Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr4 | 102014953 | . | C | A | CCDS34037.1:NM_000944.4:c.762agG>agT_NP_000935.1:p.254R>S | Homo sapiens protein phosphatase 3 catalytic subunit alpha (PPP3CA), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1aui | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
1997-12-03 | ARG | A:254 | A:254 | 4.0 | 0.018 | T | -92.3 | -18.3 | 4.0 | 0.018 | 0.0 |
ZN FE HOH |
4.855 5.929 3.301 |
NH1 NH1 NH1 |
ZN FE O |
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| 4orb | 1 | P63328 | 97.7 | 0.0 |
X-RAY |
2015-05-20 | ARG | A:254 | A:254 | 4.0 | 0.018 | T | -87.1 | -19.5 | 4.0 | 0.018 | 0.0 |
ZN FE HOH |
4.552 4.711 2.627 |
NH1 NH1 NH1 |
ZN FE O |
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| 4il1 | 1 | P62161,P63100,P63329 | 97.76 | 0.0 |
X-RAY |
2013-10-02 | ARG | A:587 | A:587 | 6.0 | 0.027 | T | -82.5 | -38.5 | 6.0 | 0.027 | 0.0 |
HOH |
4.909 |
NH1 |
O |
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| ARG | B:587 | B:587 | 10.0 | 0.044 | T | -81.0 | -38.6 | NA | NA | NA | |||||||||||||
| ARG | C:587 | C:587 | 3.0 | 0.013 | T | -82.5 | -39.0 | NA | NA | NA | |||||||||||||
| ARG | D:587 | D:587 | 6.0 | 0.027 | T | -82.8 | -37.5 | NA | NA | NA | |||||||||||||
| 4or9 | 1 | P16298 | 85.63 | 0.0 |
X-RAY |
2015-05-20 | ARG | A:283 | A:263 | 6.0 | 0.027 | T | -84.4 | -24.5 | 6.0 | 0.027 | 0.0 |
FE ZN HOH |
6.084 4.949 3.450 |
NH1 NH1 NH1 |
FE ZN O |
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| 4orc | 1 | P16298 | 85.63 | 0.0 |
X-RAY |
2015-05-20 | ARG | A:283 | A:263 | 74.0 | 0.329 | T | -74.8 | -28.8 | 74.0 | 0.329 | 0.0 |
ZN FE PO4 HOH |
4.887 5.843 2.760 4.752 |
NH1 NH1 NH1 NH2 |
ZN FE O2 O |
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| 4ora | 1 | P16298 | 85.23 | 0.0 |
X-RAY |
2015-05-20 | ARG | A:283 | A:263 | 5.0 | 0.022 | T | -80.4 | -22.5 | 5.0 | 0.022 | 0.0 |
ZN FE HOH |
3.995 5.129 4.854 |
NH1 NH1 NH1 |
ZN FE O |
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| 2p6b | 2 | Q08209 | 100.0 | 0.0 |
X-RAY |
2007-06-05 | ARG | B:257 | A:254 | 67.0 | 0.298 | T | -79.3 | -26.5 | 67.0 | 0.298 | 0.0 |
ZN FE PO4 HOH |
4.973 6.006 2.916 3.090 |
NH1 NH1 NH1 O |
ZN FE O4 O |
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| ARG | D:257 | C:254 | 67.0 | 0.298 | T | -81.3 | -25.8 | 67.0 | 0.298 | 0.0 |
ZN FE PO4 HOH |
4.828 5.940 2.805 3.808 |
NH1 NH1 NH1 NH1 |
ZN FE O4 O |
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| 1tco | 1 | P48452 | 99.73 | 0.0 |
X-RAY |
1997-02-12 | ARG | A:237 | A:254 | 65.0 | 0.289 | T | -70.4 | -18.5 | 65.0 | 0.289 | 0.0 |
ZN FE PO4 HOH |
5.138 6.152 3.206 3.071 |
NH2 NH1 NH1 O |
ZN FE O4 O |
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| 1mf8 | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2002-10-16 | ARG | A:235 | A:254 | 75.0 | 0.333 | T | -85.5 | -33.5 | 75.0 | 0.333 | 0.0 |
PO4 |
4.162 |
NH1 |
O4 |
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| 1m63 | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2002-09-25 | ARG | A:254 | A:254 | 74.0 | 0.329 | T | -70.1 | -41.3 | 74.0 | 0.329 | 0.0 |
ZN FE |
5.208 6.000 |
NH2 NH2 |
ZN FE |
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| ARG | E:254 | E:254 | 73.0 | 0.324 | T | -86.7 | -26.2 | 73.0 | 0.324 | 0.0 |
ZN FE |
4.538 5.581 |
NH2 NH2 |
ZN FE |
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| 5sve | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2017-01-11 | ARG | A:254 | A:254 | 73.0 | 0.324 | T | -89.6 | -22.6 | 73.0 | 0.324 | 0.0 |
FE ZN HOH |
6.197 4.984 3.374 |
NH1 NH1 NE |
FE ZN O |
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| 4f0z | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2013-03-06 | ARG | A:256 | A:254 | 72.0 | 0.32 | T | -78.6 | -27.9 | 72.0 | 0.32 | 0.0 |
GOL HOH |
2.172 2.319 |
HH12 HH11 |
O2 O |
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| 6nuc | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:256 | A:254 | 69.0 | 0.307 | T | -84.2 | -25.1 | 69.0 | 0.307 | 0.0 |
FE ZN PO4 HOH |
5.438 4.617 1.898 2.314 |
HH12 HH12 HH12 HH11 |
FE ZN O2 O |
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| 6nuf | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:256 | A:254 | 68.0 | 0.302 | T | -82.6 | -30.5 | 68.0 | 0.302 | 0.0 |
FE ZN PO4 PGE HOH |
5.420 4.562 1.851 3.702 2.059 |
HH12 HH12 HH12 O HH11 |
FE ZN O2 H4 O |
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| 6nuu | 1 | Q08209 | 99.46 | 0.0 |
X-RAY |
2019-07-03 | ARG | A:256 | A:254 | 65.0 | 0.289 | T | -84.9 | -23.2 | 65.0 | 0.289 | 0.0 |
FE ZN PO4 HOH |
5.471 4.591 1.825 2.005 |
HH12 HH12 HH12 HH11 |
FE ZN O2 O |
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| 3ll8 | 2 | Q08209 | 100.0 | 0.0 |
X-RAY |
2011-01-12 | ARG | B:241 | A:254 | 68.0 | 0.302 | T | -76.5 | -28.8 | 68.0 | 0.302 | 0.0 |
PO4 ZN FE HOH |
2.667 4.920 6.207 3.008 |
NH1 NH1 NH1 O |
O4 ZN FE O |
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| ARG | D:241 | C:254 | 66.0 | 0.293 | T | -75.5 | -28.4 | NA | NA | NA | |||||||||||||
| 5c1v | 1 | Q08209 | 99.42 | 0.0 |
X-RAY |
2016-02-03 | ARG | A:253 | A:254 | 68.0 | 0.302 | T | -91.1 | -19.8 | 68.0 | 0.302 | 0.0 |
FE ZN PO4 |
5.482 5.019 2.776 |
NH1 NH1 NH1 |
FE ZN O2 |
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| ARG | B:253 | B:254 | 68.0 | 0.302 | T | -87.8 | -23.0 | NA | NA | NA | |||||||||||||
| 6uuq | 1 | Q08209 | 100.0 | 0.0 |
X-RAY |
2020-09-09 | ARG | A:231 | A:254 | 67.0 | 0.298 | T | -78.6 | -23.3 | 67.0 | 0.298 | 0.0 |
PO4 PO4 ZN FE HOH |
2.756 4.996 6.213 4.915 2.840 |
NH1 NH1 NH1 NH1 O |
O4 O3 ZN FE O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q08209-f1 | 1 | Q08209 | 100.0 | 0.0 | ARG | A:254 | A:254 | 8.0 | 0.036 | T | -76.9 | -21.8 | |
| af-p16298-f1 | 1 | P16298 | 85.63 | 0.0 | ARG | A:263 | A:263 | 6.0 | 0.027 | T | -84.9 | -26.5 | |
| af-p48454-f1 | 1 | P48454 | 81.84 | 0.0 | ARG | A:250 | A:250 | 8.0 | 0.036 | T | -77.5 | -24.8 | |