Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 31545055 . C A CCDS4702.1:NM_000594.3:c.443aCc>aAc_NP_000585.2:p.148T>N Homo sapiens tumor necrosis factor (TNF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6op0 1 P01375 99.37 6e-115 X-RAY
 2019-12-25 THR A:73 A:72 118.0 0.843 S -82.2 136.9 118.0 0.843 0.0
THR B:73 NA:NA DO NA DO DO DO NA NA NA
THR C:73 C:72 77.0 NA S -62.8 131.6 77.0 NA NA
7kp9 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 THR A:73 A:72 113.0 0.807 S -76.9 145.5 113.0 0.807 0.0 HOH
 2.653
 OG1
 O
THR B:73 NA:NA DO NA DO DO DO NA NA NA
THR C:73 C:72 70.0 NA S -69.1 131.6 70.0 NA NA
7kpa 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 THR A:73 A:72 80.0 NA S -63.8 123.6 80.0 NA NA HOH
 4.973
 O
 O
THR B:73 B:72 55.0 NA S -77.7 -1.8 54.0 NA NA A:P01375:NA
 HOH
 8.719
 O
 O
THR C:73 C:72 77.0 NA S -82.7 135.2 77.0 NA NA
7kpb 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 THR A:73 A:72 76.0 NA S -68.4 119.9 76.0 NA NA
THR B:73 B:72 79.0 NA S -72.3 142.7 74.0 NA NA A:P01375:NA
 GOL
 9.768
 CB
 O1
THR C:73 C:72 74.0 NA S -73.7 157.7 71.0 NA NA D:P19438:NA
5mu8 1 P01375 100.0 9e-115 X-RAY
 2017-03-29 THR A:74 A:72 117.0 0.836 S -60.5 121.4 117.0 0.836 0.0
THR B:74 B:72 45.0 0.321 S -79.8 -33.7 45.0 0.321 0.0
THR C:74 C:72 94.0 0.671 S -83.7 145.5 NA NA NA
THR D:74 D:72 68.0 0.486 S -80.0 -46.4 NA NA NA
THR E:74 F:72 109.0 0.779 S -76.8 148.5 NA NA NA
THR F:74 G:72 50.0 0.357 T -95.2 9.6 NA NA NA
THR G:74 H:72 102.0 0.729 S -63.1 152.2 NA NA NA
THR H:74 I:72 74.0 0.529 T -76.8 -22.4 NA NA NA
THR I:74 J:72 91.0 0.65 S -66.3 132.2 NA NA NA
THR J:74 K:72 40.0 0.286 S -71.0 -8.5 NA NA NA
THR K:74 L:72 117.0 0.836 S -61.6 139.2 NA NA NA
THR L:74 M:72 45.0 0.321 S -96.9 -8.1 NA NA NA
THR M:74 N:72 103.0 0.736 S -75.1 136.9 NA NA NA
THR N:74 O:72 45.0 0.321 S -77.8 -13.5 NA NA NA
THR O:74 P:72 110.0 0.786 S -64.5 133.4 NA NA NA
THR P:74 Q:72 47.0 0.336 T -75.5 -7.6 NA NA NA
THR Q:74 R:72 96.0 0.686 S -82.0 138.3 NA NA NA
THR R:74 S:72 41.0 0.293 T -69.3 -13.3 NA NA NA
THR S:74 T:72 114.0 0.814 S -68.5 136.1 NA NA NA
THR T:74 U:72 60.0 0.429 S -78.1 -9.6 NA NA NA
THR U:74 V:72 96.0 0.686 S -66.9 134.9 NA NA NA
THR V:74 W:72 48.0 0.343 S -94.6 8.5 NA NA NA
THR W:74 X:72 107.0 0.764 S -60.8 130.0 NA NA NA
THR X:74 Y:72 60.0 0.429 S -72.0 -21.9 NA NA NA
THR Y:74 Z:72 94.0 0.671 S -73.6 136.2 NA NA NA
THR Z:74 a:72 33.0 0.236 S -72.9 -22.3 NA NA NA
THR AA:74 b:72 99.0 0.707 S -67.2 149.2 NA NA NA
THR BA:74 c:72 67.0 0.479 S -81.4 -16.3 NA NA NA
THR CA:74 d:72 105.0 0.75 S -72.4 155.0 NA NA NA
THR DA:74 e:72 59.0 0.421 T -78.1 -14.7 NA NA NA
THR EA:74 f:72 117.0 0.836 S -63.2 108.6 NA NA NA
THR FA:74 g:72 46.0 0.329 T -76.4 -13.5 NA NA NA
THR GA:74 h:72 106.0 0.757 S -86.2 151.8 NA NA NA
THR HA:74 i:72 67.0 0.479 T -72.4 -27.6 NA NA NA
THR IA:74 j:72 94.0 0.671 S -62.7 138.2 NA NA NA
THR JA:74 k:72 65.0 0.464 T -69.0 -19.7 NA NA NA
THR KA:74 l:72 105.0 0.75 S -70.1 145.3 NA NA NA
THR LA:74 m:72 55.0 0.393 S -75.8 -5.0 NA NA NA
THR MA:74 n:72 110.0 0.786 S -76.7 162.4 NA NA NA
THR NA:74 o:72 57.0 0.407 T -75.3 -4.8 NA NA NA
THR OA:74 p:72 102.0 0.729 S -73.3 133.3 NA NA NA
THR PA:74 q:72 32.0 0.229 S -63.9 -25.3 NA NA NA
THR QA:74 r:72 108.0 0.771 S -64.3 133.1 NA NA NA
THR RA:74 s:72 52.0 0.371 T -75.5 -12.5 NA NA NA
THR SA:74 t:72 108.0 0.771 S -71.6 143.5 NA NA NA
THR TA:74 u:72 53.0 0.379 T -74.7 -5.3 NA NA NA
THR UA:74 v:72 115.0 0.821 S -63.1 133.2 NA NA NA
THR VA:74 w:72 51.0 0.364 T -73.7 -14.7 NA NA NA
6x81 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 THR A:73 A:72 132.0 0.943 S 44.4 -154.3 132.0 0.943 0.0
THR B:73 B:72 63.0 0.45 T -90.4 7.8 35.0 0.25 0.2 C:P01375:0.2
 HOH
 7.237
 CG2
 O
THR C:73 C:72 130.0 0.929 S 62.5 163.9 130.0 0.929 0.0
THR D:73 D:72 75.0 0.536 S 65.1 -21.8 NA NA NA
THR E:73 E:72 94.0 0.671 S -91.1 -22.7 NA NA NA
THR F:73 F:72 125.0 0.893 S 59.9 179.8 NA NA NA
6x82 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 THR A:73 A:72 104.0 0.743 S -136.4 -144.1 104.0 0.743 0.0 HOH
 5.657
 O
 O
THR B:73 B:72 47.0 0.336 S -98.2 -1.3 37.0 0.264 0.072 C:P01375:0.071
 HOH
 2.986
 O
 O
THR C:73 C:72 87.0 0.621 S -159.7 -83.8 83.0 0.593 0.028 A:P01375:0.029
 HOH
 5.336
 O
 O
THR D:73 D:72 128.0 0.914 S 71.1 142.8 NA NA NA
THR E:73 E:72 60.0 0.429 S -93.5 5.3 NA NA NA
THR F:73 NA:NA DO NA DO DO DO NA NA NA
6x83 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 THR A:73 A:72 129.0 0.921 S 53.2 -141.3 129.0 0.921 0.0 HOH
 5.630
 O
 O
THR B:73 B:72 107.0 0.764 T -77.4 -4.1 59.0 0.421 0.343 C:P01375:0.343
 HOH
 6.530
 N
 O
THR C:73 NA:NA DO NA DO DO DO NA NA NA
THR D:73 NA:NA DO NA DO DO DO NA NA NA
THR E:73 NA:NA DO NA DO DO DO NA NA NA
THR F:73 F:72 36.0 0.257 S -70.2 -36.2 NA NA NA
6x85 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 THR A:73 A:72 75.0 0.536 -72.5 143.9 75.0 0.536 0.0
THR B:73 B:72 111.0 0.793 S -77.3 150.7 109.0 0.779 0.014 C:P01375:0.014
THR C:73 C:72 110.0 0.786 S -33.3 144.6 96.0 0.686 0.1 A:P01375:0.1
THR D:73 D:72 74.0 0.529 S -123.6 128.0 NA NA NA
THR E:73 E:72 97.0 0.693 S -72.8 137.7 NA NA NA
THR F:73 F:72 127.0 0.907 S -79.4 147.6 NA NA NA
6x86 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 THR A:73 A:72 62.0 0.443 S -129.4 165.9 62.0 0.443 0.0 HOH
 4.751
 O
 O
THR B:73 B:72 109.0 0.779 S -78.4 126.3 109.0 0.779 0.0
THR C:73 C:72 100.0 0.714 S -61.3 -157.5 97.0 0.693 0.021 A:P01375:0.021
 HOH
 3.597
 O
 O
THR D:73 D:72 97.0 0.693 S -74.4 139.1 NA NA NA
THR E:73 E:72 98.0 0.7 S -87.3 101.0 NA NA NA
THR F:73 F:72 92.0 0.657 S -75.8 155.1 NA NA NA
5yoy 1 P01375 100.0 1e-114 X-RAY
 2018-05-09 THR A:80 A:72 104.0 0.743 S -80.2 146.4 101.0 0.721 0.022 I:None:0.014
F:None:0.007
 HOH
 7.662
 N
 O
THR B:80 B:72 100.0 0.714 S -81.7 148.4 90.0 0.643 0.071 G:None:0.071
THR C:80 C:72 90.0 0.643 S -81.9 148.5 84.0 0.6 0.043 H:None:0.043
 HOH
 7.037
 C
 O
THR J:80 J:72 90.0 0.643 S -81.5 147.6 NA NA NA
THR K:80 K:72 96.0 0.686 S -80.9 148.4 NA NA NA
THR L:80 L:72 98.0 0.7 S -81.9 149.0 NA NA NA
7jra 1 P01375 100.0 1e-114 X-RAY
 2020-12-09 THR A:75 A:148 75.0 0.536 S -84.8 5.2 75.0 0.536 0.0 HOH
 2.674
 O
 O
THR B:75 B:148 120.0 0.857 S -81.3 125.2 120.0 0.857 0.0 HOH
 2.813
 OG1
 O
THR C:75 C:148 74.0 NA S -73.0 131.6 74.0 NA NA
4g3y 3 P01375 100.0 1e-114 X-RAY
 2013-03-27 THR C:72 C:72 64.0 0.457 T -65.4 -16.3 4.0 0.029 0.428 C:P01375:0.429
 HOH
 2.818
 O
 O
4twt 1 P01375 100.0 1e-114 X-RAY
 2015-02-04 THR A:72 A:72 53.0 0.379 T -71.1 -17.2 53.0 0.379 0.0 HOH
 2.667
 O
 O
THR B:72 B:72 91.0 0.65 T -71.0 -7.2 58.0 0.414 0.236 A:P01375:0.236
THR E:72 C:72 66.0 0.471 S -66.6 -34.2 NA NA NA
THR F:72 D:72 98.0 0.7 -74.5 166.7 NA NA NA
5m2i 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 THR A:72 A:72 84.0 0.6 S -75.5 136.2 58.0 0.414 0.186 H:None:0.186
 HOH
 3.175
 O
 O
THR B:72 B:72 86.0 0.614 S -74.4 139.7 59.0 0.421 0.193 G:None:0.193
 HOH
 3.910
 CG2
 O
THR C:72 C:72 83.0 0.593 S -74.3 138.1 58.0 0.414 0.179 I:None:0.179
 HOH
 5.766
 CG2
 O
THR D:72 D:72 76.0 0.543 S -94.5 136.8 NA NA NA
THR E:72 E:72 75.0 0.536 S -154.0 124.8 NA NA NA
THR F:72 F:72 83.0 0.593 S -75.6 136.8 NA NA NA
5m2j 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 THR A:72 A:72 101.0 0.721 S -113.6 125.0 101.0 0.721 0.0 HOH
 4.932
 OG1
 O
5m2m 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 THR A:72 NA:NA DO NA DO DO DO NA NA NA
THR B:72 B:72 82.0 0.586 S -73.3 152.3 70.0 0.5 0.086 D:None:0.071
C:P01375:0.007
 HOH
 4.676
 CG2
 O
THR C:72 C:72 110.0 0.786 360.0 148.9 96.0 0.686 0.1 E:None:0.1
 HOH
 3.085
 O
 O
THR G:72 G:72 126.0 0.9 360.0 154.2 NA NA NA
THR I:72 NA:NA DO NA DO DO DO NA NA NA
THR K:72 NA:NA DO NA DO DO DO NA NA NA
5wux 3 C1K3N5 100.0 1e-114 X-RAY
 2017-06-07 THR G:72 E:72 105.0 0.75 S -94.6 138.5 NA NA NA
THR H:72 F:72 98.0 0.7 S -103.7 147.9 62.0 0.443 0.257 B:None:0.257
THR I:72 G:72 99.0 0.707 S -92.6 131.9 NA NA NA
6ooy 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 THR A:72 NA:NA DO NA DO DO DO NA NA NA
THR B:72 NA:NA DO NA DO DO DO NA NA NA
THR C:72 NA:NA DO NA DO DO DO NA NA NA
6ooz 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 THR A:72 A:72 114.0 0.814 S -64.9 141.2 114.0 0.814 0.0 HOH
 3.009
 O
 O
THR B:72 NA:NA DO NA DO DO DO NA NA NA
THR C:72 C:72 136.0 NA 360.0 96.8 136.0 NA NA HOH
 7.394
 O
 O
6rmj 1 P01375 99.37 3e-114 X-RAY
 2019-10-09 THR A:78 A:72 102.0 0.729 S -83.4 158.9 100.0 0.714 0.015 B:P01375:0.014
 HOH
 6.501
 HB
 O
THR B:78 B:72 99.0 0.707 S -82.9 160.4 98.0 0.7 0.007 C:P01375:0.007
THR C:78 C:72 106.0 0.757 S -86.0 162.6 101.0 0.721 0.036 A:P01375:0.036
5uui 1 P01375 98.73 1e-113 X-RAY
 2017-08-02 THR A:73 NA:NA DO NA DO DO DO NA NA NA
1a8m 1 P01375 99.36 1e-113 X-RAY
 1998-06-17 THR A:72 A:72 88.0 0.629 S -16.0 -30.0 63.0 0.45 0.179 B:P01375:0.179
 HOH
 8.290
 N
 O
THR B:72 B:72 124.0 0.886 S 63.6 111.1 119.0 0.85 0.036 C:P01375:0.036
 HOH
 9.185
 N
 O
THR C:72 C:72 110.0 0.786 S -144.8 22.4 110.0 0.786 0.0 HOH
 4.694
 O
 O
3wd5 1 P01375 99.36 1e-113 X-RAY
 2013-08-14 THR A:72 A:72 103.0 0.736 S 3.5 -46.5 103.0 0.736 0.0
1tnf 1 P01375 99.36 5e-113 X-RAY
 1990-01-15 THR A:72 A:72 98.0 0.7 S 31.1 -60.6 67.0 0.479 0.221 B:P01375:0.221
THR B:72 B:72 128.0 0.914 S 47.2 -123.7 119.0 0.85 0.064 C:P01375:0.064
THR C:72 C:72 119.0 0.85 S 72.4 150.0 117.0 0.836 0.014 A:P01375:0.014
2tun 1 P01375 98.73 2e-112 X-RAY
 1994-01-31 THR A:72 A:72 123.0 0.879 S 42.1 -146.6 92.0 0.657 0.222 B:P01375:0.221
THR B:72 B:72 116.0 0.829 S 65.0 171.8 104.0 0.743 0.086 C:P01375:0.086
THR C:72 C:72 77.0 0.55 S 160.4 175.7 77.0 0.55 0.0
THR D:72 D:72 89.0 0.636 S 30.8 -95.4 46.0 0.329 0.307 E:P01375:0.307
THR E:72 E:72 120.0 0.857 T 69.1 -87.4 119.0 0.85 0.007 F:P01375:0.007
THR F:72 F:72 98.0 0.7 S 160.1 171.8 98.0 0.7 0.0
3it8 1 P01375 99.34 1e-109 X-RAY
 2009-10-20 THR A:76 A:72 97.0 0.693 S 30.1 -100.8 79.0 0.564 0.129 C:P01375:0.129
THR B:76 B:72 99.0 0.707 S 29.9 -100.8 80.0 0.571 0.136 A:P01375:0.136
THR C:76 C:72 98.0 0.7 S 30.0 -100.6 79.0 0.564 0.136 B:P01375:0.136
THR G:76 G:72 99.0 0.707 S 30.1 -100.8 NA NA NA
THR H:76 H:72 96.0 0.686 S 30.1 -100.9 NA NA NA
THR I:76 I:72 99.0 0.707 S 30.0 -100.9 NA NA NA
3alq 1 P01375 96.18 2e-109 X-RAY
 2010-11-17 THR A:72 A:72 81.0 0.579 S -107.6 -178.6 58.0 0.414 0.165 I:P20333:0.157
C:P01375:0.014
THR B:72 B:72 82.0 0.586 S -111.4 135.3 56.0 0.4 0.186 G:P20333:0.186
THR C:72 C:72 106.0 0.757 S -73.6 -2.3 79.0 0.564 0.193 B:P01375:0.193
THR D:72 D:72 74.0 0.529 S -123.2 169.8 NA NA NA
THR E:72 E:72 90.0 0.643 S -100.0 158.3 NA NA NA
THR F:72 F:72 105.0 0.75 S -64.7 -16.0 NA NA NA
3l9j 2 P01375 100.0 1e-108 X-RAY
 2010-02-23 THR B:64 T:72 98.0 0.7 S -69.4 133.0 69.0 0.493 0.207 A:None:0.207
 HOH
 2.568
 OG1
 O
2az5 1 P01375 100.0 6e-108 X-RAY
 2005-11-29 THR A:63 A:72 103.0 0.736 S -75.6 132.8 103.0 0.736 0.0 HOH
 3.542
 N
 O
THR B:63 B:72 67.0 0.479 T -83.0 -3.9 67.0 0.479 0.0 HOH
 2.528
 O
 O
THR C:63 C:72 106.0 0.757 S -79.6 129.5 106.0 0.757 0.0 HOH
 3.395
 O
 O
THR D:63 D:72 67.0 0.479 S -83.6 -2.7 67.0 0.479 0.0 HOH
 2.673
 O
 O
4tsv 1 P01375 98.0 6e-107 X-RAY
 1998-12-30 THR A:65 A:72 101.0 0.721 -152.5 360.0 101.0 0.721 0.0 HOH
 2.202
 OG1
 O
5tsw 1 P01375 98.0 6e-107 X-RAY
 1999-05-07 THR A:65 A:72 110.0 0.786 S 56.9 163.9 110.0 0.786 0.0 HOH
 4.787
 O
 H2
THR B:65 B:72 116.0 0.829 S 62.9 147.4 116.0 0.829 0.0 HOH
 1.021
 HG1
 H1
THR C:65 C:72 117.0 0.836 S 54.2 92.0 117.0 0.836 0.0 HOH
 2.670
 O
 H1
THR D:65 D:72 99.0 0.707 S 41.4 156.7 NA NA NA
THR E:65 E:72 121.0 0.864 S 28.4 -156.2 NA NA NA
THR F:65 F:72 120.0 0.857 S 61.5 131.5 NA NA NA
2e7a 1 P01375 92.36 9e-106 X-RAY
 2007-11-13 THR A:72 A:72 113.0 0.807 S -83.9 128.1 113.0 0.807 0.0 HOH
 2.538
 O
 O
THR B:72 B:72 99.0 0.707 S -125.9 169.3 99.0 0.707 0.0 HOH
 2.931
 O
 O
THR C:72 C:72 107.0 0.764 S -106.1 138.6 107.0 0.764 0.0 HOH
 5.065
 O
 O
2zjc 1 P01375 92.99 3e-105 X-RAY
 2009-01-20 THR A:72 A:72 137.0 0.979 S -40.5 -31.7 108.0 0.771 0.208 B:P01375:0.207
 HOH
 9.466
 C
 O
THR B:72 B:72 81.0 0.579 S -113.1 -2.5 28.0 0.2 0.379 C:P01375:0.379
 HOH
 5.431
 N
 O
THR C:72 C:72 108.0 0.771 S -115.4 144.5 108.0 0.771 0.0 HOH
 3.269
 CG2
 O
2zpx 1 P01375 92.36 3e-104 X-RAY
 2009-03-24 THR A:72 A:72 65.0 0.464 S 175.0 -4.2 20.0 0.143 0.321 B:P01375:0.321
THR B:72 B:72 63.0 0.45 S 175.5 -3.3 21.0 0.15 0.3 C:P01375:0.3
THR C:72 C:72 67.0 0.479 S 175.1 -2.7 14.0 0.1 0.379 A:P01375:0.379

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p01375-f1 1 P01375 100.0 2e-174 THR A:148 A:148 96.0 0.686 S -85.8 141.6