Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10188257 . G A CCDS2597.1:NM_000551.3:c.400Gaa>Aaa_NP_000542.1:p.134E>K Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 GLU A:154 A:134 76.0 0.4 S -78.5 -42.0 76.0 0.4 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 GLU C:118 C:134 98.0 0.516 S -98.8 -25.8 98.0 0.516 0.0 HOH
4.615
N
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 GLU C:92 C:134 113.0 0.595 S -81.0 -38.6 113.0 0.595 0.0 HOH
2.700
O
O
GLU F:92 F:134 64.0 0.337 S -79.9 -38.3 NA NA NA
GLU I:92 I:134 64.0 0.337 S -80.4 -37.3 NA NA NA
GLU L:92 L:134 39.0 0.205 S -80.1 -38.4 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 GLU C:83 C:134 77.0 0.405 S -75.2 -40.1 77.0 0.405 0.0 HOH
2.919
O
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 GLU C:83 C:134 68.0 0.358 S -96.0 -28.0 68.0 0.358 0.0
GLU F:83 F:134 51.0 0.268 S -104.0 -31.9 NA NA NA
GLU I:83 I:134 66.0 0.347 S -90.4 -26.6 NA NA NA
GLU L:83 L:134 75.0 0.395 S -93.4 -31.5 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 GLU C:83 C:134 55.0 NA S -78.8 -44.7 55.0 NA NA HOH
2.748
O
O
GLU F:83 F:134 58.0 0.305 S -78.6 -45.3 NA NA NA
GLU I:83 I:134 73.0 0.384 S -78.3 -47.1 NA NA NA
GLU L:83 L:134 60.0 0.316 S -70.5 -45.5 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:83 C:134 87.0 0.458 S -78.3 -39.2 87.0 0.458 0.0 HOH
2.518
O
O
GLU F:83 F:134 42.0 NA S -76.6 -38.4 NA NA NA
GLU I:83 I:134 51.0 0.268 S -78.9 -39.0 NA NA NA
GLU L:83 L:134 52.0 0.274 S -80.5 -38.8 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:83 C:134 93.0 0.489 S -80.5 -40.2 93.0 0.489 0.0 HOH
2.703
O
O
GLU F:83 F:134 63.0 0.332 S -80.2 -40.2 NA NA NA
GLU I:83 I:134 51.0 0.268 S -80.0 -41.4 NA NA NA
GLU L:83 L:134 48.0 0.253 S -81.6 -40.3 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 118.0 0.621 S -70.4 -51.4 118.0 0.621 0.0 HOH
2.629
O
O
GLU F:83 F:134 59.0 0.311 S -73.6 -48.4 NA NA NA
GLU I:83 I:134 64.0 0.337 S -78.9 -46.3 NA NA NA
GLU L:83 L:134 48.0 0.253 S -75.2 -46.4 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 115.0 0.605 S -78.1 -36.7 115.0 0.605 0.0 HOH
2.639
O
O
GLU F:83 F:134 76.0 0.4 S -75.7 -41.2 NA NA NA
GLU I:83 I:134 73.0 0.384 S -81.1 -46.0 NA NA NA
GLU L:83 L:134 58.0 0.305 S -76.3 -44.1 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 100.0 0.526 S -71.4 -44.0 100.0 0.526 0.0 HOH
2.801
O
O
GLU F:83 F:134 60.0 0.316 S -77.1 -40.1 NA NA NA
GLU I:83 I:134 55.0 0.289 S -74.4 -46.2 NA NA NA
GLU L:83 L:134 44.0 0.232 S -73.8 -45.7 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 90.0 0.474 S -84.7 -39.0 90.0 0.474 0.0 HOH
2.722
O
O
GLU F:83 F:134 40.0 0.211 S -83.9 -41.5 NA NA NA
GLU I:83 I:134 28.0 NA S -85.0 -40.7 NA NA NA
GLU L:83 L:134 61.0 0.321 S -85.5 -36.7 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 102.0 0.537 S -71.8 -50.7 102.0 0.537 0.0 HOH
2.693
O
O
GLU F:83 F:134 67.0 0.353 S -75.7 -46.4 NA NA NA
GLU I:83 I:134 66.0 0.347 S -76.2 -43.1 NA NA NA
GLU L:83 L:134 63.0 0.332 S -72.5 -50.0 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 68.0 0.358 S -80.7 -39.7 68.0 0.358 0.0 HOH
2.657
O
O
GLU F:83 F:134 64.0 0.337 S -81.8 -45.4 NA NA NA
GLU I:83 I:134 65.0 0.342 S -81.9 -45.2 NA NA NA
GLU L:83 L:134 51.0 0.268 S -78.6 -46.0 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 70.0 0.368 S -78.0 -48.1 70.0 0.368 0.0 HOH
2.672
O
O
GLU F:83 F:134 71.0 0.374 S -85.3 -41.5 NA NA NA
GLU I:83 I:134 57.0 0.3 S -78.5 -52.6 NA NA NA
GLU L:83 L:134 52.0 0.274 S -78.3 -53.8 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 125.0 0.658 S -73.5 -46.0 125.0 0.658 0.0 HOH
2.547
O
O
GLU F:83 F:134 69.0 0.363 S -81.9 -39.6 NA NA NA
GLU I:83 I:134 71.0 0.374 S -81.0 -48.8 NA NA NA
GLU L:83 L:134 57.0 0.3 S -80.3 -48.4 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 99.0 0.521 S -81.7 -44.3 99.0 0.521 0.0 HOH
2.627
O
O
GLU F:83 F:134 68.0 0.358 S -79.1 -43.5 NA NA NA
GLU I:83 I:134 56.0 0.295 S -81.1 -41.3 NA NA NA
GLU L:83 L:134 54.0 0.284 S -79.3 -47.9 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:83 C:134 87.0 0.458 S -78.0 -42.2 87.0 0.458 0.0 HOH
2.567
O
O
GLU F:83 F:134 69.0 0.363 S -79.6 -41.9 NA NA NA
GLU I:83 I:134 54.0 0.284 S -78.8 -44.3 NA NA NA
GLU L:83 L:134 57.0 0.3 S -81.6 -48.1 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 GLU C:83 C:134 114.0 0.6 S -78.4 -41.7 114.0 0.6 0.0 HOH
2.805
O
O
GLU F:83 F:134 63.0 0.332 S -79.5 -48.7 NA NA NA
GLU I:83 I:134 63.0 0.332 S -84.6 -51.4 NA NA NA
GLU L:83 L:134 65.0 0.342 S -82.0 -51.3 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 110.0 0.579 S -76.4 -47.5 110.0 0.579 0.0 HOH
2.702
O
O
GLU F:83 F:134 67.0 0.353 S -78.5 -51.0 NA NA NA
GLU I:83 I:134 60.0 0.316 S -80.3 -46.1 NA NA NA
GLU L:83 L:134 58.0 0.305 S -79.0 -48.6 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 112.0 0.589 S -75.4 -44.3 112.0 0.589 0.0 HOH
2.725
O
O
GLU F:83 F:134 69.0 0.363 S -75.4 -48.6 NA NA NA
GLU I:83 I:134 58.0 0.305 S -78.4 -45.9 NA NA NA
GLU L:83 L:134 59.0 0.311 S -77.5 -47.3 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 115.0 0.605 S -78.5 -47.1 115.0 0.605 0.0 HOH
2.653
O
O
GLU F:83 F:134 68.0 0.358 S -78.3 -50.2 NA NA NA
GLU I:83 I:134 60.0 0.316 S -78.6 -48.5 NA NA NA
GLU L:83 L:134 58.0 0.305 S -80.1 -47.3 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 57.0 0.3 S -67.2 -52.9 57.0 0.3 0.0 HOH
2.918
O
O
GLU F:83 F:134 38.0 0.2 S -74.1 -57.5 NA NA NA
GLU I:83 I:134 69.0 0.363 S -74.1 -52.3 NA NA NA
GLU L:83 L:134 63.0 0.332 S -71.4 -55.5 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 82.0 0.432 S -78.3 -45.8 82.0 0.432 0.0 HOH
2.817
O
O
GLU F:83 F:134 58.0 0.305 S -86.7 -36.4 NA NA NA
GLU I:83 I:134 67.0 0.353 S -76.8 -49.7 NA NA NA
GLU L:83 L:134 65.0 0.342 S -79.7 -45.7 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 122.0 0.642 S -82.1 -46.1 122.0 0.642 0.0 HOH
2.763
O
O
GLU F:83 F:134 72.0 0.379 S -89.8 -41.9 NA NA NA
GLU I:83 I:134 62.0 0.326 S -83.2 -43.9 NA NA NA
GLU L:83 L:134 65.0 0.342 S -83.7 -46.8 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 93.0 0.489 S -79.0 -41.7 93.0 0.489 0.0 HOH
2.711
O
O
GLU F:83 F:134 71.0 0.374 S -83.8 -42.9 NA NA NA
GLU I:83 I:134 69.0 0.363 S -81.5 -47.2 NA NA NA
GLU L:83 L:134 70.0 0.368 S -81.4 -46.8 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:83 C:134 87.0 0.458 S -79.7 -42.5 87.0 0.458 0.0 HOH
2.768
O
O
GLU F:83 F:134 70.0 0.368 S -81.0 -47.2 NA NA NA
GLU I:83 I:134 64.0 0.337 S -80.7 -50.8 NA NA NA
GLU L:83 L:134 69.0 0.363 S -81.1 -48.2 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 GLU D:83 D:134 62.0 0.326 S -88.6 -42.7 62.0 0.326 0.0 HOH
2.736
O
O
GLU H:83 H:134 64.0 0.337 S -87.3 -42.4 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 GLU A:83 V:134 51.0 0.268 S -83.3 -38.0 51.0 0.268 0.0 HOH
2.501
H
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:83 C:134 83.0 0.437 S -74.3 -52.5 83.0 0.437 0.0 HOH
2.891
O
O
GLU F:83 F:134 58.0 0.305 S -84.9 -45.7 NA NA NA
GLU I:83 I:134 60.0 0.316 S -76.9 -54.8 NA NA NA
GLU L:83 L:134 57.0 0.3 S -85.2 -48.6 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:83 C:134 93.0 0.489 S -85.0 -40.9 93.0 0.489 0.0 HOH
2.681
O
O
GLU F:83 F:134 69.0 0.363 S -83.1 -45.2 NA NA NA
GLU I:83 I:134 62.0 0.326 S -87.2 -47.8 NA NA NA
GLU L:83 L:134 66.0 0.347 S -88.4 -35.9 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:83 C:134 82.0 0.432 S -92.1 -26.0 82.0 0.432 0.0 HOH
2.617
O
O
GLU F:83 F:134 61.0 0.321 S -96.8 -31.7 NA NA NA
GLU L:83 L:134 49.0 0.258 S -89.1 -32.2 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU I:83 I:134 52.0 0.274 S -91.0 -28.4 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 GLU C:83 C:134 123.0 0.647 S -91.2 -29.0 123.0 0.647 0.0 HOH
3.831
N
O
GLU F:83 F:134 103.0 0.542 S -93.0 -21.0 NA NA NA
GLU I:83 I:134 73.0 0.384 S -88.5 -19.9 NA NA NA
GLU L:83 L:134 81.0 0.426 S -87.0 -22.2 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:83 C:134 78.0 0.411 S -96.9 -13.1 78.0 0.411 0.0 HOH
2.921
O
O
GLU F:83 F:134 65.0 0.342 S -96.2 -18.3 NA NA NA
GLU I:83 I:134 67.0 0.353 S -94.3 -19.5 NA NA NA
GLU L:83 L:134 77.0 0.405 S -94.8 -17.6 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:83 B:134 73.0 0.384 S -88.4 -41.1 73.0 0.384 0.0 HOH
2.591
O
O
GLU F:83 F:134 66.0 0.347 S -87.7 -41.4 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:83 B:134 68.0 0.358 S -84.3 -34.3 68.0 0.358 0.0 HOH
2.680
O
O
GLU F:83 F:134 60.0 0.316 S -84.5 -32.6 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 GLU D:83 D:134 67.0 0.353 S -84.0 -48.4 67.0 0.353 0.0
GLU H:83 H:134 67.0 0.353 S -84.1 -48.4 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU D:83 L:134 43.0 0.226 S -83.9 -35.5 43.0 0.226 0.0 HOH
2.630
O
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU C:83 L:134 61.0 0.321 S -83.5 -43.8 61.0 0.321 0.0 HOH
2.238
O
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:84 C:134 62.0 NA S -69.6 -33.1 62.0 NA NA
GLU F:84 F:134 103.0 0.542 S -81.6 -38.2 NA NA NA
GLU I:84 I:134 67.0 0.353 S -83.0 -24.1 NA NA NA
GLU L:84 L:134 71.0 0.374 S -83.4 -17.8 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:84 C:134 38.0 NA S -97.6 -36.6 38.0 NA NA
GLU F:84 F:134 91.0 0.479 S -94.8 -25.7 NA NA NA
GLU I:84 I:134 49.0 0.258 S -91.5 -24.9 NA NA NA
GLU L:84 L:134 71.0 0.374 S -82.9 -22.5 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:84 C:134 57.0 NA S -86.4 -40.1 57.0 NA NA
GLU F:84 F:134 97.0 0.511 S -88.5 -40.6 NA NA NA
GLU I:84 I:134 42.0 0.221 S -97.5 -35.2 NA NA NA
GLU L:84 L:134 49.0 0.258 S -89.7 -34.8 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:84 C:134 35.0 NA S -88.1 -35.9 35.0 NA NA HOH
2.645
O
O
GLU F:84 F:134 66.0 0.347 S -76.4 -41.1 NA NA NA
GLU I:84 I:134 75.0 0.395 S -89.1 -35.3 NA NA NA
GLU L:84 L:134 74.0 0.389 S -88.7 -44.7 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU D:84 V:134 60.0 0.316 S -82.6 -33.9 60.0 0.316 0.0 HOH
2.791
OE1
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU C:84 C:134 93.0 0.489 S -91.6 -30.2 93.0 0.489 0.0 HOH
5.321
OE2
O
GLU F:84 F:134 48.0 NA S -91.3 -29.0 NA NA NA
GLU I:84 I:134 48.0 0.253 S -96.5 -25.4 NA NA NA
GLU L:84 L:134 46.0 0.242 S -96.0 -23.9 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 GLU D:84 V:134 77.0 0.405 S -75.7 -41.1 77.0 0.405 0.0 F4K
HOH
3.583
2.694
CG
O
C13
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 GLU C:81 V:134 42.0 0.221 S -78.1 -42.1 42.0 0.221 0.0 HOH
2.771
O
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 GLU C:81 C:134 87.0 0.458 S -88.4 -39.4 87.0 0.458 0.0 HOH
2.788
O
O
GLU F:81 F:134 87.0 0.458 S -89.3 -38.1 NA NA NA
GLU I:81 I:134 83.0 0.437 S -90.3 -37.2 NA NA NA
GLU L:81 L:134 82.0 0.432 S -89.0 -37.9 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 GLU B:81 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 GLU C:81 C:134 67.0 0.353 S -82.6 -33.9 67.0 0.353 0.0 HOH
2.633
OE1
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:81 V:134 50.0 0.263 S -89.4 -33.0 50.0 0.263 0.0 HOH
2.533
OE2
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:81 V:134 52.0 0.274 S -94.5 -42.0 52.0 0.274 0.0 HOH
2.575
HG2
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 GLU I:81 V:134 64.0 0.337 S -71.4 -42.2 64.0 0.337 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 GLU C:96 C:134 48.0 0.253 S -90.2 -32.4 48.0 0.253 0.0 HOH
2.667
O
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 GLU A:84 A:134 47.0 0.247 S -80.5 -40.1 47.0 0.247 0.0
GLU E:84 E:134 45.0 0.237 S -78.2 -39.1 NA NA NA
GLU I:84 I:134 56.0 0.295 S -80.6 -41.6 NA NA NA
GLU M:84 M:134 44.0 0.232 S -79.7 -40.7 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 GLU A:76 AAA:134 49.0 0.258 S -86.0 -36.3 49.0 0.258 0.0 GOL
GOL
IOD
GOL
HOH
7.664
4.304
8.703
8.615
2.475
C
CG
OE2
CG
OE1
O1
O1
I
O1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 GLU A:76 AAA:134 62.0 0.326 S -87.7 -36.3 62.0 0.326 0.0 EDO
HOH
8.228
2.578
OE2
O
C1
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:83 C:134 103.0 0.542 S -77.5 -42.9 103.0 0.542 0.0
GLU F:83 F:134 78.0 0.411 S -72.5 -57.0 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:83 C:134 104.0 0.547 S -73.4 -53.9 104.0 0.547 0.0 HOH
2.799
O
O
GLU F:83 F:134 62.0 0.326 S -83.0 -44.1 NA NA NA
GLU I:83 I:134 58.0 0.305 S -73.3 -55.5 NA NA NA
GLU L:83 L:134 59.0 0.311 S -77.0 -49.8 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:83 C:134 78.0 0.411 S -71.0 -45.4 78.0 0.411 0.0 HOH
2.904
O
O
GLU F:83 F:134 50.0 0.263 S -78.6 -36.3 NA NA NA
GLU I:83 I:134 55.0 0.289 S -70.7 -59.6 NA NA NA
GLU L:83 L:134 65.0 0.342 S -80.3 -51.1 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 GLU B:74 B:134 73.0 0.384 S -79.8 -33.9 73.0 0.384 0.0 HOH
2.715
O
O
GLU F:74 F:134 68.0 0.358 S -76.1 -40.9 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 GLU L:75 V:134 21.0 0.111 S -58.6 -47.4 21.0 0.111 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 GLU A:134 A:134 57.0 0.3 S -80.7 -29.5