Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3192623 . G A CCDS2562.1:NM_016302.3:c.1255Cga>Tga_NP_057386.2:p.419R>* Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:440 B:419 10.0 0.044 G -66.1 -32.3 10.0 0.044 0.0
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 ARG B:440 B:419 12.0 0.053 G -69.9 -27.9 12.0 0.053 0.0
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:440 B:419 9.0 0.04 G -65.5 -34.4 9.0 0.04 0.0
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:440 B:419 23.0 0.102 T -56.8 -41.7 23.0 0.102 0.0
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ARG B:440 B:419 8.0 0.036 G -63.1 -37.0 8.0 0.036 0.0
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 ARG C:383 Z:419 24.0 0.107 G -57.1 -31.6 24.0 0.107 0.0
ARG E:383 C:419 22.0 0.098 G -57.2 -29.5 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 ARG B:383 C:419 14.0 0.062 G -46.0 -50.0 14.0 0.062 0.0
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 ARG B:383 C:419 8.0 0.036 G -62.8 -33.8 8.0 0.036 0.0
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 ARG C:383 Z:419 27.0 0.12 G -44.3 -39.9 27.0 0.12 0.0
ARG F:383 C:419 30.0 0.133 G -44.7 -40.0 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 ARG B:403 B:419 10.0 0.044 G -44.1 -40.1 10.0 0.044 0.0 HOH
 2.653
 O
 O
ARG E:403 E:419 10.0 0.044 G -44.2 -40.8 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ARG B:403 B:419 85.0 0.378 G -49.4 -46.0 85.0 0.378 0.0 HOH
 8.808
 C
 O
ARG E:403 E:419 80.0 0.356 G -51.7 -47.0 NA NA NA
ARG H:403 H:419 52.0 0.231 G -62.9 -33.8 NA NA NA
ARG K:403 K:419 82.0 0.364 G -50.9 -46.4 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ARG B:403 B:419 10.0 0.044 G -60.2 -39.7 10.0 0.044 0.0
ARG E:403 E:419 11.0 0.049 G -56.0 -42.5 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 ARG B:373 B:419 9.0 0.04 G -60.4 -39.0 9.0 0.04 0.0
ARG E:373 E:419 9.0 0.04 G -60.5 -38.8 NA NA NA
ARG H:373 H:419 8.0 0.036 G -59.8 -39.6 NA NA NA
ARG K:373 K:419 8.0 0.036 G -60.7 -38.7 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 ARG B:372 C:419 11.0 0.049 G -60.5 -35.3 11.0 0.049 0.0
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:445 B:421 13.0 0.058 G -64.9 -26.5 13.0 0.058 0.0 HOH
 3.009
 NH1
 O
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:445 B:421 9.0 0.04 G -59.4 -20.2 9.0 0.04 0.0
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ARG B:445 B:421 10.0 0.044 G -65.0 -29.9 10.0 0.044 0.0
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 ARG A:107 A:419 81.0 0.36 G -54.4 -43.8 81.0 0.36 0.0 HOH
 2.746
 O
 O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 ARG A:102 A:419 78.0 0.347 G -59.1 -39.1 78.0 0.347 0.0 HOH
 2.890
 O
 O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ARG A:103 A:422 124.0 0.551 G -56.9 -38.7 124.0 0.551 0.0 HOH
 3.243
 N
 O
ARG B:103 B:422 118.0 0.524 G -54.5 -41.2 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ARG A:103 A:422 119.0 0.529 G -57.2 -39.4 119.0 0.529 0.0 HOH
 3.340
 N
 O
ARG B:103 B:422 120.0 0.533 G -58.5 -39.3 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:103 A:422 115.0 0.511 G -57.4 -37.4 115.0 0.511 0.0 HOH
 2.743
 O
 O
ARG B:103 D:422 115.0 0.511 G -61.8 -32.4 NA NA NA
ARG C:103 G:422 117.0 0.52 G -61.2 -38.1 NA NA NA
ARG D:103 J:422 117.0 0.52 G -60.8 -33.0 NA NA NA
ARG E:103 M:422 113.0 0.502 G -56.7 -34.6 NA NA NA
ARG F:103 P:422 76.0 0.338 G -64.1 -26.1 NA NA NA
ARG G:103 S:422 80.0 0.356 G -65.0 -24.5 NA NA NA
ARG H:103 V:422 119.0 0.529 G -63.9 -32.3 NA NA NA
ARG I:103 Y:422 112.0 0.498 G -57.8 -31.9 NA NA NA
ARG J:103 b:422 75.0 0.333 G -62.1 -28.4 NA NA NA
ARG K:103 e:422 116.0 0.516 G -57.4 -34.7 NA NA NA
ARG L:103 h:422 120.0 0.533 G -62.8 -32.9 NA NA NA
ARG M:103 k:422 111.0 0.493 G -56.4 -35.3 NA NA NA
ARG N:103 n:422 117.0 0.52 G -60.1 -33.7 NA NA NA
ARG O:103 q:422 79.0 0.351 G -66.2 -28.2 NA NA NA
ARG P:103 t:422 114.0 0.507 G -59.6 -36.8 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:103 A:422 117.0 0.52 G -59.1 -37.7 117.0 0.52 0.0 HOH
 2.740
 O
 O
ARG B:103 D:422 114.0 0.507 G -59.2 -34.4 NA NA NA
ARG C:103 G:422 117.0 0.52 G -60.9 -37.4 NA NA NA
ARG D:103 J:422 118.0 0.524 G -61.3 -32.2 NA NA NA
ARG E:103 M:422 112.0 0.498 G -56.4 -37.9 NA NA NA
ARG F:103 P:422 76.0 0.338 G -62.0 -28.2 NA NA NA
ARG G:103 S:422 79.0 0.351 G -61.4 -29.1 NA NA NA
ARG H:103 V:422 121.0 0.538 G -60.3 -33.5 NA NA NA
ARG I:103 Y:422 111.0 0.493 G -59.5 -32.9 NA NA NA
ARG J:103 b:422 79.0 0.351 G -61.7 -30.1 NA NA NA
ARG K:103 e:422 118.0 0.524 G -57.5 -34.8 NA NA NA
ARG L:103 h:422 121.0 0.538 G -60.7 -32.8 NA NA NA
ARG M:103 k:422 114.0 0.507 G -57.5 -35.0 NA NA NA
ARG N:103 n:422 119.0 0.529 G -60.9 -33.9 NA NA NA
ARG O:103 q:422 77.0 0.342 G -64.3 -30.4 NA NA NA
ARG P:103 t:422 112.0 0.498 G -59.6 -38.1 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ARG A:103 A:422 128.0 0.569 G -58.7 -35.6 128.0 0.569 0.0 HOH
 2.657
 O
 O
ARG B:103 D:422 116.0 0.516 G -50.7 -43.1 NA NA NA
ARG C:103 G:422 120.0 0.533 G -56.6 -39.3 NA NA NA
ARG D:103 J:422 119.0 0.529 G -57.5 -35.7 NA NA NA
ARG E:103 M:422 124.0 0.551 G -52.4 -34.2 NA NA NA
ARG F:103 P:422 76.0 0.338 G -61.9 -30.2 NA NA NA
ARG G:103 S:422 77.0 0.342 G -59.9 -28.7 NA NA NA
ARG H:103 V:422 122.0 0.542 G -61.5 -31.4 NA NA NA
ARG I:103 Y:422 122.0 0.542 G -52.6 -35.5 NA NA NA
ARG J:103 b:422 80.0 0.356 G -62.8 -29.7 NA NA NA
ARG K:103 e:422 119.0 0.529 G -56.2 -34.0 NA NA NA
ARG L:103 h:422 118.0 0.524 G -61.7 -34.9 NA NA NA
ARG M:103 k:422 123.0 0.547 G -52.4 -36.3 NA NA NA
ARG N:103 n:422 115.0 0.511 G -60.7 -35.2 NA NA NA
ARG O:103 q:422 79.0 0.351 G -63.6 -29.4 NA NA NA
ARG P:103 t:422 120.0 0.533 G -55.9 -40.5 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 ARG A:101 A:421 146.0 0.649 G -60.7 -34.0 146.0 0.649 0.0 HOH
 2.818
 O
 O
ARG B:101 B:421 127.0 0.564 G -58.5 -33.8 127.0 0.564 0.0 HOH
 2.727
 NH1
 O
ARG C:101 C:421 147.0 0.653 G -58.3 -34.8 NA NA NA
ARG D:101 D:421 136.0 0.604 G -57.9 -36.3 136.0 0.604 0.0 HOH
 2.783
 O
 O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 ARG A:102 C:421 80.0 0.356 G -60.1 -36.9 NA NA NA
ARG B:102 A:421 117.0 0.52 G -60.4 -33.7 117.0 0.52 0.0 HOH
 2.701
 O
 O
ARG C:102 B:421 99.0 0.44 G -56.1 -36.2 NA NA NA
ARG D:102 D:421 99.0 0.44 G -57.1 -38.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 ARG A:419 A:419 8.0 0.036 G -53.7 -36.8