Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 10191609 . T A CCDS2597.1:NM_000551.3:c.602cTg>cAg_NP_000542.1:p.201L>Q Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4wqo 1 P40337 100.0 4e-156 X-RAY
2015-03-04 LEU A:221 A:201 20.0 0.118 H -59.8 -35.6 20.0 0.118 0.0
7q2j 3 P40337 94.25 1e-118 X-RAY
2021-11-24 LEU C:185 C:201 17.0 0.1 H -57.0 -36.4 17.0 0.1 0.0 HOH
7.375
CD2
O
4b9k 3 P40337 95.32 3e-118 X-RAY
2012-10-24 LEU C:159 C:201 99.0 0.582 88.1 -8.9 99.0 0.582 0.0 HOH
5.213
CD1
O
LEU F:159 F:201 33.0 0.194 H -66.6 -24.3 NA NA NA
LEU I:159 I:201 18.0 0.106 H -60.5 -45.0 NA NA NA
LEU L:159 L:201 31.0 0.182 H -64.1 -36.3 NA NA NA
1lqb 3 P40337 99.38 4e-117 X-RAY
2002-07-03 LEU C:150 C:201 17.0 0.1 H -66.8 -29.4 17.0 0.1 0.0 HOH
6.505
C
O
3ztd 3 P40337 99.38 4e-117 X-RAY
2012-07-25 LEU C:150 C:201 42.0 0.247 H -56.8 -45.7 42.0 0.247 0.0
LEU F:150 F:201 36.0 0.212 H -80.8 -18.7 NA NA NA
LEU I:150 I:201 62.0 0.365 H -76.0 -33.1 NA NA NA
LEU L:150 L:201 57.0 0.335 H -56.3 -44.3 NA NA NA
4b95 3 P40337 99.38 4e-117 X-RAY
2012-10-24 LEU C:150 C:201 47.0 NA T -94.9 58.6 47.0 NA NA HOH
9.034
CB
O
LEU F:150 F:201 38.0 NA H -63.4 -41.0 NA NA NA
LEU I:150 I:201 29.0 NA H -62.9 -45.2 NA NA NA
LEU L:150 L:201 32.0 0.188 H -64.7 -44.3 NA NA NA
4bks 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:150 C:201 60.0 0.353 70.8 39.7 60.0 0.353 0.0 HOH
3.420
CD1
O
LEU F:150 F:201 61.0 0.359 H -66.4 -44.7 NA NA NA
LEU I:150 I:201 25.0 0.147 H -64.0 -46.1 NA NA NA
LEU L:150 L:201 31.0 0.182 H -60.0 -43.8 NA NA NA
4bkt 3 P40337 99.38 4e-117 X-RAY
2013-11-27 LEU C:150 C:201 207.0 1.0 64.7 360.0 207.0 1.0 0.0 HOH
6.697
CB
O
LEU F:150 F:201 31.0 NA H -59.1 -35.1 NA NA NA
LEU I:150 I:201 26.0 0.153 H -59.5 -45.7 NA NA NA
LEU L:150 L:201 36.0 0.212 H -61.0 -42.3 NA NA NA
4w9c 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 64.0 NA H -62.3 -16.7 64.0 NA NA HOH
7.691
CB
O
LEU F:150 F:201 35.0 0.206 H -67.4 -31.0 NA NA NA
LEU I:150 I:201 40.0 0.235 H -57.7 -54.0 NA NA NA
LEU L:150 L:201 37.0 0.218 H -60.7 -42.0 NA NA NA
4w9d 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 64.0 NA T -67.7 -1.9 64.0 NA NA HOH
8.861
CB
O
LEU F:150 F:201 37.0 0.218 H -65.9 -26.8 NA NA NA
LEU I:150 I:201 45.0 0.265 H -61.5 -56.8 NA NA NA
LEU L:150 L:201 39.0 0.229 H -59.5 -37.8 NA NA NA
4w9e 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 65.0 NA H -65.0 -28.9 65.0 NA NA HOH
7.691
CB
O
LEU F:150 F:201 32.0 0.188 H -64.3 -38.6 NA NA NA
LEU I:150 I:201 39.0 0.229 H -62.8 -51.8 NA NA NA
LEU L:150 L:201 37.0 0.218 H -66.3 -49.4 NA NA NA
4w9f 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 54.0 NA H -59.5 -43.4 54.0 NA NA HOH
5.072
N
O
LEU F:150 F:201 49.0 0.288 H -70.4 -5.7 NA NA NA
LEU I:150 I:201 35.0 0.206 H -56.7 -54.0 NA NA NA
LEU L:150 L:201 36.0 0.212 H -58.2 -47.6 NA NA NA
4w9g 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 74.0 NA H -53.1 -31.3 74.0 NA NA HOH
9.135
CB
O
LEU F:150 F:201 31.0 0.182 H -59.5 -34.6 NA NA NA
LEU I:150 I:201 44.0 0.259 H -52.5 -51.2 NA NA NA
LEU L:150 L:201 41.0 0.241 H -63.1 -46.0 NA NA NA
4w9h 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 52.0 0.306 H -53.4 -28.5 52.0 0.306 0.0 HOH
5.199
CD2
O
LEU F:150 F:201 23.0 0.135 H -66.2 -32.1 NA NA NA
LEU I:150 I:201 39.0 0.229 H -50.0 -56.0 NA NA NA
LEU L:150 L:201 31.0 0.182 H -55.8 -49.4 NA NA NA
4w9i 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 55.0 0.324 H -50.3 -31.4 55.0 0.324 0.0 HOH
5.266
CD2
O
LEU F:150 F:201 30.0 0.176 H -60.8 -31.4 NA NA NA
LEU I:150 I:201 43.0 0.253 H -51.5 -54.2 NA NA NA
LEU L:150 L:201 35.0 0.206 H -55.2 -45.6 NA NA NA
4w9j 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 64.0 NA H -67.9 -27.3 64.0 NA NA HOH
6.830
C
O
LEU F:150 F:201 35.0 0.206 H -65.1 -28.3 NA NA NA
LEU I:150 I:201 35.0 0.206 H -58.5 -47.3 NA NA NA
LEU L:150 L:201 32.0 0.188 H -57.1 -41.7 NA NA NA
4w9k 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 63.0 NA -77.1 -12.4 63.0 NA NA HOH
8.108
CB
O
LEU F:150 F:201 28.0 0.165 H -59.4 -40.2 NA NA NA
LEU I:150 I:201 44.0 0.259 H -59.4 -45.9 NA NA NA
LEU L:150 L:201 33.0 0.194 H -56.0 -43.5 NA NA NA
4w9l 3 P40337 99.38 4e-117 X-RAY
2014-09-10 LEU C:150 C:201 59.0 NA H -61.6 -25.6 59.0 NA NA HOH
8.961
CB
O
LEU F:150 F:201 34.0 0.2 H -65.6 -33.4 NA NA NA
LEU I:150 I:201 45.0 0.265 H -63.3 -35.6 NA NA NA
LEU L:150 L:201 37.0 0.218 H -56.1 -41.5 NA NA NA
5lli 3 P40337 99.38 4e-117 X-RAY
2016-11-09 LEU C:150 C:201 61.0 NA H -65.2 -36.6 61.0 NA NA HOH
6.511
N
O
LEU F:150 F:201 34.0 0.2 H -62.5 -25.8 NA NA NA
LEU I:150 I:201 44.0 0.259 H -60.5 -50.5 NA NA NA
LEU L:150 L:201 41.0 0.241 H -57.7 -37.4 NA NA NA
5nvv 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 63.0 NA H -63.6 -10.1 63.0 NA NA HOH
6.242
N
O
LEU F:150 F:201 33.0 0.194 H -63.7 -31.6 NA NA NA
LEU I:150 I:201 40.0 0.235 H -51.7 -56.6 NA NA NA
LEU L:150 L:201 34.0 0.2 H -59.0 -42.0 NA NA NA
5nvw 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 63.0 NA H -60.0 -13.3 63.0 NA NA HOH
6.430
N
O
LEU F:150 F:201 36.0 0.212 H -64.7 -22.5 NA NA NA
LEU I:150 I:201 42.0 0.247 H -52.5 -56.8 NA NA NA
LEU L:150 L:201 38.0 0.224 H -58.7 -44.4 NA NA NA
5nvx 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 68.0 NA H -51.5 -14.9 68.0 NA NA HOH
6.185
N
O
LEU F:150 F:201 36.0 0.212 H -63.6 -28.9 NA NA NA
LEU I:150 I:201 43.0 0.253 H -53.6 -54.0 NA NA NA
LEU L:150 L:201 42.0 0.247 H -63.8 -33.8 NA NA NA
5nvy 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 64.0 0.376 H -51.5 -35.5 64.0 0.376 0.0 HOH
5.235
O
O
LEU F:150 F:201 25.0 0.147 H -57.6 -36.4 NA NA NA
LEU I:150 I:201 30.0 0.176 H -59.3 -41.4 NA NA NA
LEU L:150 L:201 24.0 0.141 H -58.3 -47.8 NA NA NA
5nvz 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 54.0 NA H -55.5 -20.2 54.0 NA NA
LEU F:150 F:201 39.0 0.229 H -65.8 -27.5 NA NA NA
LEU I:150 I:201 41.0 0.241 H -61.0 -48.8 NA NA NA
LEU L:150 L:201 42.0 0.247 H -60.6 -48.5 NA NA NA
5nw0 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 66.0 NA H -55.5 -20.5 66.0 NA NA HOH
6.508
N
O
LEU F:150 F:201 40.0 0.235 H -69.3 -31.2 NA NA NA
LEU I:150 I:201 45.0 0.265 H -65.0 -39.3 NA NA NA
LEU L:150 L:201 39.0 0.229 H -57.6 -40.2 NA NA NA
5nw1 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 62.0 NA H -44.0 -28.5 62.0 NA NA HOH
6.126
N
O
LEU F:150 F:201 39.0 0.229 H -66.9 -28.5 NA NA NA
LEU I:150 I:201 41.0 0.241 H -55.3 -49.0 NA NA NA
LEU L:150 L:201 39.0 0.229 H -59.0 -42.3 NA NA NA
5nw2 3 P40337 99.38 4e-117 X-RAY
2017-09-20 LEU C:150 C:201 48.0 NA T -73.2 48.8 48.0 NA NA HOH
5.267
N
O
LEU F:150 F:201 37.0 0.218 H -73.1 -27.0 NA NA NA
LEU I:150 I:201 47.0 0.276 H -61.8 -47.0 NA NA NA
LEU L:150 L:201 40.0 0.235 H -54.0 -41.7 NA NA NA
5t35 4 P40337 99.38 4e-117 X-RAY
2017-03-08 LEU D:150 D:201 22.0 0.129 H -65.6 -39.6 22.0 0.129 0.0 HOH
6.487
CD1
O
LEU H:150 H:201 21.0 0.124 H -65.7 -39.5 NA NA NA
6bvb 1 P40337 99.38 4e-117 X-RAY
2018-08-01 LEU A:150 V:201 17.0 0.1 H -69.4 -40.4 17.0 0.1 0.0 HOH
4.844
HB3
O
6gfy 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:150 C:201 55.0 NA T -72.4 32.8 55.0 NA NA
LEU F:150 F:201 38.0 0.224 H -65.8 -23.6 NA NA NA
LEU I:150 I:201 45.0 0.265 H -53.0 -44.0 NA NA NA
LEU L:150 L:201 42.0 0.247 H -63.5 -38.2 NA NA NA
6gfz 3 P40337 99.38 4e-117 X-RAY
2018-07-11 LEU C:150 C:201 62.0 NA T -55.4 -6.3 62.0 NA NA HOH
5.941
N
O
LEU F:150 F:201 35.0 0.206 H -57.5 -30.9 NA NA NA
LEU I:150 I:201 41.0 0.241 H -54.4 -40.0 NA NA NA
LEU L:150 L:201 36.0 0.212 H -57.0 -34.7 NA NA NA
6gmn 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:150 C:201 116.0 NA -3.9 360.0 116.0 NA NA HOH
8.981
CB
O
LEU F:150 F:201 48.0 0.282 H -46.9 -37.1 NA NA NA
LEU L:150 L:201 25.0 0.147 H -45.2 -44.1 NA NA NA
6gmn 5 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU I:150 I:201 33.0 0.194 H -48.1 -50.1 NA NA NA
6gmq 3 P40337 99.38 4e-117 X-RAY
2018-08-22 LEU C:150 C:201 169.0 0.994 -131.1 360.0 169.0 0.994 0.0 HOH
9.076
CD1
O
LEU F:150 F:201 46.0 NA H -87.8 1.2 NA NA NA
LEU I:150 I:201 34.0 0.2 H -77.2 -29.8 NA NA NA
LEU L:150 L:201 25.0 0.147 H -65.6 -31.9 NA NA NA
6gmx 3 P40337 99.38 4e-117 X-RAY
2018-08-08 LEU C:150 C:201 224.0 1.0 -73.0 360.0 224.0 1.0 0.0
LEU F:150 F:201 38.0 0.224 H -66.4 -25.1 NA NA NA
LEU I:150 I:201 33.0 0.194 H -67.5 -33.9 NA NA NA
LEU L:150 L:201 41.0 0.241 H -67.1 -33.4 NA NA NA
6hax 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:150 B:201 15.0 0.088 H -68.8 -38.7 15.0 0.088 0.0 HOH
6.172
CD1
O
LEU F:150 F:201 18.0 0.106 H -68.4 -39.1 NA NA NA
6hay 2 P40337 99.38 4e-117 X-RAY
2019-06-12 LEU B:150 B:201 18.0 0.106 H -63.3 -34.2 18.0 0.106 0.0 HOH
5.332
CD2
O
LEU F:150 F:201 20.0 0.118 H -64.4 -34.0 NA NA NA
6sis 4 P40337 99.38 4e-117 X-RAY
2019-12-04 LEU D:150 D:201 24.0 0.141 H -60.7 -37.3 24.0 0.141 0.0
LEU H:150 H:201 23.0 0.135 H -60.7 -37.3 NA NA NA
7jto 4 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU D:150 L:201 15.0 0.088 H -63.3 -26.8 15.0 0.088 0.0 HOH
4.797
CD2
O
7jtp 3 P40337 99.38 4e-117 X-RAY
2021-10-06 LEU C:150 L:201 37.0 0.218 H -61.7 -40.1 37.0 0.218 0.0 HOH
5.134
CD1
O
3zrc 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:151 C:201 55.0 NA H -43.9 -35.6 55.0 NA NA
LEU F:151 F:201 39.0 NA H -71.9 -19.7 NA NA NA
LEU I:151 I:201 74.0 0.435 H -62.4 -31.2 NA NA NA
LEU L:151 L:201 53.0 0.312 H -40.0 -58.5 NA NA NA
3zrf 3 P40337 98.77 4e-117 X-RAY
2012-03-07 LEU C:151 C:201 47.0 NA T -63.3 -3.2 47.0 NA NA
LEU F:151 F:201 35.0 NA H -56.1 -52.4 NA NA NA
LEU I:151 I:201 36.0 0.212 H -61.2 -36.9 NA NA NA
LEU L:151 L:201 52.0 0.306 H -47.5 -57.7 NA NA NA
3ztc 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:151 C:201 53.0 NA H -58.7 -31.1 53.0 NA NA
LEU F:151 F:201 51.0 NA H -68.2 -19.0 NA NA NA
LEU I:151 I:201 41.0 0.241 H -67.1 -36.5 NA NA NA
LEU L:151 L:201 40.0 0.235 H -61.6 -50.6 NA NA NA
3zun 3 P40337 98.77 4e-117 X-RAY
2012-07-25 LEU C:151 C:201 52.0 0.306 H -108.0 -28.1 52.0 0.306 0.0 HOH
7.243
CD2
O
LEU F:151 F:201 37.0 0.218 H -70.6 -21.7 NA NA NA
LEU I:151 I:201 39.0 NA H -67.9 -33.6 NA NA NA
LEU L:151 L:201 62.0 0.365 H -47.6 -50.1 NA NA NA
4ajy 4 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU D:151 V:201 17.0 0.1 H -64.9 -37.7 17.0 0.1 0.0 HOH
3.904
CD1
O
4awj 3 P40337 98.77 4e-117 X-RAY
2012-11-14 LEU C:151 NA:NA DO NA DO DO DO NA NA NA
LEU F:151 F:201 52.0 NA H -66.7 -19.4 NA NA NA
LEU I:151 I:201 33.0 0.194 H -59.9 -35.4 NA NA NA
LEU L:151 L:201 21.0 0.124 H -62.6 -37.7 NA NA NA
6gmr 4 P40337 98.77 4e-117 X-RAY
2018-08-08 LEU D:151 V:201 22.0 0.129 H -61.7 -36.4 22.0 0.129 0.0 F4K
HOH
3.724
2.777
CD1
O
C12
O
1lm8 3 P40337 100.0 6e-117 X-RAY
2002-06-12 LEU C:148 V:201 19.0 0.112 H -59.3 -36.2 19.0 0.112 0.0 HOH
3.836
CB
O
1vcb 3 P40337 100.0 6e-117 X-RAY
1999-04-21 LEU C:148 C:201 55.0 0.324 H -54.2 -46.1 55.0 0.324 0.0 HOH
2.926
CD2
O
LEU F:148 F:201 52.0 0.306 H -54.3 -47.4 NA NA NA
LEU I:148 I:201 56.0 0.329 H -55.0 -47.6 NA NA NA
LEU L:148 L:201 55.0 0.324 H -55.3 -46.6 NA NA NA
5n4w 2 P40337 100.0 6e-117 X-RAY
2017-06-07 LEU B:148 NA:NA DO NA DO DO DO NA NA NA
6gfx 3 P40337 100.0 6e-117 X-RAY
2018-07-11 LEU C:148 C:201 15.0 0.088 H -63.3 -37.1 15.0 0.088 0.0 HOH
4.134
CD1
O
6i7q 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:148 V:201 16.0 0.094 H -64.7 -34.3 16.0 0.094 0.0 HOH
4.250
HD11
O
6i7r 4 P40337 100.0 6e-117 X-RAY
2019-11-27 LEU D:148 V:201 26.0 0.153 H -67.1 -33.2 26.0 0.153 0.0 HOH
2.990
O
O
6r7f 9 P40337 100.0 6e-117 EM
2019-08-28 LEU I:148 V:201 10.0 0.059 H -63.5 -38.0 10.0 0.059 0.0
7khh 3 P40337 100.0 6e-116 X-RAY
2021-02-24 LEU C:163 C:201 11.0 0.065 H -62.5 -30.9 11.0 0.065 0.0 HOH
5.107
CD2
O
7cjb 1 P40337 100.0 8e-116 X-RAY
2021-07-14 LEU A:151 A:201 22.0 0.129 H -69.0 -40.7 22.0 0.129 0.0
LEU E:151 E:201 23.0 0.135 H -68.4 -41.7 NA NA NA
LEU I:151 I:201 21.0 0.124 H -68.6 -41.1 NA NA NA
LEU M:151 M:201 27.0 0.159 H -69.0 -40.5 NA NA NA
6zhc 1 P40337 100.0 4e-113 X-RAY
2020-08-05 LEU A:143 AAA:201 16.0 0.094 H -67.4 -35.6 16.0 0.094 0.0 GOL
HOH
7.653
4.648
CD1
CD2
O3
O
7pi4 1 P40337 100.0 4e-113 X-RAY
2021-09-29 LEU A:143 AAA:201 16.0 0.094 H -67.3 -37.4 16.0 0.094 0.0 HOH
3.194
O
O
6fmi 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:150 C:201 65.0 NA H -53.6 -31.0 65.0 NA NA HOH
4.976
CB
O
LEU F:150 F:201 63.0 0.371 -72.1 93.7 NA NA NA
6fmj 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:150 C:201 63.0 NA H -65.5 -22.2 63.0 NA NA HOH
5.889
N
O
LEU F:150 F:201 36.0 0.212 H -65.3 -33.8 NA NA NA
LEU I:150 I:201 46.0 0.271 H -62.1 -42.2 NA NA NA
LEU L:150 L:201 36.0 0.212 H -63.8 -35.3 NA NA NA
6fmk 3 P40337 99.34 1e-109 X-RAY
2018-04-11 LEU C:150 C:201 67.0 0.394 T -89.4 51.0 67.0 0.394 0.0 HOH
4.709
CG
O
LEU F:150 F:201 33.0 0.194 H -56.9 -31.9 NA NA NA
LEU I:150 I:201 34.0 0.2 H -65.2 -20.7 NA NA NA
LEU L:150 L:201 29.0 0.171 H -61.9 -46.4 NA NA NA
6hr2 2 P40337 100.0 3e-108 X-RAY
2019-06-12 LEU B:141 B:201 15.0 0.088 H -64.5 -34.1 15.0 0.088 0.0 HOH
2.612
HD22
O
LEU F:141 F:201 14.0 0.082 H -64.6 -35.3 NA NA NA
6r6h 12 P40337 100.0 3e-107 EM
2019-08-28 LEU L:142 V:201 1.0 0.006 H -73.4 -26.0 1.0 0.006 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p40337-f1 1 P40337 100.0 2e-156 LEU A:201 A:201 20.0 0.118 H -61.2 -34.9