Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 31545093 . G A CCDS4702.1:NM_000594.3:c.481Gtc>Atc_NP_000585.2:p.161V>I Homo sapiens tumor necrosis factor (TNF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6op0 1 P01375 99.37 6e-115 X-RAY
 2019-12-25 VAL A:86 A:85 82.0 0.529 T -58.9 -36.8 82.0 0.529 0.0 HOH
 3.235
 N
 O
VAL B:86 B:85 59.0 0.381 T -57.4 -48.2 59.0 0.381 0.0 HOH
 6.249
 CG2
 O
VAL C:86 C:85 134.0 0.865 -144.8 360.0 134.0 0.865 0.0
7kp9 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 VAL A:86 A:85 87.0 0.561 T -60.6 -33.3 87.0 0.561 0.0 HOH
 2.848
 N
 O
VAL B:86 B:85 47.0 NA T -65.6 -38.7 47.0 NA NA HOH
 3.217
 N
 O
VAL C:86 C:85 96.0 0.619 -48.7 -42.4 96.0 0.619 0.0 HOH
 3.346
 N
 O
7kpa 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 VAL A:86 A:85 87.0 0.561 T -51.5 -40.6 87.0 0.561 0.0 HOH
 3.043
 N
 O
VAL B:86 B:85 73.0 0.471 T -58.8 -35.8 73.0 0.471 0.0 HOH
 7.485
 CB
 O
VAL C:86 C:85 94.0 NA -64.7 360.0 94.0 NA NA
7kpb 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 VAL A:86 A:85 99.0 0.639 S -65.6 -46.6 99.0 0.639 0.0
VAL B:86 B:85 76.0 0.49 S -59.0 -35.0 51.0 0.329 0.161 E:P19438:0.161
 HOH
 6.299
 CG2
 O
VAL C:86 C:85 79.0 0.51 S -66.9 -36.4 59.0 0.381 0.129 D:P19438:0.129
5mu8 1 P01375 100.0 9e-115 X-RAY
 2017-03-29 VAL A:87 A:85 67.0 0.432 T -67.6 -36.3 67.0 0.432 0.0
VAL B:87 B:85 74.0 0.477 T -72.1 -62.8 74.0 0.477 0.0
VAL C:87 C:85 75.0 0.484 T -72.0 -41.8 NA NA NA
VAL D:87 D:85 81.0 0.523 T -58.0 -71.9 NA NA NA
VAL E:87 F:85 75.0 0.484 T -73.8 -27.5 NA NA NA
VAL F:87 G:85 84.0 0.542 T -68.8 -50.3 NA NA NA
VAL G:87 H:85 67.0 0.432 S -98.4 -37.3 NA NA NA
VAL H:87 I:85 93.0 0.6 T -71.2 -67.2 NA NA NA
VAL I:87 J:85 69.0 0.445 T -77.6 -32.2 NA NA NA
VAL J:87 K:85 85.0 0.548 T -66.0 -43.9 NA NA NA
VAL K:87 L:85 83.0 0.535 S -83.5 -50.6 NA NA NA
VAL L:87 M:85 92.0 0.594 T -77.4 -49.6 NA NA NA
VAL M:87 N:85 80.0 0.516 T -69.5 -25.6 NA NA NA
VAL N:87 O:85 92.0 0.594 T -78.0 -52.4 NA NA NA
VAL O:87 P:85 76.0 0.49 S -77.1 -67.1 NA NA NA
VAL P:87 Q:85 84.0 0.542 T -48.8 -56.0 NA NA NA
VAL Q:87 R:85 60.0 0.387 S -67.2 -42.1 NA NA NA
VAL R:87 S:85 83.0 0.535 T -66.1 -59.5 NA NA NA
VAL S:87 T:85 85.0 0.548 S -101.1 -54.1 NA NA NA
VAL T:87 U:85 84.0 0.542 T -66.0 -41.7 NA NA NA
VAL U:87 V:85 68.0 0.439 T -72.1 -44.5 NA NA NA
VAL V:87 W:85 98.0 0.632 T -40.0 -61.3 NA NA NA
VAL W:87 X:85 63.0 0.406 S -80.7 -57.1 NA NA NA
VAL X:87 Y:85 81.0 0.523 T -70.4 -54.5 NA NA NA
VAL Y:87 Z:85 78.0 0.503 S -85.2 -40.5 NA NA NA
VAL Z:87 a:85 84.0 0.542 T -75.8 -61.3 NA NA NA
VAL AA:87 b:85 97.0 0.626 T -70.8 -53.8 NA NA NA
VAL BA:87 c:85 89.0 0.574 S -73.4 -64.9 NA NA NA
VAL CA:87 d:85 64.0 0.413 T -71.4 -42.7 NA NA NA
VAL DA:87 e:85 83.0 0.535 T -73.9 -57.3 NA NA NA
VAL EA:87 f:85 77.0 0.497 S -77.1 -27.4 NA NA NA
VAL FA:87 g:85 79.0 0.51 T -51.1 -57.0 NA NA NA
VAL GA:87 h:85 74.0 0.477 T -84.2 -26.5 NA NA NA
VAL HA:87 i:85 85.0 0.548 T -71.9 -58.3 NA NA NA
VAL IA:87 j:85 81.0 0.523 T -75.4 -43.6 NA NA NA
VAL JA:87 k:85 86.0 0.555 T -60.2 -48.5 NA NA NA
VAL KA:87 l:85 78.0 0.503 T -71.2 -46.4 NA NA NA
VAL LA:87 m:85 94.0 0.606 T -75.1 -40.1 NA NA NA
VAL MA:87 n:85 86.0 0.555 T -74.7 -48.0 NA NA NA
VAL NA:87 o:85 82.0 0.529 T -59.1 -59.3 NA NA NA
VAL OA:87 p:85 63.0 0.406 T -75.9 -15.1 NA NA NA
VAL PA:87 q:85 82.0 0.529 T -74.7 -43.2 NA NA NA
VAL QA:87 r:85 88.0 0.568 T -67.4 -38.8 NA NA NA
VAL RA:87 s:85 83.0 0.535 T -50.6 -63.1 NA NA NA
VAL SA:87 t:85 87.0 0.561 T -81.8 -21.9 NA NA NA
VAL TA:87 u:85 91.0 0.587 T -77.3 -46.9 NA NA NA
VAL UA:87 v:85 81.0 0.523 T -87.6 -53.3 NA NA NA
VAL VA:87 w:85 96.0 0.619 S -71.6 -65.0 NA NA NA
6x81 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 VAL A:86 A:85 79.0 0.51 S -66.5 -26.1 79.0 0.51 0.0 HOH
 4.556
 CG1
 O
VAL B:86 B:85 70.0 0.452 T -44.6 -42.9 70.0 0.452 0.0 HOH
 9.397
 CG1
 O
VAL C:86 C:85 69.0 0.445 T -64.4 -40.7 69.0 0.445 0.0 HOH
 4.809
 CG2
 O
VAL D:86 D:85 82.0 0.529 S -74.7 -23.5 NA NA NA
VAL E:86 E:85 75.0 0.484 T -58.0 -34.9 NA NA NA
VAL F:86 F:85 69.0 0.445 T -65.9 118.7 NA NA NA
6x82 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 VAL A:86 A:85 93.0 0.6 S -72.3 -29.6 93.0 0.6 0.0 HOH
 3.066
 N
 O
VAL B:86 B:85 83.0 0.535 T -67.5 -33.8 83.0 0.535 0.0 HOH
 3.638
 CG1
 O
VAL C:86 C:85 66.0 0.426 T -70.3 -33.7 66.0 0.426 0.0
VAL D:86 D:85 90.0 0.581 S -62.8 -41.4 NA NA NA
VAL E:86 E:85 72.0 0.465 T -47.0 -35.3 NA NA NA
VAL F:86 F:85 88.0 0.568 T -57.5 -47.5 NA NA NA
6x83 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 VAL A:86 A:85 91.0 0.587 S -72.3 -49.3 91.0 0.587 0.0 HOH
 2.707
 O
 O
VAL B:86 B:85 69.0 0.445 T -60.4 -26.0 69.0 0.445 0.0 HOH
 3.299
 N
 O
VAL C:86 C:85 148.0 0.955 -53.2 360.0 148.0 0.955 0.0 HOH
 6.064
 CG1
 O
VAL D:86 D:85 80.0 0.516 S -73.3 -37.7 NA NA NA
VAL E:86 E:85 74.0 0.477 T -65.0 -38.7 NA NA NA
VAL F:86 F:85 80.0 0.516 T -52.8 -37.9 NA NA NA
6x85 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 VAL A:86 A:85 157.0 1.0 -93.5 360.0 157.0 1.0 0.0
VAL B:86 B:85 69.0 0.445 T -53.8 -41.2 69.0 0.445 0.0
VAL C:86 C:85 87.0 0.561 T -61.5 126.4 87.0 0.561 0.0
VAL D:86 D:85 120.0 0.774 -56.9 -32.7 NA NA NA
VAL E:86 E:85 109.0 0.703 -70.9 -16.9 NA NA NA
VAL F:86 F:85 79.0 0.51 T -56.9 -25.8 NA NA NA
6x86 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 VAL A:86 A:85 108.0 0.697 T -51.5 -59.0 108.0 0.697 0.0 HOH
 3.684
 N
 O
VAL B:86 B:85 65.0 0.419 S -56.6 -45.0 65.0 0.419 0.0
VAL C:86 C:85 98.0 0.632 S -51.7 -27.9 98.0 0.632 0.0
VAL D:86 D:85 125.0 0.806 -58.9 -48.9 NA NA NA
VAL E:86 E:85 127.0 0.819 -78.1 -18.0 NA NA NA
VAL F:86 F:85 82.0 0.529 T -58.2 -23.7 NA NA NA
5yoy 1 P01375 100.0 1e-114 X-RAY
 2018-05-09 VAL A:93 A:85 100.0 0.645 S -75.0 -18.2 100.0 0.645 0.0
VAL B:93 B:85 74.0 0.477 T -73.7 136.0 74.0 0.477 0.0 HOH
 6.227
 N
 O
VAL C:93 C:85 92.0 0.594 T -73.7 128.7 92.0 0.594 0.0 HOH
 2.183
 O
 O
VAL J:93 J:85 89.0 0.574 S -74.1 -62.6 NA NA NA
VAL K:93 K:85 96.0 0.619 S -73.1 -25.7 NA NA NA
VAL L:93 L:85 92.0 0.594 S -69.2 -58.0 NA NA NA
7jra 1 P01375 100.0 1e-114 X-RAY
 2020-12-09 VAL A:88 A:161 87.0 0.561 T -52.5 -35.5 87.0 0.561 0.0 HOH
 2.975
 N
 O
VAL B:88 B:161 94.0 0.606 T -55.3 -42.7 94.0 0.606 0.0 HOH
 2.841
 O
 O
VAL C:88 C:161 80.0 0.516 S -49.1 140.5 80.0 0.516 0.0 HOH
 3.716
 CA
 O
4g3y 3 P01375 100.0 1e-114 X-RAY
 2013-03-27 VAL C:85 C:85 70.0 0.452 T -52.5 -43.0 70.0 0.452 0.0
4twt 1 P01375 100.0 1e-114 X-RAY
 2015-02-04 VAL A:85 A:85 85.0 0.548 S -61.9 -32.0 85.0 0.548 0.0
VAL B:85 B:85 90.0 0.581 T -60.8 -32.8 90.0 0.581 0.0 HOH
 9.742
 N
 O
VAL E:85 C:85 76.0 0.49 T -61.1 -34.4 NA NA NA
VAL F:85 D:85 76.0 0.49 T -57.9 -35.9 NA NA NA
5m2i 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 VAL A:85 A:85 61.0 0.394 T -61.9 -32.0 57.0 0.368 0.026 H:None:0.026
 HOH
 3.169
 N
 O
VAL B:85 B:85 41.0 0.265 T -61.8 -31.3 41.0 0.265 0.0 HOH
 3.167
 N
 O
VAL C:85 C:85 40.0 0.258 T -61.5 -33.8 40.0 0.258 0.0 HOH
 5.019
 CG1
 O
VAL D:85 D:85 65.0 0.419 T -60.9 -32.3 NA NA NA
VAL E:85 E:85 42.0 0.271 T -61.9 -32.0 NA NA NA
VAL F:85 F:85 38.0 0.245 T -61.9 -33.0 NA NA NA
5m2j 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 VAL A:85 A:85 64.0 0.413 T -62.1 -42.7 64.0 0.413 0.0 HOH
 3.399
 O
 O
5m2m 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 VAL A:85 A:85 79.0 0.51 T -73.8 -37.8 79.0 0.51 0.0 HOH
 3.609
 N
 O
VAL B:85 B:85 76.0 0.49 T -74.5 -37.6 76.0 0.49 0.0 HOH
 3.279
 N
 O
VAL C:85 C:85 79.0 0.51 T -74.4 -37.7 79.0 0.51 0.0 HOH
 3.324
 N
 O
VAL G:85 G:85 76.0 0.49 T -74.6 -37.4 NA NA NA
VAL I:85 I:85 79.0 0.51 T -74.6 -37.6 NA NA NA
VAL K:85 M:85 79.0 0.51 T -74.5 -37.3 NA NA NA
5wux 3 C1K3N5 100.0 1e-114 X-RAY
 2017-06-07 VAL G:85 E:85 60.0 0.387 T -68.1 -33.1 NA NA NA
VAL H:85 F:85 56.0 0.361 T -50.2 -53.9 16.0 0.103 0.258 A:None:0.258
VAL I:85 G:85 51.0 0.329 T -48.5 -56.5 NA NA NA
6ooy 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 VAL A:85 A:85 77.0 0.497 T -54.2 -38.5 77.0 0.497 0.0 HOH
 3.142
 N
 O
VAL B:85 B:85 66.0 0.426 T -53.9 -42.1 66.0 0.426 0.0 HOH
 6.237
 N
 O
VAL C:85 C:85 62.0 0.4 S -73.4 -32.0 62.0 0.4 0.0
6ooz 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 VAL A:85 A:85 83.0 0.535 T -60.4 -41.9 83.0 0.535 0.0
VAL B:85 B:85 80.0 0.516 T -33.5 -57.4 80.0 0.516 0.0
VAL C:85 C:85 133.0 0.858 -90.8 360.0 133.0 0.858 0.0
6rmj 1 P01375 99.37 3e-114 X-RAY
 2019-10-09 VAL A:91 A:85 81.0 0.523 T -66.8 -38.9 81.0 0.523 0.0
VAL B:91 B:85 71.0 0.458 T -71.6 -47.8 71.0 0.458 0.0
VAL C:91 C:85 66.0 0.426 S -67.2 -44.0 66.0 0.426 0.0 HOH
 9.694
 HG21
 O
5uui 1 P01375 98.73 1e-113 X-RAY
 2017-08-02 VAL A:86 A:85 64.0 NA S -54.6 -43.6 64.0 NA NA HOH
 2.979
 N
 O
1a8m 1 P01375 99.36 1e-113 X-RAY
 1998-06-17 VAL A:85 A:85 66.0 0.426 S -68.9 -16.3 66.0 0.426 0.0 HOH
 8.315
 C
 O
VAL B:85 B:85 62.0 0.4 S -33.6 -67.8 62.0 0.4 0.0 HOH
 6.402
 CG2
 O
VAL C:85 C:85 69.0 0.445 T -54.4 -34.4 69.0 0.445 0.0 HOH
 2.975
 CG1
 O
3wd5 1 P01375 99.36 1e-113 X-RAY
 2013-08-14 VAL A:85 A:85 68.0 0.439 S -73.8 -34.0 68.0 0.439 0.0 HOH
 7.013
 CG1
 O
1tnf 1 P01375 99.36 5e-113 X-RAY
 1990-01-15 VAL A:85 A:85 73.0 0.471 S -69.8 -2.9 73.0 0.471 0.0
VAL B:85 B:85 56.0 0.361 S -140.1 -32.0 56.0 0.361 0.0
VAL C:85 C:85 80.0 0.516 E -98.4 -2.8 80.0 0.516 0.0
2tun 1 P01375 98.73 2e-112 X-RAY
 1994-01-31 VAL A:85 A:85 76.0 0.49 S -89.3 161.4 76.0 0.49 0.0
VAL B:85 B:85 79.0 0.51 T -64.1 -9.9 79.0 0.51 0.0
VAL C:85 C:85 82.0 0.529 S -79.8 -52.9 82.0 0.529 0.0
VAL D:85 D:85 85.0 0.548 T -68.1 -26.6 85.0 0.548 0.0
VAL E:85 E:85 80.0 0.516 S -138.2 -37.5 80.0 0.516 0.0
VAL F:85 F:85 80.0 0.516 S -50.7 -38.6 80.0 0.516 0.0
3it8 1 P01375 99.34 1e-109 X-RAY
 2009-10-20 VAL A:89 A:85 63.0 0.406 T -63.7 -32.6 56.0 0.361 0.045 F:Q9DHW0:0.045
VAL B:89 B:85 65.0 0.419 T -64.7 -32.5 55.0 0.355 0.064 D:Q9DHW0:0.065
VAL C:89 C:85 65.0 0.419 T -64.2 -31.8 54.0 0.348 0.071 E:Q9DHW0:0.071
 HOH
 9.864
 CG2
 O
VAL G:89 G:85 65.0 0.419 T -64.8 -32.0 NA NA NA
VAL H:89 H:85 65.0 0.419 T -63.4 -33.2 NA NA NA
VAL I:89 I:85 63.0 0.406 T -64.8 -32.1 NA NA NA
3alq 1 P01375 96.18 2e-109 X-RAY
 2010-11-17 VAL A:85 A:85 78.0 0.503 T -59.4 -33.5 49.0 0.316 0.187 I:P20333:0.187
VAL B:85 B:85 85.0 0.548 T -66.3 -29.9 56.0 0.361 0.187 G:P20333:0.187
 HOH
 9.261
 O
 O
VAL C:85 C:85 77.0 0.497 T -48.5 -35.4 51.0 0.329 0.168 H:P20333:0.168
VAL D:85 D:85 75.0 0.484 S -74.8 -27.5 NA NA NA
VAL E:85 E:85 77.0 0.497 S -70.7 -39.7 NA NA NA
VAL F:85 F:85 73.0 0.471 S -65.7 -33.7 NA NA NA
3l9j 2 P01375 100.0 1e-108 X-RAY
 2010-02-23 VAL B:77 T:85 78.0 0.503 T -48.4 -36.3 78.0 0.503 0.0 HOH
 3.334
 N
 O
2az5 1 P01375 100.0 6e-108 X-RAY
 2005-11-29 VAL A:76 A:85 76.0 0.49 T -69.1 -49.1 76.0 0.49 0.0 HOH
 5.303
 CA
 O
VAL B:76 B:85 96.0 0.619 T -58.4 -41.6 96.0 0.619 0.0 HOH
 2.920
 N
 O
VAL C:76 C:85 134.0 0.865 -63.1 360.0 134.0 0.865 0.0 HOH
 3.975
 N
 O
VAL D:76 D:85 97.0 0.626 T -56.6 -39.8 97.0 0.626 0.0 HOH
 2.919
 N
 O
4tsv 1 P01375 98.0 6e-107 X-RAY
 1998-12-30 VAL A:78 A:85 78.0 0.503 T 78.4 -95.8 78.0 0.503 0.0 HOH
 3.751
 C
 O
5tsw 1 P01375 98.0 6e-107 X-RAY
 1999-05-07 VAL A:78 A:85 104.0 0.671 T 32.7 -115.6 104.0 0.671 0.0 HOH
 3.308
 H
 H1
VAL B:78 B:85 124.0 0.8 T 51.9 -79.5 124.0 0.8 0.0 HOH
 3.812
 H
 H1
VAL C:78 C:85 90.0 0.581 T 57.4 -91.6 90.0 0.581 0.0 HOH
 3.796
 O
 H1
VAL D:78 D:85 101.0 0.652 S 59.5 -77.3 NA NA NA
VAL E:78 E:85 77.0 0.497 T 47.1 -74.6 NA NA NA
VAL F:78 F:85 122.0 0.787 T 32.4 -81.5 NA NA NA
2e7a 1 P01375 92.36 9e-106 X-RAY
 2007-11-13 THR A:85 A:85 109.0 0.779 G -53.7 -39.7 109.0 0.779 0.0 HOH
 2.693
 OG1
 O
THR B:85 B:85 108.0 0.771 T -75.3 -11.0 108.0 0.771 0.0 HOH
 3.454
 N
 O
THR C:85 C:85 104.0 0.743 T -72.8 -12.2 104.0 0.743 0.0
2zjc 1 P01375 92.99 3e-105 X-RAY
 2009-01-20 VAL A:85 A:85 93.0 0.6 T -53.3 -51.8 93.0 0.6 0.0
VAL B:85 B:85 72.0 0.465 S -66.3 -32.8 72.0 0.465 0.0 HOH
 2.791
 O
 O
VAL C:85 C:85 46.0 0.297 -158.0 151.9 46.0 0.297 0.0 HOH
 3.856
 CG1
 O
2zpx 1 P01375 92.36 3e-104 X-RAY
 2009-03-24 PRO A:85 A:85 77.0 0.531 S -46.7 -58.8 77.0 0.531 0.0
PRO B:85 B:85 86.0 0.593 S -58.9 -47.0 86.0 0.593 0.0
PRO C:85 C:85 79.0 0.545 S -83.4 -23.7 79.0 0.545 0.0
7kp7 1 P06804 80.54 4e-88 X-RAY
 2021-01-13 ILE A:76 B:85 101.0 0.577 T -53.0 -45.0 77.0 0.44 0.137 D:P19438:0.137
 SO4
SO4
HOH
 6.804
7.466
2.733
 C
O
O
 O2
O4
O
ILE B:76 A:85 102.0 0.583 T -54.8 -42.6 78.0 0.446 0.137 F:P19438:0.137
 SO4
SO4
HOH
 6.811
6.943
2.686
 C
O
O
 O2
O2
O
ILE C:76 C:85 103.0 0.589 T -53.5 -44.7 83.0 0.474 0.115 E:P19438:0.114
 SO4
HOH
 6.878
5.929
 C
N
 O3
O
7kp8 1 P06804 80.41 1e-87 X-RAY
 2021-01-13 ILE A:75 A:84 71.0 NA -83.6 360.0 71.0 NA NA
ILE B:75 B:84 90.0 0.514 S -57.9 -49.6 61.0 0.349 0.165 D:P19438:0.166
ILE C:75 C:84 89.0 0.509 S -59.2 -49.3 65.0 0.371 0.138 E:P19438:0.137
 HOH
 7.842
 CG2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p01375-f1 1 P01375 100.0 2e-174 VAL A:161 A:161 74.0 0.477 S -63.1 -39.9