Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120446754 . G A CCDS3713.1:NM_001083.3:c.1729Cgg>Tgg_NP_001074.2:p.577R>W Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 ARG A:580 A:577 45.0 0.2 H -60.8 -36.3 45.0 0.2 0.0 HOH
 3.776
 NH1
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 ARG A:68 A:577 47.0 0.209 H -63.6 -37.8 47.0 0.209 0.0 HOH
 3.835
 CD
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:43 A:577 46.0 0.204 H -61.3 -34.1 46.0 0.204 0.0 HOH
 3.648
 CD
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:43 A:577 42.0 0.187 H -58.2 -32.3 42.0 0.187 0.0 HOH
 3.622
 CD
 O
ARG B:43 B:577 45.0 0.2 H -60.1 -36.0 NA NA NA
ARG C:43 C:577 43.0 0.191 H -57.6 -37.1 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 ARG A:43 A:577 44.0 0.196 H -62.4 -37.1 44.0 0.196 0.0 HOH
 3.556
 NH1
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 ARG A:43 A:577 43.0 0.191 H -61.4 -34.8 43.0 0.191 0.0 HOH
 3.814
 CD
 O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:43 A:577 41.0 0.182 H -62.6 -36.4 41.0 0.182 0.0 HOH
 6.571
 NH2
 O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 ARG A:43 A:577 41.0 0.182 H -59.6 -38.6 41.0 0.182 0.0
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 ARG A:47 A:577 45.0 0.2 H -57.9 -40.3 45.0 0.2 0.0 HOH
 3.641
 NH1
 O
ARG B:47 B:577 46.0 0.204 H -62.9 -34.1 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:64 A:577 41.0 0.182 H -61.3 -32.0 41.0 0.182 0.0 HOH
 6.684
 NH2
 O
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:64 A:577 43.0 0.191 H -61.6 -31.9 43.0 0.191 0.0 HOH
 6.625
 NH2
 O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 ARG A:64 A:577 45.0 0.2 H -59.8 -35.7 45.0 0.2 0.0 HOH
 3.113
 NH2
 O
ARG B:64 B:577 44.0 0.196 H -61.5 -34.1 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:64 A:577 42.0 0.187 H -62.3 -33.3 42.0 0.187 0.0 HOH
 2.837
 NH2
 O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 ARG A:64 A:577 45.0 0.2 H -62.8 -31.1 45.0 0.2 0.0 HOH
 3.993
 CD
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:64 A:577 42.0 0.187 H -56.1 -40.7 42.0 0.187 0.0 HOH
 3.548
 NH1
 O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 ARG A:64 A:577 41.0 0.182 H -61.4 -34.0 41.0 0.182 0.0 HOH
 6.152
 CD
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:64 A:577 45.0 0.2 H -53.2 -36.5 45.0 0.2 0.0 HOH
 6.464
 CD
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 ARG A:64 A:577 44.0 0.196 H -59.6 -34.8 44.0 0.196 0.0 HOH
 3.542
 NH1
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 ARG A:64 A:577 44.0 0.196 H -64.7 -34.1 44.0 0.196 0.0 HOH
 3.544
 NH1
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 ARG A:43 A:577 45.0 0.2 H -59.4 -38.6 45.0 0.2 0.0 HOH
 5.321
 NH2
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 ARG A:43 A:577 43.0 0.191 H -60.8 -36.3 43.0 0.191 0.0 HOH
 3.623
 NH1
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 ARG A:43 A:577 44.0 0.196 H -62.3 -34.3 44.0 0.196 0.0 HOH
 2.979
 NH1
 O
ARG B:43 B:577 41.0 0.182 H -64.3 -34.6 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:41 A:577 36.0 0.16 H -58.4 -40.0 36.0 0.16 0.0 HOH
 3.044
 NH1
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 ARG A:41 A:577 32.0 0.142 H -61.1 -48.3 32.0 0.142 0.0
ARG B:41 B:577 32.0 0.142 H -60.7 -50.7 32.0 0.142 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 ARG A:41 A:577 38.0 0.169 H -59.0 -32.0 38.0 0.169 0.0 HOH
 3.697
 NH1
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:65 A:577 43.0 0.191 H -62.0 -35.3 43.0 0.191 0.0 HOH
 2.972
 NH1
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 ARG A:65 A:577 44.0 0.196 H -64.2 -37.2 44.0 0.196 0.0 HOH
 3.612
 CD
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 ARG E:47 C:577 43.0 0.191 H -59.4 -38.2 43.0 0.191 0.0
ARG G:47 O:577 42.0 0.187 H -59.4 -38.2 42.0 0.187 0.0
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 ARG C:47 B:577 82.0 0.364 H -63.1 -36.7 82.0 0.364 0.0
ARG F:47 F:577 82.0 0.364 H -63.1 -37.8 82.0 0.364 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:47 A:577 44.0 0.196 H -59.3 -43.0 44.0 0.196 0.0
ARG B:47 B:577 44.0 0.196 H -59.6 -43.9 NA NA NA
ARG C:47 C:577 44.0 0.196 H -59.4 -45.8 NA NA NA
ARG D:47 D:577 46.0 0.204 H -52.2 -45.5 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 ARG A:47 A:577 41.0 0.182 H -58.8 -38.6 41.0 0.182 0.0
ARG B:47 B:577 43.0 0.191 H -59.4 -38.2 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:65 A:577 45.0 0.2 H -61.5 -37.0 45.0 0.2 0.0 HOH
 3.122
 NH1
 O
ARG B:65 B:577 46.0 0.204 H -64.0 -33.5 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 ARG A:65 A:577 44.0 0.196 H -62.0 -38.3 44.0 0.196 0.0 HOH
 3.537
 NH2
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 ARG A:44 A:577 44.0 0.196 H -62.4 -34.1 44.0 0.196 0.0 HOH
 2.966
 NH1
 O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 ARG A:44 A:577 46.0 0.204 H -58.6 -38.8 46.0 0.204 0.0 HOH
 3.321
 NH1
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 ARG A:44 A:577 44.0 0.196 H -57.8 -37.5 44.0 0.196 0.0 HOH
 3.202
 NH1
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 ARG A:44 B:577 43.0 0.191 H -60.0 -39.7 43.0 0.191 0.0 HOH
 3.613
 NH1
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:42 A:577 43.0 0.191 H -62.5 -36.5 43.0 0.191 0.0 HOH
 3.119
 NH2
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 ARG A:42 A:577 42.0 0.187 H -61.8 -37.7 42.0 0.187 0.0 HOH
 3.117
 NH1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 ARG A:577 A:577 44.0 0.196 H -60.9 -40.4