Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr3 3194188 . T A CCDS2562.1:NM_016302.3:c.1100aAc>aTc_NP_057386.2:p.367N>I Homo sapiens cereblon (CRBN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6bn7 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ASN B:388 B:367 65.0 0.406 S 60.9 42.6 65.0 0.406 0.0 ZN
 6.469
 O
 ZN
6bn8 2 Q96SW2 97.06 0.0 X-RAY
 2018-06-06 ASN B:388 B:367 69.0 0.431 S 58.3 65.8 69.0 0.431 0.0 ZN
 6.948
 O
 ZN
6bn9 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ASN B:388 B:367 73.0 0.456 S 60.0 67.1 73.0 0.456 0.0 ZN
 6.861
 O
 ZN
6bnb 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ASN B:388 B:367 64.0 0.4 S 57.6 56.2 64.0 0.4 0.0 ZN
 6.499
 O
 ZN
6boy 2 Q96SW2 97.06 0.0 X-RAY
 2018-05-30 ASN B:388 B:367 69.0 0.431 S 61.1 50.4 69.0 0.431 0.0 ZN
 6.758
 O
 ZN
5hxb 3 Q96SW2 99.75 0.0 X-RAY
 2016-06-29 ASN C:331 Z:367 82.0 0.512 S 55.5 43.3 82.0 0.512 0.0 ZN
 6.985
 O
 ZN
ASN E:331 C:367 81.0 0.506 S 55.6 42.9 NA NA NA
5v3o 2 Q96SW2 99.75 0.0 X-RAY
 2017-05-03 ASN B:331 C:367 51.0 0.319 S 53.2 36.6 51.0 0.319 0.0 ZN
 6.902
 O
 ZN
6uml 2 Q96SW2 99.75 0.0 X-RAY
 2020-04-15 ASN B:331 C:367 58.0 0.362 S 54.3 44.3 58.0 0.362 0.0 ZN
 7.224
 O
 ZN
6xk9 3 Q96SW2 99.75 0.0 X-RAY
 2020-12-02 ASN C:331 Z:367 83.0 0.519 S 64.5 33.4 83.0 0.519 0.0 ZN
 6.665
 O
 ZN
ASN F:331 C:367 83.0 0.519 S 64.5 33.7 NA NA NA
5fqd 2 Q96SW2 99.02 0.0 X-RAY
 2016-02-24 ASN B:351 B:367 61.0 0.381 S 64.8 33.6 61.0 0.381 0.0 ZN
HOH
 6.608
8.577
 O
N
 ZN
O
ASN E:351 E:367 61.0 0.381 S 65.9 32.8 NA NA NA
6h0f 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ASN B:351 B:367 58.0 0.362 S 69.2 40.4 58.0 0.362 0.0 ZN
 6.946
 O
 ZN
ASN E:351 E:367 59.0 0.369 S 69.7 38.4 NA NA NA
ASN H:351 H:367 56.0 0.35 S 69.7 38.9 NA NA NA
ASN K:351 K:367 58.0 0.362 S 70.0 41.5 NA NA NA
6h0g 2 Q96SW2 99.02 0.0 X-RAY
 2018-11-07 ASN B:351 B:367 66.0 0.412 S 58.1 47.3 66.0 0.412 0.0 ZN
 6.620
 O
 ZN
ASN E:351 E:367 65.0 0.406 S 58.0 47.6 NA NA NA
7lps 2 Q96SW2 100.0 0.0 X-RAY
 2021-06-02 ASN B:321 B:367 60.0 0.375 S 58.3 45.0 60.0 0.375 0.0 ZN
 6.580
 O
 ZN
ASN E:321 E:367 60.0 0.375 S 58.4 44.7 NA NA NA
ASN H:321 H:367 62.0 0.388 S 58.5 44.7 NA NA NA
ASN K:321 K:367 60.0 0.375 S 58.4 44.7 NA NA NA
4tz4 2 Q96SW2 100.0 0.0 X-RAY
 2014-08-06 ASN B:320 C:367 54.0 0.338 S 53.2 44.4 54.0 0.338 0.0 ZN
HOH
 6.950
3.737
 O
N
 ZN
O
4ci1 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ASN B:393 B:369 46.0 0.287 S -80.2 62.4 46.0 0.287 0.0 ZN
HOH
 6.778
4.528
 O
C
 ZN
O
4ci2 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ASN B:393 B:369 47.0 0.294 S -79.7 50.5 47.0 0.294 0.0 ZN
 6.888
 O
 ZN
4ci3 2 P0CF65 84.08 0.0 X-RAY
 2014-07-16 ASN B:393 B:369 48.0 0.3 S -87.6 61.4 48.0 0.3 0.0 ZN
 6.925
 O
 ZN
7bqu 1 Q96SW2 96.43 3e-76 X-RAY
 2020-08-26 ASN A:55 A:367 69.0 0.431 S 66.6 32.2 69.0 0.431 0.0 ZN
HOH
 6.701
3.370
 O
N
 ZN
O
7bqv 1 Q96SW2 99.08 6e-76 X-RAY
 2020-08-26 ASN A:50 A:367 53.0 0.331 S 64.3 29.2 53.0 0.331 0.0 ZN
HOH
 6.792
3.120
 O
ND2
 ZN
O
3wx1 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ASN A:51 A:370 72.0 0.45 S 64.2 31.7 72.0 0.45 0.0 ZN
SO4
HOH
 6.789
8.182
2.774
 O
N
OD1
 ZN
O3
O
ASN B:51 B:370 66.0 0.412 S 64.4 28.7 NA NA NA
3wx2 1 Q8C7D2 97.25 2e-74 X-RAY
 2014-08-06 ASN A:51 A:370 72.0 0.45 S 64.7 32.7 72.0 0.45 0.0 ZN
SO4
HOH
 6.793
8.180
2.809
 O
N
OD1
 ZN
O3
O
ASN B:51 B:370 66.0 0.412 S 63.9 29.0 NA NA NA
5yiz 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ASN A:51 A:370 52.0 0.325 S 69.9 22.3 52.0 0.325 0.0 ZN
SO4
HOH
 6.937
7.993
3.810
 O
N
CA
 ZN
O4
O
ASN B:51 D:370 53.0 0.331 S 70.8 21.1 NA NA NA
ASN C:51 G:370 50.0 0.312 S 66.4 20.5 NA NA NA
ASN D:51 J:370 56.0 0.35 S 62.4 26.1 NA NA NA
ASN E:51 M:370 52.0 0.325 S 65.4 20.4 NA NA NA
ASN F:51 P:370 53.0 0.331 S 67.5 29.1 NA NA NA
ASN G:51 S:370 54.0 0.338 S 66.5 26.3 NA NA NA
ASN H:51 V:370 59.0 0.369 S 64.8 23.5 NA NA NA
ASN I:51 Y:370 55.0 0.344 S 65.1 24.2 NA NA NA
ASN J:51 b:370 53.0 0.331 S 67.2 27.1 NA NA NA
ASN K:51 e:370 55.0 0.344 S 69.3 21.2 NA NA NA
ASN L:51 h:370 59.0 0.369 S 65.3 24.6 NA NA NA
ASN M:51 k:370 57.0 0.356 S 67.4 20.9 NA NA NA
ASN N:51 n:370 54.0 0.338 S 66.8 27.8 NA NA NA
ASN O:51 q:370 56.0 0.35 S 65.9 30.0 NA NA NA
ASN P:51 t:370 49.0 0.306 S 73.0 23.9 NA NA NA
5yj0 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ASN A:51 A:370 51.0 0.319 S 68.7 24.9 51.0 0.319 0.0 ZN
SO4
HOH
 7.013
7.997
3.833
 O
N
CA
 ZN
O4
O
ASN B:51 D:370 52.0 0.325 S 70.7 22.8 NA NA NA
ASN C:51 G:370 49.0 0.306 S 67.3 21.0 NA NA NA
ASN D:51 J:370 55.0 0.344 S 64.4 26.4 NA NA NA
ASN E:51 M:370 52.0 0.325 S 64.1 23.9 NA NA NA
ASN F:51 P:370 52.0 0.325 S 69.3 25.7 NA NA NA
ASN G:51 S:370 53.0 0.331 S 67.5 26.2 NA NA NA
ASN H:51 V:370 54.0 0.338 S 64.8 26.7 NA NA NA
ASN I:51 Y:370 56.0 0.35 S 63.3 25.8 NA NA NA
ASN J:51 b:370 52.0 0.325 S 69.5 27.0 NA NA NA
ASN K:51 e:370 54.0 0.338 S 65.5 24.9 NA NA NA
ASN L:51 h:370 57.0 0.356 S 65.2 26.7 NA NA NA
ASN M:51 k:370 57.0 0.356 S 66.4 22.8 NA NA NA
ASN N:51 n:370 55.0 0.344 S 64.1 28.3 NA NA NA
ASN O:51 q:370 54.0 0.338 S 65.2 29.6 NA NA NA
ASN P:51 t:370 49.0 0.306 S 70.8 24.8 NA NA NA
5yj1 1 Q8C7D2 97.25 2e-74 X-RAY
 2018-02-07 ASN A:51 A:370 53.0 0.331 S 73.0 21.4 53.0 0.331 0.0 ZN
SO4
HOH
 6.895
8.033
3.895
 O
N
CA
 ZN
O4
O
ASN B:51 D:370 53.0 0.331 S 73.7 19.5 NA NA NA
ASN C:51 G:370 50.0 0.312 S 68.1 21.5 NA NA NA
ASN D:51 J:370 56.0 0.35 S 64.2 22.7 NA NA NA
ASN E:51 M:370 53.0 0.331 S 63.4 21.6 NA NA NA
ASN F:51 P:370 54.0 0.338 S 66.8 30.3 NA NA NA
ASN G:51 S:370 54.0 0.338 S 65.7 28.7 NA NA NA
ASN H:51 V:370 57.0 0.356 S 66.4 22.3 NA NA NA
ASN I:51 Y:370 55.0 0.344 S 61.8 24.6 NA NA NA
ASN J:51 b:370 57.0 0.356 S 66.6 28.8 NA NA NA
ASN K:51 e:370 54.0 0.338 S 62.7 24.6 NA NA NA
ASN L:51 h:370 55.0 0.344 S 64.3 25.1 NA NA NA
ASN M:51 k:370 55.0 0.344 S 63.2 21.2 NA NA NA
ASN N:51 n:370 56.0 0.35 S 65.9 21.3 NA NA NA
ASN O:51 q:370 56.0 0.35 S 65.6 27.7 NA NA NA
ASN P:51 t:370 51.0 0.319 S 71.3 22.5 NA NA NA
4tzu 1 Q8C7D2 97.22 9e-74 X-RAY
 2014-08-06 ASN A:49 A:369 56.0 0.35 S 66.3 31.8 2.0 0.013 0.337 D:Q8C7D2:0.338
 SO4
ZN
HOH
 7.879
6.839
3.397
 N
O
ND2
 O3
ZN
O
ASN B:49 B:369 54.0 0.338 S 64.7 25.8 1.0 0.006 0.332 A:Q8C7D2:0.331
 SO4
ZN
HOH
 8.099
6.877
3.721
 N
O
OD1
 O2
ZN
O
ASN C:49 C:369 52.0 0.325 S 64.2 24.0 NA NA NA
ASN D:49 D:369 53.0 0.331 S 63.0 28.0 4.0 0.025 0.306 B:Q8C7D2:0.306
 SO4
ZN
HOH
 8.400
6.864
3.278
 N
O
ND2
 O4
ZN
O
4tzc 1 Q8C7D2 97.2 4e-73 X-RAY
 2014-08-06 ASN A:50 C:369 57.0 0.356 S 67.0 29.2 NA NA NA
ASN B:50 A:369 54.0 0.338 S 66.0 29.5 54.0 0.338 0.0 ZN
HOH
 6.794
3.372
 O
ND2
 ZN
O
ASN C:50 B:369 49.0 0.306 S 65.2 21.5 NA NA NA
ASN D:50 D:369 51.0 0.319 S 65.7 25.4 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q96sw2-f1 1 Q96SW2 100.0 0.0 ASN A:367 A:367 55.0 0.344 S 58.8 35.2