80.0 0.41 66.6 9.2 80.0 0.41 0.0 HOH
 5.074
 O
 O
HIS F:74 F:125 77.0 0.395 72.5 13.2 NA NA NA
HIS I:74 I:125 83.0 0.426 65.3 13.9 NA NA NA
HIS L:74 L:125 83.0 0.426 68.8 12.1 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 73.0 0.374 64.1 16.7 73.0 0.374 0.0 HOH
 4.554
 O
 O
HIS F:74 F:125 75.0 0.385 67.7 13.9 NA NA NA
HIS I:74 I:125 78.0 0.4 64.8 13.2 NA NA NA
HIS L:74 L:125 79.0 0.405 66.3 16.5 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 75.0 0.385 66.5 12.5 75.0 0.385 0.0 HOH
 4.506
 O
 O
HIS F:74 F:125 77.0 0.395 70.9 13.6 NA NA NA
HIS I:74 I:125 79.0 0.405 64.0 14.9 NA NA NA
HIS L:74 L:125 78.0 0.4 69.8 14.3 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 75.0 0.385 64.0 13.4 75.0 0.385 0.0 HOH
 4.624
 O
 O
HIS F:74 F:125 76.0 0.39 72.4 14.2 NA NA NA
HIS I:74 I:125 81.0 0.415 66.5 13.6 NA NA NA
HIS L:74 L:125 81.0 0.415 69.1 14.7 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 74.0 0.379 59.5 14.4 74.0 0.379 0.0 HOH
 3.210
 CE1
 O
HIS F:74 F:125 68.0 0.349 64.3 20.3 NA NA NA
HIS I:74 I:125 75.0 0.385 64.5 22.7 NA NA NA
HIS L:74 L:125 80.0 0.41 65.3 19.0 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 79.0 0.405 65.5 8.5 79.0 0.405 0.0 HOH
 6.105
 N
 O
HIS F:74 F:125 78.0 0.4 70.3 17.4 NA NA NA
HIS I:74 I:125 78.0 0.4 62.3 17.7 NA NA NA
HIS L:74 L:125 82.0 0.421 68.2 14.9 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 73.0 0.374 67.6 11.5 73.0 0.374 0.0 HOH
 4.761
 O
 O
HIS F:74 F:125 75.0 0.385 66.0 13.5 NA NA NA
HIS I:74 I:125 81.0 0.415 66.0 15.4 NA NA NA
HIS L:74 L:125 81.0 0.415 66.8 13.4 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 75.0 0.385 69.6 11.9 75.0 0.385 0.0 HOH
 4.432
 NE2
 O
HIS F:74 F:125 80.0 0.41 67.6 11.0 NA NA NA
HIS I:74 I:125 84.0 0.431 67.5 13.3 NA NA NA
HIS L:74 L:125 81.0 0.415 67.4 13.2 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:74 C:125 75.0 0.385 64.9 14.1 75.0 0.385 0.0 HOH
 5.094
 O
 O
HIS F:74 F:125 77.0 0.395 66.6 11.6 NA NA NA
HIS I:74 I:125 82.0 0.421 65.4 13.8 NA NA NA
HIS L:74 L:125 80.0 0.41 66.3 13.8 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
 2017-03-08 HIS D:74 D:125 96.0 0.492 72.5 11.1 96.0 0.492 0.0 HOH
 2.930
 CD2
 O
HIS H:74 H:125 92.0 0.472 72.1 11.6 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
 2018-08-01 HIS A:74 V:125 69.0 0.354 62.9 19.5 69.0 0.354 0.0 HOH
 2.884
 O
 O
6gfy 3 P40337 99.38 4e-117 X-RAY
 2018-07-11 HIS C:74 C:125 80.0 0.41 66.5 12.7 80.0 0.41 0.0 HOH
 6.081
 N
 O
HIS F:74 F:125 83.0 0.426 75.2 10.1 NA NA NA
HIS I:74 I:125 77.0 0.395 69.9 14.7 NA NA NA
HIS L:74 L:125 82.0 0.421 67.4 13.3 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
 2018-07-11 HIS C:74 C:125 75.0 0.385 63.5 15.5 75.0 0.385 0.0 HOH
 4.675
 O
 O
HIS F:74 F:125 75.0 0.385 63.8 14.3 NA NA NA
HIS I:74 I:125 79.0 0.405 60.2 14.8 NA NA NA
HIS L:74 L:125 81.0 0.415 67.0 13.9 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS C:74 C:125 72.0 0.369 65.0 20.8 72.0 0.369 0.0 ACT
HOH
 9.712
2.798
 N
O
 O
O
HIS F:74 F:125 76.0 0.39 66.3 19.0 NA NA NA
HIS L:74 L:125 80.0 0.41 64.8 20.2 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS I:74 I:125 80.0 0.41 63.6 19.4 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
 2018-08-22 HIS C:74 C:125 81.0 0.415 67.4 11.2 81.0 0.415 0.0 HOH
 6.303
 N
 O
HIS F:74 F:125 83.0 0.426 67.6 6.9 NA NA NA
HIS I:74 I:125 80.0 0.41 72.4 9.9 NA NA NA
HIS L:74 L:125 79.0 0.405 67.7 10.9 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS C:74 C:125 74.0 0.379 67.7 15.3 74.0 0.379 0.0 HOH
 5.795
 O
 O
HIS F:74 F:125 82.0 0.421 67.5 16.7 NA NA NA
HIS I:74 I:125 78.0 0.4 64.2 15.6 NA NA NA
HIS L:74 L:125 78.0 0.4 64.9 14.7 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
 2019-06-12 HIS B:74 B:125 73.0 0.374 67.8 24.6 73.0 0.374 0.0 EDO
HOH
 7.803
2.959
 N
NE2
 O1
O
HIS F:74 F:125 73.0 0.374 68.1 24.4 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
 2019-06-12 HIS B:74 B:125 75.0 0.385 67.6 19.6 75.0 0.385 0.0 EDO
EDO
HOH
 9.232
3.746
3.434
 N
CE1
NE2
 C1
C1
O
HIS F:74 F:125 73.0 0.374 67.7 19.9 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
 2019-12-04 HIS D:74 D:125 76.0 0.39 59.4 35.9 76.0 0.39 0.0
HIS H:74 H:125 76.0 0.39 59.2 36.2 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
 2021-10-06 HIS D:74 L:125 82.0 0.421 62.8 15.0 82.0 0.421 0.0 NA
HOH
 6.909
2.209
 N
ND1
 NA
O
7jtp 3 P40337 99.38 4e-117 X-RAY
 2021-10-06 HIS C:74 L:125 72.0 0.369 67.3 18.5 72.0 0.369 0.0 HOH
 4.918
 O
 O
3zrc 3 P40337 98.77 4e-117 X-RAY
 2012-03-07 HIS C:75 C:125 86.0 0.441 20.1 16.5 86.0 0.441 0.0
HIS F:75 F:125 90.0 0.462 72.5 3.6 NA NA NA
HIS I:75 I:125 83.0 0.426 62.5 -2.0 NA NA NA
HIS L:75 L:125 81.0 0.415 84.0 2.1 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
 2012-03-07 HIS C:75 C:125 75.0 0.385 53.8 18.5 75.0 0.385 0.0 HOH
 6.102
 O
 O
HIS F:75 F:125 87.0 0.446 68.2 11.0 NA NA NA
HIS I:75 I:125 82.0 0.421 74.1 3.8 NA NA NA
HIS L:75 L:125 73.0 0.374 71.7 7.1 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
 2012-07-25 HIS C:75 C:125 69.0 0.354 56.2 25.8 69.0 0.354 0.0
HIS F:75 F:125 87.0 0.446 71.8 10.7 NA NA NA
HIS I:75 I:125 79.0 0.405 67.3 13.9 NA NA NA
HIS L:75 L:125 81.0 0.415 67.2 11.3 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
 2012-07-25 HIS C:75 C:125 75.0 0.385 59.6 14.7 75.0 0.385 0.0 HOH
 4.774
 NE2
 O
HIS F:75 F:125 76.0 0.39 70.1 14.5 NA NA NA
HIS I:75 I:125 77.0 0.395 70.0 7.4 NA NA NA
HIS L:75 L:125 79.0 0.405 77.2 11.6 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
 2012-11-14 HIS D:75 V:125 68.0 0.349 55.6 24.9 68.0 0.349 0.0 GOL
HOH
 9.501
2.775
 N
CD2
 O1
O
4awj 3 P40337 98.77 4e-117 X-RAY
 2012-11-14 HIS C:75 C:125 69.0 0.354 61.3 22.8 69.0 0.354 0.0 HOH
 6.249
 N
 O
HIS F:75 F:125 77.0 0.395 64.0 21.2 NA NA NA
HIS I:75 I:125 79.0 0.405 63.8 21.8 NA NA NA
HIS L:75 L:125 81.0 0.415 64.6 22.6 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
 2018-08-08 HIS D:75 V:125 73.0 0.374 64.0 19.3 73.0 0.374 0.0 F4K
GOL
HOH
 6.460
9.528
2.877
 O
N
ND1
 C05
O1
O
1lm8 3 P40337 100.0 6e-117 X-RAY
 2002-06-12 HIS C:72 V:125 68.0 0.349 69.2 20.1 68.0 0.349 0.0 HOH
 2.759
 CD2
 O
1vcb 3 P40337 100.0 6e-117 X-RAY
 1999-04-21 HIS C:72 C:125 79.0 0.405 59.6 18.9 79.0 0.405 0.0 HOH
 2.786
 ND1
 O
HIS F:72 F:125 81.0 0.415 63.2 15.9 NA NA NA
HIS I:72 I:125 84.0 0.431 61.5 16.1 NA NA NA
HIS L:72 L:125 81.0 0.415 62.2 16.0 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
 2017-06-07 HIS B:72 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
 2018-07-11 HIS C:72 C:125 69.0 0.354 62.6 18.6 69.0 0.354 0.0 HOH
 2.756
 ND1
 O
6i7q 4 P40337 100.0 6e-117 X-RAY
 2019-11-27 HIS D:72 V:125 89.0 0.456 60.6 14.9 89.0 0.456 0.0 GOL
HOH
 6.991
2.253
 H
HB3
 HO3
O
6i7r 4 P40337 100.0 6e-117 X-RAY
 2019-11-27 HIS D:72 V:125 71.0 0.364 64.5 19.7 71.0 0.364 0.0 FMT
HOH
 9.361
2.834
 H
ND1
 H
O
6r7f 9 P40337 100.0 6e-117 EM
 2019-08-28 HIS I:72 V:125 95.0 0.487 69.1 23.0 95.0 0.487 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
 2021-02-24 HIS C:87 C:125 69.0 0.354 68.4 23.5 62.0 0.318 0.036 D:O60885:0.036
 HOH
 2.751
 ND1
 O
7cjb 1 P40337 100.0 8e-116 X-RAY
 2021-07-14 HIS A:75 A:125 80.0 0.41 65.9 18.8 80.0 0.41 0.0
HIS E:75 E:125 82.0 0.421 65.8 18.4 NA NA NA
HIS I:75 I:125 76.0 0.39 65.5 18.7 NA NA NA
HIS M:75 M:125 79.0 0.405 65.1 18.8 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
 2020-08-05 HIS A:67 AAA:125 89.0 0.456 72.0 12.2 89.0 0.456 0.0 GOL
GOL
GOL
IOD
HOH
 9.259
6.851
6.315
3.725
2.866
 N
O
N
ND1
ND1
 O3
C3
O3
I
O
7pi4 1 P40337 100.0 4e-113 X-RAY
 2021-09-29 HIS A:67 AAA:125 74.0 0.379 74.6 11.7 74.0 0.379 0.0 EDO
HOH
 9.251
3.779
 N
CD2
 C1
O
6fmi 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:74 C:125 82.0 0.421 68.7 18.3 82.0 0.421 0.0 HOH
 5.828
 O
 O
HIS F:74 F:125 81.0 0.415 61.2 21.4 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:74 C:125 70.0 0.359 64.3 19.0 70.0 0.359 0.0 HOH
 3.433
 CE1
 O
HIS F:74 F:125 73.0 0.374 66.0 18.1 NA NA NA
HIS I:74 I:125 81.0 0.415 62.5 20.6 NA NA NA
HIS L:74 L:125 81.0 0.415 64.9 17.4 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:74 C:125 73.0 0.374 60.6 21.1 73.0 0.374 0.0 HOH
 5.072
 N
 O
HIS F:74 F:125 68.0 0.349 67.2 20.9 NA NA NA
HIS I:74 I:125 77.0 0.395 65.2 22.0 NA NA NA
HIS L:74 L:125 77.0 0.395 71.8 19.1 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
 2019-06-12 HIS B:65 B:125 73.0 0.374 67.0 20.2 73.0 0.374 0.0 HOH
 2.645
 HE2
 O
HIS F:65 F:125 73.0 0.374 66.9 21.3 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
 2019-08-28 HIS L:66 V:125 52.0 0.267 64.8 28.0 52.0 0.267 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 HIS A:125 A:125 81.0 0.415 60.6 13.9