Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr5 | 224619 | . | C | A | CCDS3853.1:NM_004168.2:c.295Cac>Aac_NP_004159.2:p.99H>N | Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 6vax | 1 | P31040 | 100.0 | 0.0 |
X-RAY |
2020-08-26 | HIS | A:67 | A:99 | 55.0 | 0.282 | G | -62.7 | -18.1 | 44.0 | 0.226 | 0.056 |
B:Q9NX18:0.056 |
FAD OAA HOH |
1.431 7.857 3.376 |
NE2 NE2 CD2 |
C8M O4 O |
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| HIS | C:67 | C:99 | 58.0 | 0.297 | G | -67.4 | -13.2 | NA | NA | NA | |||||||||||||
| 4ytp | 1 | Q0QF01 | 94.58 | 0.0 |
X-RAY |
2015-08-05 | HIS | A:99 | A:57 | 57.0 | 0.292 | S | -78.9 | -40.1 | 49.0 | 0.251 | 0.041 |
B:Q007T0:0.041 |
FAD FES |
2.665 8.710 |
NE2 ND1 |
C8M FE2 |
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| 4yxd | 1 | Q0QF01 | 94.58 | 0.0 |
X-RAY |
2016-03-02 | HIS | A:99 | A:57 | 53.0 | 0.272 | G | -71.7 | -27.7 | 48.0 | 0.246 | 0.026 |
B:Q007T0:0.026 |
FAD FES |
2.638 8.885 |
NE2 ND1 |
C8M FE2 |
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| 1zoy | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2005-07-12 | HIS | A:57 | A:57 | 58.0 | 0.297 | G | -58.4 | -32.9 | 58.0 | 0.297 | 0.0 |
FAD FES HOH |
1.710 9.267 2.665 |
NE2 CA CB |
C8M FE2 O |
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| 1zp0 | 1 | ? | 96.3 | 0.0 |
X-RAY |
2005-07-12 | HIS | A:57 | A:57 | 59.0 | 0.303 | G | -60.1 | -32.3 | 58.0 | 0.297 | 0.006 |
B:None:0.005 |
FAD 3NP FES |
1.874 9.104 9.267 |
NE2 NE2 CA |
C8M O2 FE2 |
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| 3abv | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 52.0 | 0.267 | G | -44.4 | -37.5 | 49.0 | 0.251 | 0.016 |
B:Q007T0:0.015 |
FAD MLI FES |
1.991 7.893 8.934 |
NE2 NE2 ND1 |
C8M O9 FE2 |
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| 3ae1 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 55.0 | 0.282 | G | -56.1 | -20.9 | 49.0 | 0.251 | 0.031 |
B:Q007T0:0.031 |
FAD MLI FES |
1.911 8.189 8.771 |
NE2 NE2 ND1 |
C8M O6 FE1 |
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| 3ae2 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 51.0 | 0.262 | G | -52.5 | -31.3 | 47.0 | 0.241 | 0.021 |
B:Q007T0:0.021 |
FAD MLI FES |
1.953 7.752 8.942 |
NE2 NE2 ND1 |
C8M O8 FE2 |
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| 3ae3 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 50.0 | 0.256 | T | -74.1 | -2.1 | 47.0 | 0.241 | 0.015 |
B:Q007T0:0.015 |
FAD FES |
1.960 9.068 |
NE2 ND1 |
C8M FE1 |
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| 3ae4 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 53.0 | 0.272 | G | -77.6 | -38.3 | 50.0 | 0.256 | 0.016 |
B:Q007T0:0.015 |
FAD MLI FES |
1.955 8.071 8.813 |
NE2 NE2 ND1 |
C8M O8 FE1 |
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| 3ae5 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 62.0 | 0.318 | G | -97.8 | 6.6 | 60.0 | 0.308 | 0.01 |
B:Q007T0:0.01 |
FAD MLI FES |
2.006 8.070 9.011 |
NE2 NE2 CA |
C8M O8 FE1 |
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| 3ae6 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 47.0 | 0.241 | G | -82.5 | -8.1 | 45.0 | 0.231 | 0.01 |
B:Q007T0:0.01 |
FAD FES |
1.989 9.093 |
NE2 CA |
C8M FE2 |
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| 3ae7 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 59.0 | 0.303 | G | -70.2 | -25.1 | 53.0 | 0.272 | 0.031 |
B:Q007T0:0.031 |
FAD FES |
2.080 8.676 |
NE2 ND1 |
C8M FE2 |
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| 3ae8 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 59.0 | 0.303 | G | -79.0 | 1.0 | 55.0 | 0.282 | 0.021 |
B:Q007T0:0.021 |
FAD FES |
1.988 8.950 |
NE2 CA |
C8M FE1 |
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| 3ae9 | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 56.0 | 0.287 | G | -65.2 | -6.6 | 49.0 | 0.251 | 0.036 |
B:Q007T0:0.036 |
FAD MLI FES |
2.064 8.930 8.770 |
NE2 NE2 ND1 |
C8M C1 FE1 |
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| 3aea | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 57.0 | 0.292 | G | -43.8 | -35.1 | 53.0 | 0.272 | 0.02 |
B:Q007T0:0.021 |
FAD MLI FES |
2.122 8.534 8.891 |
NE2 NE2 ND1 |
C8M O6 FE1 |
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| 3aeb | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 54.0 | 0.277 | G | -60.1 | -33.5 | 51.0 | 0.262 | 0.015 |
B:Q007T0:0.015 |
FAD MLI FES |
1.942 8.011 8.938 |
NE2 NE2 ND1 |
C8M O9 FE2 |
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| 3aec | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 62.0 | 0.318 | S | -120.7 | -21.7 | 58.0 | 0.297 | 0.021 |
B:Q007T0:0.021 |
FAD FES |
2.011 8.710 |
NE2 ND1 |
C8M FE1 |
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| 3aed | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 61.0 | 0.313 | G | -54.2 | -34.3 | 54.0 | 0.277 | 0.036 |
B:Q007T0:0.036 |
FAD MLI FES |
1.979 8.048 8.642 |
NE2 NE2 ND1 |
C8M O8 FE2 |
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| 3aee | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 53.0 | 0.272 | G | -53.5 | -36.8 | 48.0 | 0.246 | 0.026 |
B:Q007T0:0.026 |
FAD FES |
1.956 8.714 |
NE2 ND1 |
C8M FE2 |
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| 3aef | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 46.0 | 0.236 | G | -50.3 | -33.7 | 45.0 | 0.231 | 0.005 |
B:Q007T0:0.005 |
FAD FES HOH |
1.855 9.074 9.109 |
NE2 ND1 NE2 |
C8M FE1 O |
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| 3aeg | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-02-09 | HIS | A:57 | A:57 | 58.0 | 0.297 | S | -105.1 | -34.3 | 57.0 | 0.292 | 0.005 |
B:Q007T0:0.005 |
FAD FES |
1.992 9.118 |
NE2 ND1 |
C8M FE2 |
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| 3sfd | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-09-07 | HIS | A:57 | A:57 | 53.0 | 0.272 | G | -60.0 | -27.8 | 50.0 | 0.256 | 0.016 |
B:Q007T0:0.015 |
FAD OAA FES HOH |
2.120 7.951 8.885 2.908 |
NE2 NE2 ND1 ND1 |
C8M O2 FE2 O |
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| 3sfe | 1 | Q0QF01 | 96.3 | 0.0 |
X-RAY |
2011-09-07 | HIS | A:57 | A:57 | 58.0 | 0.297 | G | -60.1 | -32.6 | 54.0 | 0.277 | 0.02 |
B:Q007T0:0.021 |
FAD OAA FES |
2.198 8.146 8.895 |
NE2 NE2 ND1 |
C8M O2 FE2 |
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| 1yq3 | 1 | Q9YHT1 | 91.79 | 0.0 |
X-RAY |
2005-12-20 | HIS | A:56 | A:56 | 49.0 | 0.251 | G | -54.5 | -32.6 | 44.0 | 0.226 | 0.025 |
B:Q9YHT2:0.026 |
FAD TEO FES HOH |
1.457 7.555 9.193 2.779 |
NE2 NE2 ND1 ND1 |
C8M O2 FE2 O |
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| 1yq4 | 1 | 50736125 | 91.79 | 0.0 |
X-RAY |
2005-12-20 | HIS | A:56 | A:56 | 52.0 | 0.267 | G | -51.3 | -29.8 | 45.0 | 0.231 | 0.036 |
B:3851612:0.036 |
FAD 3NP FES HOH |
1.427 8.818 8.952 2.546 |
NE2 NE2 ND1 ND1 |
C8M N1 FE2 O |
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| 2fbw | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2005-12-20 | HIS | A:56 | A:56 | 56.0 | 0.287 | G | -58.9 | -28.6 | 51.0 | 0.262 | 0.025 |
B:Q9YHT2:0.026 |
FAD Y3P FES HOH |
1.619 7.738 9.164 2.547 |
NE2 NE2 ND1 ND1 |
C8M O3 FE2 O |
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| HIS | E:56 | N:56 | 53.0 | 0.272 | G | -56.5 | -31.9 | NA | NA | NA | |||||||||||||
| 2h88 | 1 | Q9YHT1 | 91.79 | 0.0 |
X-RAY |
2006-06-20 | HIS | A:56 | A:56 | 57.0 | 0.292 | G | -58.0 | -27.3 | 51.0 | 0.262 | 0.03 |
B:Q9YHT2:0.031 |
FAD TEO FES HOH |
1.437 7.779 9.212 2.691 |
NE2 NE2 ND1 ND1 |
C8M O2 FE2 O |
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| HIS | E:56 | N:56 | 56.0 | 0.287 | G | -58.6 | -26.6 | NA | NA | NA | |||||||||||||
| 2h89 | 1 | Q9YHT1 | 91.79 | 0.0 |
X-RAY |
2006-06-20 | HIS | A:56 | A:56 | 57.0 | 0.292 | G | -57.7 | -22.2 | 50.0 | 0.256 | 0.036 |
B:Q9YHT2:0.036 |
FAD MLI FES HOH |
1.421 8.146 8.995 3.087 |
NE2 NE2 ND1 N |
C8M O8 FE2 O |
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| 2wqy | 1 | Q9YHT1 | 91.79 | 0.0 |
X-RAY |
2010-08-25 | HIS | A:56 | A:56 | 54.0 | 0.277 | G | -50.2 | -29.7 | 49.0 | 0.251 | 0.026 |
B:Q9YHT2:0.026 |
FAD OAA FES HOH |
1.425 7.578 9.249 2.716 |
NE2 NE2 CA ND1 |
C8M O3 FE2 O |
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| HIS | E:56 | N:56 | 51.0 | 0.262 | G | -49.7 | -30.4 | NA | NA | NA | |||||||||||||
| 6myo | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 51.0 | 0.262 | G | -56.0 | -27.2 | 46.0 | 0.236 | 0.026 |
B:Q9YHT2:0.026 |
FAD OAA UNL UNL FES UNL HOH |
1.468 7.574 9.784 9.171 8.939 2.796 3.013 |
NE2 NE2 CE1 N ND1 ND1 N |
C8M O3 O2 N1 FE2 N1 O |
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| 6myp | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 51.0 | 0.262 | G | -62.6 | -20.2 | 47.0 | 0.241 | 0.021 |
B:Q9YHT2:0.021 |
FAD OAA UNL FES HOH |
1.446 7.660 9.799 8.897 2.414 |
NE2 NE2 CE1 ND1 ND1 |
C8M O3 O03 FE2 O |
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| 6myq | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 50.0 | 0.256 | G | -55.4 | -27.4 | 46.0 | 0.236 | 0.02 |
B:Q9YHT2:0.021 |
FAD Y3P UNL UNL UNL FES HOH |
1.433 7.419 9.971 2.884 9.374 9.198 3.047 |
NE2 NE2 CE1 ND1 N ND1 N |
C8M O3 O2 N1 N1 FE2 O |
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| 6myr | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-10-16 | HIS | A:56 | A:56 | 49.0 | 0.251 | G | -57.3 | -25.8 | 46.0 | 0.236 | 0.015 |
B:Q9YHT2:0.015 |
FAD OAA UNL UNL FES UNL HOH |
1.596 8.010 9.505 3.132 9.008 9.935 2.775 |
NE2 NE2 CB CD2 ND1 CE1 ND1 |
C8M O3 O O FE2 O2 O |
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| 6mys | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 48.0 | 0.246 | G | -59.8 | -21.4 | 44.0 | 0.226 | 0.02 |
B:Q9YHT2:0.021 |
FAD OAA UNL UNL FES HOH |
1.615 7.740 8.807 3.874 8.971 3.844 |
NE2 NE2 CE1 N ND1 CE1 |
C8M O3 O O FE2 O |
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| 6myt | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 51.0 | 0.262 | G | -61.0 | -20.1 | 46.0 | 0.236 | 0.026 |
B:Q9YHT2:0.026 |
FAD OAA UNL UNL UNL UNL FES HOH |
1.502 7.419 2.939 9.744 3.257 7.833 9.089 2.807 |
NE2 NE2 ND1 N CB N CA N |
C8M O3 N1 N3 O O FE2 O |
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| 6myu | 1 | F1NPJ4 | 91.79 | 0.0 |
X-RAY |
2019-11-06 | HIS | A:56 | A:56 | 50.0 | 0.256 | G | -55.5 | -24.1 | 47.0 | 0.241 | 0.015 |
B:Q9YHT2:0.015 |
FAD OAA UNL UNL FES HOH |
1.573 7.639 2.697 9.332 9.084 2.927 |
NE2 NE2 ND1 N ND1 N |
C8M O3 N1 N1 FE2 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
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| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p31040-f1 | 1 | P31040 | 100.0 | 0.0 | HIS | A:99 | A:99 | 46.0 | 0.236 | G | -59.5 | -21.2 | |