Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 43745337 . G A CCDS4907.2:NM_003376.5:c.790Ggg>Agg_NP_003367.4:p.264G>R Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5t89 1 P15692 98.28 9e-82 X-RAY
 2017-02-01 GLY A:68 V:58 17.0 0.227 E -126.0 165.0 13.0 0.173 0.054 B:P15692:0.053
GLY B:68 W:58 16.0 0.213 E -129.0 165.2 14.0 0.187 0.026 A:P15692:0.027
3v2a 2 P15692 98.28 1e-81 X-RAY
 2012-01-18 GLY B:71 A:58 13.0 0.173 E -131.8 170.5 12.0 0.16 0.013 B:P15692:0.013
6t9d 3 P15692 99.13 2e-81 X-RAY
 2020-12-16 GLY C:58 CCC:58 26.0 0.347 E -178.5 146.7 19.0 0.253 0.094 D:P15692:0.093
 HOH
 4.674
 N
 O
GLY D:58 DDD:58 26.0 0.347 E -177.5 143.9 19.0 0.253 0.094 C:P15692:0.093
 HOH
 2.937
 CA
 O
5fv1 2 P15692 97.35 1e-78 X-RAY
 2016-02-17 GLY C:58 V:58 21.0 0.28 E -146.9 153.1 15.0 0.2 0.08 D:P15692:0.08
 HOH
 5.965
 C
 O
GLY D:58 W:58 21.0 0.28 E -151.7 154.8 17.0 0.227 0.053 C:P15692:0.053
 HOH
 8.318
 O
 O
5fv2 2 P15692 97.35 1e-78 X-RAY
 2016-02-17 GLY D:58 V:58 21.0 0.28 E -102.4 155.6 17.0 0.227 0.053 E:P15692:0.053
GLY E:58 W:58 25.0 0.333 E -99.1 162.9 21.0 0.28 0.053 D:P15692:0.053
GLY F:58 X:58 23.0 0.307 E -94.6 172.3 NA NA NA
7kez 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 GLY C:58 V:58 23.0 0.307 E -140.4 150.8 17.0 0.227 0.08 C:P15692-14:0.08
 HOH
 3.319
 CA
 O
7kf0 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 GLY C:58 V:58 20.0 0.267 E -146.7 172.6 17.0 0.227 0.04 F:P15692-14:0.04
 HOH
 6.009
 CA
 O
GLY F:58 C:58 19.0 0.253 E -144.8 172.1 17.0 0.227 0.026 C:P15692-14:0.027
 HOH
 3.710
 N
 O
7kf1 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 GLY C:58 V:58 20.0 0.267 E -140.8 170.0 17.0 0.227 0.04 C:P15692-14:0.04
 HOH
 3.691
 N
 O
GLY F:58 C:58 19.0 0.253 E -139.1 169.7 NA NA NA
GLY I:58 F:58 20.0 0.267 E -137.2 171.0 NA NA NA
GLY L:58 J:58 20.0 0.267 E -140.0 169.5 NA NA NA
3p9w 1 P15692 99.06 5e-73 X-RAY
 2012-04-18 GLY A:52 A:58 19.0 0.253 E -157.2 178.4 19.0 0.253 0.0 HOH
 3.417
 CA
 O
GLY C:52 C:58 23.0 0.307 E -153.3 173.0 NA NA NA
GLY E:52 E:58 20.0 0.267 E -147.9 -176.5 NA NA NA
GLY G:52 G:58 22.0 0.293 E -158.4 171.3 NA NA NA
6v7k 1 P15692 100.0 3e-72 X-RAY
 2020-12-09 GLY A:52 A:58 21.0 0.28 E -146.6 179.1 20.0 0.267 0.013 B:P15692:0.013
GLY B:52 B:58 21.0 0.28 E -157.7 -168.6 20.0 0.267 0.013 A:P15692:0.013
1bj1 3 P15692 100.0 6e-72 X-RAY
 1999-01-13 GLY C:51 V:58 20.0 0.267 E -159.4 176.7 20.0 0.267 0.0 HOH
 4.322
 CA
 O
GLY D:51 W:58 17.0 0.227 E -158.3 160.7 16.0 0.213 0.014 C:P15692:0.013
 HOH
 4.076
 CA
 O
1qty 1 P15692 100.0 6e-72 X-RAY
 2000-01-12 GLY A:51 V:58 20.0 0.267 E -158.5 169.1 18.0 0.24 0.027 B:P15692:0.027
GLY B:51 W:58 19.0 0.253 E -161.5 166.9 18.0 0.24 0.013 A:P15692:0.013
GLY C:51 R:58 19.0 0.253 E -160.2 165.8 NA NA NA
GLY D:51 S:58 18.0 0.24 E -163.4 170.4 NA NA NA
1tzh 1 P15692 100.0 6e-72 X-RAY
 2004-08-31 GLY A:51 V:58 25.0 0.333 E -140.8 165.3 20.0 0.267 0.066 B:P15692:0.067
 HOH
 3.223
 CA
 O
GLY B:51 W:58 43.0 0.573 -128.8 -52.6 31.0 0.413 0.16 A:P15692:0.16
 HOH
 2.814
 O
 O
1tzi 3 P15692 100.0 6e-72 X-RAY
 2004-08-31 GLY C:51 V:58 16.0 0.213 E -152.2 167.6 15.0 0.2 0.013 C:P15692:0.013
1vpf 1 P15692 100.0 6e-72 X-RAY
 1998-04-08 GLY A:51 A:58 20.0 0.267 E -154.3 174.4 18.0 0.24 0.027 B:P15692:0.027
 HOH
 3.227
 CA
 O
GLY B:51 B:58 20.0 0.267 E -156.5 176.5 19.0 0.253 0.014 A:P15692:0.013
 HOH
 3.121
 CA
 O
GLY C:51 C:58 18.0 0.24 E -150.8 174.0 NA NA NA
GLY D:51 D:58 19.0 0.253 E -148.6 173.0 NA NA NA
1vpp 1 P15692 100.0 6e-72 X-RAY
 1999-02-23 GLY A:51 V:58 21.0 0.28 E -156.1 163.9 19.0 0.253 0.027 B:P15692:0.027
 HOH
 3.783
 N
 O
GLY B:51 W:58 20.0 0.267 E -155.3 -179.7 18.0 0.24 0.027 A:P15692:0.027
 HOH
 3.680
 CA
 O
2fjg 1 Q96NW5 100.0 6e-72 X-RAY
 2006-02-07 GLY A:51 V:58 21.0 0.28 E -145.1 170.6 19.0 0.253 0.027 B:Q96NW5:0.027
GLY B:51 W:58 21.0 0.28 E -157.5 171.6 19.0 0.253 0.027 A:Q96NW5:0.027
2fjh 1 Q96NW5 100.0 6e-72 X-RAY
 2006-02-07 GLY A:51 V:58 18.0 0.24 E -165.8 170.0 17.0 0.227 0.013 A:Q96NW5:0.013
GLY D:51 W:58 17.0 0.227 E -149.1 167.0 NA NA NA
2vpf 1 P15692 100.0 6e-72 X-RAY
 1998-07-29 GLY A:51 A:58 20.0 0.267 E -162.4 167.8 NA NA NA
GLY B:51 B:58 17.0 0.227 E -156.9 172.4 NA NA NA
GLY C:51 C:58 20.0 0.267 E -153.5 167.7 18.0 0.24 0.027 D:P15692:0.027
 HOH
 3.895
 CA
 O
GLY D:51 D:58 18.0 0.24 E -151.3 167.4 16.0 0.213 0.027 C:P15692:0.027
 HOH
 3.637
 CA
 O
GLY E:51 E:58 20.0 0.267 E -159.2 174.1 NA NA NA
GLY F:51 F:58 18.0 0.24 E -149.2 176.5 NA NA NA
GLY G:51 G:58 19.0 0.253 E -157.7 169.3 NA NA NA
GLY H:51 H:58 19.0 0.253 E -148.8 -177.2 NA NA NA
3bdy 3 P15692 100.0 6e-72 X-RAY
 2008-11-18 GLY C:51 V:58 21.0 0.28 E -143.5 176.4 NA NA NA
3qtk 1 P15692 100.0 6e-72 X-RAY
 2011-07-27 GLY A:51 A:51 19.0 0.253 E -153.9 177.4 17.0 0.227 0.026 B:P15692:0.027
 ACT
HOH
 5.656
3.387
 C
CA
 O
O
GLY B:51 D:51 22.0 0.293 E -155.2 169.1 19.0 0.253 0.04 A:P15692:0.04
 TFA
HOH
 3.538
3.721
 CA
CA
 O
O
GLY C:51 B:51 18.0 0.24 E -154.2 177.6 NA NA NA
GLY D:51 C:51 19.0 0.253 E -163.8 173.4 NA NA NA
GLY E:51 E:51 17.0 0.227 E -151.7 159.4 NA NA NA
GLY F:51 F:51 19.0 0.253 E -154.3 162.6 NA NA NA
3s1k 2 P15692 100.0 6e-72 X-RAY
 2011-08-17 GLY C:51 V:58 21.0 0.28 E -154.2 168.0 17.0 0.227 0.053 D:P15692:0.053
 HOH
 6.565
 O
 O
GLY D:51 W:58 20.0 0.267 E -144.0 165.5 17.0 0.227 0.04 C:P15692:0.04
 HOH
 3.896
 CA
 O
4gln 2 P15692 100.0 6e-72 X-RAY
 2012-09-05 GLY B:51 E:51 15.0 0.2 E -155.9 167.7 15.0 0.2 0.0 DPN
HOH
 9.839
3.409
 O
CA
 CZ
O
GLY C:51 F:51 20.0 0.267 E -155.3 165.4 17.0 0.227 0.04 B:P15692:0.04
 DPN
HOH
 9.706
3.416
 O
CA
 CZ
O
4gls 4 P15692 100.0 6e-72 X-RAY
 2012-09-05 GLY E:51 E:51 19.0 0.253 E -154.2 167.3 17.0 0.227 0.026 F:P15692:0.027
 DPN
GOL
HOH
 9.848
5.415
3.214
 O
C
CA
 CZ
C1
O
GLY F:51 F:51 20.0 0.267 E -160.5 166.4 17.0 0.227 0.04 E:P15692:0.04
 DPN
HOH
 9.734
3.297
 O
CA
 CZ
O
4wpb 1 P15692 100.0 6e-72 X-RAY
 2015-04-15 GLY A:51 A:58 21.0 0.28 E -148.0 166.6 18.0 0.24 0.04 B:P15692:0.04
GLY B:51 B:58 12.0 0.16 E -146.9 165.3 11.0 0.147 0.013 A:P15692:0.013
5hhc 1 P15692 100.0 6e-72 X-RAY
 2016-03-09 GLY A:51 A:51 19.0 0.253 E -153.3 168.9 17.0 0.227 0.026 B:P15692:0.027
 DPN
GOL
HOH
 9.694
3.422
3.373
 O
CA
CA
 CZ
O1
O
GLY B:51 B:51 20.0 0.267 E -157.2 164.0 17.0 0.227 0.04 A:P15692:0.04
 DPN
GOL
HOH
 9.510
3.403
3.687
 O
CA
CA
 CZ
O1
O
5hhd 1 P15692 100.0 6e-72 X-RAY
 2016-03-09 GLY A:51 A:51 18.0 0.24 E -149.1 166.9 17.0 0.227 0.013 B:P15692:0.013
 DPN
GOL
GOL
HOH
 9.692
3.838
8.543
3.092
 O
CA
O
CA
 CZ
O3
O3
O
GLY B:51 B:51 19.0 0.253 E -161.0 163.3 17.0 0.227 0.026 A:P15692:0.027
 DPN
GOL
HOH
 9.437
4.610
3.415
 O
C
CA
 CZ
O3
O
6d3o 2 P15692 100.0 6e-72 X-RAY
 2019-04-24 GLY B:51 B:58 20.0 0.267 E -144.9 166.6 18.0 0.24 0.027 A:P15692:0.027
7ll8 1 P15692 100.0 8e-72 X-RAY
 2021-02-17 GLY A:52 A:85 22.0 0.293 E -155.8 165.9 19.0 0.253 0.04 B:P15692:0.04
 HOH
 3.387
 CA
 O
GLY B:52 B:85 24.0 0.32 E -148.7 168.9 20.0 0.267 0.053 A:P15692:0.053
 HOH
 4.042
 C
 O
7ll9 1 P15692 100.0 8e-72 X-RAY
 2021-03-03 GLY A:52 A:84 26.0 0.347 E -154.8 149.0 18.0 0.24 0.107 B:P15692:0.107
GLY B:52 B:84 27.0 0.36 E -151.6 147.0 18.0 0.24 0.12 A:P15692:0.12
GLY E:52 E:84 25.0 0.333 E -152.5 147.0 17.0 0.227 0.106 F:P15692:0.107
GLY F:52 F:84 27.0 0.36 E -151.7 148.0 17.0 0.227 0.133 E:P15692:0.133
4qaf 2 P15692 99.04 2e-71 X-RAY
 2015-05-06 GLY B:51 C:58 18.0 0.24 E -150.6 169.8 17.0 0.227 0.013 C:P15692:0.013
 SO4
HOH
 8.987
3.519
 O
CA
 O3
O
GLY C:51 D:58 18.0 0.24 E -154.7 -176.9 18.0 0.24 0.0 HOH
 3.293
 CA
 O
6bft 3 P15692 99.02 1e-70 X-RAY
 2018-10-31 GLY E:51 G:58 13.0 0.173 E -147.8 -179.9 13.0 0.173 0.0 HOH
 7.613
 CA
 O
GLY F:51 C:58 19.0 0.253 E -163.4 179.3 17.0 0.227 0.026 E:P15692:0.027
 HOH
 7.566
 CA
 O
6d3o 1 P15692 97.06 3e-70 X-RAY
 2019-04-24 GLY A:51 A:58 20.0 0.267 E -147.5 166.5 19.0 0.253 0.014 B:P15692:0.013
4zff 3 P15692 100.0 1e-69 X-RAY
 2015-07-01 GLY C:48 C:58 16.0 0.213 E -141.8 169.6 14.0 0.187 0.026 D:P15692:0.027
 HOH
 3.682
 CA
 O
GLY D:48 D:58 17.0 0.227 E -144.2 169.0 16.0 0.213 0.014 C:P15692:0.013
 HOH
 3.802
 CA
 O
4kzn 1 P15692 98.02 2e-69 X-RAY
 2014-06-04 GLY A:53 A:58 16.0 0.213 E -167.5 -179.4 16.0 0.213 0.0 SO4
HOH
 7.849
3.364
 C
CA
 O3
O
1flt 1 P15692 100.0 1e-68 X-RAY
 1999-01-13 GLY A:47 V:58 19.0 0.253 E -161.9 165.7 18.0 0.24 0.013 B:P15692:0.013
 HOH
 3.504
 CA
 O
GLY B:47 W:58 17.0 0.227 E -150.6 170.6 16.0 0.213 0.014 A:P15692:0.013
 HOH
 3.444
 CA
 O
2qr0 3 P15692 100.0 1e-67 X-RAY
 2007-08-14 GLY C:46 C:58 23.0 0.307 E -122.8 -170.0 21.0 0.28 0.027 D:P15692:0.027
GLY D:46 D:58 22.0 0.293 E -122.0 -169.8 20.0 0.267 0.026 C:P15692:0.027
GLY I:46 I:58 22.0 0.293 E -122.9 -170.4 NA NA NA
GLY J:46 J:58 24.0 0.32 E -122.7 -170.0 NA NA NA
GLY O:46 O:58 22.0 0.293 E -122.6 -170.5 NA NA NA
GLY P:46 P:58 23.0 0.307 E -122.7 -170.3 NA NA NA
GLY U:46 U:58 22.0 0.293 E -122.7 -169.6 NA NA NA
GLY V:46 V:58 22.0 0.293 E -122.5 -169.7 NA NA NA
3s1b 1 P15692 100.0 5e-67 X-RAY
 2011-08-17 GLY A:47 V:58 22.0 0.293 E -168.5 157.8 18.0 0.24 0.053 A:P15692:0.053
6zfl 1 P15692 100.0 3e-66 X-RAY
 2021-06-30 GLY A:47 V:58 20.0 0.267 E -156.1 168.9 18.0 0.24 0.027 B:P15692:0.027
 MPD
HOH
 2.073
2.627
 HA2
HA3
 HO4
O
GLY B:47 W:58 19.0 0.253 E -156.5 175.6 18.0 0.24 0.013 A:P15692:0.013
 MPD
HOH
 2.188
2.642
 HA2
HA3
 HO4
O
5o4e 4 P15692 100.0 4e-66 X-RAY
 2017-08-30 GLY E:46 E:58 24.0 0.32 E -162.3 159.0 18.0 0.24 0.08 F:P15692:0.08
 MPD
MPD
HOH
 7.521
2.400
5.492
 O
HA3
HA3
 H12
H51
O
GLY F:46 F:58 23.0 0.307 E -153.4 165.9 18.0 0.24 0.067 E:P15692:0.067
 MPD
HOH
 7.780
5.855
 O
HA2
 O2
O
6z13 2 P15692 100.0 6e-66 X-RAY
 2021-05-26 GLY B:46 V:58 20.0 0.267 E -150.9 173.6 18.0 0.24 0.027 C:P15692:0.027
 HOH
 2.948
 HA3
 O
GLY C:46 W:58 18.0 0.24 E -146.7 172.4 16.0 0.213 0.027 B:P15692:0.027
 HOH
 2.760
 HA3
 O
6z3f 2 P15692 100.0 6e-66 X-RAY
 2021-06-02 GLY B:46 V:58 19.0 0.253 E -148.4 168.5 17.0 0.227 0.026 C:P15692:0.027
 HOH
 2.554
 HA3
 O
GLY C:46 W:58 19.0 0.253 E -150.9 166.8 16.0 0.213 0.04 B:P15692:0.04
 HOH
 2.818
 HA3
 O
6zbr 2 P15692 100.0 6e-66 X-RAY
 2021-06-23 GLY B:46 V:58 19.0 0.253 E -157.3 168.0 17.0 0.227 0.026 C:P15692:0.027
 HOH
 2.746
 HA3
 O
GLY C:46 W:58 17.0 0.227 E -153.1 169.3 16.0 0.213 0.014 B:P15692:0.013
 HOH
 2.768
 HA3
 O
6zcd 2 P15692 100.0 6e-66 X-RAY
 2021-06-23 GLY B:46 V:58 21.0 0.28 E -155.4 170.4 18.0 0.24 0.04 C:P15692:0.04
 HOH
 2.601
 HA3
 O
GLY C:46 W:58 18.0 0.24 E -158.1 165.8 16.0 0.213 0.027 B:P15692:0.027
 HOH
 2.759
 HA3
 O
1cz8 1 P15692 100.0 2e-65 X-RAY
 2000-03-20 GLY A:45 V:58 20.0 0.267 E -153.6 149.7 18.0 0.24 0.027 B:P15692:0.027
 HOH
 3.517
 CA
 O
GLY B:45 W:58 19.0 0.253 E -143.1 153.1 16.0 0.213 0.04 A:P15692:0.04
 HOH
 3.888
 CA
 O
4gls 1 ? 96.08 5e-65 X-RAY
 2012-09-05 GLY A:51 A:51 20.0 0.267 E 152.1 -164.6 17.0 0.227 0.04 B:None:0.04
GLY B:51 B:51 16.0 0.213 E 156.8 -171.5 15.0 0.2 0.013 A:None:0.013
4glu 1 ? 96.08 5e-65 X-RAY
 2012-09-05 GLY A:51 A:51 16.0 0.213 E 156.3 179.7 16.0 0.213 0.0
GLY B:51 D:51 22.0 0.293 E 160.2 -169.6 19.0 0.253 0.04 A:None:0.04
GLY C:51 B:51 18.0 0.24 E 155.2 -174.1 NA NA NA
GLY D:51 C:51 20.0 0.267 E 151.6 -175.3 NA NA NA
GLY E:51 E:51 19.0 0.253 E 153.2 -165.4 NA NA NA
GLY F:51 F:51 20.0 0.267 E 158.1 -169.4 NA NA NA
5hhd 3 ? 96.08 5e-65 X-RAY
 2016-03-09 GLY E:51 E:51 20.0 0.267 E 155.7 -170.4 NA NA NA
GLY F:51 F:51 21.0 0.28 E 155.4 -163.8 NA NA NA
1mkg 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 GLY A:46 A:58 20.0 0.267 E -159.3 171.5 17.0 0.227 0.04 B:P15692:0.04
 HOH
 3.869
 CA
 O
GLY B:46 B:58 19.0 0.253 E -144.3 -178.9 17.0 0.227 0.026 A:P15692:0.027
 HOH
 4.687
 C
 O
GLY C:46 C:58 18.0 0.24 E -152.6 165.4 NA NA NA
GLY D:46 D:58 19.0 0.253 E -158.6 173.3 NA NA NA
1mjv 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 GLY A:46 A:58 23.0 0.307 E -161.7 158.7 19.0 0.253 0.054 B:P15692:0.053
 HOH
 3.708
 CA
 O
GLY B:46 B:58 20.0 0.267 E -160.3 153.4 17.0 0.227 0.04 A:P15692:0.04
 HOH
 3.677
 CA
 O
1mkk 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 GLY A:46 A:58 21.0 0.28 E -143.3 143.1 17.0 0.227 0.053 B:P15692:0.053
 HOH
 2.833
 O
 O
GLY B:46 B:58 20.0 0.267 E -147.8 145.7 17.0 0.227 0.04 A:P15692:0.04
 HOH
 2.893
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15692-f1 1 P15692 100.0 3e-178 GLY A:84 A:84 19.0 0.253 E -145.6 169.0