Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120440278 . A C CCDS3713.1:NM_001083.3:c.1922cTg>cGg_NP_001074.2:p.641L>R Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 LEU A:644 A:641 32.0 0.188 H -65.0 -43.6 32.0 0.188 0.0 HOH
 3.112
 N
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 LEU A:132 A:641 33.0 0.194 H -63.1 -41.3 33.0 0.194 0.0 HOH
 8.052
 N
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 LEU A:107 A:641 29.0 0.171 H -69.5 -35.4 29.0 0.171 0.0 HOH
 3.635
 CB
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 LEU A:107 A:641 31.0 0.182 H -71.1 -43.5 31.0 0.182 0.0 HOH
 3.288
 N
 O
LEU B:107 B:641 32.0 0.188 H -64.6 -35.7 NA NA NA
LEU C:107 C:641 43.0 0.253 H -64.8 -41.6 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 LEU A:107 A:641 38.0 0.224 H -69.2 -33.6 38.0 0.224 0.0 HOH
 2.897
 N
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 LEU A:107 A:641 32.0 0.188 H -66.3 -38.8 32.0 0.188 0.0 HOH
 3.148
 N
 O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 LEU A:107 A:641 36.0 0.212 H -64.3 -40.7 36.0 0.212 0.0 HOH
 3.652
 CB
 O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 LEU A:107 A:641 31.0 0.182 H -66.9 -43.3 31.0 0.182 0.0 HOH
 9.718
 CD2
 O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 LEU A:111 A:641 31.0 0.182 H -73.8 -37.5 31.0 0.182 0.0 HOH
 7.288
 C
 O
LEU B:111 B:641 30.0 0.176 H -65.2 -38.9 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 LEU A:128 A:641 29.0 0.171 H -67.7 -39.4 29.0 0.171 0.0 HOH
 9.810
 CD2
 O
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 LEU A:128 A:641 29.0 0.171 H -73.0 -37.3 29.0 0.171 0.0 MG
HOH
 5.838
9.837
 N
CD2
 MG
O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 LEU A:128 A:641 28.0 0.165 H -60.6 -39.9 28.0 0.165 0.0 HOH
 3.286
 N
 O
LEU B:128 B:641 32.0 0.188 H -63.5 -38.3 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 LEU A:128 A:641 29.0 0.171 H -64.3 -41.6 29.0 0.171 0.0 HOH
 3.922
 CD1
 O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 LEU A:128 A:641 33.0 0.194 H -61.7 -38.5 33.0 0.194 0.0 HOH
 4.066
 CD1
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 LEU A:128 A:641 30.0 0.176 H -63.7 -38.4 30.0 0.176 0.0 HOH
 3.061
 N
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 LEU A:128 A:641 36.0 0.212 H -66.0 -39.2 36.0 0.212 0.0 HOH
 5.033
 N
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 LEU A:128 A:641 32.0 0.188 H -66.7 -36.9 32.0 0.188 0.0 HOH
 5.760
 N
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 LEU A:128 A:641 34.0 0.2 H -69.6 -38.0 34.0 0.2 0.0 HOH
 3.567
 CD1
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 LEU A:128 A:641 32.0 0.188 H -67.7 -35.1 32.0 0.188 0.0 HOH
 4.054
 CD1
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 LEU A:107 A:641 46.0 0.271 H -67.0 -39.4 46.0 0.271 0.0 HOH
 3.785
 CB
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 LEU A:107 A:641 34.0 0.2 H -66.6 -35.8 34.0 0.2 0.0 HOH
 3.199
 N
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 LEU A:107 A:641 31.0 0.182 H -68.2 -33.8 31.0 0.182 0.0 HOH
 3.963
 CB
 O
LEU B:107 B:641 31.0 0.182 H -65.6 -36.8 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 LEU A:105 A:641 30.0 0.176 H -67.7 -38.8 30.0 0.176 0.0 HOH
 8.615
 O
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 LEU A:105 A:641 40.0 0.235 H -69.0 -66.4 40.0 0.235 0.0
LEU B:105 B:641 38.0 0.224 H -77.7 -67.9 38.0 0.224 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 LEU A:105 A:641 29.0 0.171 H -68.7 -37.1 29.0 0.171 0.0 HOH
 3.690
 CB
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 LEU A:129 A:641 26.0 0.153 H -67.0 -37.9 26.0 0.153 0.0 HOH
 3.340
 N
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 LEU A:129 A:641 33.0 0.194 H -64.5 -39.8 33.0 0.194 0.0 HOH
 3.238
 N
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 LEU E:111 C:641 33.0 0.194 H -65.2 -36.4 33.0 0.194 0.0 IBM
 9.922
 CD2
 C10
LEU G:111 O:641 31.0 0.182 H -65.2 -36.4 31.0 0.182 0.0 IBM
 9.922
 CD2
 C10
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 LEU C:111 B:641 37.0 0.218 H -57.0 -47.5 37.0 0.218 0.0
LEU F:111 F:641 39.0 0.229 H -57.2 -47.7 39.0 0.229 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 LEU A:111 A:641 39.0 0.229 H -66.7 -35.7 39.0 0.229 0.0
LEU B:111 B:641 39.0 0.229 H -62.8 -36.7 NA NA NA
LEU C:111 C:641 39.0 0.229 H -61.3 -37.0 NA NA NA
LEU D:111 D:641 39.0 0.229 H -65.1 -37.8 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 LEU A:111 A:641 31.0 0.182 H -68.1 -36.6 31.0 0.182 0.0
LEU B:111 B:641 33.0 0.194 H -65.2 -36.4 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 LEU A:129 A:641 36.0 0.212 H -66.2 -35.0 36.0 0.212 0.0 HOH
 3.201
 N
 O
LEU B:129 B:641 40.0 0.235 H -66.8 -35.7 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 LEU A:129 A:641 49.0 0.288 H -64.7 -40.1 49.0 0.288 0.0 HOH
 2.948
 O
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 LEU A:108 A:641 22.0 0.129 H -66.7 -38.9 22.0 0.129 0.0 HOH
 3.481
 N
 O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 LEU A:108 A:641 24.0 0.141 H -63.0 -45.2 24.0 0.141 0.0 HOH
 3.344
 N
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 LEU A:108 A:641 23.0 0.135 H -62.9 -43.2 23.0 0.135 0.0 HOH
 3.145
 N
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 LEU A:108 B:641 20.0 0.118 H -66.0 -37.7 20.0 0.118 0.0 HOH
 3.282
 N
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 LEU A:106 A:641 17.0 0.1 H -59.9 -44.5 17.0 0.1 0.0 MG
HOH
 8.216
3.729
 CD1
CB
 MG
O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 LEU A:106 A:641 23.0 0.135 H -65.7 -40.0 23.0 0.135 0.0 HOH
 3.465
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 LEU A:641 A:641 31.0 0.182 H -67.5 -41.1