Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191524 . G A CCDS2597.1:NM_000551.3:c.517Gag>Aag_NP_000542.1:p.173E>K Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 GLU A:193 A:173 137.0 0.721 G -62.8 -5.2 137.0 0.721 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 GLU C:157 C:173 119.0 0.626 G -57.4 -26.8 119.0 0.626 0.0
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 GLU C:131 C:173 124.0 0.653 G -65.9 -23.4 124.0 0.653 0.0 HOH
3.637
O
O
GLU F:131 F:173 139.0 0.732 G -67.0 -22.9 NA NA NA
GLU I:131 I:173 141.0 0.742 G -67.1 -22.6 NA NA NA
GLU L:131 L:173 141.0 0.742 G -66.2 -23.3 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 GLU C:122 C:173 151.0 0.795 G -65.3 -2.2 151.0 0.795 0.0 HOH
6.292
CG
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 GLU C:122 C:173 161.0 0.847 G -62.8 -37.9 161.0 0.847 0.0
GLU F:122 F:173 152.0 0.8 T -81.9 -12.7 NA NA NA
GLU I:122 I:173 118.0 0.621 S -69.2 -50.7 NA NA NA
GLU L:122 L:173 134.0 0.705 T -69.2 -20.1 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 GLU C:122 C:173 90.0 NA G -59.0 -39.4 90.0 NA NA HOH
8.289
N
O
GLU F:122 F:173 153.0 0.805 G -61.2 -39.5 NA NA NA
GLU I:122 I:173 164.0 0.863 G -60.8 -41.2 NA NA NA
GLU L:122 L:173 129.0 0.679 T -65.6 -40.1 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:122 C:173 138.0 0.726 G -67.2 -26.3 138.0 0.726 0.0 HOH
6.168
O
O
GLU F:122 F:173 105.0 NA G -67.3 -24.6 NA NA NA
GLU I:122 I:173 132.0 0.695 G -66.4 -26.8 NA NA NA
GLU L:122 L:173 110.0 0.579 G -67.0 -26.0 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 GLU C:122 C:173 138.0 0.726 G -63.9 -27.9 138.0 0.726 0.0 HOH
7.147
OE2
O
GLU F:122 F:173 126.0 0.663 G -64.3 -27.4 NA NA NA
GLU I:122 I:173 130.0 0.684 G -63.4 -28.1 NA NA NA
GLU L:122 L:173 146.0 0.768 G -63.9 -27.8 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 176.0 0.926 G -54.0 -37.1 176.0 0.926 0.0 HOH
6.543
N
O
GLU F:122 F:173 92.0 NA G -60.9 -12.6 NA NA NA
GLU I:122 I:173 93.0 NA G -60.8 -22.2 NA NA NA
GLU L:122 L:173 92.0 NA G -62.7 -25.7 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 186.0 0.979 G -59.7 -22.3 186.0 0.979 0.0 HOH
6.700
N
O
GLU F:122 F:173 89.0 NA G -55.9 -22.8 NA NA NA
GLU I:122 I:173 92.0 NA G -67.7 -22.0 NA NA NA
GLU L:122 L:173 92.0 NA G -62.1 -24.6 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 174.0 0.916 G -65.1 -23.3 174.0 0.916 0.0 HOH
6.649
N
O
GLU F:122 F:173 91.0 NA G -56.0 -14.6 NA NA NA
GLU I:122 I:173 89.0 NA G -67.9 -29.0 NA NA NA
GLU L:122 L:173 79.0 NA G -77.3 1.8 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 137.0 0.721 G -57.9 -31.7 137.0 0.721 0.0 HOH
2.881
OE1
O
GLU F:122 F:173 149.0 0.784 G -53.5 -41.2 NA NA NA
GLU I:122 I:173 156.0 0.821 G -65.5 -25.1 NA NA NA
GLU L:122 L:173 99.0 NA G -64.7 -23.3 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 176.0 0.926 G -58.0 -32.2 176.0 0.926 0.0
GLU F:122 F:173 89.0 NA G -55.9 -16.5 NA NA NA
GLU I:122 I:173 82.0 NA G -60.5 -31.7 NA NA NA
GLU L:122 L:173 86.0 NA G -60.7 -22.1 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 170.0 0.895 G -55.2 -29.5 170.0 0.895 0.0 HOH
6.546
N
O
GLU F:122 F:173 133.0 0.7 G -67.7 -25.6 NA NA NA
GLU I:122 I:173 87.0 NA G -65.5 -27.0 NA NA NA
GLU L:122 L:173 90.0 NA T -63.8 -25.4 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 163.0 0.858 T -65.7 -36.1 163.0 0.858 0.0 HOH
6.621
N
O
GLU F:122 F:173 136.0 0.716 G -63.1 -26.2 NA NA NA
GLU I:122 I:173 85.0 NA T -68.8 -32.6 NA NA NA
GLU L:122 L:173 90.0 NA T -75.4 -9.1 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 133.0 0.7 G -68.9 -13.5 133.0 0.7 0.0 HOH
3.272
O
O
GLU F:122 F:173 133.0 0.7 G -66.7 -16.7 NA NA NA
GLU I:122 I:173 90.0 NA T -73.1 -16.6 NA NA NA
GLU L:122 L:173 137.0 0.721 T -63.9 -43.7 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 180.0 0.947 G -60.4 -29.7 180.0 0.947 0.0 HOH
6.583
N
O
GLU F:122 F:173 96.0 NA G -66.0 -1.1 NA NA NA
GLU I:122 I:173 82.0 NA T -66.5 -43.4 NA NA NA
GLU L:122 L:173 86.0 NA T -72.6 -26.5 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 GLU C:122 C:173 181.0 0.953 G -70.4 -11.5 181.0 0.953 0.0 HOH
6.862
N
O
GLU F:122 F:173 91.0 NA G -54.9 -18.7 NA NA NA
GLU I:122 I:173 87.0 NA T -69.2 -25.7 NA NA NA
GLU L:122 L:173 93.0 NA G -76.1 15.4 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 GLU C:122 C:173 119.0 0.626 G -66.5 -23.1 119.0 0.626 0.0 HOH
3.638
OE1
O
GLU F:122 F:173 139.0 0.732 G -71.1 -12.8 NA NA NA
GLU I:122 I:173 128.0 0.674 T -88.8 -14.6 NA NA NA
GLU L:122 L:173 90.0 NA T -55.1 -39.3 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 117.0 0.616 G -60.9 -27.0 117.0 0.616 0.0 HOH
3.789
OE1
O
GLU F:122 F:173 133.0 0.7 G -66.1 -22.9 NA NA NA
GLU I:122 I:173 127.0 0.668 T -79.2 -29.7 NA NA NA
GLU L:122 L:173 99.0 NA G -64.3 -20.1 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 125.0 0.658 G -67.5 -22.9 125.0 0.658 0.0 HOH
2.779
OE1
O
GLU F:122 F:173 137.0 0.721 G -72.4 -16.4 NA NA NA
GLU I:122 I:173 145.0 0.763 T -72.1 -33.4 NA NA NA
GLU L:122 L:173 100.0 NA G -63.3 -9.4 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 123.0 0.647 G -63.3 -23.1 123.0 0.647 0.0 HOH
3.268
OE1
O
GLU F:122 F:173 135.0 0.711 G -70.0 -17.7 NA NA NA
GLU I:122 I:173 130.0 0.684 T -79.0 -30.5 NA NA NA
GLU L:122 L:173 98.0 NA G -64.5 -18.1 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 127.0 0.668 G -59.0 -35.6 127.0 0.668 0.0 HOH
2.950
OE1
O
GLU F:122 F:173 134.0 0.705 G -63.4 -38.8 NA NA NA
GLU I:122 I:173 146.0 0.768 G -53.3 -46.6 NA NA NA
GLU L:122 L:173 141.0 0.742 T -65.8 -29.8 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 127.0 0.668 G -61.1 -24.0 127.0 0.668 0.0
GLU F:122 F:173 138.0 0.726 G -72.8 1.6 NA NA NA
GLU I:122 I:173 137.0 0.721 T -76.8 -31.6 NA NA NA
GLU L:122 L:173 102.0 NA T -69.8 -9.8 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 126.0 0.663 G -67.2 -21.8 126.0 0.663 0.0 HOH
3.227
O
O
GLU F:122 F:173 127.0 0.668 G -67.3 -18.4 NA NA NA
GLU I:122 I:173 130.0 0.684 T -86.1 -34.5 NA NA NA
GLU L:122 L:173 94.0 NA G -66.1 -5.2 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 120.0 0.632 G -67.3 -25.8 120.0 0.632 0.0 HOH
6.463
C
O
GLU F:122 F:173 138.0 0.726 G -70.8 -13.8 NA NA NA
GLU I:122 I:173 139.0 0.732 T -85.1 -29.3 NA NA NA
GLU L:122 L:173 137.0 0.721 G -74.0 -17.2 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 GLU C:122 C:173 125.0 0.658 G -64.4 -24.4 125.0 0.658 0.0 HOH
2.984
OE1
O
GLU F:122 F:173 139.0 0.732 G -69.5 -17.9 NA NA NA
GLU I:122 I:173 145.0 0.763 T -77.1 -27.3 NA NA NA
GLU L:122 L:173 139.0 0.732 G -67.9 -18.6 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 GLU D:122 D:173 130.0 0.684 G -73.7 -12.3 130.0 0.684 0.0 HOH
6.475
C
O
GLU H:122 H:173 127.0 0.668 G -73.5 -12.7 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 GLU A:122 V:173 155.0 0.816 G -59.4 -18.0 155.0 0.816 0.0 HOH
6.420
HB2
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:122 C:173 121.0 0.637 G -67.2 -22.9 121.0 0.637 0.0 HOH
6.495
N
O
GLU F:122 F:173 139.0 0.732 G -68.3 -10.5 NA NA NA
GLU I:122 I:173 129.0 0.679 T -73.3 -41.8 NA NA NA
GLU L:122 L:173 100.0 NA T -70.6 -3.4 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 GLU C:122 C:173 113.0 0.595 G -66.5 -20.5 113.0 0.595 0.0 HOH
3.877
OE1
O
GLU F:122 F:173 140.0 0.737 G -61.4 -22.5 NA NA NA
GLU I:122 I:173 128.0 0.674 T -75.7 -24.5 NA NA NA
GLU L:122 L:173 91.0 NA G -56.2 -28.8 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:122 C:173 138.0 0.726 G -56.2 -33.2 138.0 0.726 0.0 HOH
7.907
OE1
O
GLU F:122 F:173 87.0 NA G -54.9 -32.2 NA NA NA
GLU L:122 L:173 142.0 0.747 G -52.5 -34.8 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU I:122 I:173 132.0 0.695 G -53.6 -32.7 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 GLU C:122 C:173 135.0 0.711 G -53.1 -41.3 135.0 0.711 0.0 HOH
6.658
OE1
O
GLU F:122 F:173 143.0 0.753 G -49.8 -40.9 NA NA NA
GLU I:122 I:173 139.0 0.732 G -54.2 -42.2 NA NA NA
GLU L:122 L:173 112.0 0.589 G -56.0 -33.0 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 GLU C:122 C:173 142.0 0.747 G -49.2 -45.1 142.0 0.747 0.0 HOH
8.544
OE2
O
GLU F:122 F:173 159.0 0.837 G -66.4 -31.5 NA NA NA
GLU I:122 I:173 138.0 0.726 G -48.2 -47.4 NA NA NA
GLU L:122 L:173 121.0 0.637 G -49.1 -44.9 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:122 B:173 131.0 0.689 G -70.4 -29.7 131.0 0.689 0.0 HOH
2.727
O
O
GLU F:122 F:173 152.0 0.8 G -70.1 -29.0 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 GLU B:122 B:173 145.0 0.763 G -70.2 -17.8 145.0 0.763 0.0 HOH
2.612
OE1
O
GLU F:122 F:173 146.0 0.768 G -70.3 -26.9 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 GLU D:122 D:173 129.0 0.679 G -80.5 -12.5 129.0 0.679 0.0
GLU H:122 H:173 117.0 0.616 G -80.3 -12.7 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU D:122 L:173 139.0 0.732 G -56.4 -24.8 139.0 0.732 0.0 HOH
2.904
O
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 GLU C:122 L:173 157.0 0.826 G -63.4 -43.6 157.0 0.826 0.0 HOH
4.463
N
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:123 C:173 95.0 NA S -61.8 -64.7 95.0 NA NA
GLU F:123 F:173 133.0 0.7 G -57.5 -44.5 NA NA NA
GLU I:123 I:173 125.0 0.658 T -96.0 17.4 NA NA NA
GLU L:123 L:173 137.0 0.721 G -73.2 -15.7 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 GLU C:123 C:173 97.0 NA G -42.4 -69.4 97.0 NA NA
GLU F:123 F:173 148.0 0.779 G -30.9 -42.1 NA NA NA
GLU I:123 I:173 114.0 0.6 T -58.2 -50.8 NA NA NA
GLU L:123 L:173 114.0 0.6 T -62.3 -35.0 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:123 C:173 99.0 NA G -46.3 -53.0 99.0 NA NA
GLU F:123 F:173 118.0 0.621 G -66.1 -1.0 NA NA NA
GLU I:123 I:173 124.0 0.653 G -71.4 -13.6 NA NA NA
GLU L:123 L:173 125.0 0.658 G -72.8 -25.9 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 GLU C:123 C:173 155.0 0.816 G -73.9 -27.2 155.0 0.816 0.0 HOH
9.024
O
O
GLU F:123 F:173 138.0 0.726 G -63.9 -20.2 NA NA NA
GLU I:123 I:173 93.0 NA G -58.1 -13.7 NA NA NA
GLU L:123 L:173 127.0 0.668 T -86.4 -8.1 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU D:123 V:173 149.0 0.784 G -66.5 -17.3 149.0 0.784 0.0 HOH
2.857
OE1
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 GLU C:123 C:173 144.0 0.758 G -69.7 -30.4 144.0 0.758 0.0 HOH
7.925
OE2
O
GLU F:123 F:173 89.0 NA G -74.8 -16.9 NA NA NA
GLU I:123 I:173 143.0 0.753 G -69.7 -34.7 NA NA NA
GLU L:123 L:173 142.0 0.747 G -72.0 -34.2 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 GLU D:123 V:173 144.0 0.758 G -62.8 -15.8 144.0 0.758 0.0 HOH
2.323
OE1
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 GLU C:120 V:173 125.0 0.658 G -63.0 -4.4 125.0 0.658 0.0 HOH
2.695
OE1
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 GLU C:120 C:173 138.0 0.726 G -69.2 -12.0 138.0 0.726 0.0 HOH
4.994
O
O
GLU F:120 F:173 137.0 0.721 G -69.5 -13.1 NA NA NA
GLU I:120 I:173 135.0 0.711 G -70.5 -13.1 NA NA NA
GLU L:120 L:173 135.0 0.711 G -70.3 -12.4 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 GLU B:120 V:173 140.0 0.737 T -92.5 6.5 140.0 0.737 0.0
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 GLU C:120 C:173 138.0 0.726 G -62.5 -18.6 138.0 0.726 0.0 HOH
3.376
O
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:120 V:173 148.0 0.779 G -65.2 -14.9 148.0 0.779 0.0 HOH
2.064
H
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 GLU D:120 V:173 152.0 0.8 G -63.2 -7.1 152.0 0.8 0.0 HOH
3.455
O
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 GLU I:120 V:173 133.0 0.7 G -64.7 -30.7 133.0 0.7 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 GLU C:135 C:173 147.0 0.774 G -73.9 -16.7 147.0 0.774 0.0 HOH
4.427
N
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 GLU A:123 A:173 159.0 0.837 G -57.8 -20.9 159.0 0.837 0.0
GLU E:123 E:173 118.0 0.621 G -58.9 -19.6 NA NA NA
GLU I:123 I:173 132.0 0.695 G -57.7 -21.6 NA NA NA
GLU M:123 M:173 126.0 0.663 G -58.2 -20.4 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 GLU A:115 AAA:173 112.0 0.589 G -69.1 -14.1 112.0 0.589 0.0 EDO
EDO
HOH
6.790
8.894
2.815
OE2
O
O
C2
O1
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 GLU A:115 AAA:173 140.0 0.737 G -66.3 -9.7 140.0 0.737 0.0 EDO
HOH
7.658
6.655
OE2
N
C1
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:122 C:173 136.0 0.716 G -51.7 -39.4 136.0 0.716 0.0 HOH
9.936
O
O
GLU F:122 F:173 132.0 0.695 G -63.3 -29.4 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:122 C:173 120.0 0.632 G -65.4 -31.1 120.0 0.632 0.0 HOH
4.954
O
O
GLU F:122 F:173 150.0 0.789 G -67.0 -32.1 NA NA NA
GLU I:122 I:173 143.0 0.753 G -55.5 -57.6 NA NA NA
GLU L:122 L:173 89.0 NA G -70.0 -24.6 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 GLU C:122 C:173 118.0 0.621 G -65.5 -32.9 118.0 0.621 0.0 HOH
6.466
OE2
O
GLU F:122 F:173 132.0 0.695 G -64.1 -36.0 NA NA NA
GLU I:122 I:173 152.0 0.8 T -73.2 -35.3 NA NA NA
GLU L:122 L:173 132.0 0.695 T -69.0 -39.9 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 GLU B:113 B:173 157.0 0.826 G -67.7 -25.2 157.0 0.826 0.0 HOH
6.485
H
O
GLU F:113 F:173 147.0 0.774 G -67.6 -25.4 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 GLU L:114 V:173 128.0 0.674 H -58.9 -33.2 128.0 0.674 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 GLU A:173 A:173 136.0 0.716 G -61.6 -18.9