Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 31545253 . G A CCDS4702.1:NM_000594.3:c.641cGg>cAg_NP_000585.2:p.214R>Q Homo sapiens tumor necrosis factor (TNF), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6op0 1 P01375 99.37 6e-115 X-RAY
 2019-12-25 ARG A:139 A:138 76.0 0.338 -132.0 78.2 76.0 0.338 0.0 HOH
 6.626
 N
 O
ARG B:139 B:138 78.0 0.347 -124.3 77.7 78.0 0.347 0.0 HOH
 6.715
 N
 O
ARG C:139 C:138 79.0 0.351 -126.3 72.8 79.0 0.351 0.0
7kp9 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 ARG A:139 A:138 79.0 0.351 -127.2 68.4 79.0 0.351 0.0 HOH
 3.037
 NH2
 O
ARG B:139 B:138 75.0 0.333 -124.5 73.4 75.0 0.333 0.0 HOH
 5.553
 C
 O
ARG C:139 C:138 73.0 0.324 -129.6 72.2 73.0 0.324 0.0 HOH
 6.769
 N
 O
7kpa 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 ARG A:139 A:138 75.0 0.333 -134.3 65.3 75.0 0.333 0.0 HOH
 3.281
 NH2
 O
ARG B:139 B:138 84.0 0.373 -129.3 81.5 84.0 0.373 0.0 HOH
 6.565
 N
 O
ARG C:139 C:138 70.0 0.311 -132.0 71.7 70.0 0.311 0.0 HOH
 7.038
 N
 O
7kpb 1 P01375 99.37 6e-115 X-RAY
 2021-01-13 ARG A:139 A:138 100.0 0.444 -123.5 92.0 54.0 0.24 0.204 G:None:0.204
 GOL
 5.910
 N
 O2
ARG B:139 B:138 81.0 0.36 -139.2 85.0 70.0 0.311 0.049 E:P19438:0.049
 GOL
GOL
HOH
 5.554
3.287
6.635
 N
CD
N
 C3
O3
O
ARG C:139 C:138 69.0 0.307 -134.2 77.8 61.0 0.271 0.036 D:P19438:0.036
 GOL
GOL
 9.572
6.381
 N
N
 C3
C3
5mu8 1 P01375 100.0 9e-115 X-RAY
 2017-03-29 ARG A:140 A:138 78.0 0.347 -124.0 79.3 78.0 0.347 0.0
ARG B:140 B:138 75.0 0.333 -138.4 80.0 75.0 0.333 0.0
ARG C:140 C:138 70.0 0.311 -116.1 86.0 NA NA NA
ARG D:140 D:138 73.0 0.324 -125.9 79.1 NA NA NA
ARG E:140 F:138 80.0 0.356 -118.3 76.3 NA NA NA
ARG F:140 G:138 67.0 0.298 -125.4 78.0 NA NA NA
ARG G:140 H:138 75.0 0.333 -116.7 87.4 NA NA NA
ARG H:140 I:138 74.0 0.329 -121.2 79.4 NA NA NA
ARG I:140 J:138 69.0 0.307 -118.9 89.6 NA NA NA
ARG J:140 K:138 73.0 0.324 -118.6 93.7 NA NA NA
ARG K:140 L:138 81.0 0.36 -127.2 87.2 NA NA NA
ARG L:140 M:138 73.0 0.324 -126.3 79.4 NA NA NA
ARG M:140 N:138 83.0 0.369 -120.0 88.5 NA NA NA
ARG N:140 O:138 78.0 0.347 -119.7 81.2 NA NA NA
ARG O:140 P:138 76.0 0.338 -129.2 79.9 NA NA NA
ARG P:140 Q:138 65.0 0.289 -116.6 79.9 NA NA NA
ARG Q:140 R:138 73.0 0.324 -116.7 84.7 NA NA NA
ARG R:140 S:138 68.0 0.302 -127.1 78.9 NA NA NA
ARG S:140 T:138 84.0 0.373 -119.8 72.1 NA NA NA
ARG T:140 U:138 73.0 0.324 -117.1 70.5 NA NA NA
ARG U:140 V:138 77.0 0.342 -127.7 70.7 NA NA NA
ARG V:140 W:138 73.0 0.324 -127.7 81.4 NA NA NA
ARG W:140 X:138 91.0 0.404 -128.2 79.9 NA NA NA
ARG X:140 Y:138 87.0 0.387 -124.9 79.9 NA NA NA
ARG Y:140 Z:138 76.0 0.338 -118.2 74.1 NA NA NA
ARG Z:140 a:138 69.0 0.307 -118.7 73.4 NA NA NA
ARG AA:140 b:138 81.0 0.36 -127.8 84.3 NA NA NA
ARG BA:140 c:138 86.0 0.382 -122.4 84.8 NA NA NA
ARG CA:140 d:138 73.0 0.324 -125.4 77.7 NA NA NA
ARG DA:140 e:138 70.0 0.311 -113.5 84.2 NA NA NA
ARG EA:140 f:138 76.0 0.338 -118.5 73.1 NA NA NA
ARG FA:140 g:138 78.0 0.347 -131.5 79.0 NA NA NA
ARG GA:140 h:138 85.0 0.378 -123.5 76.8 NA NA NA
ARG HA:140 i:138 72.0 0.32 -107.3 84.7 NA NA NA
ARG IA:140 j:138 90.0 0.4 -121.1 85.6 NA NA NA
ARG JA:140 k:138 66.0 0.293 -113.3 73.7 NA NA NA
ARG KA:140 l:138 83.0 0.369 -119.3 79.6 NA NA NA
ARG LA:140 m:138 75.0 0.333 -129.0 84.6 NA NA NA
ARG MA:140 n:138 72.0 0.32 -122.6 75.1 NA NA NA
ARG NA:140 o:138 79.0 0.351 -112.5 86.3 NA NA NA
ARG OA:140 p:138 87.0 0.387 -115.4 78.7 NA NA NA
ARG PA:140 q:138 82.0 0.364 -111.5 79.9 NA NA NA
ARG QA:140 r:138 78.0 0.347 -111.3 72.6 NA NA NA
ARG RA:140 s:138 73.0 0.324 -121.6 82.3 NA NA NA
ARG SA:140 t:138 81.0 0.36 -117.9 72.2 NA NA NA
ARG TA:140 u:138 70.0 0.311 -110.4 83.5 NA NA NA
ARG UA:140 v:138 77.0 0.342 -131.4 73.9 NA NA NA
ARG VA:140 w:138 83.0 0.369 -117.5 81.0 NA NA NA
6x81 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 ARG A:139 A:138 77.0 0.342 -125.6 79.4 77.0 0.342 0.0 HOH
 4.327
 CA
 O
ARG B:139 B:138 74.0 0.329 -122.6 72.1 74.0 0.329 0.0 HOH
 5.693
 N
 O
ARG C:139 C:138 81.0 0.36 -124.8 79.2 81.0 0.36 0.0 HOH
 4.782
 NH2
 O
ARG D:139 D:138 70.0 0.311 -125.3 83.7 NA NA NA
ARG E:139 E:138 72.0 0.32 -126.6 69.8 NA NA NA
ARG F:139 F:138 78.0 0.347 -121.0 82.0 NA NA NA
6x82 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 ARG A:139 A:138 75.0 0.333 -125.0 79.1 75.0 0.333 0.0 HOH
 2.878
 NH2
 O
ARG B:139 B:138 74.0 0.329 -118.5 71.4 74.0 0.329 0.0 HOH
 4.499
 NH1
 O
ARG C:139 C:138 75.0 0.333 -122.9 78.0 75.0 0.333 0.0 HOH
 4.562
 NH2
 O
ARG D:139 D:138 72.0 0.32 -120.1 75.8 NA NA NA
ARG E:139 E:138 71.0 0.316 -122.3 75.0 NA NA NA
ARG F:139 F:138 76.0 0.338 -120.2 78.7 NA NA NA
6x83 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 ARG A:139 A:138 86.0 0.382 -117.3 93.2 86.0 0.382 0.0 HOH
 6.444
 N
 O
ARG B:139 B:138 77.0 0.342 -117.6 92.4 77.0 0.342 0.0 HOH
 4.124
 NE
 O
ARG C:139 C:138 91.0 0.404 -116.6 92.7 91.0 0.404 0.0 HOH
 4.160
 NE
 O
ARG D:139 D:138 95.0 0.422 -117.4 92.7 NA NA NA
ARG E:139 E:138 82.0 0.364 -117.0 92.9 NA NA NA
ARG F:139 F:138 84.0 0.373 -117.2 92.6 NA NA NA
6x85 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 ARG A:139 A:138 77.0 0.342 -125.3 82.2 77.0 0.342 0.0
ARG B:139 B:138 86.0 0.382 -117.6 82.5 86.0 0.382 0.0
ARG C:139 C:138 80.0 0.356 -125.2 85.1 80.0 0.356 0.0
ARG D:139 D:138 88.0 0.391 -119.4 87.4 NA NA NA
ARG E:139 E:138 81.0 0.36 -121.0 85.6 NA NA NA
ARG F:139 F:138 81.0 0.36 -129.4 82.9 NA NA NA
6x86 1 P01375 100.0 9e-115 X-RAY
 2021-01-13 ARG A:139 A:138 78.0 0.347 -119.5 79.7 78.0 0.347 0.0 HOH
 6.683
 O
 O
ARG B:139 B:138 77.0 0.342 -121.0 80.1 77.0 0.342 0.0
ARG C:139 C:138 78.0 0.347 -122.3 81.7 78.0 0.347 0.0
ARG D:139 D:138 77.0 0.342 -120.1 80.0 NA NA NA
ARG E:139 E:138 78.0 0.347 -121.5 80.4 NA NA NA
ARG F:139 F:138 79.0 0.351 -122.2 81.0 NA NA NA
5yoy 1 P01375 100.0 1e-114 X-RAY
 2018-05-09 ARG A:146 A:138 73.0 0.324 -127.9 80.1 56.0 0.249 0.075 I:None:0.067
F:None:0.04
 HOH
 4.159
 NE
 O
ARG B:146 B:138 69.0 0.307 -128.6 80.2 55.0 0.244 0.063 D:None:0.031
G:None:0.058
 HOH
 7.595
 C
 O
ARG C:146 C:138 66.0 0.293 -127.6 81.0 56.0 0.249 0.044 H:None:0.044
E:None:0.031
 HOH
 3.266
 NH1
 O
ARG J:146 J:138 63.0 0.28 -128.1 79.5 NA NA NA
ARG K:146 K:138 72.0 0.32 -127.7 78.6 NA NA NA
ARG L:146 L:138 74.0 0.329 -128.0 81.2 NA NA NA
7jra 1 P01375 100.0 1e-114 X-RAY
 2020-12-09 ARG A:141 A:214 77.0 0.342 -120.1 74.0 77.0 0.342 0.0 HOH
 3.057
 NH2
 O
ARG B:141 B:214 74.0 0.329 -121.3 73.8 74.0 0.329 0.0 HOH
 2.783
 NH1
 O
ARG C:141 C:214 75.0 0.333 -119.5 73.9 75.0 0.333 0.0 HOH
 6.587
 N
 O
4g3y 3 P01375 100.0 1e-114 X-RAY
 2013-03-27 ARG C:138 C:138 75.0 0.333 -120.0 67.9 3.0 0.013 0.32 B:None:0.116
A:None:0.253
 HOH
 2.880
 NH1
 O
4twt 1 P01375 100.0 1e-114 X-RAY
 2015-02-04 ARG A:138 A:138 75.0 0.333 -127.1 76.0 75.0 0.333 0.0 HOH
 6.681
 N
 O
ARG B:138 B:138 73.0 0.324 -128.0 77.6 73.0 0.324 0.0 GOL
HOH
 5.886
9.942
 N
O
 O3
O
ARG E:138 C:138 79.0 0.351 -126.5 75.6 NA NA NA
ARG F:138 D:138 58.0 0.258 -126.4 75.9 NA NA NA
5m2i 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 ARG A:138 A:138 76.0 0.338 -122.2 78.8 13.0 0.058 0.28 H:None:0.28
 HOH
 2.768
 NH2
 O
ARG B:138 B:138 76.0 0.338 -124.5 79.6 15.0 0.067 0.271 G:None:0.271
 HOH
 4.577
 N
 O
ARG C:138 C:138 80.0 0.356 -121.9 79.0 14.0 0.062 0.294 I:None:0.293
 HOH
 4.763
 N
 O
ARG D:138 D:138 78.0 0.347 -121.2 78.0 NA NA NA
ARG E:138 E:138 77.0 0.342 -123.6 79.4 NA NA NA
ARG F:138 F:138 76.0 0.338 -122.0 77.5 NA NA NA
5m2j 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 ARG A:138 A:138 68.0 0.302 -125.9 76.2 68.0 0.302 0.0 HOH
 2.784
 NH2
 O
5m2m 1 P01375 100.0 1e-114 X-RAY
 2017-08-30 ARG A:138 A:138 82.0 0.364 -123.2 83.8 30.0 0.133 0.231 F:None:0.231
 HOH
 2.882
 NE
 O
ARG B:138 B:138 79.0 0.351 -124.2 84.4 27.0 0.12 0.231 D:None:0.231
 HOH
 4.653
 N
 O
ARG C:138 C:138 78.0 0.347 -122.9 83.7 23.0 0.102 0.245 E:None:0.244
 HOH
 2.893
 NH2
 O
ARG G:138 G:138 80.0 0.356 -123.2 84.3 NA NA NA
ARG I:138 I:138 80.0 0.356 -123.5 84.4 NA NA NA
ARG K:138 M:138 102.0 0.453 -123.4 85.1 NA NA NA
5wux 3 C1K3N5 100.0 1e-114 X-RAY
 2017-06-07 ARG G:138 E:138 118.0 0.524 -129.6 88.5 NA NA NA
ARG H:138 F:138 117.0 0.52 -122.4 86.0 23.0 0.102 0.418 B:None:0.418
ARG I:138 G:138 114.0 0.507 -121.8 90.4 NA NA NA
6ooy 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 ARG A:138 A:138 77.0 0.342 -122.9 75.4 77.0 0.342 0.0 HOH
 6.672
 N
 O
ARG B:138 B:138 82.0 0.364 -132.4 77.4 82.0 0.364 0.0 HOH
 6.541
 N
 O
ARG C:138 C:138 78.0 0.347 -117.9 74.4 78.0 0.347 0.0 HOH
 6.851
 N
 O
6ooz 1 P01375 100.0 1e-114 X-RAY
 2019-12-25 ARG A:138 A:138 77.0 0.342 -130.6 81.9 77.0 0.342 0.0 HOH
 8.979
 NH1
 O
ARG B:138 B:138 80.0 0.356 -134.4 82.2 80.0 0.356 0.0 HOH
 6.494
 N
 O
ARG C:138 C:138 77.0 0.342 -121.9 79.2 77.0 0.342 0.0 HOH
 2.544
 NH1
 O
6rmj 1 P01375 99.37 3e-114 X-RAY
 2019-10-09 ARG A:144 A:138 71.0 0.316 -118.8 73.0 71.0 0.316 0.0 HOH
 2.502
 HH11
 O
ARG B:144 B:138 65.0 0.289 -119.0 74.9 65.0 0.289 0.0 HOH
 6.834
 H
 O
ARG C:144 C:138 71.0 0.316 -119.5 73.9 71.0 0.316 0.0 HOH
 6.603
 H
 O
5uui 1 P01375 98.73 1e-113 X-RAY
 2017-08-02 ARG A:139 A:138 94.0 0.418 -127.8 82.9 94.0 0.418 0.0 MTN
HOH
 6.826
3.817
 CG
CD
 C4
O
1a8m 1 P01375 99.36 1e-113 X-RAY
 1998-06-17 ARG A:138 A:138 67.0 0.298 -131.0 69.9 67.0 0.298 0.0 HOH
 9.566
 O
 O
ARG B:138 B:138 80.0 0.356 -132.3 84.6 80.0 0.356 0.0 HOH
 7.155
 NE
 O
ARG C:138 C:138 77.0 0.342 -113.7 75.9 77.0 0.342 0.0 HOH
 4.676
 CD
 O
3wd5 1 P01375 99.36 1e-113 X-RAY
 2013-08-14 ARG A:138 A:138 85.0 0.378 -120.8 78.4 85.0 0.378 0.0 HOH
 9.663
 NH2
 O
1tnf 1 P01375 99.36 5e-113 X-RAY
 1990-01-15 ARG A:138 A:138 74.0 0.329 -124.2 69.9 74.0 0.329 0.0
ARG B:138 B:138 68.0 0.302 -137.0 87.6 68.0 0.302 0.0
ARG C:138 C:138 68.0 0.302 -136.7 83.1 68.0 0.302 0.0
2tun 1 P01375 98.73 2e-112 X-RAY
 1994-01-31 ARG A:138 A:138 100.0 0.444 -139.2 83.4 47.0 0.209 0.235 D:P01375:0.236
ARG B:138 B:138 61.0 0.271 -116.8 77.7 61.0 0.271 0.0
ARG C:138 C:138 66.0 0.293 -116.4 92.0 66.0 0.293 0.0
ARG D:138 D:138 83.0 0.369 -115.0 82.1 17.0 0.076 0.293 A:P01375:0.293
ARG E:138 E:138 87.0 0.387 -127.2 95.2 87.0 0.387 0.0
ARG F:138 F:138 88.0 0.391 -143.1 114.4 88.0 0.391 0.0
3it8 1 P01375 99.34 1e-109 X-RAY
 2009-10-20 ARG A:142 A:138 71.0 0.316 -120.0 67.0 71.0 0.316 0.0 HOH
 7.004
 N
 O
ARG B:142 B:138 72.0 0.32 -120.5 68.4 72.0 0.32 0.0 HOH
 6.946
 N
 O
ARG C:142 C:138 71.0 0.316 -119.7 68.4 71.0 0.316 0.0 HOH
 6.456
 N
 O
ARG G:142 G:138 69.0 0.307 -120.4 68.6 NA NA NA
ARG H:142 H:138 68.0 0.302 -119.8 68.3 NA NA NA
ARG I:142 I:138 71.0 0.316 -120.0 68.8 NA NA NA
3alq 1 P01375 96.18 2e-109 X-RAY
 2010-11-17 ARG A:138 A:138 72.0 0.32 -122.0 75.4 72.0 0.32 0.0
ARG B:138 B:138 76.0 0.338 -126.3 82.1 76.0 0.338 0.0
ARG C:138 C:138 75.0 0.333 -135.4 74.2 75.0 0.333 0.0
ARG D:138 D:138 79.0 0.351 -117.2 86.1 NA NA NA
ARG E:138 E:138 75.0 0.333 -125.3 72.6 NA NA NA
ARG F:138 F:138 81.0 0.36 -117.3 77.2 NA NA NA
3l9j 2 P01375 100.0 1e-108 X-RAY
 2010-02-23 ARG B:130 T:138 67.0 0.298 -130.3 71.9 27.0 0.12 0.178 A:None:0.178
 HOH
 2.961
 NH1
 O
2az5 1 P01375 100.0 6e-108 X-RAY
 2005-11-29 ARG A:129 A:138 83.0 0.369 -132.0 74.3 83.0 0.369 0.0 HOH
 4.079
 NE
 O
ARG B:129 B:138 75.0 0.333 -130.5 73.2 75.0 0.333 0.0 HOH
 2.883
 NH1
 O
ARG C:129 C:138 87.0 0.387 -130.5 75.7 87.0 0.387 0.0 HOH
 5.643
 C
 O
ARG D:129 D:138 71.0 0.316 -128.2 71.2 71.0 0.316 0.0 HOH
 2.829
 NH1
 O
4tsv 1 P01375 98.0 6e-107 X-RAY
 1998-12-30 ARG A:131 A:138 98.0 0.436 -121.0 87.4 98.0 0.436 0.0 HOH
 4.195
 NE
 O
5tsw 1 P01375 98.0 6e-107 X-RAY
 1999-05-07 ARG A:131 A:138 78.0 0.347 -135.8 78.2 78.0 0.347 0.0 HOH
 1.657
 HH11
 H2
ARG B:131 B:138 70.0 0.311 -125.8 77.0 70.0 0.311 0.0 HOH
 3.096
 HH12
 H1
ARG C:131 C:138 64.0 0.284 -124.7 73.6 64.0 0.284 0.0 HOH
 4.495
 HH21
 H1
ARG D:131 D:138 72.0 0.32 -125.2 77.2 NA NA NA
ARG E:131 E:138 82.0 0.364 -123.1 72.2 NA NA NA
ARG F:131 F:138 70.0 0.311 -122.8 76.7 NA NA NA
2e7a 1 P01375 92.36 9e-106 X-RAY
 2007-11-13 ARG A:138 A:138 71.0 0.316 -126.7 72.6 71.0 0.316 0.0 HOH
 2.781
 NH1
 O
ARG B:138 B:138 73.0 0.324 -125.1 78.7 73.0 0.324 0.0 HOH
 3.871
 NH2
 O
ARG C:138 C:138 66.0 0.293 -123.9 79.5 66.0 0.293 0.0 HOH
 2.946
 NH1
 O
2zjc 1 P01375 92.99 3e-105 X-RAY
 2009-01-20 ARG A:138 A:138 76.0 0.338 -121.4 72.0 76.0 0.338 0.0 HOH
 3.078
 NH1
 O
ARG B:138 B:138 78.0 0.347 -123.9 79.3 78.0 0.347 0.0 HOH
 3.950
 NH1
 O
ARG C:138 C:138 95.0 0.422 -119.8 110.8 95.0 0.422 0.0 HOH
 6.354
 C
 O
2zpx 1 P01375 92.36 3e-104 X-RAY
 2009-03-24 ARG A:138 A:138 73.0 0.324 -120.2 77.6 73.0 0.324 0.0 HOH
 8.207
 O
 O
ARG B:138 B:138 73.0 0.324 -120.2 76.9 73.0 0.324 0.0
ARG C:138 C:138 74.0 0.329 -119.0 78.6 74.0 0.329 0.0
7kp7 1 P06804 80.54 4e-88 X-RAY
 2021-01-13 LEU A:129 B:138 48.0 0.282 -129.4 78.6 40.0 0.235 0.047 D:P19438:0.047
 HOH
 3.445
 C
 O
LEU B:129 A:138 63.0 0.371 -129.1 82.4 53.0 0.312 0.059 F:P19438:0.059
 HOH
 3.557
 CA
 O
LEU C:129 C:138 65.0 0.382 -129.8 80.9 56.0 0.329 0.053 E:P19438:0.053
 HOH
 3.404
 C
 O
7kp8 1 P06804 80.41 1e-87 X-RAY
 2021-01-13 LEU A:128 A:137 61.0 0.359 -126.5 83.6 61.0 0.359 0.0
LEU B:128 B:137 63.0 0.371 -126.4 84.8 48.0 0.282 0.089 D:P19438:0.088
LEU C:128 C:137 61.0 0.359 -127.6 83.3 52.0 0.306 0.053 E:P19438:0.053

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p01375-f1 1 P01375 100.0 2e-174 ARG A:214 A:214 92.0 0.409 -136.9 79.5