Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr4 120446798 . C A CCDS3713.1:NM_001083.3:c.1685aGt>aTt_NP_001074.2:p.562S>I Homo sapiens phosphodiesterase 5A (PDE5A), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3bjc 1 O76074 99.89 0.0 X-RAY
 2008-04-29 SER A:565 A:562 17.0 0.148 -138.0 149.5 17.0 0.148 0.0 HOH
 2.794
 OG
 O
1t9r 1 O76074 99.71 0.0 X-RAY
 2004-08-03 SER A:53 A:562 36.0 0.313 -103.7 -72.7 36.0 0.313 0.0 HOH
 3.590
 CB
 O
2h40 1 O76074 100.0 0.0 X-RAY
 2006-06-06 SER A:28 A:562 17.0 0.148 -134.9 152.4 17.0 0.148 0.0 HOH
 2.699
 O
 O
2h42 1 O76074 100.0 0.0 X-RAY
 2006-06-06 SER A:28 A:562 38.0 0.33 -125.6 150.3 38.0 0.33 0.0 HOH
 3.551
 OG
 O
SER B:28 B:562 41.0 0.357 -134.8 146.2 NA NA NA
SER C:28 C:562 40.0 0.348 -134.0 141.5 NA NA NA
2h44 1 O76074 100.0 0.0 X-RAY
 2006-06-06 SER A:28 A:562 25.0 0.217 -127.7 135.7 25.0 0.217 0.0 HOH
 2.650
 O
 O
4md6 1 O76074 100.0 0.0 X-RAY
 2014-07-09 SER A:28 A:562 18.0 0.157 -133.5 148.4 18.0 0.157 0.0 HOH
 2.778
 OG
 O
5zz2 1 O76074 100.0 0.0 X-RAY
 2018-09-19 SER A:28 A:562 16.0 0.139 -137.2 153.0 16.0 0.139 0.0 HOH
 2.813
 OG
 O
6acb 1 O76074 100.0 0.0 X-RAY
 2018-09-19 SER A:28 A:562 16.0 0.139 -131.4 144.7 16.0 0.139 0.0 HOH
 3.139
 N
 O
3b2r 1 O76074 100.0 0.0 X-RAY
 2008-05-20 SER A:32 A:562 43.0 0.374 -132.8 142.2 43.0 0.374 0.0 HOH
 2.637
 O
 O
SER B:32 B:562 43.0 0.374 -130.6 137.3 NA NA NA
3shy 1 O76074 100.0 0.0 X-RAY
 2011-08-24 SER A:49 A:562 18.0 0.157 -149.2 153.0 18.0 0.157 0.0 HOH
 7.636
 CA
 O
3shz 1 O76074 100.0 0.0 X-RAY
 2011-08-24 SER A:49 A:562 20.0 0.174 -142.5 147.3 20.0 0.174 0.0 MG
HOH
 9.591
2.868
 N
O
 MG
O
3sie 1 O76074 100.0 0.0 X-RAY
 2011-08-24 SER A:49 A:562 41.0 0.357 -127.7 141.3 41.0 0.357 0.0 HOH
 2.518
 OG
 O
SER B:49 B:562 43.0 0.374 -123.2 133.8 NA NA NA
4g2w 1 O76074 100.0 0.0 X-RAY
 2013-06-26 SER A:49 A:562 20.0 0.174 -140.2 147.5 20.0 0.174 0.0 HOH
 2.744
 OG
 O
4g2y 1 O76074 100.0 0.0 X-RAY
 2013-06-26 SER A:49 A:562 19.0 0.165 -143.0 145.9 19.0 0.165 0.0 HOH
 5.919
 N
 O
4i9z 1 O76074 100.0 0.0 X-RAY
 2014-01-01 SER A:49 A:562 15.0 0.13 -137.9 148.2 15.0 0.13 0.0 PEG
HOH
 2.968
2.739
 OG
OG
 O1
O
4ia0 1 O76074 100.0 0.0 X-RAY
 2014-01-01 SER A:49 A:562 18.0 0.157 -136.5 158.4 18.0 0.157 0.0 HOH
 2.807
 O
 O
4oew 1 O76074 100.0 0.0 X-RAY
 2015-04-01 SER A:49 A:562 17.0 0.148 -140.4 158.7 17.0 0.148 0.0 HOH
 2.641
 OG
 O
4oex 1 O76074 100.0 0.0 X-RAY
 2015-04-01 SER A:49 A:562 18.0 0.157 -136.5 149.5 18.0 0.157 0.0 HOH
 2.688
 OG
 O
6iwi 1 O76074 100.0 0.0 X-RAY
 2019-12-11 SER A:49 A:562 20.0 0.174 -138.1 149.5 20.0 0.174 0.0 HOH
 2.845
 O
 O
6l6e 1 O76074 100.0 0.0 X-RAY
 2020-09-02 SER A:28 A:562 21.0 0.183 -127.5 142.8 21.0 0.183 0.0 HOH
 2.990
 OG
 O
1rkp 1 O76074 99.69 0.0 X-RAY
 2004-03-30 SER A:28 A:562 17.0 0.148 -137.8 149.1 17.0 0.148 0.0 HOH
 2.655
 OG
 O
6vbi 1 O76074 100.0 0.0 X-RAY
 2021-01-20 SER A:28 A:562 55.0 0.478 -119.7 130.5 55.0 0.478 0.0 FZA
HOH
 6.469
2.873
 CA
N
 C26
O
SER B:28 B:562 36.0 0.313 -128.6 128.6 NA NA NA
1udt 1 O76074 100.0 0.0 X-RAY
 2004-05-11 SER A:26 A:562 31.0 0.27 -135.5 135.0 31.0 0.27 0.0 HOH
 3.118
 N
 O
1udu 1 O76074 100.0 0.0 X-RAY
 2004-05-11 SER A:26 A:562 17.0 0.148 -138.4 155.5 17.0 0.148 0.0
SER B:26 B:562 18.0 0.157 -134.9 155.6 18.0 0.157 0.0
1uho 1 O76074 100.0 0.0 X-RAY
 2004-07-09 SER A:26 A:562 29.0 0.252 -142.7 138.6 29.0 0.252 0.0 HOH
 2.708
 O
 O
1xoz 1 O76074 93.95 0.0 X-RAY
 2004-12-14 SER A:50 A:562 45.0 0.391 -120.7 133.9 45.0 0.391 0.0 HOH
 2.796
 OG
 O
1xp0 1 O76074 93.95 0.0 X-RAY
 2004-12-14 SER A:50 A:562 44.0 0.383 -129.5 134.0 44.0 0.383 0.0 HOH
 2.515
 OG
 O
3jab 3 ? 93.25 0.0 EM
 2015-06-10 SER E:32 C:562 20.0 0.174 -136.8 149.0 20.0 0.174 0.0
SER G:32 O:562 20.0 0.174 -136.8 149.0 20.0 0.174 0.0
3jbq 3 ? 93.25 0.0 EM
 2015-09-30 SER C:32 B:562 30.0 0.261 -84.4 89.9 30.0 0.261 0.0
SER F:32 F:562 28.0 0.243 -83.0 88.0 28.0 0.243 0.0
3jwq 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 SER A:32 A:562 27.0 0.235 -120.8 134.3 27.0 0.235 0.0 HOH
 7.068
 OG
 O
SER B:32 B:562 29.0 0.252 -122.3 137.9 NA NA NA
SER C:32 C:562 29.0 0.252 -122.6 134.5 NA NA NA
SER D:32 D:562 28.0 0.243 -123.7 138.1 NA NA NA
3jwr 1 O76074,P51160 93.25 0.0 X-RAY
 2009-10-13 SER A:32 A:562 20.0 0.174 -135.9 147.4 20.0 0.174 0.0 HOH
 2.870
 OG
 O
SER B:32 B:562 21.0 0.183 -136.8 149.0 NA NA NA
1t9s 1 O76074 93.64 0.0 X-RAY
 2004-08-03 SER A:50 A:562 47.0 0.409 -128.7 136.5 47.0 0.409 0.0 HOH
 2.676
 OG
 O
SER B:50 B:562 34.0 0.296 -125.4 134.9 NA NA NA
1tbf 1 O76074 93.64 0.0 X-RAY
 2004-08-03 SER A:50 A:562 35.0 0.304 -117.1 139.0 35.0 0.304 0.0 HOH
 2.898
 OG
 O
2chm 1 O76074,Q07343 94.17 0.0 X-RAY
 2006-06-08 SER A:29 A:562 33.0 0.287 -125.5 132.1 33.0 0.287 0.0 HOH
 2.654
 O
 O
3tge 1 O76074 94.17 0.0 X-RAY
 2011-11-09 SER A:29 A:562 38.0 0.33 -128.8 140.1 38.0 0.33 0.0 HOH
 2.933
 O
 O
3tgg 1 O76074 94.17 0.0 X-RAY
 2012-01-25 SER A:29 A:562 15.0 0.13 -132.6 134.7 15.0 0.13 0.0 HOH
 3.078
 N
 O
5jo3 1 O76074 94.17 0.0 X-RAY
 2017-05-03 SER A:29 B:562 26.0 0.226 -119.8 131.8 26.0 0.226 0.0 HOH
 2.775
 OG
 O
3hc8 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 SER A:27 A:562 18.0 0.157 -131.1 138.3 18.0 0.157 0.0 HOH
 2.822
 N
 O
3hdz 1 O76074,P27815 94.14 0.0 X-RAY
 2009-07-07 SER A:27 A:562 26.0 0.226 -123.3 129.5 26.0 0.226 0.0 HOH
 2.748
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-o76074-f1 1 O76074 100.0 0.0 SER A:562 A:562 40.0 0.348 -132.2 134.0