Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 112035605 . T A CCDS5094.1:NM_002037.5:c.289Aca>Tca_NP_002028.1:p.97T>S Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1g83 1 P06241 98.18 1e-115 X-RAY
 2001-05-30 THR A:16 A:97 69.0 0.493 S -58.4 -169.0 69.0 0.493 0.0
THR B:16 B:97 64.0 0.457 S -83.3 -154.6 NA NA NA
3uf4 1 P39688 96.95 6e-113 X-RAY
 2011-12-07 THR A:17 A:97 79.0 0.564 S -140.6 170.0 79.0 0.564 0.0 HOH
 2.952
 O
 O
3h0h 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 THR A:28 A:97 67.0 0.479 S -135.7 150.4 67.0 0.479 0.0 HOH
 2.888
 O
 O
3h0i 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 THR A:28 A:97 65.0 0.464 S -95.2 157.8 65.0 0.464 0.0 HOH
 3.538
 CA
 O
THR B:28 B:97 69.0 0.493 S -110.3 163.3 NA NA NA
3h0f 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 THR A:28 A:97 79.0 0.564 S -122.6 -168.9 79.0 0.564 0.0 PG5
HOH
 4.071
2.977
 OG1
CG2
 O2
O
6ipz 1 P06241 94.2 9e-38 X-RAY
 2018-11-28 THR A:23 Z:97 73.0 0.521 S -126.1 -167.9 73.0 0.521 0.0 O4B
HOH
 2.087
2.637
 HG21
O
 HAC1
O
3ua6 1 P06241 100.0 2e-37 X-RAY
 2012-07-25 THR A:18 A:97 74.0 0.529 S -133.4 -171.9 74.0 0.529 0.0 NA
FMT
HOH
 2.624
5.837
4.443
 O
CG2
O
 NA
O1
O
THR B:18 B:97 76.0 0.543 S -144.3 173.9 NA NA NA
3ua7 1 P06241 100.0 2e-37 X-RAY
 2012-07-25 THR A:18 A:97 79.0 0.564 S -147.1 163.8 79.0 0.564 0.0 GOL
HOH
 2.779
5.330
 OG1
O
 O2
O
THR B:18 B:97 86.0 0.614 S -136.4 164.8 NA NA NA
THR C:18 C:97 79.0 0.564 S -142.3 168.9 NA NA NA
THR D:18 D:97 79.0 0.564 S -127.6 170.4 NA NA NA
4eik 1 P06241 100.0 2e-37 X-RAY
 2013-04-10 THR A:18 A:97 70.0 0.5 S -134.8 160.9 54.0 0.386 0.114 B:None:0.114
 HOH
 2.829
 O
 O
6ipy 1 P06241 98.41 3e-37 X-RAY
 2018-11-28 THR A:26 A:97 62.0 0.443 S -139.1 153.9 62.0 0.443 0.0 HOH
 3.352
 H
 O
7d7s 2 E5RFS5 98.41 5e-37 X-RAY
 2020-11-18 THR C:17 C:97 75.0 0.536 S -80.9 139.5 NA NA NA
THR D:17 D:97 78.0 0.557 S -83.0 141.8 10.0 0.071 0.486 A:P03407:0.486
1fyn 1 P06241 100.0 8e-37 X-RAY
 1996-11-08 THR A:17 A:97 78.0 0.557 S -115.3 -176.1 44.0 0.314 0.243 B:None:0.243
 HOH
 3.815
 O
 O
1m27 3 P06241 100.0 6e-36 X-RAY
 2003-05-06 THR C:14 C:97 73.0 0.521 S -119.5 -178.6 13.0 0.093 0.428 A:O60880:0.429
 HOH
 3.832
 CG2
 O
7a2j 1 P06241 100.0 2e-35 X-RAY
 2021-08-25 THR A:15 A:97 80.0 0.571 S -134.0 -170.8 80.0 0.571 0.0 HOH
 2.440
 HB
 O
THR B:15 B:97 76.0 0.543 S -128.4 166.8 NA NA NA
7a2k 1 P06241 100.0 2e-35 X-RAY
 2021-08-25 THR A:15 A:97 78.0 0.557 S -138.2 -173.0 78.0 0.557 0.0 HOH
 2.361
 HB
 O
THR B:15 B:97 72.0 0.514 S -134.3 -176.0 NA NA NA
THR C:15 C:97 76.0 0.543 S -130.4 179.1 NA NA NA
THR D:15 D:97 79.0 0.564 S -128.0 179.2 NA NA NA
7a2l 1 P06241 98.33 5e-35 X-RAY
 2021-08-25 THR A:15 A:97 72.0 0.514 S -129.6 -179.8 72.0 0.514 0.0 FMT
HOH
 9.812
5.472
 H
O
 H
O
THR B:15 B:97 75.0 0.536 S -128.0 175.6 NA NA NA
1shf 1 P06241 100.0 1e-34 X-RAY
 1993-10-31 THR A:14 A:97 72.0 0.514 S -124.6 -162.6 72.0 0.514 0.0
THR B:14 B:97 79.0 0.564 S -136.7 178.4 79.0 0.564 0.0
7a2u 1 P06241 95.0 4e-34 X-RAY
 2021-08-25 THR A:15 A:97 79.0 0.564 S -99.8 161.2 79.0 0.564 0.0 ACT
HOH
 3.037
2.218
 HB
HG1
 O
O
7a2m 1 P06241 96.67 5e-34 X-RAY
 2021-08-25 THR A:15 A:97 72.0 0.514 S -137.7 -172.6 72.0 0.514 0.0 NA
HOH
 2.307
2.511
 O
HB
 NA
O
THR B:15 B:97 49.0 NA S -131.0 159.3 NA NA NA
7a2n 1 P06241 96.67 5e-34 X-RAY
 2021-08-25 THR A:15 A:97 72.0 0.514 S -133.4 -170.9 72.0 0.514 0.0 FMT
NA
HOH
 4.730
2.325
2.708
 HG23
O
HB
 O1
NA
O
THR B:15 B:97 74.0 0.529 S -136.2 -178.4 NA NA NA
THR C:15 C:97 70.0 0.5 S -135.8 -172.5 NA NA NA
THR D:15 D:97 57.0 0.407 S -133.9 164.8 NA NA NA
4znx 1 P06241 100.0 6e-34 X-RAY
 2016-06-29 THR A:14 A:97 75.0 0.536 S -153.9 161.9 21.0 0.15 0.386 E:None:0.071
D:P06241:0.386
 HOH
 3.678
 O
 O
THR B:14 B:97 76.0 0.543 S -155.2 161.4 23.0 0.164 0.379 A:P06241:0.371
F:None:0.079
 HOH
 5.923
 O
 O
THR C:14 C:97 78.0 0.557 S -153.8 161.1 23.0 0.164 0.393 B:P06241:0.386
G:None:0.086
 HOH
 2.734
 HG1
 O
THR D:14 D:97 78.0 0.557 S -153.6 163.6 23.0 0.164 0.393 H:None:0.079
C:P06241:0.393
 HOH
 5.213
 O
 O
7a2v 1 P06241 93.33 1e-33 X-RAY
 2021-08-25 THR A:15 A:97 69.0 0.493 S -95.1 160.6 69.0 0.493 0.0 HOH
 3.563
 HG22
 O
1avz 2 P06241 100.0 3e-33 X-RAY
 1998-03-25 THR C:13 C:97 81.0 0.579 S -138.1 148.5 11.0 0.079 0.5 B:P03406:0.5
5zau 1 P06241 100.0 3e-33 NMR
 2019-09-11 THR A:13 A:97 85.0 0.607 S -146.4 -166.5 55.0 0.393 0.214 B:None:0.214
1efn 1 P06241 98.28 7e-33 X-RAY
 1997-01-11 THR A:13 A:97 53.0 0.379 S -156.6 163.0 27.0 0.193 0.186 B:P03406:0.186
 HOH
 4.130
 N
 O
THR C:13 C:97 85.0 0.607 S -75.6 170.1 14.0 0.1 0.507 D:P03406:0.507
 HOH
 5.301
 CG2
 O
7a2p 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 THR A:15 A:97 89.0 0.636 S -135.1 -178.9 89.0 0.636 0.0 HOH
 2.602
 HB
 O
7a2q 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 THR A:15 A:97 91.0 0.65 S -132.5 174.2 91.0 0.65 0.0 SO4
HOH
 4.800
2.669
 O
HB
 O3
O
7a2t 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 THR A:15 A:97 89.0 0.636 S -137.5 166.6 89.0 0.636 0.0 ACT
HOH
 4.283
2.724
 OG1
OG1
 O
O
7a2r 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 THR A:16 A:97 84.0 0.6 S -133.5 162.7 84.0 0.6 0.0 HOH
 2.688
 OG1
 O
7a2s 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 THR A:16 A:97 84.0 0.6 S -136.3 163.7 84.0 0.6 0.0 HOH
 2.682
 OG1
 O
4d8d 1 P06241 98.28 9e-33 X-RAY
 2013-01-16 THR A:14 A:97 86.0 0.614 S -107.8 152.1 12.0 0.086 0.528 B:P03406:0.529
 HOH
 2.917
 N
 O
THR C:14 C:97 87.0 0.621 S -87.6 166.2 NA NA NA
6edf 1 ? 87.5 2e-32 X-RAY
 2018-08-29 THR A:16 A:14 86.0 0.614 S -132.9 -168.0 86.0 0.614 0.0 UNX
UNX
HOH
 8.291
9.769
2.539
 O
N
O
 UNK
UNK
O
7a2o 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 THR A:15 A:97 90.0 0.643 S -133.5 172.9 90.0 0.643 0.0 HOH
 2.690
 O
 O
7a2x 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 THR A:15 A:97 67.0 0.479 S -136.5 147.8 57.0 0.407 0.072 B:None:0.071
 HOH
 1.937
 HG1
 O
7a2y 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 THR A:15 A:97 64.0 0.457 S -135.2 146.5 54.0 0.386 0.071 B:None:0.071
 HOH
 1.903
 HG1
 O
7a2z 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 THR A:15 A:97 64.0 0.457 S -134.0 147.5 54.0 0.386 0.071 B:None:0.071
 HOH
 1.930
 HG1
 O
7a2w 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 THR A:16 A:97 65.0 0.464 S -135.7 148.0 54.0 0.386 0.078 B:None:0.079
 CIT
HOH
 8.601
2.303
 HG21
HG1
 H22
O
4ag2 2 ? 82.35 7e-32 X-RAY
 2012-07-11 ARG C:19 C:15 180.0 0.8 S -118.2 147.8 26.0 0.116 0.684 A:P23946:0.684
 LMR
NA
NA
NA
HOH
 2.562
9.691
8.575
7.901
3.693
 NH2
NH1
NH2
O
O
 O1B
NA
NA
NA
O
ARG D:19 D:15 181.0 0.804 S -111.1 146.9 NA NA NA
3cqt 1 Q05876 91.67 2e-31 X-RAY
 2008-07-01 THR A:18 A:14 78.0 0.557 S -124.4 165.6 78.0 0.557 0.0 HOH
 3.273
 O
 O
4afq 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ARG C:19 C:15 114.0 0.507 S -106.2 141.4 26.0 0.116 0.391 A:P23946:0.391
 HOH
 2.948
 NH1
 O
ARG D:19 D:15 116.0 0.516 S -106.2 139.7 NA NA NA
4afs 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ARG B:19 C:15 109.0 0.484 S -109.4 138.9 25.0 0.111 0.373 A:P23946:0.373
 PO4
HOH
 8.544
3.127
 O
O
 O1
O
4afu 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ARG C:19 C:15 128.0 0.569 S -93.5 141.4 13.0 0.058 0.511 A:P23946:0.511
 HOH
 3.626
 CG
 O
ARG D:19 D:15 125.0 0.556 S -112.9 155.1 NA NA NA
4afz 2 ? 82.35 5e-31 X-RAY
 2012-07-11 ARG C:19 C:15 116.0 0.516 S -108.9 139.4 23.0 0.102 0.414 A:P23946:0.413
 TAR
HOH
 7.769
2.852
 O
NH1
 O11
O
ARG D:19 D:15 124.0 0.551 S -98.8 139.7 NA NA NA
4ag1 2 ? 82.35 5e-31 X-RAY
 2012-07-11 ARG B:19 C:15 120.0 0.533 S -109.2 142.0 21.0 0.093 0.44 A:P23946:0.44
 HOH
 3.395
 HG2
 O
2l2p 1 Q05876 93.1 8e-31 NMR
 2011-09-14 THR A:20 A:14 99.0 0.707 S -109.6 -31.8 99.0 0.707 0.0
2lp5 1 Q05876 93.1 8e-31 NMR
 2012-05-16 THR A:20 A:14 77.0 0.55 S -130.1 171.3 77.0 0.55 0.0
3zl7 2 ? 81.94 2e-30 X-RAY
 2013-05-29 PRO B:19 C:19 113.0 0.779 T -54.6 -34.3 113.0 0.779 0.0
7jt9 1 P09769 80.95 2e-30 X-RAY
 2022-01-26 THR A:17 A:106 87.0 0.621 S -136.3 173.8 87.0 0.621 0.0 HOH
 3.533
 CA
 O
7a31 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 THR A:15 A:96 80.0 0.571 S -147.8 168.6 80.0 0.571 0.0 HOH
 2.700
 HB
 O
THR B:15 B:96 74.0 0.529 S -144.0 168.1 NA NA NA
7a32 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 THR A:15 A:96 73.0 0.521 S -143.6 166.7 73.0 0.521 0.0 HOH
 2.842
 HB
 O
THR B:15 B:96 78.0 0.557 S -143.8 169.0 NA NA NA
THR C:15 C:96 75.0 0.536 S -146.1 166.6 NA NA NA
THR D:15 D:96 71.0 0.507 S -135.6 160.4 NA NA NA
7a33 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 THR A:15 A:96 77.0 0.55 S -139.9 165.5 77.0 0.55 0.0 FMT
HOH
 3.107
2.006
 HG23
HG1
 H
O
THR B:15 B:96 76.0 0.543 S -144.0 164.2 NA NA NA
7a38 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 THR A:15 A:96 91.0 0.65 S -140.4 -159.8 91.0 0.65 0.0 MES
HOH
 8.530
2.663
 H
O
 O3S
O
THR B:15 B:96 77.0 0.55 S -90.3 159.0 NA NA NA
7a39 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 THR A:15 A:96 83.0 0.593 S -137.8 -175.8 83.0 0.593 0.0 HOH
 6.412
 H
 O
THR B:15 B:96 71.0 0.507 S -129.4 175.9 NA NA NA
7a3a 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 THR A:15 A:96 76.0 0.543 S -136.7 -177.4 28.0 0.2 0.343 A:P00523:0.343
 PGE
SO4
PGE
SO4
HOH
 2.777
2.572
2.768
2.622
2.933
 HG1
HB
HG23
HB
O
 H1
O3
HO4
O1
O
7a34 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 THR A:15 A:96 81.0 0.579 S -136.4 -179.5 45.0 0.321 0.258 A:P00523:0.257
 PGE
PGE
HOH
 2.656
2.751
2.839
 HG23
HG1
O
 HO1
H62
O
7a35 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 THR A:15 A:96 72.0 0.514 S -119.7 179.5 72.0 0.514 0.0 HOH
 1.760
 HG1
 O
THR B:15 B:96 82.0 0.586 S -139.4 -166.3 NA NA NA
7a36 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 THR A:15 A:96 76.0 0.543 S -127.8 -179.9 76.0 0.543 0.0 URE
URE
URE
HOH
 6.542
6.972
9.208
1.870
 O
H
O
HG1
 HN12
HN11
HN11
O
THR B:15 B:96 87.0 0.621 S -135.1 -158.2 NA NA NA
7a37 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 THR A:15 A:96 74.0 0.529 S -126.5 178.4 74.0 0.529 0.0 URE
URE
HOH
 6.553
6.808
1.759
 O
H
HG1
 HN12
HN11
O
THR B:15 B:96 86.0 0.614 S -140.2 -161.6 NA NA NA
6xx3 1 P00523 82.14 6e-26 X-RAY
 2020-04-22 THR A:16 A:96 74.0 0.529 S -135.0 179.7 74.0 0.529 0.0 HOH
 2.720
 O
 O
6xx4 1 P00523 82.14 6e-26 X-RAY
 2020-04-22 THR A:16 A:96 76.0 0.543 S -136.6 -178.1 76.0 0.543 0.0 HOH
 2.514
 HB
 O
6xx2 1 P00523 80.36 2e-25 X-RAY
 2020-04-22 THR A:16 A:96 77.0 0.55 S -135.4 -175.1 77.0 0.55 0.0 HOH
 2.758
 O
 O
6xx5 1 P00523 80.36 2e-25 X-RAY
 2020-05-27 THR A:16 A:96 77.0 0.55 S -133.1 -175.3 77.0 0.55 0.0 HOH
 2.699
 HB
 O
4hvu 1 P00523 80.36 2e-25 X-RAY
 2013-05-01 THR A:16 A:96 72.0 0.514 S -142.1 162.8 52.0 0.371 0.143 B:None:0.143
 SO4
ACE
HOH
 5.975
4.253
3.147
 O
HG22
O
 O2
CH3
O
4omo 1 P00523 80.36 4e-25 X-RAY
 2014-12-10 THR A:16 A:96 75.0 0.536 S -102.0 144.5 75.0 0.536 0.0 EPE
HOH
 3.598
2.476
 HG21
O
 H62
O
THR B:16 B:96 75.0 0.536 S -100.2 129.8 NA NA NA
5ob0 1 P00523 80.36 4e-25 X-RAY
 2017-07-12 THR A:16 A:96 78.0 0.557 S -140.7 163.5 60.0 0.429 0.128 B:None:0.129
 SO4
HOH
 5.735
2.971
 O
HG21
 O1
O
4rtv 1 P00523 80.36 6e-25 X-RAY
 2015-10-28 THR A:16 A:96 72.0 0.514 S -140.4 163.8 52.0 0.371 0.143 B:None:0.143
 HOH
 3.335
 O
 O
5i11 1 P00523 80.36 8e-25 X-RAY
 2016-03-09 THR A:16 A:96 78.0 0.557 S -144.1 -176.3 32.0 0.229 0.328 A:P00523:0.329
 PGE
SO4
ACT
PGE
SO4
HOH
 2.808
2.711
5.548
2.397
2.705
2.882
 HG1
HB
O
HG23
HB
O
 H12
O3
H2
HO4
O2
O
4omn 1 P00523 81.48 2e-24 X-RAY
 2014-12-10 THR A:33 A:96 78.0 0.557 S -134.5 -179.1 24.0 0.171 0.386 A:P00523:0.386
 PGE
SO4
PGE
SO4
HOH
 3.436
2.559
3.241
2.597
2.689
 HG23
HB
HG23
HB
HG21
 O1
O3
O4
O1
O
4omm 1 P00523 81.48 3e-24 X-RAY
 2015-01-28 THR A:33 A:96 81.0 0.579 S -133.6 -177.1 33.0 0.236 0.343 A:P00523:0.343
 PGE
SO4
PGE
GOL
SO4
HOH
 2.900
2.736
2.991
5.371
2.714
3.005
 HG23
HB
HG23
O
HB
O
 O1
O4
O4
H12
O2
O
4omq 1 P00523 81.48 3e-24 X-RAY
 2015-01-28 THR A:33 A:96 84.0 0.6 S -142.4 -176.8 38.0 0.271 0.329 A:P00523:0.329
 PGE
SO4
PGE
SO4
HOH
 3.063
2.687
3.142
2.712
2.896
 HG1
HB
HG23
HB
O
 O1
O3
O4
O2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06241-f1 1 P06241 100.0 0.0 THR A:97 A:97 22.0 0.157 S -138.9 167.8