Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120442121 . A C CCDS3713.1:NM_001083.3:c.1874aTg>aGg_NP_001074.2:p.625M>R Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 MET A:628 A:625 0.0 0.0 H -61.7 -43.7 0.0 0.0 0.0 HOH
 6.744
 N
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 MET A:116 A:625 0.0 0.0 H -59.6 -47.0 0.0 0.0 0.0 HOH
 5.892
 N
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:91 A:625 0.0 0.0 H -59.7 -45.5 0.0 0.0 0.0 HOH
 5.787
 N
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:91 A:625 0.0 0.0 H -66.2 -42.2 0.0 0.0 0.0 HOH
 7.110
 N
 O
MET B:91 B:625 0.0 0.0 H -66.0 -47.8 NA NA NA
MET C:91 C:625 0.0 0.0 H -61.7 -40.1 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 MET A:91 A:625 0.0 0.0 H -62.3 -44.2 0.0 0.0 0.0 HOH
 6.001
 N
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 MET A:91 A:625 0.0 0.0 H -63.6 -47.1 0.0 0.0 0.0 HOH
 6.623
 N
 O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 MET A:91 A:625 0.0 0.0 H -59.2 -48.3 0.0 0.0 0.0 HOH
 7.145
 N
 O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 MET A:91 A:625 0.0 0.0 H -64.1 -41.9 0.0 0.0 0.0
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 MET A:95 A:625 0.0 0.0 H -64.8 -41.0 0.0 0.0 0.0 HOH
 5.799
 N
 O
MET B:95 B:625 0.0 0.0 H -63.0 -44.3 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:112 A:625 0.0 0.0 H -57.8 -52.3 0.0 0.0 0.0 HOH
 7.530
 N
 O
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:112 A:625 0.0 0.0 H -58.9 -48.9 0.0 0.0 0.0 HOH
 6.795
 N
 O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 MET A:112 A:625 0.0 0.0 H -58.4 -48.2 0.0 0.0 0.0 HOH
 5.840
 N
 O
MET B:112 B:625 0.0 0.0 H -58.4 -49.5 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 MET A:112 A:625 0.0 0.0 H -62.0 -44.0 0.0 0.0 0.0 HOH
 7.935
 N
 O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 MET A:112 A:625 0.0 0.0 H -56.9 -48.4 0.0 0.0 0.0 HOH
 6.843
 N
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 MET A:112 A:625 0.0 0.0 H -58.6 -46.4 0.0 0.0 0.0 HOH
 6.678
 N
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 MET A:112 A:625 0.0 0.0 H -57.9 -47.3 0.0 0.0 0.0 HOH
 6.956
 N
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 MET A:112 A:625 0.0 0.0 H -56.7 -45.3 0.0 0.0 0.0 HOH
 7.391
 N
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 MET A:112 A:625 0.0 0.0 H -63.4 -45.5 0.0 0.0 0.0 HOH
 6.906
 N
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 MET A:112 A:625 0.0 0.0 H -61.1 -44.1 0.0 0.0 0.0 HOH
 5.795
 N
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 MET A:91 A:625 0.0 0.0 H -60.1 -44.3 0.0 0.0 0.0 HOH
 6.921
 N
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 MET A:91 A:625 0.0 0.0 H -62.7 -44.6 0.0 0.0 0.0 HOH
 6.038
 N
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 MET A:91 A:625 0.0 0.0 H -57.5 -46.6 0.0 0.0 0.0 FZA
HOH
 8.109
6.216
 N
N
 C25
O
MET B:91 B:625 0.0 0.0 H -63.1 -48.8 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 MET A:89 A:625 0.0 0.0 H -59.7 -42.5 0.0 0.0 0.0 HOH
 8.122
 N
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 MET A:89 A:625 5.0 0.027 H -85.2 -47.5 5.0 0.027 0.0
MET B:89 B:625 5.0 0.027 H -82.8 -54.0 5.0 0.027 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 MET A:89 A:625 0.0 0.0 H -58.3 -49.9 0.0 0.0 0.0 HOH
 8.098
 N
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 MET A:113 A:625 0.0 0.0 H -59.4 -47.2 0.0 0.0 0.0 HOH
 5.871
 N
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 MET A:113 A:625 0.0 0.0 H -60.0 -46.8 0.0 0.0 0.0 HOH
 5.794
 N
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 MET E:95 C:625 0.0 0.0 H -48.7 -47.7 0.0 0.0 0.0
MET G:95 O:625 0.0 0.0 H -48.7 -47.7 0.0 0.0 0.0
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 MET C:95 B:625 0.0 0.0 H -72.4 -49.4 0.0 0.0 0.0
MET F:95 F:625 0.0 0.0 H -72.2 -49.5 0.0 0.0 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 MET A:95 A:625 0.0 0.0 H -56.5 -45.4 0.0 0.0 0.0
MET B:95 B:625 0.0 0.0 H -59.5 -46.3 NA NA NA
MET C:95 C:625 0.0 0.0 H -60.3 -47.0 NA NA NA
MET D:95 D:625 0.0 0.0 H -58.6 -45.6 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 MET A:95 A:625 0.0 0.0 H -49.0 -47.7 0.0 0.0 0.0
MET B:95 B:625 0.0 0.0 H -48.7 -47.7 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 MET A:113 A:625 0.0 0.0 H -63.9 -46.3 0.0 0.0 0.0 HOH
 5.913
 N
 O
MET B:113 B:625 0.0 0.0 H -61.3 -44.1 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 MET A:113 A:625 0.0 0.0 H -58.3 -47.9 0.0 0.0 0.0 HOH
 5.829
 N
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 MET A:92 A:625 0.0 0.0 H -62.1 -45.0 0.0 0.0 0.0 HOH
 5.733
 N
 O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 MET A:92 A:625 0.0 0.0 H -58.0 -48.5 0.0 0.0 0.0 HOH
 6.891
 N
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 MET A:92 A:625 0.0 0.0 H -60.4 -45.8 0.0 0.0 0.0 HOH
 6.645
 N
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 MET A:92 B:625 0.0 0.0 H -60.2 -47.9 0.0 0.0 0.0 HOH
 5.856
 N
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 MET A:90 A:625 0.0 0.0 H -57.9 -48.1 0.0 0.0 0.0 HOH
 7.030
 N
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 MET A:90 A:625 0.0 0.0 H -56.4 -52.2 0.0 0.0 0.0 HOH
 6.056
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 MET A:625 A:625 0.0 0.0 H -58.1 -48.3