Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3192625 . G A CCDS2562.1:NM_016302.3:c.1253aCg>aTg_NP_057386.2:p.418T>M Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 THR B:439 B:418 4.0 0.029 E -79.1 138.0 4.0 0.029 0.0 RN3
 8.527
 CB
 O5
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 THR B:439 B:418 2.0 0.014 E -80.0 141.4 2.0 0.014 0.0
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 THR B:439 B:418 3.0 0.021 E -79.4 137.4 3.0 0.021 0.0
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 THR B:439 B:418 0.0 0.0 E -79.2 149.9 0.0 0.0 0.0
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 THR B:439 B:418 1.0 0.007 E -76.6 136.2 1.0 0.007 0.0 RN6
 8.411
 CB
 O4
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 THR C:382 Z:418 2.0 0.014 E -73.0 131.8 2.0 0.014 0.0 85C
 8.810
 OG1
 O1
THR E:382 C:418 1.0 0.007 E -73.2 130.7 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 THR B:382 C:418 4.0 0.029 E -84.3 123.1 4.0 0.029 0.0 8W7
 8.561
 CB
 O1
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 THR B:382 C:418 4.0 0.029 E -72.0 134.4 4.0 0.029 0.0 Y70
 9.022
 CB
 O13
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 THR C:382 Z:418 2.0 0.014 E -83.7 119.6 2.0 0.014 0.0 V4M
 8.723
 OG1
 O1
THR F:382 C:418 3.0 0.021 E -84.0 119.2 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 THR B:402 B:418 4.0 0.029 E -83.5 119.1 4.0 0.029 0.0 LVY
HOH
 9.153
2.729
 CB
OG1
 C3
O
THR E:402 E:418 3.0 0.021 E -82.6 119.6 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 THR B:402 B:418 5.0 0.036 E -84.1 120.8 5.0 0.036 0.0 Y70
ZN
HOH
 7.240
8.879
4.254
 HB
HG21
HG21
 H182
ZN
O
THR E:402 E:418 5.0 0.036 E -71.2 122.5 NA NA NA
THR H:402 H:418 6.0 0.043 E -71.0 118.5 NA NA NA
THR K:402 K:418 5.0 0.036 E -63.5 121.8 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 THR B:402 B:418 2.0 0.014 E -77.6 131.6 2.0 0.014 0.0 Y70
ZN
 8.179
8.843
 HB
HG21
 C14
ZN
THR E:402 E:418 1.0 0.007 E -81.3 129.1 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 THR B:372 B:418 2.0 0.014 E -78.8 132.7 2.0 0.014 0.0 RN9
ZN
 9.511
9.417
 CB
CG2
 C4
ZN
THR E:372 E:418 2.0 0.014 E -79.1 132.3 NA NA NA
THR H:372 H:418 2.0 0.014 E -78.9 132.9 NA NA NA
THR K:372 K:418 2.0 0.014 E -78.9 132.8 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 THR B:371 C:418 5.0 0.036 E -72.8 131.2 5.0 0.036 0.0 LVY
 8.401
 CB
 O16
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 THR B:444 B:420 3.0 0.021 E -75.9 133.6 3.0 0.021 0.0 EF2
HOH
 7.175
3.833
 CG2
CB
 O18
O
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 THR B:444 B:420 3.0 0.021 E -80.1 123.3 3.0 0.021 0.0 LVY
 7.606
 CG2
 O16
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 THR B:444 B:420 3.0 0.021 E -73.4 134.2 3.0 0.021 0.0 Y70
 7.533
 CG2
 O13
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 THR A:106 A:418 3.0 0.021 E -81.9 133.5 3.0 0.021 0.0 EF2
HOH
 8.189
3.752
 CG2
CB
 O18
O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 THR A:101 A:418 4.0 0.029 E -81.0 134.6 4.0 0.029 0.0 F4U
ZN
HOH
 8.815
9.478
2.652
 OG1
CG2
OG1
 OAS
ZN
O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 THR A:102 A:421 34.0 0.243 E -68.3 117.4 34.0 0.243 0.0 HOH
 2.890
 OG1
 O
THR B:102 B:421 32.0 0.229 E -64.7 117.3 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 THR A:102 A:421 35.0 0.25 E -67.6 117.6 35.0 0.25 0.0 HOH
 2.857
 OG1
 O
THR B:102 B:421 30.0 0.214 E -65.9 120.7 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 THR A:102 A:421 33.0 0.236 E -69.8 113.9 33.0 0.236 0.0 EF2
HOH
 7.948
2.747
 OG1
OG1
 O18
O
THR B:102 D:421 34.0 0.243 E -70.6 116.9 NA NA NA
THR C:102 G:421 38.0 0.271 E -71.7 117.4 NA NA NA
THR D:102 J:421 40.0 0.286 E -71.7 115.7 NA NA NA
THR E:102 M:421 25.0 0.179 E -66.9 115.3 NA NA NA
THR F:102 P:421 28.0 0.2 E -73.3 115.4 NA NA NA
THR G:102 S:421 28.0 0.2 E -71.8 114.8 NA NA NA
THR H:102 V:421 39.0 0.279 E -69.4 117.3 NA NA NA
THR I:102 Y:421 25.0 0.179 E -67.7 115.4 NA NA NA
THR J:102 b:421 27.0 0.193 E -70.6 114.4 NA NA NA
THR K:102 e:421 23.0 0.164 E -65.4 115.5 NA NA NA
THR L:102 h:421 41.0 0.293 E -73.8 117.7 NA NA NA
THR M:102 k:421 25.0 0.179 E -68.5 114.7 NA NA NA
THR N:102 n:421 30.0 0.214 E -73.2 115.1 NA NA NA
THR O:102 q:421 39.0 0.279 E -72.1 116.4 NA NA NA
THR P:102 t:421 44.0 0.314 E -68.5 115.0 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 THR A:102 A:421 32.0 0.229 E -68.8 115.3 32.0 0.229 0.0 EF2
HOH
 7.935
2.808
 OG1
OG1
 O18
O
THR B:102 D:421 34.0 0.243 E -69.9 114.3 NA NA NA
THR C:102 G:421 39.0 0.279 E -70.3 116.0 NA NA NA
THR D:102 J:421 39.0 0.279 E -72.4 115.8 NA NA NA
THR E:102 M:421 26.0 0.186 E -72.4 115.3 NA NA NA
THR F:102 P:421 27.0 0.193 E -75.5 113.1 NA NA NA
THR G:102 S:421 28.0 0.2 E -77.1 113.5 NA NA NA
THR H:102 V:421 38.0 0.271 E -72.7 115.5 NA NA NA
THR I:102 Y:421 28.0 0.2 E -73.2 116.1 NA NA NA
THR J:102 b:421 26.0 0.186 E -75.5 113.7 NA NA NA
THR K:102 e:421 24.0 0.171 E -72.2 115.3 NA NA NA
THR L:102 h:421 43.0 0.307 E -74.1 115.7 NA NA NA
THR M:102 k:421 24.0 0.171 E -74.6 115.1 NA NA NA
THR N:102 n:421 29.0 0.207 E -71.6 116.3 NA NA NA
THR O:102 q:421 39.0 0.279 E -73.8 114.9 NA NA NA
THR P:102 t:421 43.0 0.307 E -71.4 114.7 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 THR A:102 A:421 32.0 0.229 E -67.9 115.6 32.0 0.229 0.0 6EL
HOH
 8.119
2.660
 OG1
OG1
 OAC
O
THR B:102 D:421 31.0 0.221 E -71.1 112.9 NA NA NA
THR C:102 G:421 40.0 0.286 E -70.6 115.8 NA NA NA
THR D:102 J:421 39.0 0.279 E -67.5 113.8 NA NA NA
THR E:102 M:421 32.0 0.229 E -65.6 113.8 NA NA NA
THR F:102 P:421 28.0 0.2 E -70.2 114.2 NA NA NA
THR G:102 S:421 27.0 0.193 E -72.9 112.0 NA NA NA
THR H:102 V:421 34.0 0.243 E -67.6 115.4 NA NA NA
THR I:102 Y:421 22.0 0.157 E -71.1 113.7 NA NA NA
THR J:102 b:421 24.0 0.171 E -73.9 115.4 NA NA NA
THR K:102 e:421 26.0 0.186 E -69.7 116.0 NA NA NA
THR L:102 h:421 41.0 0.293 E -70.3 116.3 NA NA NA
THR M:102 k:421 24.0 0.171 E -66.5 114.5 NA NA NA
THR N:102 n:421 31.0 0.221 E -68.3 115.6 NA NA NA
THR O:102 q:421 39.0 0.279 E -69.9 116.0 NA NA NA
THR P:102 t:421 44.0 0.314 E -67.9 116.3 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 THR A:100 A:420 29.0 0.207 E -70.0 117.6 29.0 0.207 0.0 Y70
HOH
 7.804
2.774
 OG1
OG1
 O11
O
THR B:100 B:420 27.0 0.193 E -68.5 116.7 27.0 0.193 0.0 Y70
HOH
 8.051
2.772
 OG1
OG1
 O11
O
THR C:100 C:420 34.0 0.243 E -76.5 116.4 NA NA NA
THR D:100 D:420 28.0 0.2 E -69.4 115.0 28.0 0.2 0.0 Y70
HOH
 8.076
2.553
 OG1
OG1
 O11
O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 THR A:101 C:420 39.0 0.279 E -74.1 115.0 NA NA NA
THR B:101 A:420 43.0 0.307 E -73.9 116.4 43.0 0.307 0.0 EF2
HOH
 7.702
2.610
 OG1
OG1
 O18
O
THR C:101 B:420 35.0 0.25 E -77.1 112.2 NA NA NA
THR D:101 D:420 22.0 0.157 E -71.8 117.7 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 THR A:418 A:418 3.0 0.021 E -75.9 123.3