Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 112035608 . G A CCDS5094.1:NM_002037.5:c.286Cgg>Tgg_NP_002028.1:p.96R>W Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1g83 1 P06241 98.18 1e-115 X-RAY
 2001-05-30 ARG A:15 A:96 195.0 0.867 -79.6 -93.1 195.0 0.867 0.0
ARG B:15 B:96 200.0 0.889 S -62.7 -66.8 NA NA NA
3uf4 1 P39688 96.95 6e-113 X-RAY
 2011-12-07 ARG A:16 A:96 173.0 0.769 S -115.1 -9.7 173.0 0.769 0.0 CL
GOL
HOH
 5.068
7.264
2.972
 NH2
NH2
NE
 CL
C3
O
3h0h 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 ILE A:27 A:96 152.0 0.869 S -119.5 -0.6 152.0 0.869 0.0 HOH
 2.820
 N
 O
3h0i 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 ILE A:27 A:96 132.0 0.754 S -95.8 -55.6 132.0 0.754 0.0 HOH
 4.780
 O
 O
ILE B:27 B:96 126.0 0.72 S -98.2 -42.7 NA NA NA
3h0f 1 P06241 97.22 1e-41 X-RAY
 2010-04-21 TRP A:27 A:96 195.0 0.765 -147.1 -2.2 195.0 0.765 0.0 PG5
HOH
 4.176
3.608
 CH2
CD1
 O2
O
6ipz 1 P06241 94.2 9e-38 X-RAY
 2018-11-28 TRP A:22 Z:96 192.0 0.753 -147.5 5.0 192.0 0.753 0.0 O4B
HOH
 2.945
3.088
 HH2
HB3
 HAA2
O
3ua6 1 P06241 100.0 2e-37 X-RAY
 2012-07-25 ARG A:17 A:96 221.0 0.982 S -86.0 -36.5 221.0 0.982 0.0 GOL
NA
FMT
HOH
 5.322
5.600
2.906
2.772
 NH2
N
NE
NH1
 O3
NA
O1
O
ARG B:17 B:96 164.0 0.729 S -82.4 -33.1 NA NA NA
3ua7 1 P06241 100.0 2e-37 X-RAY
 2012-07-25 ARG A:17 A:96 175.0 0.778 S -125.1 6.0 149.0 0.662 0.116 E:Q9YKI6:0.116
 GOL
HOH
 4.093
3.212
 CB
NH1
 O1
O
ARG B:17 B:96 188.0 0.836 -134.4 19.5 NA NA NA
ARG C:17 C:96 176.0 0.782 -98.7 -11.6 NA NA NA
ARG D:17 D:96 205.0 0.911 -106.8 -24.1 NA NA NA
4eik 1 P06241 100.0 2e-37 X-RAY
 2013-04-10 ARG A:17 A:96 198.0 0.88 S -115.4 7.7 168.0 0.747 0.133 B:None:0.133
 HOH
 2.761
 N
 O
6ipy 1 P06241 98.41 3e-37 X-RAY
 2018-11-28 ILE A:25 A:96 152.0 0.869 S -118.5 3.5 152.0 0.869 0.0 HOH
 2.105
 H
 O
7d7s 2 E5RFS5 98.41 5e-37 X-RAY
 2020-11-18 ILE C:16 C:96 165.0 0.943 S -113.6 -32.6 NA NA NA
ILE D:16 D:96 166.0 0.949 S -116.9 -37.0 23.0 0.131 0.818 A:P03407:0.817
1fyn 1 P06241 100.0 8e-37 X-RAY
 1996-11-08 ARG A:16 A:96 92.0 NA -88.1 -35.2 57.0 NA NA B:None:NA
 HOH
 4.912
 O
 O
1m27 3 P06241 100.0 6e-36 X-RAY
 2003-05-06 ARG C:13 C:96 202.0 0.898 S -87.1 -35.4 156.0 0.693 0.205 A:O60880:0.204
 HOH
 3.116
 CD
 O
7a2j 1 P06241 100.0 2e-35 X-RAY
 2021-08-25 ARG A:14 A:96 228.0 1.0 S -93.8 -30.7 228.0 1.0 0.0 HOH
 5.432
 O
 O
ARG B:14 B:96 78.0 NA S -90.6 -38.3 NA NA NA
7a2k 1 P06241 100.0 2e-35 X-RAY
 2021-08-25 ARG A:14 A:96 226.0 1.0 S -91.4 -30.0 226.0 1.0 0.0 HOH
 3.189
 HH21
 O
ARG B:14 B:96 222.0 0.987 S -92.3 -32.1 NA NA NA
ARG C:14 C:96 221.0 0.982 S -92.2 -36.4 NA NA NA
ARG D:14 D:96 79.0 NA S -85.0 -41.9 NA NA NA
7a2l 1 P06241 98.33 5e-35 X-RAY
 2021-08-25 ARG A:14 A:96 222.0 0.987 S -85.3 -36.6 222.0 0.987 0.0 FMT
HOH
 6.603
7.000
 HH21
N
 H
O
ARG B:14 B:96 82.0 NA S -84.6 -39.3 NA NA NA
1shf 1 P06241 100.0 1e-34 X-RAY
 1993-10-31 ARG A:13 A:96 206.0 0.916 S -91.5 -41.0 206.0 0.916 0.0
ARG B:13 B:96 159.0 0.707 S -87.5 -28.4 109.0 0.484 0.223 A:P06241:0.222
7a2u 1 P06241 95.0 4e-34 X-RAY
 2021-08-25 ARG A:14 A:96 89.0 NA S -82.6 -62.7 89.0 NA NA ACT
HOH
 5.310
3.902
 O
O
 O
O
7a2m 1 P06241 96.67 5e-34 X-RAY
 2021-08-25 ARG A:14 A:96 217.0 0.964 S -91.8 -35.8 217.0 0.964 0.0 NA
HOH
 5.132
3.365
 N
HB2
 NA
O
ARG B:14 B:96 108.0 NA S -122.9 0.3 NA NA NA
7a2n 1 P06241 96.67 5e-34 X-RAY
 2021-08-25 ARG A:14 A:96 222.0 0.987 S -90.8 -38.0 222.0 0.987 0.0 FMT
NA
HOH
 1.774
5.172
1.991
 HH21
N
HH11
 HO2
NA
O
ARG B:14 B:96 180.0 0.8 -118.5 -11.6 NA NA NA
ARG C:14 C:96 220.0 0.978 S -86.2 -38.1 NA NA NA
ARG D:14 D:96 191.0 0.849 -129.1 13.3 NA NA NA
4znx 1 P06241 100.0 6e-34 X-RAY
 2016-06-29 ARG A:13 A:96 178.0 0.791 S -100.1 -8.7 100.0 0.444 0.347 E:None:0.133
D:P06241:0.284
 HOH
 3.881
 HG3
 O
ARG B:13 B:96 185.0 0.822 S -99.3 -10.1 98.0 0.436 0.386 A:P06241:0.298
F:None:0.124
 HOH
 2.021
 HH12
 O
ARG C:13 C:96 192.0 0.853 S -103.2 -3.2 101.0 0.449 0.404 B:P06241:0.316
G:None:0.138
 HOH
 3.522
 HD3
 O
ARG D:13 D:96 180.0 0.8 S -100.4 -9.8 96.0 0.427 0.373 H:None:0.124
C:P06241:0.298
 HOH
 3.928
 HG3
 O
7a2v 1 P06241 93.33 1e-33 X-RAY
 2021-08-25 ARG A:14 A:96 227.0 1.0 S -105.3 -45.2 227.0 1.0 0.0 HOH
 4.664
 O
 O
1avz 2 P06241 100.0 3e-33 X-RAY
 1998-03-25 ARG C:12 C:96 200.0 0.889 -132.2 18.9 48.0 0.213 0.676 B:P03406:0.676
5zau 1 P06241 100.0 3e-33 NMR
 2019-09-11 ARG A:12 A:96 224.0 0.996 S -97.0 -12.1 136.0 0.604 0.392 B:None:0.391
1efn 1 P06241 98.28 7e-33 X-RAY
 1997-01-11 ILE A:12 A:96 159.0 0.909 S -102.9 5.4 9.0 0.051 0.858 B:P03406:0.857
 HOH
 2.806
 N
 O
ILE C:12 C:96 156.0 0.891 S -120.9 -38.8 27.0 0.154 0.737 D:P03406:0.737
 HOH
 3.774
 CD1
 O
7a2p 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 ARG A:14 A:96 185.0 0.822 -118.9 -14.1 185.0 0.822 0.0 HOH
 1.986
 HE
 O
7a2q 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 ARG A:14 A:96 91.0 NA -125.9 5.5 91.0 NA NA SO4
HOH
 6.325
2.078
 HA
H
 O1
O
7a2t 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 ARG A:14 A:96 86.0 NA -123.8 0.2 86.0 NA NA ACT
HOH
 7.420
2.017
 H
H
 O
O
7a2r 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 ARG A:15 A:96 189.0 0.84 -119.3 -5.1 189.0 0.84 0.0 HOH
 1.997
 H
 O
7a2s 1 P06241 91.8 8e-33 X-RAY
 2021-08-25 ARG A:15 A:96 223.0 0.991 -125.5 3.1 223.0 0.991 0.0 HOH
 1.972
 HE
 O
4d8d 1 P06241 98.28 9e-33 X-RAY
 2013-01-16 TRP A:13 A:96 234.0 0.918 S -101.2 -42.3 28.0 0.11 0.808 B:P03406:0.808
 HOH
 2.449
 N
 O
TRP C:13 C:96 237.0 0.929 S -110.9 -41.3 NA NA NA
6edf 1 ? 87.5 2e-32 X-RAY
 2018-08-29 ARG A:15 A:13 197.0 0.876 -109.1 -18.7 197.0 0.876 0.0 UNX
UNX
UNX
HOH
 9.867
8.174
4.491
3.139
 N
NH2
NH2
NE
 UNK
UNK
UNK
O
7a2o 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 ARG A:14 A:96 92.0 NA -126.2 7.2 92.0 NA NA HOH
 2.048
 H
 O
7a2x 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 ARG A:14 A:96 231.0 1.0 S -101.8 -12.2 231.0 1.0 0.0 HOH
 2.025
 H
 O
7a2y 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 ARG A:14 A:96 231.0 1.0 S -101.9 -13.9 231.0 1.0 0.0 HOH
 2.048
 H
 O
7a2z 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 ARG A:14 A:96 225.0 1.0 S -98.2 -17.8 225.0 1.0 0.0 HOH
 2.052
 H
 O
7a2w 1 P06241 91.67 3e-32 X-RAY
 2021-08-25 ARG A:15 A:96 224.0 0.996 S -99.0 -15.2 224.0 0.996 0.0 HOH
 2.030
 H
 O
4ag2 2 ? 82.35 7e-32 X-RAY
 2012-07-11 THR C:18 C:14 119.0 0.85 S -115.2 -23.2 88.0 0.629 0.221 A:P23946:0.221
 MES
LMR
HOH
 9.256
2.655
2.703
 O
OG1
O
 C5
O1A
O
THR D:18 D:14 120.0 0.857 S -110.3 -27.5 NA NA NA
3cqt 1 Q05876 91.67 2e-31 X-RAY
 2008-07-01 ARG A:17 A:13 203.0 0.902 -110.5 -23.2 203.0 0.902 0.0 HOH
 2.853
 O
 O
4afq 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ASP C:18 C:14 154.0 1.0 S -110.1 -20.5 122.0 0.813 0.187 A:P23946:0.213
 HOH
 2.791
 N
 O
ASP D:18 D:14 154.0 1.0 S -116.3 -21.9 NA NA NA
4afs 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ASP B:18 C:14 149.0 0.993 S -105.2 -23.4 116.0 0.773 0.22 A:P23946:0.22
 HOH
 2.802
 N
 O
4afu 2 ? 82.61 5e-31 X-RAY
 2012-07-11 ASP C:18 C:14 146.0 0.973 S -98.3 -38.1 117.0 0.78 0.193 A:P23946:0.193
 HOH
 3.550
 OD2
 O
ASP D:18 D:14 146.0 0.973 S -84.8 -36.6 NA NA NA
4afz 2 ? 82.35 5e-31 X-RAY
 2012-07-11 THR C:18 C:14 124.0 0.886 S -108.4 -22.7 93.0 0.664 0.222 A:P23946:0.221
 HOH
 2.728
 N
 O
THR D:18 D:14 129.0 0.921 S -123.1 -22.4 NA NA NA
4ag1 2 ? 82.35 5e-31 X-RAY
 2012-07-11 THR B:18 C:14 122.0 0.871 S -112.0 -24.0 92.0 0.657 0.214 A:P23946:0.214
 HOH
 1.995
 H
 O
2l2p 1 Q05876 93.1 8e-31 NMR
 2011-09-14 ARG A:19 A:13 175.0 0.778 S -81.0 -36.2 175.0 0.778 0.0
2lp5 1 Q05876 93.1 8e-31 NMR
 2012-05-16 ARG A:19 A:13 208.0 0.924 -93.6 -20.4 208.0 0.924 0.0
3zl7 2 ? 81.94 2e-30 X-RAY
 2013-05-29 ARG B:18 C:18 145.0 0.644 -70.5 141.7 145.0 0.644 0.0 HOH
 8.983
 CG
 O
7jt9 1 P09769 80.95 2e-30 X-RAY
 2022-01-26 ARG A:16 A:105 177.0 0.787 -105.6 -14.7 177.0 0.787 0.0 HOH
 2.719
 NH1
 O
7a31 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 ARG A:14 A:95 181.0 0.804 S -114.2 6.8 181.0 0.804 0.0 HOH
 2.098
 HH11
 O
ARG B:14 B:95 229.0 1.0 S -95.9 -18.2 NA NA NA
7a32 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 ARG A:14 A:95 205.0 0.911 S -115.6 1.9 205.0 0.911 0.0 HOH
 2.069
 HH11
 O
ARG B:14 B:95 200.0 0.889 S -110.4 -0.3 NA NA NA
ARG C:14 C:95 194.0 0.862 S -112.7 0.5 NA NA NA
ARG D:14 D:95 197.0 0.876 S -122.7 8.6 NA NA NA
7a33 1 P00523 86.67 3e-29 X-RAY
 2021-08-25 ARG A:14 A:95 222.0 0.987 S -109.1 3.2 222.0 0.987 0.0 FMT
HOH
 4.318
2.222
 HB2
HD3
 H
O
ARG B:14 B:95 209.0 0.929 S -104.1 -11.9 NA NA NA
7a38 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 ARG A:14 A:95 186.0 0.827 -119.2 -13.0 186.0 0.827 0.0 HOH
 2.157
 HH22
 O
ARG B:14 B:95 97.0 NA -102.6 -51.8 NA NA NA
7a39 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 ARG A:14 A:95 193.0 0.858 -116.3 -6.5 193.0 0.858 0.0 HOH
 4.462
 HA
 O
ARG B:14 B:95 87.0 NA -120.9 -9.0 NA NA NA
7a3a 1 P00523 85.0 3e-28 X-RAY
 2021-08-25 ARG A:14 A:95 178.0 0.791 -115.3 -12.8 134.0 0.596 0.195 A:P00523:0.196
 PGE
SO4
PGE
SO4
HOH
 2.381
4.705
2.395
4.796
2.803
 HH21
O
HH21
O
HD3
 O1
O4
O4
O2
O
7a34 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 ARG A:14 A:95 180.0 0.8 -111.5 -13.6 136.0 0.604 0.196 A:P00523:0.196
 PGE
PGE
HOH
 2.860
2.814
2.573
 HE
HE
HD3
 HO1
HO4
O
7a35 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 ARG A:14 A:95 159.0 0.707 -129.0 -6.5 159.0 0.707 0.0 HOH
 2.091
 HH12
 O
ARG B:14 B:95 214.0 0.951 -117.6 -10.0 NA NA NA
7a36 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 ARG A:14 A:95 185.0 0.822 -129.2 -0.6 185.0 0.822 0.0 URE
URE
URE
HOH
 9.060
2.349
9.366
2.165
 H
HG2
H
HH11
 HN12
HN11
HN11
O
ARG B:14 B:95 215.0 0.956 -113.9 -18.5 NA NA NA
7a37 1 P00523 83.33 6e-28 X-RAY
 2021-08-25 ARG A:14 A:95 187.0 0.831 -126.1 -2.8 187.0 0.831 0.0 URE
URE
HOH
 9.181
2.713
2.794
 H
HG2
HG3
 HN12
HN11
O
ARG B:14 B:95 215.0 0.956 -113.3 -16.8 NA NA NA
6xx3 1 P00523 82.14 6e-26 X-RAY
 2020-04-22 ARG A:15 A:95 174.0 0.773 -104.3 -25.2 174.0 0.773 0.0 HOH
 2.070
 HH12
 O
6xx4 1 P00523 82.14 6e-26 X-RAY
 2020-04-22 ARG A:15 A:95 176.0 0.782 -102.6 -24.4 176.0 0.782 0.0 HOH
 1.996
 HH12
 O
6xx2 1 P00523 80.36 2e-25 X-RAY
 2020-04-22 ARG A:15 A:95 181.0 0.804 -103.1 -26.9 181.0 0.804 0.0 HOH
 2.010
 HH12
 O
6xx5 1 P00523 80.36 2e-25 X-RAY
 2020-05-27 ARG A:15 A:95 180.0 0.8 -105.7 -27.3 180.0 0.8 0.0 HOH
 2.180
 HH12
 O
4hvu 1 P00523 80.36 2e-25 X-RAY
 2013-05-01 ARG A:15 A:95 172.0 0.764 -114.0 -3.4 147.0 0.653 0.111 B:None:0.111
 SO4
ACE
HOH
 6.763
2.776
2.035
 N
HD3
HH21
 O2
C
O
4omo 1 P00523 80.36 4e-25 X-RAY
 2014-12-10 ARG A:15 A:95 193.0 0.858 -116.6 6.6 193.0 0.858 0.0 EPE
HOH
 7.284
1.838
 H
HH11
 O8
O
ARG B:15 B:95 250.0 1.0 -98.6 0.8 NA NA NA
5ob0 1 P00523 80.36 4e-25 X-RAY
 2017-07-12 ARG A:15 A:95 177.0 0.787 S -110.7 -7.6 148.0 0.658 0.129 B:None:0.129
 SO4
HOH
 6.329
2.081
 N
HE
 O3
O
4rtv 1 P00523 80.36 6e-25 X-RAY
 2015-10-28 ARG A:15 A:95 174.0 0.773 -115.2 -5.0 147.0 0.653 0.12 B:None:0.12
 HOH
 2.001
 HH21
 O
5i11 1 P00523 80.36 8e-25 X-RAY
 2016-03-09 ARG A:15 A:95 177.0 0.787 -106.5 -13.4 136.0 0.604 0.183 A:P00523:0.182
 PGE
SO4
ACT
PGE
SO4
PEG
HOH
 2.666
4.987
7.115
2.554
4.964
8.477
2.451
 HH21
O
N
HB2
O
HH12
HD3
 O1
O4
O
HO4
O1
H32
O
4omn 1 P00523 81.48 2e-24 X-RAY
 2014-12-10 ARG A:32 A:95 181.0 0.804 -115.2 -15.9 141.0 0.627 0.177 A:P00523:0.178
 PGE
PEG
SO4
GOL
PGE
SO4
HOH
 3.040
8.583
4.631
8.296
2.402
4.378
2.850
 HH21
HH12
O
N
HH21
O
O
 O1
H11
O1
H2
O4
O2
O
4omm 1 P00523 81.48 3e-24 X-RAY
 2015-01-28 ARG A:32 A:95 179.0 0.796 -115.7 -14.4 134.0 0.596 0.2 A:P00523:0.2
 PGE
PEG
SO4
PGE
GOL
SO4
HOH
 3.005
8.970
4.986
2.240
5.980
4.960
2.660
 HH21
HH12
O
HH21
N
O
HD3
 O1
C1
O3
O4
H31
O1
O
4omq 1 P00523 81.48 3e-24 X-RAY
 2015-01-28 ARG A:32 A:95 176.0 0.782 S -98.8 -12.2 136.0 0.604 0.178 A:P00523:0.178
 PGE
PEG
SO4
PGE
SO4
HOH
 3.679
8.624
5.160
2.516
5.203
2.815
 HH21
HH12
O
HE
O
HD3
 C1
C2
O1
O4
O4
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p06241-f1 1 P06241 100.0 0.0 ARG A:96 A:96 44.0 0.196 S -103.0 -15.8