Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191578 . C A CCDS2597.1:NM_000551.3:c.571Cac>Aac_NP_000542.1:p.191H>N Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
 2015-03-04 HIS A:211 A:191 70.0 0.359 -68.2 156.1 70.0 0.359 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
 2021-11-24 HIS C:175 C:191 87.0 0.446 -47.6 152.2 87.0 0.446 0.0 HOH
 5.863
 O
 O
4b9k 3 P40337 95.32 3e-118 X-RAY
 2012-10-24 HIS C:149 C:191 99.0 0.508 -63.8 150.5 99.0 0.508 0.0 HOH
 3.286
 CB
 O
HIS F:149 F:191 107.0 0.549 -61.1 148.1 NA NA NA
HIS I:149 I:191 73.0 0.374 -58.7 139.4 NA NA NA
HIS L:149 L:191 71.0 0.364 -61.1 142.9 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
 2002-07-03 HIS C:140 C:191 101.0 0.518 -72.6 153.5 101.0 0.518 0.0 HOH
 5.315
 CB
 O
3ztd 3 P40337 99.38 4e-117 X-RAY
 2012-07-25 HIS C:140 C:191 84.0 0.431 -14.5 129.8 84.0 0.431 0.0
HIS F:140 F:191 86.0 0.441 -60.6 149.8 NA NA NA
HIS I:140 I:191 78.0 0.4 -59.2 142.6 NA NA NA
HIS L:140 L:191 79.0 0.405 -40.8 135.8 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
 2012-10-24 HIS C:140 C:191 80.0 0.41 -57.5 151.0 80.0 0.41 0.0 HOH
 7.034
 NE2
 O
HIS F:140 F:191 79.0 0.405 -56.7 151.1 NA NA NA
HIS I:140 I:191 76.0 0.39 -59.5 149.1 NA NA NA
HIS L:140 L:191 76.0 0.39 -57.7 149.1 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
 2013-11-27 HIS C:140 C:191 74.0 0.379 -57.0 147.7 74.0 0.379 0.0 HOH
 3.021
 CD2
 O
HIS F:140 F:191 76.0 0.39 -57.1 146.8 NA NA NA
HIS I:140 I:191 74.0 0.379 -56.8 145.8 NA NA NA
HIS L:140 L:191 73.0 0.374 -57.3 148.2 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
 2013-11-27 HIS C:140 C:191 81.0 0.415 -57.6 149.0 81.0 0.415 0.0 HOH
 5.649
 CA
 O
HIS F:140 F:191 79.0 0.405 -60.6 144.8 NA NA NA
HIS I:140 I:191 81.0 0.415 -60.2 143.5 NA NA NA
HIS L:140 L:191 79.0 0.405 -61.2 144.0 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 71.0 0.364 -54.8 154.3 71.0 0.364 0.0 HOH
 4.356
 NE2
 O
HIS F:140 F:191 80.0 0.41 -61.3 146.1 NA NA NA
HIS I:140 I:191 77.0 0.395 -60.5 148.4 NA NA NA
HIS L:140 L:191 76.0 0.39 -61.6 150.3 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 75.0 0.385 -54.0 149.9 75.0 0.385 0.0 HOH
 4.237
 NE2
 O
HIS F:140 F:191 78.0 0.4 -56.7 142.6 NA NA NA
HIS I:140 I:191 81.0 0.415 -57.0 151.8 NA NA NA
HIS L:140 L:191 80.0 0.41 -55.8 144.5 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 78.0 0.4 -60.4 158.0 78.0 0.4 0.0 HOH
 2.770
 ND1
 O
HIS F:140 F:191 85.0 0.436 -58.9 151.9 NA NA NA
HIS I:140 I:191 81.0 0.415 -64.9 149.2 NA NA NA
HIS L:140 L:191 80.0 0.41 -60.6 149.7 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 94.0 0.482 -76.1 159.8 94.0 0.482 0.0 HOH
 3.516
 CB
 O
HIS F:140 F:191 78.0 0.4 -57.7 148.9 NA NA NA
HIS I:140 I:191 78.0 0.4 -63.0 146.1 NA NA NA
HIS L:140 L:191 79.0 0.405 -59.9 145.5 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 77.0 0.395 -66.4 153.4 77.0 0.395 0.0 HOH
 5.439
 CA
 O
HIS F:140 F:191 83.0 0.426 -63.1 153.0 NA NA NA
HIS I:140 I:191 81.0 0.415 -63.0 156.6 NA NA NA
HIS L:140 L:191 77.0 0.395 -66.1 153.8 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 75.0 0.385 -58.0 144.7 75.0 0.385 0.0 HOH
 3.550
 CD2
 O
HIS F:140 F:191 81.0 0.415 -55.0 153.2 NA NA NA
HIS I:140 I:191 76.0 0.39 -59.9 146.0 NA NA NA
HIS L:140 L:191 76.0 0.39 -62.9 145.3 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 76.0 0.39 -58.5 146.3 76.0 0.39 0.0 HOH
 4.334
 NE2
 O
HIS F:140 F:191 78.0 0.4 -59.1 145.3 NA NA NA
HIS I:140 I:191 77.0 0.395 -61.5 144.6 NA NA NA
HIS L:140 L:191 81.0 0.415 -56.1 140.4 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 98.0 0.503 -77.1 158.2 98.0 0.503 0.0 HOH
 3.567
 CB
 O
HIS F:140 F:191 89.0 0.456 -60.4 147.8 NA NA NA
HIS I:140 I:191 80.0 0.41 -58.5 142.9 NA NA NA
HIS L:140 L:191 78.0 0.4 -52.9 142.0 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 74.0 0.379 -61.2 151.1 74.0 0.379 0.0 HOH
 3.703
 C
 O
HIS F:140 F:191 80.0 0.41 -55.1 143.7 NA NA NA
HIS I:140 I:191 78.0 0.4 -55.3 154.3 NA NA NA
HIS L:140 L:191 78.0 0.4 -52.8 149.2 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
 2014-09-10 HIS C:140 C:191 103.0 0.528 -77.2 160.3 103.0 0.528 0.0 HOH
 4.899
 CA
 O
HIS F:140 F:191 85.0 0.436 -58.3 147.0 NA NA NA
HIS I:140 I:191 77.0 0.395 -56.2 150.1 NA NA NA
HIS L:140 L:191 79.0 0.405 -53.7 144.1 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
 2016-11-09 HIS C:140 C:191 97.0 0.497 -77.6 162.9 97.0 0.497 0.0 HOH
 3.496
 CB
 O
HIS F:140 F:191 102.0 0.523 -80.1 154.3 NA NA NA
HIS I:140 I:191 83.0 0.426 -66.8 149.4 NA NA NA
HIS L:140 L:191 88.0 0.451 -60.7 142.8 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 93.0 0.477 -76.2 161.9 93.0 0.477 0.0 HOH
 3.452
 C
 O
HIS F:140 F:191 103.0 0.528 -77.3 157.3 NA NA NA
HIS I:140 I:191 82.0 0.421 -62.5 148.5 NA NA NA
HIS L:140 L:191 81.0 0.415 -57.4 141.9 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 94.0 0.482 -73.2 163.3 94.0 0.482 0.0 HOH
 2.543
 ND1
 O
HIS F:140 F:191 99.0 0.508 -75.0 161.0 NA NA NA
HIS I:140 I:191 84.0 0.431 -57.8 147.4 NA NA NA
HIS L:140 L:191 81.0 0.415 -58.9 143.5 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 94.0 0.482 -74.3 161.6 94.0 0.482 0.0 HOH
 2.490
 ND1
 O
HIS F:140 F:191 99.0 0.508 -74.7 159.5 NA NA NA
HIS I:140 I:191 78.0 0.4 -62.0 151.0 NA NA NA
HIS L:140 L:191 81.0 0.415 -57.1 141.9 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 96.0 0.492 -69.3 159.3 96.0 0.492 0.0 HOH
 3.123
 CD2
 O
HIS F:140 F:191 97.0 0.497 -80.0 144.9 NA NA NA
HIS I:140 I:191 73.0 0.374 -64.7 152.1 NA NA NA
HIS L:140 L:191 80.0 0.41 -62.7 134.2 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 98.0 0.503 -79.1 156.4 98.0 0.503 0.0 HOH
 4.899
 CA
 O
HIS F:140 F:191 102.0 0.523 -72.8 152.1 NA NA NA
HIS I:140 I:191 88.0 0.451 -65.0 151.6 NA NA NA
HIS L:140 L:191 88.0 0.451 -64.5 142.9 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 97.0 0.497 -76.9 163.2 97.0 0.497 0.0 HOH
 3.036
 CD2
 O
HIS F:140 F:191 100.0 0.513 -79.2 158.2 NA NA NA
HIS I:140 I:191 85.0 0.436 -61.1 151.7 NA NA NA
HIS L:140 L:191 85.0 0.436 -61.5 145.0 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 99.0 0.508 -77.8 159.5 99.0 0.508 0.0 HOH
 2.952
 CD2
 O
HIS F:140 F:191 105.0 0.538 -78.1 159.2 NA NA NA
HIS I:140 I:191 82.0 0.421 -55.4 146.1 NA NA NA
HIS L:140 L:191 83.0 0.426 -58.6 145.6 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
 2017-09-20 HIS C:140 C:191 98.0 0.503 -77.5 161.2 98.0 0.503 0.0 HOH
 2.807
 O
 O
HIS F:140 F:191 105.0 0.538 -77.7 158.7 NA NA NA
HIS I:140 I:191 84.0 0.431 -52.0 146.8 NA NA NA
HIS L:140 L:191 84.0 0.431 -57.8 141.4 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
 2017-03-08 HIS D:140 D:191 77.0 0.395 -68.6 154.3 77.0 0.395 0.0 HOH
 2.874
 ND1
 O
HIS H:140 H:191 83.0 0.426 -67.7 153.5 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
 2018-08-01 HIS A:140 V:191 75.0 0.385 -65.7 154.5 75.0 0.385 0.0 HOH
 2.399
 HD2
 O
6gfy 3 P40337 99.38 4e-117 X-RAY
 2018-07-11 HIS C:140 C:191 93.0 0.477 -66.8 158.0 93.0 0.477 0.0 HOH
 4.867
 CA
 O
HIS F:140 F:191 100.0 0.513 -69.3 149.5 NA NA NA
HIS I:140 I:191 87.0 0.446 -60.7 144.0 NA NA NA
HIS L:140 L:191 87.0 0.446 -60.6 139.4 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
 2018-07-11 HIS C:140 C:191 98.0 0.503 -73.6 160.7 98.0 0.503 0.0 HOH
 2.984
 CD2
 O
HIS F:140 F:191 102.0 0.523 -81.1 155.3 NA NA NA
HIS I:140 I:191 80.0 0.41 -53.9 143.7 NA NA NA
HIS L:140 L:191 86.0 0.441 -56.9 141.3 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS C:140 C:191 106.0 0.544 -69.4 156.8 106.0 0.544 0.0 HOH
 3.683
 CB
 O
HIS F:140 F:191 66.0 0.338 -60.7 154.3 NA NA NA
HIS L:140 L:191 76.0 0.39 -63.5 144.4 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS I:140 I:191 78.0 0.4 -58.2 146.2 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
 2018-08-22 HIS C:140 C:191 75.0 0.385 -60.8 143.9 75.0 0.385 0.0 HOH
 5.673
 CD2
 O
HIS F:140 F:191 77.0 0.395 -61.8 146.7 NA NA NA
HIS I:140 I:191 77.0 0.395 -60.3 144.8 NA NA NA
HIS L:140 L:191 81.0 0.415 -60.7 144.8 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
 2018-08-08 HIS C:140 C:191 83.0 0.426 -51.1 140.1 83.0 0.426 0.0 HOH
 3.856
 C
 O
HIS F:140 F:191 77.0 0.395 -64.5 149.1 NA NA NA
HIS I:140 I:191 80.0 0.41 -62.7 151.1 NA NA NA
HIS L:140 L:191 76.0 0.39 -61.9 152.0 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
 2019-06-12 HIS B:140 B:191 84.0 0.431 -64.3 150.9 84.0 0.431 0.0 HOH
 3.982
 C
 O
HIS F:140 F:191 82.0 0.421 -67.1 149.5 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
 2019-06-12 HIS B:140 B:191 77.0 0.395 -61.2 149.5 77.0 0.395 0.0 EDO
HOH
 6.518
3.076
 ND1
ND1
 O1
O
HIS F:140 F:191 75.0 0.385 -60.1 149.8 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
 2019-12-04 HIS D:140 D:191 79.0 0.405 -75.2 161.3 79.0 0.405 0.0
HIS H:140 H:191 78.0 0.4 -75.3 160.8 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
 2021-10-06 HIS D:140 L:191 83.0 0.426 -67.0 152.8 83.0 0.426 0.0 HOH
 3.326
 N
 O
7jtp 3 P40337 99.38 4e-117 X-RAY
 2021-10-06 HIS C:140 L:191 71.0 0.364 -60.9 157.0 71.0 0.364 0.0 HOH
 2.404
 NE2
 O
3zrc 3 P40337 98.77 4e-117 X-RAY
 2012-03-07 HIS C:141 C:191 102.0 0.523 -13.6 142.3 102.0 0.523 0.0
HIS F:141 F:191 84.0 0.431 -49.3 156.9 NA NA NA
HIS I:141 I:191 80.0 0.41 -46.1 146.8 NA NA NA
HIS L:141 L:191 73.0 0.374 -48.3 142.4 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
 2012-03-07 HIS C:141 C:191 94.0 0.482 -19.9 122.1 94.0 0.482 0.0 HOH
 5.578
 C
 O
HIS F:141 F:191 89.0 0.456 -36.5 137.7 NA NA NA
HIS I:141 I:191 83.0 0.426 -64.8 143.9 NA NA NA
HIS L:141 L:191 86.0 0.441 -57.6 148.2 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
 2012-07-25 HIS C:141 C:191 83.0 0.426 -29.1 135.9 83.0 0.426 0.0 HOH
 5.325
 N
 O
HIS F:141 F:191 92.0 0.472 -47.8 139.9 NA NA NA
HIS I:141 I:191 85.0 0.436 -46.1 141.3 NA NA NA
HIS L:141 L:191 81.0 0.415 -53.3 143.3 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
 2012-07-25 HIS C:141 C:191 84.0 0.431 -39.3 141.5 84.0 0.431 0.0 HOH
 5.137
 CD2
 O
HIS F:141 F:191 88.0 0.451 -55.9 142.6 NA NA NA
HIS I:141 I:191 80.0 0.41 -48.6 143.8 NA NA NA
HIS L:141 L:191 73.0 0.374 -51.1 141.9 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
 2012-11-14 HIS D:141 V:191 106.0 0.544 -70.1 158.6 106.0 0.544 0.0 HOH
 2.674
 O
 O
4awj 3 P40337 98.77 4e-117 X-RAY
 2012-11-14 HIS C:141 C:191 78.0 0.4 -58.9 149.0 78.0 0.4 0.0 HOH
 5.603
 C
 O
HIS F:141 F:191 76.0 0.39 -61.1 143.4 NA NA NA
HIS I:141 I:191 78.0 0.4 -61.7 149.3 NA NA NA
HIS L:141 L:191 81.0 0.415 -60.2 148.4 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
 2018-08-08 HIS D:141 V:191 104.0 0.533 -71.3 157.2 104.0 0.533 0.0 F4K
HOH
 9.451
2.912
 C
O
 C04
O
1lm8 3 P40337 100.0 6e-117 X-RAY
 2002-06-12 HIS C:138 V:191 106.0 0.544 -70.7 156.3 106.0 0.544 0.0 HOH
 2.602
 O
 O
1vcb 3 P40337 100.0 6e-117 X-RAY
 1999-04-21 HIS C:138 C:191 80.0 0.41 -55.2 151.9 80.0 0.41 0.0 HOH
 2.920
 CB
 O
HIS F:138 F:191 82.0 0.421 -55.5 151.1 NA NA NA
HIS I:138 I:191 81.0 0.415 -55.3 151.5 NA NA NA
HIS L:138 L:191 79.0 0.405 -54.6 151.3 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
 2017-06-07 HIS B:138 V:191 60.0 0.308 -123.3 84.1 60.0 0.308 0.0
6gfx 3 P40337 100.0 6e-117 X-RAY
 2018-07-11 HIS C:138 C:191 106.0 0.544 -74.6 161.8 106.0 0.544 0.0 HOH
 2.680
 O
 O
6i7q 4 P40337 100.0 6e-117 X-RAY
 2019-11-27 HIS D:138 V:191 71.0 0.364 -61.7 147.5 71.0 0.364 0.0 HOH
 2.942
 HE1
 O
6i7r 4 P40337 100.0 6e-117 X-RAY
 2019-11-27 HIS D:138 V:191 70.0 0.359 -70.8 150.3 70.0 0.359 0.0 HOH
 2.957
 O
 O
6r7f 9 P40337 100.0 6e-117 EM
 2019-08-28 HIS I:138 V:191 67.0 0.344 -73.7 167.6 67.0 0.344 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
 2021-02-24 HIS C:153 C:191 77.0 0.395 -66.1 142.9 77.0 0.395 0.0 HOH
 3.573
 CD2
 O
7cjb 1 P40337 100.0 8e-116 X-RAY
 2021-07-14 HIS A:141 A:191 75.0 0.385 -54.5 146.9 75.0 0.385 0.0
HIS E:141 E:191 76.0 0.39 -54.2 147.5 NA NA NA
HIS I:141 I:191 74.0 0.379 -55.2 148.1 NA NA NA
HIS M:141 M:191 74.0 0.379 -55.1 149.6 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
 2020-08-05 HIS A:133 AAA:191 68.0 0.349 -59.9 147.8 68.0 0.349 0.0 EDO
GOL
IOD
HOH
 7.815
8.823
7.601
2.563
 CE1
C
O
NE2
 O2
O3
I
O
7pi4 1 P40337 100.0 4e-113 X-RAY
 2021-09-29 HIS A:133 AAA:191 75.0 0.385 -58.1 143.9 75.0 0.385 0.0 EDO
HOH
 7.532
3.236
 CE1
ND1
 O2
O
6fmi 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:140 C:191 86.0 0.441 -64.1 152.1 86.0 0.441 0.0 HOH
 7.067
 C
 O
HIS F:140 F:191 84.0 0.431 -62.7 146.4 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:140 C:191 96.0 0.492 -83.0 157.9 96.0 0.492 0.0 HOH
 3.154
 CD2
 O
HIS F:140 F:191 106.0 0.544 -78.6 156.6 NA NA NA
HIS I:140 I:191 82.0 0.421 -68.8 152.7 NA NA NA
HIS L:140 L:191 83.0 0.426 -61.3 142.8 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
 2018-04-11 HIS C:140 C:191 108.0 0.554 -75.4 152.5 108.0 0.554 0.0 HOH
 3.488
 CB
 O
HIS F:140 F:191 100.0 0.513 -73.3 153.5 NA NA NA
HIS I:140 I:191 84.0 0.431 -64.9 154.5 NA NA NA
HIS L:140 L:191 83.0 0.426 -60.5 137.0 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
 2019-06-12 HIS B:131 B:191 81.0 0.415 -64.4 150.9 81.0 0.415 0.0 HOH
 2.456
 HD2
 O
HIS F:131 F:191 81.0 0.415 -64.1 150.8 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
 2019-08-28 HIS L:132 V:191 86.0 0.441 -137.0 120.4 86.0 0.441 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 HIS A:191 A:191 74.0 0.379 -62.6 151.9