Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr5 88100503 . T A CCDS47244.1:NM_001131005.2:c.170tAt>tTt_NP_001124477.1:p.57Y>F Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5f28 1 Q8CFN5 97.8 5e-59 X-RAY
 2016-07-13 TYR A:57 A:57 37.0 0.161 E -149.4 142.7 0.0 0.0 0.161 B:Q8CFN5:0.161
 HOH
 7.106
 OH
 O
TYR B:57 B:57 41.0 0.178 E -137.5 140.2 0.0 0.0 0.178 A:Q8CFN5:0.178
 HOH
 8.075
 CE1
 O
TYR C:57 C:57 38.0 0.165 E -141.3 135.2 NA NA NA
TYR D:57 D:57 43.0 0.187 E -133.3 142.4 NA NA NA
3kov 1 Q02078 96.67 1e-57 X-RAY
 2010-02-16 TYR A:56 A:57 36.0 0.157 E -123.6 151.3 0.0 0.0 0.157 B:Q02078:0.157
TYR B:56 B:57 35.0 0.152 E -124.3 152.4 0.0 0.0 0.152 A:Q02078:0.152
TYR C:56 I:57 35.0 0.152 E -122.4 151.7 NA NA NA
TYR D:56 J:57 35.0 0.152 E -122.5 152.3 NA NA NA
3p57 1 Q02078 96.67 1e-57 X-RAY
 2011-08-10 TYR A:56 A:57 39.0 0.17 E -148.7 143.2 0.0 0.0 0.17 B:Q02078:0.17
 HOH
 4.056
 C
 O
TYR B:56 B:57 38.0 0.165 E -148.7 138.7 0.0 0.0 0.165 A:Q02078:0.165
 HOH
 4.068
 C
 O
TYR C:56 C:57 36.0 0.157 E -132.3 141.8 0.0 0.0 0.157 D:Q02078:0.157
 HOH
 6.792
 OH
 O
TYR D:56 D:57 36.0 0.157 E -136.4 141.0 0.0 0.0 0.157 C:Q02078:0.157
 HOH
 4.127
 C
 O
TYR E:56 I:57 40.0 0.174 E -134.5 151.6 0.0 0.0 0.174 F:Q02078:0.174
 HOH
 9.342
 OH
 O
TYR F:56 J:57 35.0 0.152 E -130.3 146.8 0.0 0.0 0.152 E:Q02078:0.152
 HOH
 4.382
 C
 O
6byy 1 Q02078,Q02080 89.47 3e-57 X-RAY
 2018-01-31 TYR A:57 A:57 35.0 0.152 E -135.0 144.4 0.0 0.0 0.152 B:Q02078+Q02080:0.152
 HOH
 4.154
 C
 O
TYR B:57 B:57 37.0 0.161 E -136.3 150.8 0.0 0.0 0.161 A:Q02078+Q02080:0.161
 HOH
 4.056
 C
 O
TYR C:57 C:57 35.0 0.152 E -147.0 137.9 NA NA NA
TYR D:57 D:57 37.0 0.161 E -131.5 146.0 NA NA NA
6wc2 1 Q02078,Q02080 89.47 3e-57 X-RAY
 2020-07-22 TYR A:57 A:57 34.0 0.148 E -129.3 142.4 0.0 0.0 0.148 B:Q02078+Q02080:0.148
 HOH
 4.231
 C
 O
TYR B:57 B:57 40.0 0.174 E -134.2 142.8 0.0 0.0 0.174 A:Q02078+Q02080:0.174
 HOH
 4.116
 C
 O
TYR C:57 C:57 34.0 0.148 E -132.0 143.8 NA NA NA
TYR D:57 D:57 39.0 0.17 E -133.5 143.6 NA NA NA
TYR I:57 I:57 35.0 0.152 E -137.2 142.7 NA NA NA
TYR J:57 J:57 37.0 0.161 E -131.7 145.7 NA NA NA
1tqe 3 Q02080 86.02 8e-56 X-RAY
 2004-12-21 TYR E:57 P:57 36.0 0.157 E -146.2 158.7 0.0 0.0 0.157 F:Q02080:0.157
TYR F:57 Q:57 38.0 0.165 E -148.1 160.3 0.0 0.0 0.165 E:Q02080:0.165
TYR H:57 R:57 37.0 0.161 E -146.6 158.3 NA NA NA
TYR I:57 S:57 39.0 0.17 E -147.2 159.3 NA NA NA
6c9l 1 Q02080 86.02 8e-56 X-RAY
 2018-02-07 TYR A:57 A:57 37.0 0.161 E -134.1 141.4 0.0 0.0 0.161 B:Q02080:0.161
 HOH
 4.051
 C
 O
TYR B:57 B:57 32.0 0.139 E -134.5 140.7 0.0 0.0 0.139 A:Q02080:0.139
 HOH
 4.202
 C
 O
TYR C:57 C:57 38.0 0.165 E -134.6 141.3 NA NA NA
TYR D:57 D:57 35.0 0.152 E -133.1 140.2 NA NA NA
TYR E:57 E:57 40.0 0.174 E -135.5 140.3 NA NA NA
TYR F:57 F:57 41.0 0.178 E -136.1 140.9 NA NA NA
6bz1 1 Q02078,Q02080 88.42 9e-56 X-RAY
 2018-02-07 TYR A:57 C:57 41.0 0.178 E -133.6 139.3 4.0 0.017 0.161 B:Q02078+Q02080:0.161
TYR B:57 D:57 41.0 0.178 E -134.4 137.5 4.0 0.017 0.161 A:Q02078+Q02080:0.161
TYR E:57 A:57 42.0 0.183 E -133.7 140.0 NA NA NA
TYR F:57 B:57 42.0 0.183 E -133.2 138.8 NA NA NA
1n6j 3 Q02080 85.87 6e-55 X-RAY
 2003-11-11 TYR C:56 A:57 37.0 0.161 E -145.3 141.2 0.0 0.0 0.161 D:Q02080:0.161
 HOH
 4.225
 CA
 O
TYR D:56 B:57 37.0 0.161 E -145.8 142.0 1.0 0.004 0.157 C:Q02080:0.157
 HOH
 4.004
 CA
 O
6wc5 1 Q02080 86.67 8e-54 X-RAY
 2020-07-22 TYR A:56 A:57 36.0 0.157 E -122.0 142.7 0.0 0.0 0.157 B:Q02080:0.157
TYR B:56 B:57 35.0 0.152 E -122.1 142.9 0.0 0.0 0.152 A:Q02080:0.152
TYR C:56 C:57 35.0 0.152 E -121.6 142.1 NA NA NA
TYR D:56 D:57 34.0 0.148 E -122.1 142.4 NA NA NA
1egw 3 Q02078 98.7 9e-50 X-RAY
 2000-03-20 TYR E:56 A:57 39.0 0.17 E -145.0 139.8 39.0 0.17 0.0 HOH
 2.638
 OH
 O
TYR F:56 B:57 40.0 0.174 E -145.5 138.2 40.0 0.174 0.0 HOH
 2.685
 OH
 O
TYR G:56 C:57 39.0 0.17 E -146.0 139.5 NA NA NA
TYR H:56 D:57 40.0 0.174 E -143.7 138.7 NA NA NA
3mu6 1 Q02078 97.18 2e-43 X-RAY
 2011-11-02 TYR A:56 A:57 44.0 0.191 E -142.4 142.4 44.0 0.191 0.0 BXL
 7.606
 C
 C17
TYR B:56 B:57 45.0 0.196 E -142.7 141.4 45.0 0.196 0.0
TYR E:56 C:57 42.0 0.183 E -143.4 140.8 NA NA NA
TYR F:56 D:57 42.0 0.183 E -142.9 140.9 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q06413-f1 1 Q06413 100.0 0.0 TYR A:57 A:57 45.0 0.196 E -149.9 140.9