Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3192707 . A C CCDS2562.1:NM_016302.3:c.1171Tgt>Ggt_NP_057386.2:p.391C>G Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 CYS B:412 B:391 1.0 0.007 E -69.2 142.0 1.0 0.007 0.0 ZN
 2.302
 SG
 ZN
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 CYS B:412 B:391 0.0 0.0 E -69.8 150.6 0.0 0.0 0.0 ZN
 2.495
 SG
 ZN
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 CYS B:412 B:391 1.0 0.007 E -64.6 144.0 1.0 0.007 0.0 ZN
 2.319
 SG
 ZN
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 CYS B:412 B:391 6.0 0.044 E -72.5 153.5 6.0 0.044 0.0 ZN
 2.558
 SG
 ZN
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 CYS B:412 B:391 0.0 0.0 E -66.6 144.3 0.0 0.0 0.0 ZN
 2.397
 SG
 ZN
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 CYS C:355 Z:391 1.0 0.007 E -53.3 113.3 1.0 0.007 0.0 ZN
 2.216
 SG
 ZN
CYS E:355 C:391 1.0 0.007 E -53.4 114.0 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 CYS B:355 C:391 3.0 0.022 E -62.3 110.3 3.0 0.022 0.0 ZN
 1.790
 SG
 ZN
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 CYS B:355 C:391 0.0 0.0 E -54.1 118.6 0.0 0.0 0.0 ZN
 2.491
 SG
 ZN
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 CYS C:355 Z:391 2.0 0.015 E -68.6 136.4 2.0 0.015 0.0 ZN
 2.497
 SG
 ZN
CYS F:355 C:391 2.0 0.015 E -68.8 136.6 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 CYS B:375 B:391 1.0 0.007 E -69.2 136.9 1.0 0.007 0.0 ZN
HOH
 2.455
6.244
 SG
CB
 ZN
O
CYS E:375 E:391 1.0 0.007 E -69.0 136.4 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 CYS B:375 B:391 0.0 0.0 E -58.8 132.8 0.0 0.0 0.0 ZN
HOH
 2.324
8.712
 SG
H
 ZN
O
CYS E:375 E:391 0.0 0.0 E -59.0 133.1 NA NA NA
CYS H:375 H:391 0.0 0.0 E -59.1 132.8 NA NA NA
CYS K:375 K:391 0.0 0.0 E -59.0 133.0 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 CYS B:375 B:391 2.0 0.015 E -71.2 129.2 2.0 0.015 0.0 ZN
 2.542
 SG
 ZN
CYS E:375 E:391 2.0 0.015 E -71.2 129.3 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 CYS B:345 B:391 2.0 0.015 E -71.0 136.4 2.0 0.015 0.0 ZN
 2.274
 SG
 ZN
CYS E:345 E:391 1.0 0.007 E -70.2 136.4 NA NA NA
CYS H:345 H:391 1.0 0.007 E -66.0 137.5 NA NA NA
CYS K:345 K:391 0.0 0.0 E -66.7 140.7 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 CYS B:344 C:391 0.0 0.0 E -51.2 112.8 0.0 0.0 0.0 ZN
HOH
 2.109
8.872
 SG
CA
 ZN
O
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 CYS B:417 B:393 3.0 0.022 E -57.3 133.1 3.0 0.022 0.0 ZN
HOH
 2.290
6.992
 SG
O
 ZN
O
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 CYS B:417 B:393 2.0 0.015 E -61.1 127.4 2.0 0.015 0.0 ZN
 2.265
 SG
 ZN
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 CYS B:417 B:393 2.0 0.015 E -59.0 136.1 2.0 0.015 0.0 ZN
 2.388
 SG
 ZN
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 CYS A:79 A:391 1.0 0.007 E -56.6 131.4 1.0 0.007 0.0 ZN
HOH
 2.207
5.987
 SG
CB
 ZN
O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 CYS A:74 A:391 0.0 0.0 E -61.4 128.0 0.0 0.0 0.0 ZN
HOH
 2.283
5.846
 SG
CB
 ZN
O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 CYS A:75 A:394 1.0 0.007 E -59.8 129.9 1.0 0.007 0.0 ZN
HOH
 2.345
2.902
 SG
O
 ZN
O
CYS B:75 B:394 1.0 0.007 E -63.6 132.1 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 CYS A:75 A:394 1.0 0.007 E -58.1 130.1 1.0 0.007 0.0 ZN
HOH
 2.353
2.758
 SG
O
 ZN
O
CYS B:75 B:394 0.0 0.0 E -63.2 133.8 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 CYS A:75 A:394 1.0 0.007 E -56.2 132.4 1.0 0.007 0.0 ZN
HOH
 2.373
6.142
 SG
CB
 ZN
O
CYS B:75 D:394 0.0 0.0 E -57.9 132.9 NA NA NA
CYS C:75 G:394 2.0 0.015 E -59.0 134.0 NA NA NA
CYS D:75 J:394 1.0 0.007 E -55.7 134.0 NA NA NA
CYS E:75 M:394 0.0 0.0 E -61.0 127.7 NA NA NA
CYS F:75 P:394 1.0 0.007 E -55.5 134.2 NA NA NA
CYS G:75 S:394 1.0 0.007 E -55.1 133.7 NA NA NA
CYS H:75 V:394 0.0 0.0 E -55.1 133.4 NA NA NA
CYS I:75 Y:394 1.0 0.007 E -59.4 129.0 NA NA NA
CYS J:75 b:394 1.0 0.007 E -56.9 135.1 NA NA NA
CYS K:75 e:394 1.0 0.007 E -53.0 126.1 NA NA NA
CYS L:75 h:394 0.0 0.0 E -54.2 134.5 NA NA NA
CYS M:75 k:394 0.0 0.0 E -58.5 126.0 NA NA NA
CYS N:75 n:394 0.0 0.0 E -54.8 133.2 NA NA NA
CYS O:75 q:394 1.0 0.007 E -58.9 132.4 NA NA NA
CYS P:75 t:394 1.0 0.007 E -56.4 135.7 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 CYS A:75 A:394 1.0 0.007 E -56.2 130.5 1.0 0.007 0.0 ZN
HOH
 2.339
6.243
 SG
CB
 ZN
O
CYS B:75 D:394 0.0 0.0 E -57.1 130.8 NA NA NA
CYS C:75 G:394 2.0 0.015 E -60.5 129.0 NA NA NA
CYS D:75 J:394 1.0 0.007 E -60.9 135.3 NA NA NA
CYS E:75 M:394 1.0 0.007 E -58.6 130.6 NA NA NA
CYS F:75 P:394 1.0 0.007 E -55.2 136.9 NA NA NA
CYS G:75 S:394 1.0 0.007 E -53.7 134.1 NA NA NA
CYS H:75 V:394 0.0 0.0 E -61.9 133.6 NA NA NA
CYS I:75 Y:394 1.0 0.007 E -57.5 131.2 NA NA NA
CYS J:75 b:394 1.0 0.007 E -56.2 134.5 NA NA NA
CYS K:75 e:394 1.0 0.007 E -57.6 130.5 NA NA NA
CYS L:75 h:394 1.0 0.007 E -61.0 134.7 NA NA NA
CYS M:75 k:394 1.0 0.007 E -62.7 130.1 NA NA NA
CYS N:75 n:394 1.0 0.007 E -59.9 134.4 NA NA NA
CYS O:75 q:394 1.0 0.007 E -55.2 135.2 NA NA NA
CYS P:75 t:394 1.0 0.007 E -56.5 131.9 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 CYS A:75 A:394 1.0 0.007 E -48.2 133.7 1.0 0.007 0.0 ZN
HOH
 2.340
5.971
 SG
CB
 ZN
O
CYS B:75 D:394 0.0 0.0 E -56.1 133.5 NA NA NA
CYS C:75 G:394 1.0 0.007 E -64.5 129.6 NA NA NA
CYS D:75 J:394 1.0 0.007 E -58.5 132.6 NA NA NA
CYS E:75 M:394 0.0 0.0 E -60.6 126.8 NA NA NA
CYS F:75 P:394 1.0 0.007 E -53.6 134.8 NA NA NA
CYS G:75 S:394 1.0 0.007 E -53.0 132.1 NA NA NA
CYS H:75 V:394 1.0 0.007 E -60.7 132.3 NA NA NA
CYS I:75 Y:394 1.0 0.007 E -57.6 127.7 NA NA NA
CYS J:75 b:394 1.0 0.007 E -56.9 135.1 NA NA NA
CYS K:75 e:394 1.0 0.007 E -55.1 129.5 NA NA NA
CYS L:75 h:394 1.0 0.007 E -59.5 134.8 NA NA NA
CYS M:75 k:394 0.0 0.0 E -61.3 127.0 NA NA NA
CYS N:75 n:394 0.0 0.0 E -53.9 135.2 NA NA NA
CYS O:75 q:394 1.0 0.007 E -58.6 135.1 NA NA NA
CYS P:75 t:394 1.0 0.007 E -58.3 131.9 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 CYS A:73 A:393 0.0 0.0 E -58.8 132.7 0.0 0.0 0.0 ZN
HOH
 2.347
2.686
 SG
O
 ZN
O
CYS B:73 B:393 1.0 0.007 E -56.1 126.0 1.0 0.007 0.0 ZN
HOH
 2.368
6.058
 SG
CB
 ZN
O
CYS C:73 C:393 0.0 0.0 E -55.9 134.1 NA NA NA
CYS D:73 D:393 0.0 0.0 E -59.5 130.0 0.0 0.0 0.0 ZN
HOH
 2.360
2.739
 SG
O
 ZN
O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 CYS A:74 C:393 1.0 0.007 E -59.7 134.6 NA NA NA
CYS B:74 A:393 0.0 0.0 E -56.9 131.2 0.0 0.0 0.0 ZN
HOH
 2.332
2.724
 SG
O
 ZN
O
CYS C:74 B:393 1.0 0.007 E -53.3 131.3 NA NA NA
CYS D:74 D:393 1.0 0.007 E -60.5 127.6 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 CYS A:391 A:391 2.0 0.015 E -61.7 126.5