Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191562 . C A CCDS2597.1:NM_000551.3:c.555taC>taA_NP_000542.1:p.185Y>* Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 TYR A:205 A:185 39.0 0.17 H -57.6 -46.3 39.0 0.17 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 TYR C:169 C:185 39.0 0.17 H -56.3 -57.9 39.0 0.17 0.0
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 TYR C:143 C:185 105.0 0.457 H -62.0 -43.5 105.0 0.457 0.0 HOH
3.274
CE1
O
TYR F:143 F:185 57.0 0.248 H -62.9 -45.6 NA NA NA
TYR I:143 I:185 35.0 0.152 H -65.3 -39.3 NA NA NA
TYR L:143 L:185 30.0 0.13 H -65.7 -39.5 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 TYR C:134 C:185 17.0 0.074 H -62.8 -44.5 17.0 0.074 0.0 HOH
6.541
CE2
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 TYR C:134 C:185 46.0 0.2 H -57.3 -42.2 46.0 0.2 0.0
TYR F:134 F:185 50.0 0.217 H -59.5 -40.8 NA NA NA
TYR I:134 I:185 65.0 0.283 H -65.7 -58.1 NA NA NA
TYR L:134 L:185 34.0 0.148 H -50.7 -55.7 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 TYR C:134 C:185 34.0 NA H -60.1 -50.1 34.0 NA NA HOH
9.138
CB
O
TYR F:134 F:185 24.0 NA H -59.5 -49.0 NA NA NA
TYR I:134 I:185 70.0 0.304 H -60.3 -49.0 NA NA NA
TYR L:134 L:185 47.0 0.204 H -63.3 -46.3 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 TYR C:134 C:185 72.0 0.313 H -64.3 -38.9 72.0 0.313 0.0 HOH
2.852
OH
O
TYR F:134 F:185 40.0 0.174 H -62.2 -48.4 NA NA NA
TYR I:134 I:185 45.0 0.196 H -61.1 -47.1 NA NA NA
TYR L:134 L:185 38.0 0.165 H -63.1 -44.8 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 TYR C:134 C:185 62.0 0.27 H -59.2 -42.0 62.0 0.27 0.0 HOH
6.547
CE2
O
TYR F:134 F:185 9.0 NA H -57.6 -48.1 NA NA NA
TYR I:134 I:185 46.0 0.2 H -62.0 -48.4 NA NA NA
TYR L:134 L:185 40.0 0.174 H -76.7 -39.9 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 7.0 NA H -60.1 -44.3 7.0 NA NA HOH
7.308
O
O
TYR F:134 F:185 37.0 0.161 H -57.5 -48.2 NA NA NA
TYR I:134 I:185 37.0 0.161 H -57.1 -46.9 NA NA NA
TYR L:134 L:185 35.0 0.152 H -56.5 -45.5 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 7.0 NA H -59.5 -46.0 7.0 NA NA HOH
7.240
O
O
TYR F:134 F:185 41.0 0.178 H -58.0 -47.9 NA NA NA
TYR I:134 I:185 29.0 0.126 H -55.3 -39.3 NA NA NA
TYR L:134 L:185 25.0 0.109 H -62.1 -49.5 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 6.0 NA H -59.0 -44.7 6.0 NA NA HOH
8.966
O
O
TYR F:134 F:185 41.0 0.178 H -60.2 -49.3 NA NA NA
TYR I:134 I:185 29.0 0.126 H -55.4 -49.2 NA NA NA
TYR L:134 L:185 38.0 0.165 H -51.0 -46.7 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 28.0 NA H -62.2 -45.3 28.0 NA NA HOH
5.046
O
O
TYR F:134 F:185 60.0 0.261 H -54.5 -48.2 NA NA NA
TYR I:134 I:185 37.0 0.161 H -59.7 -42.0 NA NA NA
TYR L:134 NA:NA DO NA DO DO DO NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 8.0 NA H -58.8 -48.2 8.0 NA NA HOH
8.760
O
O
TYR F:134 F:185 38.0 0.165 H -62.2 -46.8 NA NA NA
TYR I:134 I:185 41.0 0.178 H -59.4 -49.8 NA NA NA
TYR L:134 L:185 42.0 0.183 H -54.4 -44.8 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 5.0 NA H -57.4 -45.4 5.0 NA NA HOH
7.051
N
O
TYR F:134 F:185 39.0 0.17 H -56.0 -50.0 NA NA NA
TYR I:134 I:185 32.0 0.139 H -58.7 -40.7 NA NA NA
TYR L:134 L:185 26.0 0.113 H -62.9 -49.1 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 6.0 NA H -64.0 -41.6 6.0 NA NA HOH
7.452
N
O
TYR F:134 F:185 39.0 0.17 H -64.9 -47.2 NA NA NA
TYR I:134 I:185 23.0 0.1 H -58.1 -43.2 NA NA NA
TYR L:134 L:185 22.0 0.096 H -62.3 -49.5 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 8.0 NA H -59.4 -50.0 8.0 NA NA HOH
6.504
O
O
TYR F:134 F:185 38.0 0.165 H -54.7 -51.7 NA NA NA
TYR I:134 I:185 29.0 0.126 H -60.5 -43.9 NA NA NA
TYR L:134 L:185 49.0 0.213 H -57.5 -50.7 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 4.0 NA H -59.1 -54.1 4.0 NA NA HOH
8.920
O
O
TYR F:134 F:185 36.0 0.157 H -54.7 -49.7 NA NA NA
TYR I:134 I:185 50.0 0.217 H -59.3 -40.7 NA NA NA
TYR L:134 L:185 35.0 0.152 H -54.1 -43.5 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 TYR C:134 C:185 20.0 NA H -58.7 -51.3 20.0 NA NA HOH
9.019
O
O
TYR F:134 F:185 39.0 0.17 H -56.6 -48.7 NA NA NA
TYR I:134 I:185 30.0 0.13 H -60.9 -43.6 NA NA NA
TYR L:134 L:185 39.0 0.17 H -63.8 -47.1 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 TYR C:134 C:185 20.0 NA H -56.8 -49.6 20.0 NA NA HOH
6.203
N
O
TYR F:134 F:185 48.0 0.209 H -58.8 -54.0 NA NA NA
TYR I:134 I:185 20.0 0.087 H -59.4 -35.5 NA NA NA
TYR L:134 L:185 26.0 0.113 H -62.5 -49.2 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 16.0 NA H -58.6 -44.2 16.0 NA NA HOH
6.255
N
O
TYR F:134 F:185 50.0 0.217 H -57.4 -50.3 NA NA NA
TYR I:134 I:185 31.0 0.135 H -55.6 -40.4 NA NA NA
TYR L:134 L:185 21.0 0.091 H -65.0 -52.5 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 15.0 NA H -59.4 -45.7 15.0 NA NA HOH
5.029
O
O
TYR F:134 F:185 49.0 0.213 H -58.6 -48.5 NA NA NA
TYR I:134 I:185 28.0 0.122 H -57.9 -40.6 NA NA NA
TYR L:134 L:185 22.0 0.096 H -62.3 -54.1 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 18.0 NA H -60.3 -45.8 18.0 NA NA HOH
5.007
O
O
TYR F:134 F:185 52.0 0.226 H -61.0 -46.5 NA NA NA
TYR I:134 I:185 26.0 0.113 H -54.8 -40.5 NA NA NA
TYR L:134 L:185 22.0 0.096 H -60.7 -52.9 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 30.0 0.13 H -61.2 -44.0 30.0 0.13 0.0 HOH
2.991
OH
O
TYR F:134 F:185 26.0 0.113 H -64.4 -49.7 NA NA NA
TYR I:134 I:185 25.0 0.109 H -54.9 -46.9 NA NA NA
TYR L:134 L:185 23.0 0.1 H -56.2 -42.6 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 18.0 NA H -58.0 -45.1 18.0 NA NA HOH
8.669
N
O
TYR F:134 F:185 56.0 0.243 H -54.5 -54.9 NA NA NA
TYR I:134 I:185 28.0 0.122 H -51.1 -47.1 NA NA NA
TYR L:134 L:185 26.0 0.113 H -52.8 -47.6 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 54.0 0.235 H -60.4 -43.5 54.0 0.235 0.0 HOH
3.450
CE1
O
TYR F:134 F:185 60.0 0.261 H -63.3 -41.8 NA NA NA
TYR I:134 I:185 55.0 0.239 H -60.0 -46.7 NA NA NA
TYR L:134 L:185 33.0 0.143 H -59.9 -50.4 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 20.0 NA H -61.8 -47.2 20.0 NA NA HOH
6.209
N
O
TYR F:134 F:185 51.0 0.222 H -59.9 -46.7 NA NA NA
TYR I:134 I:185 26.0 0.113 H -64.5 -49.7 NA NA NA
TYR L:134 L:185 25.0 0.109 H -61.9 -52.4 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 TYR C:134 C:185 16.0 NA H -63.1 -44.9 16.0 NA NA HOH
6.300
N
O
TYR F:134 F:185 48.0 0.209 H -59.1 -48.6 NA NA NA
TYR I:134 I:185 22.0 0.096 H -66.1 -50.6 NA NA NA
TYR L:134 L:185 22.0 0.096 H -63.9 -52.9 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 TYR D:134 D:185 39.0 0.17 H -61.6 -53.8 39.0 0.17 0.0 HOH
7.691
OH
O
TYR H:134 H:185 39.0 0.17 H -61.0 -53.6 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 TYR A:134 V:185 35.0 0.152 H -56.8 -51.6 35.0 0.152 0.0 HOH
8.858
O
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 TYR C:134 C:185 17.0 NA H -58.0 -43.9 17.0 NA NA HOH
5.572
O
O
TYR F:134 F:185 52.0 0.226 H -56.1 -50.9 NA NA NA
TYR I:134 I:185 25.0 0.109 H -49.1 -42.9 NA NA NA
TYR L:134 L:185 23.0 0.1 H -52.3 -49.0 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 TYR C:134 C:185 16.0 NA H -56.0 -51.7 16.0 NA NA HOH
6.251
N
O
TYR F:134 F:185 50.0 0.217 H -57.6 -53.6 NA NA NA
TYR I:134 I:185 26.0 0.113 H -57.3 -42.6 NA NA NA
TYR L:134 L:185 21.0 0.091 H -60.0 -52.5 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 TYR C:134 C:185 79.0 0.343 H -53.7 -48.0 79.0 0.343 0.0 HOH
5.133
O
O
TYR F:134 F:185 33.0 0.143 H -58.3 -37.8 NA NA NA
TYR L:134 L:185 79.0 0.343 H -64.7 -37.5 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 TYR I:134 I:185 7.0 NA H -63.6 -36.8 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 TYR C:134 C:185 40.0 0.174 H -78.9 -35.3 40.0 0.174 0.0 HOH
6.904
O
O
TYR F:134 F:185 52.0 0.226 H -72.9 -33.0 NA NA NA
TYR I:134 I:185 59.0 0.257 H -68.3 -38.6 NA NA NA
TYR L:134 L:185 42.0 0.183 H -71.4 -43.8 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 TYR C:134 C:185 27.0 NA H -60.5 -46.8 27.0 NA NA HOH
8.310
N
O
TYR F:134 F:185 39.0 0.17 H -59.4 -50.0 NA NA NA
TYR I:134 I:185 43.0 0.187 H -58.1 -48.1 NA NA NA
TYR L:134 L:185 28.0 0.122 H -58.1 -45.8 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 TYR B:134 B:185 29.0 0.126 H -68.6 -44.2 29.0 0.126 0.0 EPE
HOH
6.474
2.782
OH
OH
C6
O
TYR F:134 F:185 33.0 0.143 H -69.4 -44.3 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 TYR B:134 B:185 36.0 0.157 H -68.5 -41.1 36.0 0.157 0.0 HOH
5.498
O
O
TYR F:134 F:185 28.0 0.122 H -68.2 -43.0 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 TYR D:134 D:185 43.0 0.187 H -61.3 -45.5 43.0 0.187 0.0
TYR H:134 H:185 42.0 0.183 H -61.2 -45.6 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 TYR D:134 L:185 36.0 0.157 H -55.1 -49.4 36.0 0.157 0.0 EDO
HOH
8.069
2.828
CE1
OH
O1
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 TYR C:134 L:185 32.0 0.139 H -50.6 -44.0 32.0 0.139 0.0 HOH
3.229
OH
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 TYR C:135 C:185 36.0 NA H -67.8 -35.9 36.0 NA NA HOH
9.829
N
O
TYR F:135 F:185 52.0 0.226 H -54.6 -49.8 NA NA NA
TYR I:135 I:185 62.0 0.27 H -61.1 -70.8 NA NA NA
TYR L:135 L:185 43.0 0.187 H -65.8 -48.6 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 TYR C:135 C:185 43.0 NA H -70.4 -19.9 43.0 NA NA HOH
9.841
CB
O
TYR F:135 F:185 16.0 NA H -58.2 -31.3 NA NA NA
TYR I:135 I:185 28.0 0.122 H -43.6 -42.7 NA NA NA
TYR L:135 L:185 51.0 0.222 H -51.3 -44.9 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 TYR C:135 C:185 17.0 NA H -52.0 -42.2 17.0 NA NA HOH
7.167
O
O
TYR F:135 F:185 41.0 0.178 H -65.2 -43.1 NA NA NA
TYR I:135 I:185 33.0 0.143 H -39.2 -47.0 NA NA NA
TYR L:135 L:185 19.0 0.083 H -54.1 -45.3 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 TYR C:135 C:185 20.0 NA H -66.8 -38.0 20.0 NA NA HOH
7.831
CB
O
TYR F:135 F:185 80.0 0.348 H -56.1 -43.4 NA NA NA
TYR I:135 I:185 64.0 0.278 H -53.9 -55.1 NA NA NA
TYR L:135 L:185 50.0 0.217 H -49.5 -43.2 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 TYR D:135 V:185 37.0 0.161 H -58.9 -47.3 37.0 0.161 0.0 HOH
3.850
OH
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 TYR C:135 C:185 23.0 NA H -62.8 -37.4 23.0 NA NA HOH
8.250
N
O
TYR F:135 F:185 51.0 0.222 H -60.0 -48.3 NA NA NA
TYR I:135 I:185 26.0 NA H -67.1 -29.9 NA NA NA
TYR L:135 L:185 34.0 0.148 H -59.8 -48.7 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 TYR D:135 V:185 31.0 0.135 H -59.6 -49.4 31.0 0.135 0.0 HOH
3.128
OH
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 TYR C:132 V:185 26.0 0.113 H -57.7 -46.4 26.0 0.113 0.0 HOH
2.939
OH
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 TYR C:132 C:185 31.0 0.135 H -65.1 -43.5 31.0 0.135 0.0 HOH
7.633
O
O
TYR F:132 F:185 31.0 0.135 H -66.1 -41.5 NA NA NA
TYR I:132 I:185 32.0 0.139 H -64.7 -42.7 NA NA NA
TYR L:132 L:185 33.0 0.143 H -66.4 -41.2 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 TYR B:132 V:185 55.0 0.239 T -68.8 -17.1 34.0 0.148 0.091 A:Q13617:0.091
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 TYR C:132 C:185 31.0 0.135 H -60.5 -46.7 31.0 0.135 0.0 HOH
4.190
OH
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 TYR D:132 V:185 35.0 0.152 H -65.0 -47.2 35.0 0.152 0.0 HOH
2.762
HB2
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 TYR D:132 V:185 39.0 0.17 H -59.7 -53.9 39.0 0.17 0.0 HOH
2.568
HB2
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 TYR I:132 V:185 31.0 0.135 H -56.2 -46.4 31.0 0.135 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 TYR C:147 C:185 34.0 0.148 H -68.4 -50.2 34.0 0.148 0.0 HOH
3.490
OH
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 TYR A:135 A:185 41.0 0.178 H -55.9 -50.6 41.0 0.178 0.0
TYR E:135 E:185 29.0 0.126 H -55.6 -50.8 NA NA NA
TYR I:135 I:185 68.0 0.296 H -55.8 -50.9 NA NA NA
TYR M:135 M:185 40.0 0.174 H -55.5 -51.1 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 TYR A:127 AAA:185 67.0 0.291 H -56.4 -44.2 67.0 0.291 0.0 EDO
EDO
HOH
7.141
7.763
2.615
CB
N
OH
O2
O2
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 TYR A:127 AAA:185 39.0 0.17 H -53.6 -49.6 39.0 0.17 0.0 HOH
5.697
CE2
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 TYR C:134 C:185 39.0 0.17 H -57.3 -49.4 39.0 0.17 0.0 HOH
4.066
CE2
O
TYR F:134 F:185 28.0 0.122 H -62.0 -50.3 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 TYR C:134 C:185 16.0 NA H -56.7 -41.3 16.0 NA NA HOH
3.189
CB
O
TYR F:134 F:185 41.0 0.178 H -62.4 -47.5 NA NA NA
TYR I:134 I:185 27.0 0.117 H -56.8 -47.8 NA NA NA
TYR L:134 L:185 22.0 0.096 H -62.1 -49.7 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 TYR C:134 C:185 29.0 0.126 H -64.7 -46.0 29.0 0.126 0.0 HOH
3.914
CE2
O
TYR F:134 F:185 41.0 0.178 H -63.3 -48.7 NA NA NA
TYR I:134 I:185 37.0 0.161 H -64.6 -44.6 NA NA NA
TYR L:134 L:185 37.0 0.161 H -60.9 -48.9 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 TYR B:125 B:185 29.0 0.126 H -65.1 -40.9 29.0 0.126 0.0 HOH
5.706
HH
O
TYR F:125 F:185 25.0 0.109 H -67.6 -33.5 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 TYR L:126 V:185 55.0 0.239 H -50.5 -64.3 47.0 0.204 0.035 H:Q13617:0.035

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 TYR A:185 A:185 40.0 0.174 H -65.6 -45.6