Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120425692 . C A CCDS3713.1:NM_001083.3:c.2330cGg>cTg_NP_001074.2:p.777R>L Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 ARG A:780 A:777 148.0 0.658 H -66.5 -45.0 148.0 0.658 0.0 WAN
HOH
 8.717
3.500
 C
NE
 O16
O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 ARG A:268 A:777 134.0 0.596 H -54.9 -54.3 134.0 0.596 0.0 HOH
 3.704
 CA
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:243 A:777 142.0 0.631 H -65.2 -44.9 142.0 0.631 0.0 HOH
 3.767
 NE
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:243 A:777 126.0 0.56 H -59.5 -42.9 126.0 0.56 0.0 VIA
HOH
 8.791
5.911
 C
NH2
 O27
O
ARG B:243 B:777 124.0 0.551 H -69.7 -39.3 NA NA NA
ARG C:243 C:777 138.0 0.613 H -62.6 -38.9 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:243 A:777 61.0 0.271 H -63.5 -43.1 61.0 0.271 0.0 7CA
HOH
 6.406
2.769
 C
O
 C1
O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 ARG A:243 A:777 146.0 0.649 H -65.9 -43.6 146.0 0.649 0.0 24E
HOH
 7.609
6.857
 C
CB
 C15
O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:243 A:777 150.0 0.667 H -72.0 -40.1 150.0 0.667 0.0 9M0
HOH
 6.845
6.796
 C
CB
 C28
O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:243 A:777 147.0 0.653 H -69.0 -38.1 147.0 0.653 0.0 9T9
HOH
 8.481
3.400
 C
NH2
 C28
O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 ARG A:247 A:777 117.0 0.52 H -66.9 -44.2 117.0 0.52 0.0 VDN
HOH
 8.370
3.798
 O
CB
 C1
O
ARG B:247 B:777 124.0 0.551 H -67.4 -46.6 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:264 A:777 155.0 0.689 H -73.9 -40.6 155.0 0.689 0.0 5FO
 8.091
 C
 OAD
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:264 A:777 149.0 0.662 H -66.6 -48.0 149.0 0.662 0.0 5CO
HOH
 8.267
6.875
 C
CB
 OAD
O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:264 A:777 108.0 0.48 H -71.2 -43.3 108.0 0.48 0.0 5BO
HOH
 8.060
2.880
 O
NH2
 CAA
O
ARG B:264 B:777 56.0 0.249 H -68.3 -42.6 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:264 A:777 143.0 0.636 H -67.8 -43.6 143.0 0.636 0.0 NI0
HOH
 8.159
2.778
 O
NH1
 CAA
O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:264 A:777 146.0 0.649 H -68.5 -44.4 146.0 0.649 0.0 NI5
HOH
 7.921
2.777
 C
NH1
 OAC
O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:264 A:777 146.0 0.649 H -69.9 -43.1 146.0 0.649 0.0 5BA
PEG
HOH
 8.076
3.224
3.890
 O
NE
NH1
 CAA
O4
O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:264 A:777 145.0 0.644 H -64.7 -45.5 145.0 0.644 0.0 5BB
HOH
 8.432
6.789
 O
CB
 CAB
O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:264 A:777 152.0 0.676 H -72.0 -45.1 152.0 0.676 0.0 5IO
HOH
 7.963
5.036
 O
N
 CAA
O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:264 A:777 146.0 0.649 H -70.3 -43.0 146.0 0.649 0.0 5EO
HOH
 8.130
5.017
 O
N
 CAA
O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 ARG A:264 A:777 149.0 0.662 H -72.7 -42.0 149.0 0.662 0.0 B0C
HOH
 8.287
2.816
 O
NE
 CAA
O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 ARG A:243 A:777 138.0 0.613 H -72.2 -42.8 138.0 0.613 0.0 E6L
HOH
 7.726
4.810
 O
N
 CL1
O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 ARG A:243 A:777 142.0 0.631 H -71.3 -47.1 142.0 0.631 0.0 IBM
HOH
 8.758
4.571
 C
N
 O6
O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 ARG A:243 A:777 128.0 0.569 H -71.1 -28.0 128.0 0.569 0.0 FZA
HOH
 6.473
2.730
 CG
O
 C26
O
ARG B:243 B:777 149.0 0.662 H -61.7 -46.1 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:241 A:777 54.0 0.24 H -66.7 -47.5 54.0 0.24 0.0 VIA
HOH
 8.165
2.549
 O
NH1
 C1
O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:241 A:777 38.0 0.169 H -47.6 -27.0 38.0 0.169 0.0 CIA
 8.090
 C
 C3
ARG B:241 B:777 38.0 0.169 H -53.5 -25.1 38.0 0.169 0.0 CIA
 7.462
 C
 C3
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 ARG A:241 A:777 62.0 0.276 H -62.5 -39.3 62.0 0.276 0.0 VDN
HOH
 8.979
2.782
 O
O
 C1
O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:266 A:777 53.0 0.236 H -65.8 -42.0 53.0 0.236 0.0 CIA
HOH
 7.139
2.663
 C
NE
 C3
O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:266 A:777 57.0 0.253 H -68.3 -47.3 57.0 0.253 0.0 VDN
HOH
 8.534
2.776
 C
NH2
 O27
O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 ARG E:247 C:777 59.0 0.262 H -74.8 -40.5 59.0 0.262 0.0 IBM
 9.334
 C
 O6
ARG G:247 O:777 60.0 0.267 H -74.8 -40.5 60.0 0.267 0.0 IBM
 9.334
 C
 O6
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 ARG C:247 B:777 72.0 0.32 H -59.8 -45.3 72.0 0.32 0.0
ARG F:247 F:777 66.0 0.293 H -58.7 -47.4 66.0 0.293 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:247 A:777 66.0 0.293 H -60.4 -46.7 66.0 0.293 0.0 VIA
HOH
 8.903
2.815
 C
NH1
 O27
O
ARG B:247 B:777 65.0 0.289 H -62.2 -48.3 NA NA NA
ARG C:247 C:777 67.0 0.298 H -61.6 -46.1 NA NA NA
ARG D:247 D:777 65.0 0.289 H -61.9 -47.5 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:247 A:777 59.0 0.262 H -72.7 -40.7 59.0 0.262 0.0 IBM
HOH
 9.112
2.957
 C
NH2
 C10
O
ARG B:247 B:777 60.0 0.267 H -74.8 -40.5 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:266 A:777 69.0 0.307 H -66.2 -45.8 69.0 0.307 0.0 5GP
HOH
 8.868
2.707
 C
O
 O6
O
ARG B:266 B:777 58.0 0.258 H -65.0 -46.9 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:266 A:777 152.0 0.676 H -66.4 -42.6 152.0 0.676 0.0 VIA
HOH
 8.625
2.807
 O
O
 C1
O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 ARG A:245 A:777 52.0 0.231 H -62.3 -43.9 52.0 0.231 0.0 3P4
HOH
 7.514
2.696
 C
NE
 C16
O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 ARG A:245 A:777 138.0 0.613 H -67.0 -41.7 138.0 0.613 0.0 TGE
HOH
 5.677
5.867
 C
NE
 H17
O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 ARG A:245 A:777 140.0 0.622 H -67.0 -41.1 140.0 0.622 0.0 0H3
HOH
 5.849
5.013
 C
CG
 H30
O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 ARG A:245 B:777 54.0 0.24 H -63.0 -42.5 54.0 0.24 0.0 6LK
HOH
 6.616
2.765
 C
O
 C1
O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:243 A:777 62.0 0.276 H -67.9 -42.4 62.0 0.276 0.0 PD4
HOH
 6.530
2.965
 C
O
 C23
O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:243 A:777 53.0 0.236 H -61.0 -46.3 53.0 0.236 0.0 PD6
HOH
 7.393
2.713
 C
O
 C21
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 ARG A:777 A:777 129.0 0.573 H -63.7 -40.3