Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10188240 . T A CCDS2597.1:NM_000551.3:c.383cTt>cAt_NP_000542.1:p.128L>H Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 LEU A:148 A:128 8.0 0.047 -132.0 164.0 8.0 0.047 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 LEU C:112 C:128 5.0 0.029 -113.8 166.5 5.0 0.029 0.0 HOH
7.810
O
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 LEU C:86 C:128 2.0 0.012 -121.0 162.6 2.0 0.012 0.0 HOH
2.783
O
O
LEU F:86 F:128 6.0 0.035 -122.6 163.0 NA NA NA
LEU I:86 I:128 1.0 0.006 -124.5 162.7 NA NA NA
LEU L:86 L:128 0.0 0.0 -123.1 164.0 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 LEU C:77 C:128 2.0 0.012 -133.3 166.3 2.0 0.012 0.0 HOH
2.668
O
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 LEU C:77 C:128 3.0 0.018 E -139.0 161.1 3.0 0.018 0.0 HOH
9.940
CD2
O
LEU F:77 F:128 5.0 0.029 -138.2 143.0 NA NA NA
LEU I:77 I:128 1.0 0.006 -131.1 164.6 NA NA NA
LEU L:77 L:128 1.0 0.006 -135.2 157.7 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 LEU C:77 C:128 4.0 0.024 -125.2 162.1 4.0 0.024 0.0 HOH
3.198
O
O
LEU F:77 F:128 0.0 0.0 -124.4 161.7 NA NA NA
LEU I:77 I:128 0.0 0.0 -124.6 161.6 NA NA NA
LEU L:77 L:128 3.0 0.018 -124.1 161.9 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:77 C:128 2.0 0.012 -122.8 164.3 2.0 0.012 0.0 ACT
HOH
9.036
2.847
CD2
O
CH3
O
LEU F:77 F:128 5.0 0.029 -122.5 164.1 NA NA NA
LEU I:77 I:128 1.0 0.006 -123.0 164.6 NA NA NA
LEU L:77 L:128 5.0 0.029 -123.7 165.7 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:77 C:128 0.0 0.0 -123.7 165.8 0.0 0.0 0.0 HOH
2.913
O
O
LEU F:77 F:128 4.0 0.024 -124.1 165.0 NA NA NA
LEU I:77 I:128 0.0 0.0 -123.8 165.2 NA NA NA
LEU L:77 L:128 0.0 0.0 -123.1 166.0 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 5.0 0.029 -131.0 158.9 5.0 0.029 0.0 HOH
2.900
O
O
LEU F:77 F:128 3.0 0.018 -129.7 161.4 NA NA NA
LEU I:77 I:128 4.0 0.024 -124.5 163.3 NA NA NA
LEU L:77 L:128 2.0 0.012 -126.4 162.3 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 4.0 0.024 -120.9 160.9 4.0 0.024 0.0 HOH
2.800
O
O
LEU F:77 F:128 4.0 0.024 -120.4 164.4 NA NA NA
LEU I:77 I:128 4.0 0.024 -122.6 163.7 NA NA NA
LEU L:77 L:128 3.0 0.018 -122.3 163.3 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 3.0 0.018 -123.1 164.7 3.0 0.018 0.0 HOH
2.875
O
O
LEU F:77 F:128 9.0 0.053 -135.4 158.1 NA NA NA
LEU I:77 I:128 3.0 0.018 -128.9 159.5 NA NA NA
LEU L:77 L:128 2.0 0.012 -129.6 161.5 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 2.0 0.012 -122.8 166.2 2.0 0.012 0.0 HOH
2.844
O
O
LEU F:77 F:128 3.0 0.018 -123.7 166.0 NA NA NA
LEU I:77 I:128 4.0 0.024 -121.4 164.6 NA NA NA
LEU L:77 L:128 7.0 0.041 -125.2 164.0 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 4.0 0.024 -120.5 161.3 4.0 0.024 0.0 HOH
2.858
O
O
LEU F:77 F:128 5.0 0.029 -128.2 157.7 NA NA NA
LEU I:77 I:128 3.0 0.018 -124.1 151.8 NA NA NA
LEU L:77 L:128 5.0 0.029 -125.9 160.1 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 8.0 0.047 -116.0 162.3 8.0 0.047 0.0 HOH
2.886
O
O
LEU F:77 F:128 7.0 0.041 -121.5 164.9 NA NA NA
LEU I:77 I:128 3.0 0.018 -125.3 162.5 NA NA NA
LEU L:77 L:128 3.0 0.018 -123.2 162.6 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 6.0 0.035 -126.5 162.6 6.0 0.035 0.0 HOH
2.735
O
O
LEU F:77 F:128 8.0 0.047 -126.3 163.5 NA NA NA
LEU I:77 I:128 3.0 0.018 -124.3 163.1 NA NA NA
LEU L:77 L:128 3.0 0.018 -126.0 163.4 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 7.0 0.041 -121.9 160.9 7.0 0.041 0.0 HOH
2.839
O
O
LEU F:77 F:128 8.0 0.047 -122.0 161.8 NA NA NA
LEU I:77 I:128 7.0 0.041 -118.8 165.8 NA NA NA
LEU L:77 L:128 4.0 0.024 -128.1 164.9 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 2.0 0.012 -122.8 162.9 2.0 0.012 0.0 HOH
2.756
O
O
LEU F:77 F:128 3.0 0.018 -125.1 161.3 NA NA NA
LEU I:77 I:128 3.0 0.018 -124.1 162.7 NA NA NA
LEU L:77 L:128 3.0 0.018 -124.9 165.1 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:77 C:128 2.0 0.012 -122.5 159.5 2.0 0.012 0.0 HOH
2.924
O
O
LEU F:77 F:128 2.0 0.012 -125.3 159.4 NA NA NA
LEU I:77 I:128 3.0 0.018 -120.7 167.1 NA NA NA
LEU L:77 L:128 4.0 0.024 -127.9 164.3 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 LEU C:77 C:128 7.0 0.041 -126.1 162.2 7.0 0.041 0.0 HOH
2.884
O
O
LEU F:77 F:128 8.0 0.047 -122.8 166.4 NA NA NA
LEU I:77 I:128 5.0 0.029 -123.9 165.2 NA NA NA
LEU L:77 L:128 5.0 0.029 -121.2 169.3 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 4.0 0.024 -127.2 162.2 4.0 0.024 0.0 HOH
2.805
O
O
LEU F:77 F:128 6.0 0.035 -126.6 164.4 NA NA NA
LEU I:77 I:128 4.0 0.024 -124.9 162.4 NA NA NA
LEU L:77 L:128 4.0 0.024 -127.1 164.4 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 6.0 0.035 -125.1 158.8 6.0 0.035 0.0 HOH
2.910
O
O
LEU F:77 F:128 9.0 0.053 -125.7 162.6 NA NA NA
LEU I:77 I:128 4.0 0.024 -128.9 163.5 NA NA NA
LEU L:77 L:128 4.0 0.024 -124.5 163.6 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 6.0 0.035 -121.5 161.2 6.0 0.035 0.0 HOH
2.872
O
O
LEU F:77 F:128 6.0 0.035 -125.2 164.8 NA NA NA
LEU I:77 I:128 4.0 0.024 -127.2 163.5 NA NA NA
LEU L:77 L:128 4.0 0.024 -127.4 162.8 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 1.0 0.006 -114.0 164.2 1.0 0.006 0.0 HOH
2.850
O
O
LEU F:77 F:128 2.0 0.012 E -126.8 142.5 NA NA NA
LEU I:77 I:128 4.0 0.024 -118.8 153.0 NA NA NA
LEU L:77 L:128 4.0 0.024 -113.4 167.7 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 4.0 0.024 -119.1 165.6 4.0 0.024 0.0 HOH
2.957
O
O
LEU F:77 F:128 7.0 0.041 -134.6 155.8 NA NA NA
LEU I:77 I:128 4.0 0.024 -117.9 160.3 NA NA NA
LEU L:77 L:128 5.0 0.029 -122.4 166.9 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 9.0 0.053 -125.1 162.1 9.0 0.053 0.0 HOH
2.934
O
O
LEU F:77 F:128 11.0 0.065 -125.6 160.0 NA NA NA
LEU I:77 I:128 6.0 0.035 -125.3 167.1 NA NA NA
LEU L:77 L:128 5.0 0.029 -127.2 166.9 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 7.0 0.041 -125.7 162.4 7.0 0.041 0.0 HOH
2.807
O
O
LEU F:77 F:128 9.0 0.053 -123.3 165.4 NA NA NA
LEU I:77 I:128 8.0 0.047 -124.9 166.2 NA NA NA
LEU L:77 L:128 5.0 0.029 -126.8 165.1 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:77 C:128 7.0 0.041 -125.9 160.1 7.0 0.041 0.0 HOH
2.775
O
O
LEU F:77 F:128 8.0 0.047 -127.0 162.4 NA NA NA
LEU I:77 I:128 6.0 0.035 -128.7 164.5 NA NA NA
LEU L:77 L:128 5.0 0.029 -127.4 164.9 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 LEU D:77 D:128 10.0 0.059 -127.8 169.0 10.0 0.059 0.0 HOH
3.008
O
O
LEU H:77 H:128 10.0 0.059 -127.8 168.0 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 LEU A:77 V:128 2.0 0.012 -122.3 163.2 2.0 0.012 0.0 HOH
2.645
O
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:77 C:128 4.0 0.024 -120.0 166.3 4.0 0.024 0.0 HOH
2.981
O
O
LEU F:77 F:128 7.0 0.041 -116.3 161.5 NA NA NA
LEU I:77 I:128 4.0 0.024 -122.6 162.2 NA NA NA
LEU L:77 L:128 4.0 0.024 -122.8 166.9 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:77 C:128 2.0 0.012 -125.5 164.2 2.0 0.012 0.0 HOH
2.908
O
O
LEU F:77 F:128 8.0 0.047 -123.0 169.0 NA NA NA
LEU I:77 I:128 5.0 0.029 -126.9 168.2 NA NA NA
LEU L:77 L:128 9.0 0.053 -124.7 165.9 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:77 C:128 0.0 0.0 -125.3 161.9 0.0 0.0 0.0 ACT
HOH
9.119
2.811
CD2
O
CH3
O
LEU F:77 F:128 1.0 0.006 -123.7 162.7 NA NA NA
LEU L:77 L:128 2.0 0.012 -125.2 162.3 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU I:77 I:128 4.0 0.024 -124.7 162.5 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 LEU C:77 C:128 3.0 0.018 -124.1 161.0 3.0 0.018 0.0 HOH
5.666
N
O
LEU F:77 F:128 0.0 0.0 E -127.5 155.5 NA NA NA
LEU I:77 I:128 6.0 0.035 -121.8 159.9 NA NA NA
LEU L:77 L:128 8.0 0.047 -124.2 158.3 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:77 C:128 1.0 0.006 -125.9 162.2 1.0 0.006 0.0 HOH
2.773
O
O
LEU F:77 F:128 2.0 0.012 -125.4 160.5 NA NA NA
LEU I:77 I:128 3.0 0.018 -123.9 161.0 NA NA NA
LEU L:77 L:128 7.0 0.041 -127.4 161.5 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:77 B:128 8.0 0.047 -122.7 165.8 8.0 0.047 0.0 EDO
HOH
9.262
2.844
CD2
O
C1
O
LEU F:77 F:128 8.0 0.047 -121.2 166.0 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:77 B:128 6.0 0.035 -121.1 165.3 6.0 0.035 0.0 EDO
HOH
9.272
2.741
CD2
O
C2
O
LEU F:77 F:128 7.0 0.041 -122.1 165.1 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 LEU D:77 D:128 9.0 0.053 -119.2 172.6 9.0 0.053 0.0
LEU H:77 H:128 9.0 0.053 -119.1 172.8 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU D:77 L:128 5.0 0.029 -124.9 169.3 5.0 0.029 0.0 NA
HOH
8.833
2.891
CD2
O
NA
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU C:77 L:128 6.0 0.035 -132.2 163.8 6.0 0.035 0.0 HOH
2.856
O
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:78 C:128 6.0 0.035 -101.8 168.4 6.0 0.035 0.0
LEU F:78 F:128 4.0 0.024 -132.9 147.6 NA NA NA
LEU I:78 I:128 0.0 0.0 -103.7 174.2 NA NA NA
LEU L:78 L:128 1.0 0.006 -113.6 167.4 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:78 C:128 3.0 0.018 -137.8 155.0 3.0 0.018 0.0 HOH
8.969
N
O
LEU F:78 F:128 3.0 0.018 -146.2 148.8 NA NA NA
LEU I:78 I:128 0.0 0.0 -129.9 145.4 NA NA NA
LEU L:78 L:128 2.0 0.012 -128.4 170.5 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:78 C:128 6.0 0.035 -131.8 166.2 6.0 0.035 0.0 HOH
9.751
CD2
O
LEU F:78 F:128 5.0 0.029 -137.7 150.6 NA NA NA
LEU I:78 I:128 1.0 0.006 -116.3 161.2 NA NA NA
LEU L:78 L:128 0.0 0.0 -128.4 160.5 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:78 C:128 3.0 0.018 -132.8 163.6 3.0 0.018 0.0 HOH
2.927
O
O
LEU F:78 F:128 2.0 0.012 -129.6 154.6 NA NA NA
LEU I:78 I:128 1.0 0.006 -129.6 159.9 NA NA NA
LEU L:78 L:128 1.0 0.006 -123.3 161.5 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU D:78 V:128 1.0 0.006 -127.4 167.4 1.0 0.006 0.0 GOL
HOH
8.798
2.664
CD2
O
O1
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU C:78 C:128 0.0 0.0 -123.2 162.4 0.0 0.0 0.0 ACT
HOH
9.344
5.548
CD2
N
CH3
O
LEU F:78 F:128 4.0 0.024 -135.9 156.4 NA NA NA
LEU I:78 I:128 1.0 0.006 -127.5 156.6 NA NA NA
LEU L:78 L:128 2.0 0.012 -127.3 158.3 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 LEU D:78 V:128 9.0 0.053 -124.3 167.7 9.0 0.053 0.0 F4K
GOL
HOH
3.311
9.256
2.721
O
CD2
O
C10
O2
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 LEU C:75 V:128 1.0 0.006 -132.6 163.6 1.0 0.006 0.0 HOH
2.883
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 LEU C:75 C:128 1.0 0.006 -132.4 164.4 1.0 0.006 0.0 HOH
2.904
O
O
LEU F:75 F:128 1.0 0.006 -132.4 162.4 NA NA NA
LEU I:75 I:128 1.0 0.006 -133.8 162.9 NA NA NA
LEU L:75 L:128 1.0 0.006 -132.4 163.5 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 LEU B:75 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 LEU C:75 C:128 4.0 0.024 -126.8 161.4 4.0 0.024 0.0 HOH
2.740
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:75 V:128 8.0 0.047 -120.1 167.2 8.0 0.047 0.0 GOL
HOH
7.276
2.767
HD21
O
H32
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:75 V:128 7.0 0.041 -124.7 169.9 7.0 0.041 0.0 FMT
HOH
9.203
2.700
HD21
O
O2
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 LEU I:75 V:128 8.0 0.047 -133.4 163.0 8.0 0.047 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 LEU C:90 C:128 1.0 0.006 -117.8 168.1 1.0 0.006 0.0 HOH
2.704
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 LEU A:78 A:128 0.0 0.0 -119.1 159.6 0.0 0.0 0.0
LEU E:78 E:128 1.0 0.006 -119.6 159.6 NA NA NA
LEU I:78 I:128 0.0 0.0 -120.2 162.5 NA NA NA
LEU M:78 M:128 0.0 0.0 -119.7 160.5 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 LEU A:70 AAA:128 6.0 0.035 -119.4 166.4 6.0 0.035 0.0 GOL
GOL
GOL
IOD
IOD
GOL
HOH
8.808
4.755
7.148
9.384
9.185
8.369
2.828
CD2
O
CD1
N
N
C
O
O3
O1
O2
I
I
O1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 LEU A:70 AAA:128 5.0 0.029 -122.5 155.9 5.0 0.029 0.0 EDO
EDO
HOH
9.004
8.793
2.973
CD2
C
O
O1
C2
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:77 C:128 7.0 0.041 -125.8 160.6 7.0 0.041 0.0 HOH
7.490
N
O
LEU F:77 F:128 2.0 0.012 -113.1 166.1 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:77 C:128 2.0 0.012 -125.9 159.9 2.0 0.012 0.0 HOH
2.897
O
O
LEU F:77 F:128 8.0 0.047 -125.6 160.3 NA NA NA
LEU I:77 I:128 3.0 0.018 -127.8 161.5 NA NA NA
LEU L:77 L:128 4.0 0.024 -129.1 164.7 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:77 C:128 1.0 0.006 -123.0 159.0 1.0 0.006 0.0 HOH
2.905
O
O
LEU F:77 F:128 3.0 0.018 -115.5 152.5 NA NA NA
LEU I:77 I:128 3.0 0.018 -127.8 160.2 NA NA NA
LEU L:77 L:128 6.0 0.035 -119.6 173.0 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 LEU B:68 B:128 7.0 0.041 -123.1 166.1 7.0 0.041 0.0 HOH
2.749
O
O
LEU F:68 F:128 9.0 0.053 -118.7 170.2 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 LEU L:69 V:128 5.0 0.029 -115.9 142.4 5.0 0.029 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 LEU A:128 A:128 5.0 0.029 E -106.5 154.2