Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120425749 . A C CCDS3713.1:NM_001083.3:c.2273aTg>aGg_NP_001074.2:p.758M>R Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 MET A:761 A:758 4.0 0.022 H -66.5 -38.0 4.0 0.022 0.0 HOH
 3.738
 CE
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 MET A:249 A:758 4.0 0.022 H -62.0 -36.1 4.0 0.022 0.0 CIT
HOH
 9.050
3.612
 SD
CE
 O7
O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:224 A:758 3.0 0.016 H -65.8 -38.4 3.0 0.016 0.0 HOH
 3.751
 CE
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:224 A:758 5.0 0.027 H -66.1 -37.9 5.0 0.027 0.0 HOH
 4.320
 N
 O
MET B:224 B:758 5.0 0.027 H -63.0 -38.6 NA NA NA
MET C:224 C:758 4.0 0.022 H -63.9 -33.4 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:224 A:758 6.0 0.032 H -66.2 -38.1 6.0 0.032 0.0 HOH
 4.276
 N
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 MET A:224 A:758 4.0 0.022 H -63.8 -39.1 4.0 0.022 0.0 HOH
 3.485
 CE
 O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 MET A:224 A:758 2.0 0.011 H -68.6 -36.1 2.0 0.011 0.0 HOH
 3.959
 CE
 O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 MET A:224 A:758 2.0 0.011 H -74.6 -40.2 2.0 0.011 0.0 HOH
 6.251
 CE
 O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 MET A:228 A:758 3.0 0.016 H -65.4 -37.1 3.0 0.016 0.0 HOH
 3.797
 CE
 O
MET B:228 B:758 3.0 0.016 H -60.2 -37.5 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:245 A:758 5.0 0.027 H -67.2 -48.5 5.0 0.027 0.0 HOH
 3.874
 CE
 O
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:245 A:758 4.0 0.022 H -72.1 -33.9 4.0 0.022 0.0 HOH
 3.739
 CE
 O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:245 A:758 5.0 0.027 H -68.1 -37.6 5.0 0.027 0.0 HOH
 3.809
 CE
 O
MET B:245 B:758 4.0 0.022 H -60.7 -39.9 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 MET A:245 A:758 4.0 0.022 H -62.3 -44.8 4.0 0.022 0.0 HOH
 3.518
 CE
 O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 MET A:245 A:758 5.0 0.027 H -62.9 -43.6 5.0 0.027 0.0 HOH
 6.682
 O
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 MET A:245 A:758 4.0 0.022 H -64.2 -39.7 4.0 0.022 0.0 HOH
 3.922
 CE
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 MET A:245 A:758 5.0 0.027 H -67.3 -41.4 5.0 0.027 0.0 5BB
HOH
 8.199
5.569
 O
SD
 CAA
O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 MET A:245 A:758 4.0 0.022 H -66.6 -41.4 4.0 0.022 0.0 HOH
 3.557
 CE
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 MET A:245 A:758 4.0 0.022 H -63.8 -42.1 4.0 0.022 0.0 HOH
 3.951
 CE
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 MET A:245 A:758 4.0 0.022 H -65.9 -36.2 4.0 0.022 0.0 HOH
 3.798
 CE
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 MET A:224 A:758 4.0 0.022 H -64.1 -37.2 4.0 0.022 0.0 HOH
 6.051
 N
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 MET A:224 A:758 6.0 0.032 H -66.4 -39.9 6.0 0.032 0.0 HOH
 4.234
 N
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 MET A:224 A:758 4.0 0.022 H -63.3 -33.6 4.0 0.022 0.0 HOH
 4.234
 CE
 O
MET B:224 B:758 3.0 0.016 H -59.2 -41.3 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 MET A:222 A:758 3.0 0.016 H -60.4 -38.6 3.0 0.016 0.0 HOH
 4.315
 CE
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 MET A:222 A:758 2.0 0.011 H -41.4 -30.2 2.0 0.011 0.0
MET B:222 B:758 2.0 0.011 H -44.9 -20.4 2.0 0.011 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 MET A:222 A:758 4.0 0.022 H -57.0 -40.9 4.0 0.022 0.0 HOH
 4.557
 N
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 MET A:247 A:758 4.0 0.022 H -64.7 -38.8 4.0 0.022 0.0 HOH
 3.707
 CE
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 MET A:247 A:758 3.0 0.016 H -65.1 -40.8 3.0 0.016 0.0 HOH
 3.741
 CE
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 MET E:228 C:758 4.0 0.022 H -54.1 -35.6 4.0 0.022 0.0
MET G:228 O:758 4.0 0.022 H -54.1 -35.6 4.0 0.022 0.0
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 MET C:228 B:758 1.0 0.005 H -65.9 -40.3 1.0 0.005 0.0
MET F:228 F:758 1.0 0.005 H -65.6 -40.3 1.0 0.005 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 MET A:228 A:758 4.0 0.022 H -56.7 -46.8 4.0 0.022 0.0
MET B:228 B:758 5.0 0.027 H -58.0 -40.5 NA NA NA
MET C:228 C:758 5.0 0.027 H -58.1 -43.1 NA NA NA
MET D:228 D:758 4.0 0.022 H -64.2 -39.3 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 MET A:228 A:758 5.0 0.027 H -55.1 -34.7 5.0 0.027 0.0 HOH
 7.771
 CE
 O
MET B:228 B:758 4.0 0.022 H -54.1 -35.6 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 MET A:247 A:758 5.0 0.027 H -67.7 -32.4 5.0 0.027 0.0 HOH
 4.036
 CE
 O
MET B:247 B:758 5.0 0.027 H -67.2 -38.6 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 MET A:247 A:758 4.0 0.022 H -63.7 -40.8 4.0 0.022 0.0 HOH
 3.917
 CE
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 MET A:226 A:758 4.0 0.022 H -65.9 -38.2 4.0 0.022 0.0 HOH
 3.649
 CE
 O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 MET A:226 A:758 5.0 0.027 H -63.5 -42.3 5.0 0.027 0.0 HOH
 4.189
 N
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 MET A:226 A:758 4.0 0.022 H -62.8 -41.7 4.0 0.022 0.0 HOH
 3.518
 CE
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 MET A:226 B:758 4.0 0.022 H -66.6 -39.1 4.0 0.022 0.0 HOH
 3.704
 CE
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 MET A:224 A:758 6.0 0.032 H -62.1 -44.7 6.0 0.032 0.0 HOH
 4.327
 N
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 MET A:224 A:758 4.0 0.022 H -68.0 -40.7 4.0 0.022 0.0 HOH
 3.446
 CE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 MET A:758 A:758 5.0 0.027 H -64.6 -38.6