Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 31544934 . C A CCDS4702.1:NM_000594.3:c.322Cgg>Agg_NP_000585.2:p.108R>R Homo sapiens tumor necrosis factor (TNF), mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6op0 1 P01375 99.37 6e-115 X-RAY
2019-12-25 ARG A:33 A:32 109.0 0.484 S -167.0 157.2 109.0 0.484 0.0 HOH
5.267
CD
O
ARG B:33 B:32 133.0 0.591 S -150.7 164.2 133.0 0.591 0.0 HOH
3.933
O
O
ARG C:33 NA:NA DO NA DO DO DO NA NA NA
7kp9 1 P01375 99.37 6e-115 X-RAY
2021-01-13 ARG A:33 A:32 110.0 0.489 S -172.7 148.9 110.0 0.489 0.0 HOH
2.970
O
O
ARG B:33 B:32 126.0 0.56 S -145.8 159.6 126.0 0.56 0.0 HOH
2.657
NH2
O
ARG C:33 NA:NA DO NA DO DO DO NA NA NA
7kpa 1 P01375 99.37 6e-115 X-RAY
2021-01-13 ARG A:33 A:32 109.0 0.484 S -162.7 148.0 109.0 0.484 0.0 HOH
3.011
NH2
O
ARG B:33 B:32 136.0 0.604 S -149.1 159.9 136.0 0.604 0.0 HOH
4.765
NH1
O
ARG C:33 NA:NA DO NA DO DO DO NA NA NA
7kpb 1 P01375 99.37 6e-115 X-RAY
2021-01-13 ARG A:33 A:32 131.0 0.582 S -122.4 166.5 22.0 0.098 0.484 E:P19438:0.484
GOL
HOH
4.187
7.482
NH2
NE
O1
O
ARG B:33 B:32 128.0 0.569 S -141.1 162.9 21.0 0.093 0.476 D:P19438:0.476
GOL
HOH
3.994
8.782
NH1
CB
O2
O
ARG C:33 C:32 89.0 NA -63.9 360.0 89.0 NA NA HOH
5.149
O
O
5mu8 1 P01375 100.0 9e-115 X-RAY
2017-03-29 ARG A:34 NA:NA DO NA DO DO DO NA NA NA
ARG B:34 B:32 104.0 0.462 S -144.4 177.1 104.0 0.462 0.0
ARG C:34 C:32 177.0 0.787 S -125.2 -167.6 NA NA NA
ARG D:34 D:32 97.0 0.431 S -173.5 172.7 NA NA NA
ARG E:34 NA:NA DO NA DO DO DO NA NA NA
ARG F:34 G:32 115.0 0.511 S -145.4 173.5 NA NA NA
ARG G:34 H:32 158.0 0.702 S -138.4 -170.3 NA NA NA
ARG H:34 I:32 93.0 0.413 B -161.9 163.4 NA NA NA
ARG I:34 NA:NA DO NA DO DO DO NA NA NA
ARG J:34 K:32 99.0 0.44 S -158.1 153.4 NA NA NA
ARG K:34 L:32 131.0 0.582 S -118.8 -171.7 NA NA NA
ARG L:34 M:32 119.0 0.529 S -141.8 168.9 NA NA NA
ARG M:34 NA:NA DO NA DO DO DO NA NA NA
ARG N:34 O:32 148.0 0.658 S -139.1 -174.0 NA NA NA
ARG O:34 P:32 146.0 0.649 S -92.5 -175.9 NA NA NA
ARG P:34 Q:32 98.0 0.436 B -166.1 162.6 NA NA NA
ARG Q:34 NA:NA DO NA DO DO DO NA NA NA
ARG R:34 S:32 113.0 0.502 S -137.7 154.1 NA NA NA
ARG S:34 T:32 142.0 0.631 S -130.1 -171.2 NA NA NA
ARG T:34 U:32 101.0 0.449 S -152.1 153.4 NA NA NA
ARG U:34 NA:NA DO NA DO DO DO NA NA NA
ARG V:34 W:32 119.0 0.529 S -133.8 164.7 NA NA NA
ARG W:34 X:32 154.0 0.684 S -137.2 -169.2 NA NA NA
ARG X:34 Y:32 102.0 0.453 S -149.2 168.8 NA NA NA
ARG Y:34 NA:NA DO NA DO DO DO NA NA NA
ARG Z:34 a:32 103.0 0.458 S -138.2 162.1 NA NA NA
ARG AA:34 b:32 161.0 0.716 S -133.1 -176.1 NA NA NA
ARG BA:34 c:32 94.0 0.418 S -139.1 164.9 NA NA NA
ARG CA:34 NA:NA DO NA DO DO DO NA NA NA
ARG DA:34 e:32 101.0 0.449 S -153.9 153.7 NA NA NA
ARG EA:34 f:32 136.0 0.604 S -138.8 174.6 NA NA NA
ARG FA:34 g:32 103.0 0.458 S -139.2 160.8 NA NA NA
ARG GA:34 NA:NA DO NA DO DO DO NA NA NA
ARG HA:34 i:32 107.0 0.476 B -151.2 142.5 NA NA NA
ARG IA:34 j:32 138.0 0.613 S -142.7 176.9 NA NA NA
ARG JA:34 k:32 113.0 0.502 S -151.3 156.9 NA NA NA
ARG KA:34 NA:NA DO NA DO DO DO NA NA NA
ARG LA:34 m:32 113.0 0.502 S -148.0 139.1 NA NA NA
ARG MA:34 n:32 144.0 0.64 S -97.8 -160.2 NA NA NA
ARG NA:34 o:32 94.0 0.418 B -154.7 155.4 NA NA NA
ARG OA:34 NA:NA DO NA DO DO DO NA NA NA
ARG PA:34 q:32 113.0 0.502 S -148.5 159.4 NA NA NA
ARG QA:34 r:32 140.0 0.622 S -80.2 -170.8 NA NA NA
ARG RA:34 s:32 95.0 0.422 S -129.3 152.0 NA NA NA
ARG SA:34 NA:NA DO NA DO DO DO NA NA NA
ARG TA:34 u:32 126.0 0.56 S -146.9 169.6 NA NA NA
ARG UA:34 v:32 151.0 0.671 S -137.1 -173.8 NA NA NA
ARG VA:34 w:32 121.0 0.538 S -152.6 169.7 NA NA NA
6x81 1 P01375 100.0 9e-115 X-RAY
2021-01-13 ARG A:33 A:32 256.0 1.0 T -55.8 -46.6 252.0 1.0 0.0 C:P01375:0.018
HOH
3.199
NH2
O
ARG B:33 B:32 117.0 0.52 S -157.8 167.4 117.0 0.52 0.0 HOH
4.151
NH2
O
ARG C:33 C:32 124.0 0.551 S -66.5 -114.9 124.0 0.551 0.0 HOH
3.380
NH1
O
ARG D:33 D:32 255.0 1.0 T -53.0 -36.6 NA NA NA
ARG E:33 E:32 281.0 1.0 -63.2 360.0 NA NA NA
ARG F:33 F:32 120.0 0.533 S -140.4 174.8 NA NA NA
6x82 1 P01375 100.0 9e-115 X-RAY
2021-01-13 ARG A:33 A:32 256.0 1.0 T -58.9 -34.6 249.0 1.0 0.0 C:P01375:0.031
ARG B:33 NA:NA DO NA DO DO DO NA NA NA
ARG C:33 C:32 101.0 0.449 S -68.3 165.5 101.0 0.449 0.0 HOH
2.883
NH2
O
ARG D:33 D:32 254.0 1.0 T -51.2 -50.3 NA NA NA
ARG E:33 NA:NA DO NA DO DO DO NA NA NA
ARG F:33 F:32 105.0 0.467 S -137.4 160.9 NA NA NA
6x83 1 P01375 100.0 9e-115 X-RAY
2021-01-13 ARG A:33 A:32 125.0 0.556 S -127.5 155.6 125.0 0.556 0.0 HOH
2.651
O
O
ARG B:33 NA:NA DO NA DO DO DO NA NA NA
ARG C:33 C:32 124.0 0.551 S -154.7 58.7 124.0 0.551 0.0 HOH
2.669
O
O
ARG D:33 NA:NA DO NA DO DO DO NA NA NA
ARG E:33 NA:NA DO NA DO DO DO NA NA NA
ARG F:33 NA:NA DO NA DO DO DO NA NA NA
6x85 1 P01375 100.0 9e-115 X-RAY
2021-01-13 ARG A:33 A:32 121.0 0.538 S -149.4 165.0 121.0 0.538 0.0
ARG B:33 NA:NA DO NA DO DO DO NA NA NA
ARG C:33 C:32 119.0 0.529 S -149.0 168.1 119.0 0.529 0.0
ARG D:33 D:32 247.0 1.0 T -61.5 -36.5 NA NA NA
ARG E:33 E:32 108.0 0.48 S -51.5 171.3 NA NA NA
ARG F:33 F:32 111.0 0.493 S -156.4 161.1 NA NA NA
6x86 1 P01375 100.0 9e-115 X-RAY
2021-01-13 ARG A:33 A:32 108.0 0.48 B -149.0 163.9 108.0 0.48 0.0 HOH
2.743
O
O
ARG B:33 NA:NA DO NA DO DO DO NA NA NA
ARG C:33 C:32 88.0 0.391 S -142.0 166.8 88.0 0.391 0.0 HOH
5.649
N
O
ARG D:33 D:32 245.0 1.0 T -26.0 -57.2 NA NA NA
ARG E:33 E:32 100.0 0.444 S -34.7 166.0 NA NA NA
ARG F:33 F:32 100.0 0.444 S -153.2 167.9 NA NA NA
5yoy 1 P01375 100.0 1e-114 X-RAY
2018-05-09 ARG A:40 A:32 107.0 0.476 S -174.4 176.5 107.0 0.476 0.0
ARG B:40 B:32 117.0 0.52 S -91.0 152.8 117.0 0.52 0.0 HOH
2.974
C
O
ARG C:40 C:32 133.0 0.591 B -143.4 176.5 133.0 0.591 0.0 HOH
8.588
CG
O
ARG J:40 J:32 123.0 0.547 B -147.2 172.7 NA NA NA
ARG K:40 K:32 138.0 0.613 S -99.8 162.9 NA NA NA
ARG L:40 L:32 228.0 1.0 T -76.7 -15.2 NA NA NA
7jra 1 P01375 100.0 1e-114 X-RAY
2020-12-09 ARG A:35 A:108 99.0 0.44 S -160.5 148.1 99.0 0.44 0.0 HOH
2.776
NE
O
ARG B:35 B:108 127.0 0.564 S -141.2 157.4 127.0 0.564 0.0 HOH
2.694
NE
O
ARG C:35 C:108 78.0 NA S -159.2 160.7 78.0 NA NA HOH
8.290
CD
O
4g3y 3 P01375 100.0 1e-114 X-RAY
2013-03-27 ARG C:32 C:32 122.0 0.542 S -135.8 -158.1 122.0 0.542 0.0 HOH
5.994
CD
O
4twt 1 P01375 100.0 1e-114 X-RAY
2015-02-04 ARG A:32 A:32 45.0 NA S -89.7 158.5 45.0 NA NA HOH
6.768
O
O
ARG B:32 NA:NA DO NA DO DO DO NA NA NA
ARG E:32 C:32 123.0 0.547 S -159.5 170.5 NA NA NA
ARG F:32 NA:NA DO NA DO DO DO NA NA NA
5m2i 1 P01375 100.0 1e-114 X-RAY
2017-08-30 ARG A:32 A:32 89.0 0.396 S -153.8 155.6 70.0 0.311 0.085 I:None:0.084
HOH
3.257
CD
O
ARG B:32 B:32 95.0 0.422 S -154.7 157.3 77.0 0.342 0.08 H:None:0.08
HOH
2.902
NH2
O
ARG C:32 C:32 98.0 0.436 S -155.8 162.7 79.0 0.351 0.085 G:None:0.084
HOH
2.829
NH2
O
ARG D:32 D:32 93.0 0.413 S -153.5 154.9 NA NA NA
ARG E:32 E:32 94.0 0.418 S -154.6 157.4 NA NA NA
ARG F:32 F:32 99.0 0.44 S -154.4 157.1 NA NA NA
5m2j 1 P01375 100.0 1e-114 X-RAY
2017-08-30 ARG A:32 A:32 252.0 1.0 S -69.4 -45.3 252.0 1.0 0.0 HOH
2.753
O
O
5m2m 1 P01375 100.0 1e-114 X-RAY
2017-08-30 ARG A:32 A:32 82.0 0.364 S -143.8 156.6 82.0 0.364 0.0 HOH
2.791
NH1
O
ARG B:32 B:32 81.0 0.36 S -146.3 155.8 81.0 0.36 0.0 HOH
3.230
NH2
O
ARG C:32 C:32 84.0 0.373 S -147.6 157.3 84.0 0.373 0.0 HOH
2.739
NH1
O
ARG G:32 G:32 89.0 0.396 S -144.8 161.5 NA NA NA
ARG I:32 I:32 87.0 0.387 S -148.9 160.0 NA NA NA
ARG K:32 M:32 88.0 0.391 S -154.8 159.1 NA NA NA
5wux 3 C1K3N5 100.0 1e-114 X-RAY
2017-06-07 ARG G:32 NA:NA DO NA DO DO DO NA NA NA
ARG H:32 F:32 115.0 0.511 S 176.8 158.4 115.0 0.511 0.0
ARG I:32 G:32 138.0 0.613 S -129.5 159.5 NA NA NA
6ooy 1 P01375 100.0 1e-114 X-RAY
2019-12-25 ARG A:32 A:32 117.0 0.52 S -174.8 153.8 117.0 0.52 0.0 HOH
2.925
O
O
ARG B:32 B:32 130.0 0.578 S -144.9 156.3 130.0 0.578 0.0 HOH
4.336
CB
O
ARG C:32 C:32 39.0 NA S -117.4 173.8 39.0 NA NA
6ooz 1 P01375 100.0 1e-114 X-RAY
2019-12-25 ARG A:32 A:32 104.0 0.462 S -170.6 146.8 104.0 0.462 0.0 HOH
5.546
NH2
O
ARG B:32 B:32 124.0 0.551 S -153.8 157.9 124.0 0.551 0.0 HOH
3.199
NE
O
ARG C:32 NA:NA DO NA DO DO DO NA NA NA
6rmj 1 P01375 99.37 3e-114 X-RAY
2019-10-09 ARG A:38 A:32 107.0 0.476 S -145.0 159.1 107.0 0.476 0.0 HOH
2.526
HA
O
ARG B:38 B:32 244.0 1.0 S -97.1 -10.7 244.0 1.0 0.0 HOH
7.431
O
O
ARG C:38 NA:NA DO NA DO DO DO NA NA NA
5uui 1 P01375 98.73 1e-113 X-RAY
2017-08-02 ARG A:33 A:32 132.0 0.587 S -133.5 157.3 132.0 0.587 0.0 HOH
2.308
NH1
O
1a8m 1 P01375 99.36 1e-113 X-RAY
1998-06-17 ARG A:32 A:32 51.0 0.227 S -120.2 170.1 51.0 0.227 0.0 HOH
2.857
CB
O
ARG B:32 B:32 99.0 0.44 S -122.9 173.2 99.0 0.44 0.0 HOH
7.898
O
O
ARG C:32 C:32 65.0 0.289 S -56.0 177.3 65.0 0.289 0.0 HOH
5.568
N
O
3wd5 1 P01375 99.36 1e-113 X-RAY
2013-08-14 ARG A:32 A:32 118.0 0.524 S -147.1 171.8 118.0 0.524 0.0 HOH
3.518
CB
O
1tnf 1 P01375 99.36 5e-113 X-RAY
1990-01-15 ARG A:32 A:32 91.0 0.404 S -65.0 -163.7 91.0 0.404 0.0
ARG B:32 B:32 94.0 0.418 S -142.5 162.1 94.0 0.418 0.0
ARG C:32 C:32 69.0 0.307 S -43.7 151.1 69.0 0.307 0.0
2tun 1 P01375 98.73 2e-112 X-RAY
1994-01-31 ARG A:32 A:32 93.0 0.413 S -106.1 -177.2 93.0 0.413 0.0
ARG B:32 B:32 119.0 0.529 -123.7 165.0 119.0 0.529 0.0
ARG C:32 C:32 47.0 0.209 S -91.0 83.4 47.0 0.209 0.0
ARG D:32 D:32 67.0 0.298 S -110.5 163.2 67.0 0.298 0.0
ARG E:32 E:32 125.0 0.556 T 7.3 -84.7 125.0 0.556 0.0
ARG F:32 F:32 67.0 0.298 S -122.3 -175.7 67.0 0.298 0.0
3it8 1 P01375 99.34 1e-109 X-RAY
2009-10-20 ARG A:36 A:32 111.0 0.493 S -132.2 173.8 32.0 0.142 0.351 D:Q9DHW0:0.351
HOH
6.329
CB
O
ARG B:36 B:32 111.0 0.493 S -132.1 174.8 35.0 0.156 0.337 E:Q9DHW0:0.338
HOH
6.339
CB
O
ARG C:36 C:32 111.0 0.493 S -131.4 174.5 33.0 0.147 0.346 F:Q9DHW0:0.347
HOH
6.129
CB
O
ARG G:36 G:32 110.0 0.489 S -131.3 173.1 NA NA NA
ARG H:36 H:32 112.0 0.498 S -131.8 174.8 NA NA NA
ARG I:36 I:32 111.0 0.493 S -133.1 175.3 NA NA NA
3alq 1 P01375 96.18 2e-109 X-RAY
2010-11-17 ARG A:32 A:32 121.0 0.538 S -138.3 158.5 34.0 0.151 0.387 G:P20333:0.387
CO
8.796
N
CO
ARG B:32 B:32 123.0 0.547 S -135.3 163.8 31.0 0.138 0.409 H:P20333:0.409
CO
9.048
N
CO
ARG C:32 C:32 117.0 0.52 S -128.9 155.8 37.0 0.164 0.356 I:P20333:0.356
CO
8.812
N
CO
ARG D:32 D:32 126.0 0.56 S -134.5 162.1 NA NA NA
ARG E:32 E:32 131.0 0.582 S -152.7 153.8 NA NA NA
ARG F:32 F:32 111.0 0.493 S -130.5 158.1 NA NA NA
3l9j 2 P01375 100.0 1e-108 X-RAY
2010-02-23 ARG B:24 T:32 111.0 0.493 S -151.1 155.2 111.0 0.493 0.0 HOH
3.193
NE
O
2az5 1 P01375 100.0 6e-108 X-RAY
2005-11-29 ARG A:23 NA:NA DO NA DO DO DO NA NA NA
ARG B:23 B:32 104.0 0.462 S -122.0 151.8 104.0 0.462 0.0 HOH
3.562
NH1
O
ARG C:23 NA:NA DO NA DO DO DO NA NA NA
ARG D:23 D:32 102.0 0.453 S -128.3 155.9 102.0 0.453 0.0 HOH
2.874
NH1
O
4tsv 1 P01375 98.0 6e-107 X-RAY
1998-12-30 ARG A:25 A:32 118.0 0.524 S -151.1 148.9 118.0 0.524 0.0 HOH
3.805
NH2
O
5tsw 1 P01375 98.0 6e-107 X-RAY
1999-05-07 ARG A:25 A:32 89.0 0.396 S -132.7 157.2 89.0 0.396 0.0 HOH
2.396
HH12
H2
ARG B:25 B:32 89.0 0.396 S -165.2 156.1 89.0 0.396 0.0 HOH
1.520
HH12
H1
ARG C:25 C:32 76.0 0.338 S -145.2 168.7 76.0 0.338 0.0 HOH
1.405
HH22
H2
ARG D:25 D:32 100.0 0.444 S -149.5 162.8 NA NA NA
ARG E:25 E:32 84.0 0.373 S -153.9 159.8 NA NA NA
ARG F:25 F:32 106.0 0.471 S -86.4 176.4 NA NA NA
2e7a 1 P01375 92.36 9e-106 X-RAY
2007-11-13 ARG A:32 A:32 112.0 0.498 S -167.0 164.1 112.0 0.498 0.0 HOH
2.860
NH1
O
ARG B:32 B:32 112.0 0.498 S -170.7 152.1 112.0 0.498 0.0 HOH
3.592
NH1
O
ARG C:32 C:32 112.0 0.498 S -159.3 154.1 112.0 0.498 0.0 HOH
2.704
O
O
2zjc 1 P01375 92.99 3e-105 X-RAY
2009-01-20 GLY A:32 A:32 67.0 0.893 S 109.0 167.8 67.0 0.893 0.0 HOH
8.166
O
O
GLY B:32 B:32 56.0 0.747 S 107.1 173.3 56.0 0.747 0.0 HOH
8.400
O
O
GLY C:32 C:32 65.0 0.867 S 66.0 137.8 65.0 0.867 0.0 HOH
2.924
CA
O
2zpx 1 P01375 92.36 3e-104 X-RAY
2009-03-24 ARG A:32 A:32 170.0 0.756 S -151.2 148.3 170.0 0.756 0.0 HOH
7.187
O
O
ARG B:32 B:32 213.0 0.947 S -52.8 -139.1 213.0 0.947 0.0 HOH
7.146
C
O
ARG C:32 C:32 220.0 0.978 T -147.2 9.4 220.0 0.978 0.0
7kp7 1 P06804 80.54 4e-88 X-RAY
2021-01-13 ARG A:24 B:33 130.0 0.578 S -142.7 160.3 21.0 0.093 0.485 E:P19438:0.484
SO4
HOH
6.914
3.573
O
CB
O2
O
ARG B:24 A:33 128.0 0.569 S -143.7 160.0 22.0 0.098 0.471 D:P19438:0.471
SO4
SO4
HOH
7.048
7.440
3.657
N
O
NH2
O4
O1
O
ARG C:24 C:33 130.0 0.578 S -142.9 159.8 22.0 0.098 0.48 F:P19438:0.48
SO4
HOH
6.811
4.069
O
O
O3
O
7kp8 1 P06804 80.41 1e-87 X-RAY
2021-01-13 ARG A:23 A:32 146.0 0.649 S -158.7 146.4 43.0 0.191 0.458 D:P19438:0.458
HOH
3.549
O
O
ARG B:23 B:32 151.0 0.671 S -148.1 147.5 34.0 0.151 0.52 E:P19438:0.52
ARG C:23 C:32 44.0 NA S -173.5 -162.8 44.0 NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p01375-f1 1 P01375 100.0 2e-174 ARG A:108 A:108 117.0 0.52 S -137.8 156.6