Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr3 | 3192553 | . | A | C | CCDS2562.1:NM_016302.3:c.1325tTg>tGg_NP_057386.2:p.442L>W | Homo sapiens cereblon (CRBN), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6bn7 | 2 | Q96SW2 | 97.06 | 0.0 |
X-RAY |
2018-05-30 | LEU | B:463 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6bn8 | 2 | Q96SW2 | 97.06 | 0.0 |
X-RAY |
2018-06-06 | LEU | B:463 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6bn9 | 2 | Q96SW2 | 97.06 | 0.0 |
X-RAY |
2018-05-30 | LEU | B:463 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6bnb | 2 | Q96SW2 | 97.06 | 0.0 |
X-RAY |
2018-05-30 | LEU | B:463 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6boy | 2 | Q96SW2 | 97.06 | 0.0 |
X-RAY |
2018-05-30 | LEU | B:463 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 5hxb | 3 | Q96SW2 | 99.75 | 0.0 |
X-RAY |
2016-06-29 | LEU | C:406 | Z:442 | 76.0 | NA | -111.5 | 360.0 | 35.0 | NA | NA |
B:Q16531:NA |
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| LEU | E:406 | C:442 | 105.0 | NA | -56.7 | 360.0 | NA | NA | NA | ||||||||||||||
| 5v3o | 2 | Q96SW2 | 99.75 | 0.0 |
X-RAY |
2017-05-03 | LEU | B:406 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6uml | 2 | Q96SW2 | 99.75 | 0.0 |
X-RAY |
2020-04-15 | LEU | B:406 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6xk9 | 3 | Q96SW2 | 99.75 | 0.0 |
X-RAY |
2020-12-02 | LEU | C:406 | Z:442 | 65.0 | NA | -78.7 | 360.0 | 20.0 | NA | NA |
B:Q16531:NA |
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| LEU | F:406 | C:442 | 100.0 | 0.588 | -77.4 | 360.0 | NA | NA | NA | ||||||||||||||
| 5fqd | 2 | Q96SW2 | 99.02 | 0.0 |
X-RAY |
2016-02-24 | LEU | B:426 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | E:426 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6h0f | 2 | Q96SW2 | 99.02 | 0.0 |
X-RAY |
2018-11-07 | LEU | B:426 | B:442 | 82.0 | NA | -106.6 | 360.0 | 24.0 | NA | NA |
A:None:NA |
HOH |
6.281 |
OXT |
O |
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| LEU | E:426 | E:442 | 77.0 | NA | -116.6 | 360.0 | NA | NA | NA | ||||||||||||||
| LEU | H:426 | H:442 | 83.0 | NA | -103.4 | 360.0 | NA | NA | NA | ||||||||||||||
| LEU | K:426 | K:442 | 80.0 | NA | -142.2 | 360.0 | NA | NA | NA | ||||||||||||||
| 6h0g | 2 | Q96SW2 | 99.02 | 0.0 |
X-RAY |
2018-11-07 | LEU | B:426 | B:442 | 94.0 | NA | 71.8 | 360.0 | 14.0 | NA | NA |
A:Q16531:NA |
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| LEU | E:426 | E:442 | 90.0 | NA | 69.9 | 360.0 | NA | NA | NA | ||||||||||||||
| 4ci1 | 2 | P0CF65 | 84.08 | 0.0 |
X-RAY |
2014-07-16 | LEU | B:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 4ci2 | 2 | P0CF65 | 84.08 | 0.0 |
X-RAY |
2014-07-16 | LEU | B:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 4ci3 | 2 | P0CF65 | 84.08 | 0.0 |
X-RAY |
2014-07-16 | LEU | B:469 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
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| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q96sw2-f1 | 1 | Q96SW2 | 100.0 | 0.0 | LEU | A:442 | A:442 | 169.0 | 0.994 | -91.0 | 360.0 | ||