Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120423780 . C A CCDS3713.1:NM_001083.3:c.2362Gat>Tat_NP_001074.2:p.788D>Y Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 ASP A:791 A:788 112.0 0.747 S -99.4 24.0 112.0 0.747 0.0 WAN
HOH
 9.567
4.756
 OD2
OD2
 C11
O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 ASP A:279 A:788 94.0 0.627 T -116.1 33.5 94.0 0.627 0.0 HOH
 3.113
 O
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ASP A:254 A:788 74.0 0.493 S -59.6 15.6 74.0 0.493 0.0 HOH
 5.977
 OD2
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ASP A:254 A:788 63.0 0.42 H -58.9 -38.8 63.0 0.42 0.0 HOH
 2.705
 OD2
 O
ASP B:254 B:788 58.0 0.387 H -61.1 -39.9 NA NA NA
ASP C:254 C:788 58.0 0.387 H -60.3 -32.5 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ASP A:254 A:788 65.0 0.433 H -65.4 -36.7 65.0 0.433 0.0 HOH
 2.550
 OD2
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 ASP A:254 A:788 122.0 0.813 S -59.4 7.2 122.0 0.813 0.0 24E
HOH
 7.846
6.187
 N
C
 O3
O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ASP A:254 A:788 119.0 0.793 T -81.3 -0.0 119.0 0.793 0.0 9M0
 8.171
 N
 C24
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ASP A:254 A:788 108.0 0.72 -105.3 34.1 108.0 0.72 0.0 9T9
HOH
 7.953
4.943
 N
O
 O25
O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 ASP A:258 A:788 88.0 0.587 H -67.9 -33.9 88.0 0.587 0.0 HOH
 2.708
 OD2
 O
ASP B:258 B:788 117.0 0.78 -114.1 44.2 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ASP A:275 A:788 122.0 0.813 H -116.4 7.1 122.0 0.813 0.0 5FO
 9.210
 OD1
 CAK
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ASP A:275 A:788 129.0 0.86 H -115.9 2.4 129.0 0.86 0.0 5CO
 9.056
 OD2
 CAK
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ASP A:275 A:788 79.0 0.527 H -60.0 -43.7 79.0 0.527 0.0 HOH
 2.829
 OD2
 O
ASP B:275 B:788 62.0 NA H -65.8 -41.4 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ASP A:275 A:788 130.0 0.867 H -98.4 17.2 130.0 0.867 0.0 NI0
 9.521
 N
 CAK
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ASP A:275 A:788 140.0 0.933 -135.7 360.0 140.0 0.933 0.0 HOH
 3.645
 O
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ASP A:275 A:788 151.0 1.0 -61.0 360.0 151.0 1.0 0.0 HOH
 2.526
 OD1
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ASP A:275 A:788 138.0 0.92 -53.7 360.0 138.0 0.92 0.0 HOH
 3.814
 O
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ASP A:275 A:788 132.0 0.88 H -128.2 27.1 132.0 0.88 0.0 5IO
HOH
 9.631
8.610
 N
OD2
 CAK
O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ASP A:275 A:788 122.0 0.813 S -96.5 7.5 122.0 0.813 0.0 5EO
HOH
 9.480
5.095
 N
OD2
 CAK
O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 ASP A:275 A:788 122.0 0.813 H -115.5 -6.7 122.0 0.813 0.0 B0C
HOH
 9.882
5.253
 N
OD2
 CAJ
O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 ASP A:254 A:788 85.0 0.567 H -66.7 -37.4 85.0 0.567 0.0 E6L
HOH
 8.327
5.178
 N
N
 C1
O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 ASP A:254 A:788 68.0 0.453 I -85.8 -39.4 68.0 0.453 0.0 HOH
 6.221
 C
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 ASP A:254 A:788 184.0 1.0 -78.9 360.0 184.0 1.0 0.0 HOH
 8.351
 C
 O
ASP B:254 NA:NA DO NA DO DO DO NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ASP A:252 A:788 67.0 0.447 H -55.9 -43.4 67.0 0.447 0.0 HOH
 3.825
 CB
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ASP A:252 A:788 67.0 0.447 H -61.6 -21.5 67.0 0.447 0.0 CIA
 8.353
 N
 C29
ASP B:252 B:788 64.0 0.427 H -63.4 -20.4 64.0 0.427 0.0 CIA
 8.420
 N
 C29
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 ASP A:252 A:788 71.0 0.473 H -62.9 -38.7 71.0 0.473 0.0 HOH
 3.671
 OD1
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ASP A:277 A:788 73.0 0.487 H -62.1 -45.8 73.0 0.487 0.0 CIA
HOH
 9.000
2.666
 N
OD2
 C29
O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ASP A:277 A:788 75.0 0.5 H -69.0 -35.4 75.0 0.5 0.0 HOH
 2.878
 O
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 GLU E:258 C:788 97.0 0.511 H -60.0 -42.6 91.0 0.479 0.032 J:None:0.032
GLU G:258 O:788 98.0 0.516 H -60.0 -42.6 91.0 0.479 0.037 L:None:0.037
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 GLU C:258 B:788 98.0 0.516 T -91.6 -45.8 58.0 0.305 0.211 J:None:0.211
GLU F:258 F:788 104.0 0.547 H -82.6 -44.9 62.0 0.326 0.221 B:None:0.221
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 GLU A:258 A:788 116.0 0.611 H -67.5 -32.7 116.0 0.611 0.0
GLU B:258 B:788 93.0 0.489 H -66.3 -34.0 NA NA NA
GLU C:258 C:788 131.0 0.689 H -68.0 -41.1 NA NA NA
GLU D:258 D:788 78.0 0.411 H -73.1 -40.4 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 GLU A:258 A:788 98.0 0.516 H -60.4 -42.4 98.0 0.516 0.0
GLU B:258 B:788 98.0 0.516 H -60.1 -42.5 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ASP A:277 A:788 84.0 0.56 H -63.9 -41.2 84.0 0.56 0.0 HOH
 2.358
 OD2
 O
ASP B:277 B:788 86.0 0.573 H -64.8 -40.5 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ASP A:277 A:788 81.0 0.54 H -65.0 -40.5 81.0 0.54 0.0 GOL
HOH
 9.848
2.298
 C
OD1
 O2
O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 ASP A:256 A:788 76.0 0.507 H -68.5 -41.1 76.0 0.507 0.0 3P4
HOH
 8.770
2.628
 N
OD1
 C22
O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 ASP A:256 A:788 66.0 0.44 H -66.1 -38.4 66.0 0.44 0.0 TGE
HOH
 9.611
2.783
 N
OD1
 H21A
O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 ASP A:256 A:788 66.0 0.44 H -64.6 -38.2 66.0 0.44 0.0 0H3
HOH
 9.464
2.847
 N
OD2
 H22
O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 ASP A:256 B:788 76.0 0.507 H -63.0 -42.2 76.0 0.507 0.0 HOH
 2.553
 OD1
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ASP A:254 A:788 73.0 0.487 H -62.3 -40.1 73.0 0.487 0.0 HOH
 2.699
 OD1
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ASP A:254 A:788 75.0 0.5 H -61.5 -44.9 75.0 0.5 0.0 HOH
 2.592
 OD1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 ASP A:788 A:788 71.0 0.473 H -64.8 -38.8