Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120427058 . C A CCDS3713.1:NM_001083.3:c.2219aGa>aTa_NP_001074.2:p.740R>I Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 ARG A:743 A:740 148.0 0.658 H -58.8 -50.3 148.0 0.658 0.0 HOH
 9.398
 NH2
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 ARG A:231 A:740 157.0 0.698 H -60.7 -39.1 157.0 0.698 0.0 CIT
HOH
 3.259
3.320
 NH2
NH1
 O3
O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:206 A:740 162.0 0.72 H -52.7 -26.8 162.0 0.72 0.0
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:206 A:740 175.0 0.778 H -55.7 -40.1 175.0 0.778 0.0 HOH
 5.356
 N
 O
ARG B:206 B:740 169.0 0.751 H -55.0 -40.5 NA NA NA
ARG C:206 C:740 167.0 0.742 H -62.9 -40.8 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:206 A:740 168.0 0.747 H -59.0 -36.9 168.0 0.747 0.0 HOH
 2.810
 NE
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 ARG A:206 A:740 193.0 0.858 H -56.1 -50.9 193.0 0.858 0.0
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:206 A:740 200.0 0.889 H -60.8 -43.2 200.0 0.889 0.0
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:206 A:740 171.0 0.76 H -57.4 -59.8 171.0 0.76 0.0 HOH
 8.476
 CB
 O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 ARG A:210 A:740 160.0 0.711 H -57.2 -38.1 160.0 0.711 0.0 HOH
 7.275
 NH2
 O
ARG B:210 B:740 155.0 0.689 H -60.3 -36.2 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:227 A:740 188.0 0.836 H -67.0 -26.3 188.0 0.836 0.0
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:227 A:740 180.0 0.8 H -71.9 -35.0 180.0 0.8 0.0
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:227 A:740 161.0 0.716 H -58.6 -40.7 161.0 0.716 0.0 HOH
 3.548
 N
 O
ARG B:227 B:740 161.0 0.716 H -59.9 -34.3 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:227 A:740 172.0 0.764 H -45.9 -52.7 172.0 0.764 0.0
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:227 A:740 193.0 0.858 H -46.1 -49.4 193.0 0.858 0.0
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:227 A:740 178.0 0.791 H -52.9 -26.3 178.0 0.791 0.0 HOH
 5.559
 N
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:227 A:740 164.0 0.729 H -53.9 -40.3 164.0 0.729 0.0 HOH
 9.163
 NH2
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:227 A:740 185.0 0.822 H -53.9 -39.0 185.0 0.822 0.0 HOH
 3.041
 CD
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:227 A:740 188.0 0.836 H -50.1 -36.7 188.0 0.836 0.0 HOH
 2.907
 NH2
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 ARG A:227 A:740 174.0 0.773 H -73.1 -16.4 174.0 0.773 0.0 HOH
 9.225
 NH1
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 ARG A:206 A:740 178.0 0.791 H -57.4 -42.3 178.0 0.791 0.0 HOH
 3.890
 N
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 ARG A:206 A:740 167.0 0.742 H -58.6 -57.3 167.0 0.742 0.0 HOH
 2.651
 NH2
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 ARG A:206 A:740 174.0 0.773 H -54.5 -51.9 174.0 0.773 0.0
ARG B:206 B:740 169.0 0.751 H -59.5 -37.6 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:204 A:740 150.0 0.667 H -69.6 -54.4 150.0 0.667 0.0 HOH
 3.613
 CB
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:204 A:740 189.0 0.84 T -67.8 -0.2 189.0 0.84 0.0
ARG B:204 B:740 188.0 0.836 T -73.0 3.2 188.0 0.836 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 ARG A:204 A:740 154.0 0.684 H -73.7 -36.6 154.0 0.684 0.0 HOH
 7.823
 O
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:229 A:740 183.0 0.813 H -58.8 -33.3 183.0 0.813 0.0 HOH
 2.574
 NH2
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:229 A:740 164.0 0.729 H -55.0 -43.7 164.0 0.729 0.0 HOH
 3.733
 N
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 ARG E:210 C:740 169.0 0.751 H -42.9 -49.9 107.0 0.476 0.275 G:None:0.276
ARG G:210 O:740 165.0 0.733 H -42.9 -49.9 104.0 0.462 0.271 E:None:0.271
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 ARG C:210 B:740 181.0 0.804 T -61.8 -29.1 90.0 0.4 0.404 F:None:0.404
ARG F:210 F:740 184.0 0.818 T -62.3 -29.0 92.0 0.409 0.409 C:None:0.409
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:210 A:740 168.0 0.747 H -51.9 -30.3 168.0 0.747 0.0
ARG B:210 B:740 171.0 0.76 H -51.1 -31.9 NA NA NA
ARG C:210 C:740 170.0 0.756 H -52.7 -31.1 NA NA NA
ARG D:210 D:740 170.0 0.756 H -51.7 -30.3 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:210 A:740 170.0 0.756 H -41.0 -51.9 170.0 0.756 0.0
ARG B:210 B:740 167.0 0.742 H -42.9 -49.9 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:229 A:740 148.0 0.658 H -59.3 -38.1 148.0 0.658 0.0 HOH
 3.144
 NH1
 O
ARG B:229 B:740 166.0 0.738 H -65.0 -36.8 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:229 A:740 156.0 0.693 H -58.2 -37.8 156.0 0.693 0.0 HOH
 2.580
 NE
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 ARG A:208 A:740 165.0 0.733 H -60.0 -36.5 165.0 0.733 0.0 MES
HOH
 7.838
2.761
 N
NH1
 O1S
O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 ARG A:208 A:740 162.0 0.72 H -60.3 -39.8 162.0 0.72 0.0 HOH
 7.049
 C
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 ARG A:208 A:740 178.0 0.791 H -55.1 -39.1 178.0 0.791 0.0 HOH
 4.221
 CD
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 ARG A:208 B:740 158.0 0.702 H -60.6 -38.7 158.0 0.702 0.0 HOH
 2.750
 NH1
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:206 A:740 162.0 0.72 H -60.3 -38.8 162.0 0.72 0.0 HOH
 5.407
 N
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:206 A:740 161.0 0.716 H -61.8 -34.4 161.0 0.716 0.0 HOH
 3.087
 NE
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 ARG A:740 A:740 165.0 0.733 H -58.6 -33.0