Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr5 88100569 . A C CCDS47244.1:NM_001131005.2:c.104cTg>cGg_NP_001124477.1:p.35L>R Homo sapiens myocyte enhancer factor 2C (MEF2C), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5f28 1 Q8CFN5 97.8 5e-59 X-RAY
 2016-07-13 LEU A:35 A:35 89.0 0.524 H -67.0 -30.4 0.0 0.0 0.524 B:Q8CFN5:0.524
 HOH
 7.413
 O
 O
LEU B:35 B:35 80.0 0.471 H -66.9 -36.5 0.0 0.0 0.471 A:Q8CFN5:0.471
 HOH
 8.318
 CB
 O
LEU C:35 C:35 90.0 0.529 H -67.9 -30.6 NA NA NA
LEU D:35 D:35 88.0 0.518 H -68.4 -33.6 NA NA NA
3kov 1 Q02078 96.67 1e-57 X-RAY
 2010-02-16 LEU A:34 A:35 91.0 0.535 H -52.6 -54.1 2.0 0.012 0.523 B:Q02078:0.524
 DA
DT
DA
DA
DT
DA
 8.854
6.653
8.383
8.800
7.841
8.805
 CB
CB
N
N
CB
CD1
 O3'
OP1
OP1
OP1
OP1
OP2
LEU B:34 B:35 89.0 0.524 H -60.6 -53.6 2.0 0.012 0.512 A:Q02078:0.512
 DA
DT
DA
DA
DT
DA
 9.362
6.914
8.391
8.372
7.694
8.573
 CB
CB
CD1
N
CB
N
 O3'
OP1
OP1
OP1
OP1
OP1
LEU C:34 I:35 90.0 0.529 H -59.8 -51.6 NA NA NA
LEU D:34 J:35 91.0 0.535 H -59.4 -53.3 NA NA NA
3p57 1 Q02078 96.67 1e-57 X-RAY
 2011-08-10 LEU A:34 A:35 87.0 0.512 H -61.1 -41.9 1.0 0.006 0.506 B:Q02078:0.506
 DA
DA
DT
DA
HOH
 9.304
9.969
7.547
8.154
3.532
 N
CB
CB
CD1
CB
 OP1
O3'
OP1
OP2
O
LEU B:34 B:35 87.0 0.512 H -64.8 -39.9 1.0 0.006 0.506 A:Q02078:0.506
 DT
DA
DA
HOH
 7.682
8.335
9.261
3.698
 CB
CD1
N
N
 OP1
OP2
OP1
O
LEU C:34 C:35 84.0 0.494 H -63.3 -46.6 1.0 0.006 0.488 D:Q02078:0.488
 DT
DA
DA
HOH
 7.677
8.044
9.459
3.819
 CB
CD1
N
CB
 OP1
OP2
OP1
O
LEU D:34 D:35 90.0 0.529 H -56.6 -53.4 1.0 0.006 0.523 C:Q02078:0.524
 DA
DT
DA
HOH
 9.371
7.740
8.748
3.649
 N
CD1
CD1
N
 OP1
OP1
OP2
O
LEU E:34 I:35 84.0 0.494 H -62.3 -42.8 0.0 0.0 0.494 F:Q02078:0.494
 DT
DA
DA
HOH
 7.734
8.292
9.379
3.582
 CB
CD1
N
N
 OP1
OP1
OP1
O
LEU F:34 J:35 85.0 0.5 H -63.1 -41.8 1.0 0.006 0.494 E:Q02078:0.494
 DA
DT
DA
HOH
 9.124
7.624
8.318
3.698
 N
CB
N
N
 OP1
OP1
OP1
O
6byy 1 Q02078,Q02080 89.47 3e-57 X-RAY
 2018-01-31 LEU A:35 A:35 91.0 0.535 H -59.2 -45.8 1.0 0.006 0.529 B:Q02078+Q02080:0.529
 DA
DT
DA
DA
1PG
HOH
 9.761
7.390
8.239
9.349
9.406
3.633
 CB
CB
CD1
N
CD1
N
 O3'
OP1
OP2
OP1
O4
O
LEU B:35 B:35 84.0 0.494 H -61.8 -38.5 1.0 0.006 0.488 A:Q02078+Q02080:0.488
 DA
DA
DT
DA
HOH
 9.316
9.915
7.542
8.098
3.585
 N
CB
CB
CD1
CB
 OP1
O3'
OP1
OP2
O
LEU C:35 C:35 73.0 0.429 H -68.2 -45.1 NA NA NA
LEU D:35 D:35 74.0 0.435 H -59.1 -38.6 NA NA NA
6wc2 1 Q02078,Q02080 89.47 3e-57 X-RAY
 2020-07-22 LEU A:35 A:35 89.0 0.524 H -59.0 -45.9 1.0 0.006 0.518 B:Q02078+Q02080:0.518
 DA
DT
DA
DA
HOH
 9.207
9.972
7.477
8.139
3.611
 N
CB
CB
CD1
N
 OP1
O3'
OP1
OP1
O
LEU B:35 B:35 86.0 0.506 H -60.0 -44.2 1.0 0.006 0.5 A:Q02078+Q02080:0.5
 DT
DA
DT
HOH
 7.604
7.968
9.411
3.729
 CB
CD1
N
CB
 OP1
OP2
OP1
O
LEU C:35 C:35 87.0 0.512 H -59.7 -44.5 NA NA NA
LEU D:35 D:35 85.0 0.5 H -59.3 -44.3 NA NA NA
LEU I:35 I:35 85.0 0.5 H -59.6 -44.3 NA NA NA
LEU J:35 J:35 88.0 0.518 H -59.7 -43.5 NA NA NA
1tqe 3 Q02080 86.02 8e-56 X-RAY
 2004-12-21 LEU E:35 P:35 91.0 0.535 H -47.7 -39.5 1.0 0.006 0.529 F:Q02080:0.529
 DA
DA
DT
DA
 9.438
9.752
7.257
8.323
 N
CB
CB
CD1
 OP1
O3'
OP1
OP2
LEU F:35 Q:35 91.0 0.535 H -47.4 -40.6 1.0 0.006 0.529 E:Q02080:0.529
 DA
DT
DA
DA
 9.937
7.434
8.845
9.422
 CB
CB
N
N
 O3'
OP1
OP1
OP1
LEU H:35 R:35 91.0 0.535 H -48.1 -39.1 NA NA NA
LEU I:35 S:35 91.0 0.535 H -47.8 -40.3 NA NA NA
6c9l 1 Q02080 86.02 8e-56 X-RAY
 2018-02-07 LEU A:35 A:35 84.0 0.494 H -58.6 -43.1 1.0 0.006 0.488 B:Q02080:0.488
 HOH
 3.780
 N
 O
LEU B:35 B:35 84.0 0.494 H -58.9 -42.3 0.0 0.0 0.494 A:Q02080:0.494
 HOH
 3.739
 N
 O
LEU C:35 C:35 83.0 0.488 H -58.8 -42.5 NA NA NA
LEU D:35 D:35 84.0 0.494 H -58.1 -43.2 NA NA NA
LEU E:35 E:35 82.0 0.482 H -59.2 -42.0 NA NA NA
LEU F:35 F:35 85.0 0.5 H -59.3 -42.1 NA NA NA
6bz1 1 Q02078,Q02080 88.42 9e-56 X-RAY
 2018-02-07 LEU A:35 C:35 89.0 0.524 H -54.5 -48.7 1.0 0.006 0.518 B:Q02078+Q02080:0.518
 DA
DA
DT
DA
 9.489
9.896
7.347
7.915
 N
CB
CB
CD1
 OP1
O3'
OP1
OP2
LEU B:35 D:35 89.0 0.524 H -54.0 -48.9 0.0 0.0 0.524 A:Q02078+Q02080:0.524
 DA
DT
DA
DA
 9.790
7.416
8.242
9.330
 CB
CB
CD1
N
 O3'
OP1
OP2
OP1
LEU E:35 A:35 88.0 0.518 H -54.1 -48.7 NA NA NA
LEU F:35 B:35 90.0 0.529 H -54.3 -48.8 NA NA NA
1n6j 3 Q02080 85.87 6e-55 X-RAY
 2003-11-11 LEU C:34 A:35 86.0 0.506 H -62.2 -41.4 1.0 0.006 0.5 D:Q02080:0.5
 DA
DT
DA
DA
HOH
 9.937
7.448
8.351
9.597
3.589
 CB
CB
CD1
N
CB
 O3'
OP1
OP2
OP1
O
LEU D:34 B:35 87.0 0.512 H -61.3 -42.0 1.0 0.006 0.506 C:Q02080:0.506
 DA
DA
DT
DA
HOH
 9.475
9.925
7.520
8.153
3.470
 N
CB
CB
CD1
CB
 OP1
O3'
OP1
OP2
O
6wc5 1 Q02080 86.67 8e-54 X-RAY
 2020-07-22 LEU A:34 A:35 84.0 0.494 H -58.2 -51.2 1.0 0.006 0.488 B:Q02080:0.488
 DA
DA
DA
HOH
 9.474
7.518
8.212
5.098
 N
CB
CD1
CB
 OP1
OP1
OP1
O
LEU B:34 B:35 88.0 0.518 H -58.2 -51.3 1.0 0.006 0.512 A:Q02080:0.512
 DA
DT
DA
DT
 9.982
7.548
8.461
9.280
 CB
CB
N
N
 O3'
OP1
OP1
OP1
LEU C:34 C:35 85.0 0.5 H -57.7 -51.6 NA NA NA
LEU D:34 D:35 87.0 0.512 H -58.0 -51.5 NA NA NA
1egw 3 Q02078 98.7 9e-50 X-RAY
 2000-03-20 LEU E:34 A:35 86.0 0.506 H -64.4 -40.4 0.0 0.0 0.506 F:Q02078:0.506
 DT
DT
DA
DA
DT
DA
HOH
 9.655
7.620
8.200
9.523
7.687
8.518
3.693
 N
CB
CD1
N
CB
CD1
CB
 OP1
OP1
OP2
OP1
OP1
OP2
O
LEU F:34 B:35 88.0 0.518 H -63.4 -41.1 1.0 0.006 0.512 E:Q02078:0.512
 DT
DT
DA
DA
DT
DA
HOH
 9.497
7.730
8.008
9.532
7.640
8.264
3.689
 N
CB
CD1
N
CB
CD1
N
 OP1
OP1
OP2
OP1
OP1
OP2
O
LEU G:34 C:35 90.0 0.529 H -64.9 -39.8 NA NA NA
LEU H:34 D:35 88.0 0.518 H -64.7 -40.8 NA NA NA
3mu6 1 Q02078 97.18 2e-43 X-RAY
 2011-11-02 LEU A:34 A:35 89.0 0.524 H -68.4 -38.3 1.0 0.006 0.518 B:Q02078:0.518
 DT
DT
DA
 9.624
7.651
8.002
 N
CB
CD1
 OP1
OP1
OP2
LEU B:34 B:35 88.0 0.518 H -68.7 -39.1 1.0 0.006 0.512 A:Q02078:0.512
 DT
DA
DA
 7.652
8.180
9.510
 CB
CD1
N
 OP1
OP2
OP1
LEU E:34 C:35 87.0 0.512 H -68.4 -38.2 NA NA NA
LEU F:34 D:35 86.0 0.506 H -69.9 -37.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q06413-f1 1 Q06413 100.0 0.0 LEU A:35 A:35 94.0 0.553 H -67.6 -42.8