Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr6 43746261 . A C CCDS4907.2:NM_003376.5:c.920aAa>aCa_NP_003367.4:p.307K>T Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
5t89 1 P15692 98.28 9e-82 X-RAY
 2017-02-01 LYS A:111 V:101 121.0 0.605 E -140.7 140.6 121.0 0.605 0.0
LYS B:111 W:101 116.0 0.58 E -142.5 139.0 107.0 0.535 0.045 C:P17948:0.045
3v2a 2 P15692 98.28 1e-81 X-RAY
 2012-01-18 LYS B:114 A:101 26.0 NA E -121.4 132.5 26.0 NA NA
6t9d 3 P15692 99.13 2e-81 X-RAY
 2020-12-16 LYS C:101 CCC:101 107.0 0.535 E -144.0 149.2 13.0 0.065 0.47 E:None:0.29
F:None:0.365
 HOH
 4.368
 NZ
 O
LYS D:101 DDD:101 110.0 0.55 E -143.9 148.2 17.0 0.085 0.465 A:None:0.295
B:None:0.355
 HOH
 3.557
 NZ
 O
5fv1 2 P15692 97.35 1e-78 X-RAY
 2016-02-17 LYS C:101 V:101 118.0 0.59 E -143.3 142.4 118.0 0.59 0.0 HOH
 8.240
 C
 O
LYS D:101 W:101 109.0 0.545 E -139.9 141.2 109.0 0.545 0.0
5fv2 2 P15692 97.35 1e-78 X-RAY
 2016-02-17 LYS D:101 V:101 115.0 0.575 E -155.1 142.2 111.0 0.555 0.02 B:None:0.02
LYS E:101 W:101 118.0 0.59 E -136.2 133.2 118.0 0.59 0.0
LYS F:101 X:101 112.0 0.56 E -141.6 133.8 NA NA NA
7kez 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 LYS C:101 V:101 130.0 0.65 E -136.9 127.6 130.0 0.65 0.0
7kf0 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 LYS C:101 V:101 121.0 0.605 E -142.0 136.3 121.0 0.605 0.0 HOH
 7.786
 O
 O
LYS F:101 C:101 116.0 0.58 E -140.8 136.0 116.0 0.58 0.0 HOH
 5.026
 C
 O
7kf1 3 P15692-14 97.35 1e-78 X-RAY
 2021-11-10 LYS C:101 V:101 109.0 0.545 E -148.1 136.5 109.0 0.545 0.0 HOH
 3.426
 C
 O
LYS F:101 C:101 122.0 0.61 E -147.7 136.4 NA NA NA
LYS I:101 F:101 120.0 0.6 E -146.5 137.7 NA NA NA
LYS L:101 J:101 127.0 0.635 E -148.5 136.1 NA NA NA
3p9w 1 P15692 99.06 5e-73 X-RAY
 2012-04-18 LYS A:95 A:101 87.0 0.435 E -150.9 142.8 87.0 0.435 0.0 HOH
 3.258
 NZ
 O
LYS C:95 C:101 87.0 0.435 E -157.5 149.2 NA NA NA
LYS E:95 E:101 93.0 0.465 E -160.5 140.9 NA NA NA
LYS G:95 G:101 93.0 0.465 E -157.7 144.3 NA NA NA
6v7k 1 P15692 100.0 3e-72 X-RAY
 2020-12-09 LYS A:95 A:101 32.0 NA E -135.4 146.2 32.0 NA NA
LYS B:95 B:101 30.0 NA E -142.7 152.5 30.0 NA NA
1bj1 3 P15692 100.0 6e-72 X-RAY
 1999-01-13 LYS C:94 V:101 98.0 0.49 E -145.3 136.9 98.0 0.49 0.0 HOH
 3.856
 CG
 O
LYS D:94 W:101 103.0 0.515 E -142.6 140.4 103.0 0.515 0.0 HOH
 3.562
 CG
 O
1qty 1 P15692 100.0 6e-72 X-RAY
 2000-01-12 LYS A:94 V:101 121.0 0.605 E -143.8 132.7 121.0 0.605 0.0
LYS B:94 W:101 118.0 0.59 E -137.4 133.9 108.0 0.54 0.05 E:P17948:0.05
LYS C:94 R:101 116.0 0.58 E -142.8 132.4 NA NA NA
LYS D:94 S:101 120.0 0.6 E -141.7 138.0 NA NA NA
1tzh 1 P15692 100.0 6e-72 X-RAY
 2004-08-31 LYS A:94 V:101 92.0 0.46 E -136.8 149.3 92.0 0.46 0.0 HOH
 6.030
 O
 O
LYS B:94 W:101 115.0 0.575 E -141.5 131.0 115.0 0.575 0.0 HOH
 3.625
 CA
 O
1tzi 3 P15692 100.0 6e-72 X-RAY
 2004-08-31 LYS C:94 V:101 116.0 0.58 E -152.1 140.5 116.0 0.58 0.0
1vpf 1 P15692 100.0 6e-72 X-RAY
 1998-04-08 LYS A:94 A:101 110.0 0.55 E -154.7 136.8 110.0 0.55 0.0 HOH
 3.678
 CA
 O
LYS B:94 B:101 110.0 0.55 E -155.9 139.8 110.0 0.55 0.0 HOH
 2.972
 CG
 O
LYS C:94 C:101 113.0 0.565 E -150.5 134.2 NA NA NA
LYS D:94 D:101 107.0 0.535 E -153.6 137.5 NA NA NA
1vpp 1 P15692 100.0 6e-72 X-RAY
 1999-02-23 LYS A:94 V:101 128.0 0.64 E -141.1 150.3 128.0 0.64 0.0 HOH
 2.864
 NZ
 O
LYS B:94 W:101 113.0 0.565 E -147.7 146.4 113.0 0.565 0.0 HOH
 3.390
 CG
 O
2fjg 1 Q96NW5 100.0 6e-72 X-RAY
 2006-02-07 LYS A:94 V:101 123.0 0.615 E -124.7 150.1 123.0 0.615 0.0
LYS B:94 W:101 109.0 0.545 E -130.8 149.3 109.0 0.545 0.0
2fjh 1 Q96NW5 100.0 6e-72 X-RAY
 2006-02-07 LYS A:94 V:101 116.0 0.58 E -132.0 140.3 42.0 0.21 0.37 B:None:0.37
LYS D:94 W:101 90.0 0.45 E -130.2 131.9 NA NA NA
2vpf 1 P15692 100.0 6e-72 X-RAY
 1998-07-29 LYS A:94 A:101 126.0 0.63 E -146.7 142.4 NA NA NA
LYS B:94 B:101 122.0 0.61 E -147.9 150.4 NA NA NA
LYS C:94 C:101 123.0 0.615 E -155.5 138.7 123.0 0.615 0.0 HOH
 3.885
 C
 O
LYS D:94 D:101 105.0 0.525 E -147.3 144.6 105.0 0.525 0.0 HOH
 4.067
 CA
 O
LYS E:94 E:101 115.0 0.575 E -151.1 151.0 NA NA NA
LYS F:94 F:101 105.0 0.525 E -150.1 150.4 NA NA NA
LYS G:94 G:101 116.0 0.58 E -141.8 145.3 NA NA NA
LYS H:94 H:101 104.0 0.52 E -143.7 145.9 NA NA NA
3bdy 3 P15692 100.0 6e-72 X-RAY
 2008-11-18 LYS C:94 V:101 106.0 0.53 E -151.2 145.7 NA NA NA
3qtk 1 P15692 100.0 6e-72 X-RAY
 2011-07-27 LYS A:94 A:94 107.0 0.535 E -158.5 149.4 107.0 0.535 0.0 GOL
HOH
 6.964
2.931
 O
CE
 C2
O
LYS B:94 D:94 114.0 0.57 E -142.6 148.6 114.0 0.57 0.0 TFA
HOH
 6.561
3.371
 O
CA
 F3
O
LYS C:94 B:94 109.0 0.545 E -160.7 149.3 NA NA NA
LYS D:94 C:94 99.0 0.495 E -152.3 145.7 NA NA NA
LYS E:94 E:94 81.0 0.405 E -144.5 141.4 NA NA NA
LYS F:94 F:94 122.0 0.61 E -148.5 146.2 NA NA NA
3s1k 2 P15692 100.0 6e-72 X-RAY
 2011-08-17 LYS C:94 V:101 116.0 0.58 E -135.8 139.0 116.0 0.58 0.0 HOH
 4.152
 CD
 O
LYS D:94 W:101 112.0 0.56 E -131.6 142.2 112.0 0.56 0.0 HOH
 5.655
 N
 O
4gln 2 P15692 100.0 6e-72 X-RAY
 2012-09-05 LYS B:94 E:94 107.0 0.535 E -145.9 145.2 107.0 0.535 0.0 DAS
HOH
 8.874
3.777
 CE
CA
 OD2
O
LYS C:94 F:94 115.0 0.575 E -151.2 145.0 115.0 0.575 0.0 DVA
DAS
HOH
 9.852
8.517
3.192
 NZ
CE
CE
 CG2
OD2
O
4gls 4 P15692 100.0 6e-72 X-RAY
 2012-09-05 LYS E:94 E:94 107.0 0.535 E -148.7 142.7 107.0 0.535 0.0 DAS
DPN
HOH
 7.364
8.777
3.178
 NZ
NZ
NZ
 OD1
CD1
O
LYS F:94 F:94 100.0 0.5 E -151.6 143.9 100.0 0.5 0.0 DVA
DAS
HOH
 9.798
8.600
2.913
 NZ
CE
NZ
 CG1
OD2
O
4wpb 1 P15692 100.0 6e-72 X-RAY
 2015-04-15 LYS A:94 A:101 99.0 0.495 -150.8 149.7 99.0 0.495 0.0
LYS B:94 B:101 23.0 NA E -152.0 149.7 23.0 NA NA
5hhc 1 P15692 100.0 6e-72 X-RAY
 2016-03-09 LYS A:94 A:94 115.0 0.575 E -148.4 145.3 115.0 0.575 0.0 HOH
 3.696
 C
 O
LYS B:94 B:94 109.0 0.545 E -150.7 145.8 109.0 0.545 0.0 DVA
DAS
HOH
 9.581
8.834
3.579
 CD
CD
CA
 CG2
OD2
O
5hhd 1 P15692 100.0 6e-72 X-RAY
 2016-03-09 LYS A:94 A:94 127.0 0.635 E -147.2 146.9 127.0 0.635 0.0 DAR
HOH
 8.625
3.633
 NZ
CA
 NH2
O
LYS B:94 B:94 133.0 0.665 E -147.8 152.6 133.0 0.665 0.0 DVA
DAS
HOH
 8.792
8.467
3.711
 NZ
NZ
CA
 CG2
OD2
O
6d3o 2 P15692 100.0 6e-72 X-RAY
 2019-04-24 LYS B:94 B:101 41.0 NA E -133.6 147.0 41.0 NA NA
7ll8 1 P15692 100.0 8e-72 X-RAY
 2021-02-17 LYS A:95 A:128 95.0 0.475 E -144.0 146.1 75.0 0.375 0.1 D:None:0.1
 DTH
DIL
DPR
DTY
HOH
 9.758
6.925
8.448
4.410
3.512
 NZ
NZ
NZ
NZ
CG
 CA
CG1
CB
OH
O
LYS B:95 B:128 25.0 NA E -148.2 149.0 25.0 NA NA DTY
HOH
 8.332
3.572
 CB
C
 OH
O
7ll9 1 P15692 100.0 8e-72 X-RAY
 2021-03-03 LYS A:95 A:127 117.0 0.585 E -139.4 130.6 117.0 0.585 0.0
LYS B:95 B:127 109.0 0.545 E -139.0 130.1 109.0 0.545 0.0
LYS E:95 E:127 123.0 0.615 E -139.5 131.2 123.0 0.615 0.0 DGN
DSG
DGL
 8.537
8.858
6.866
 CB
O
O
 NE2
OD1
OE1
LYS F:95 F:127 118.0 0.59 E -138.8 130.0 118.0 0.59 0.0
4qaf 2 P15692 99.04 2e-71 X-RAY
 2015-05-06 LYS B:94 C:101 121.0 0.605 E -151.4 149.9 58.0 0.29 0.315 A:P31025:0.315
 SO4
HOH
 4.446
3.304
 NZ
NZ
 O1
O
LYS C:94 D:101 120.0 0.6 E -149.0 144.2 102.0 0.51 0.09 D:P31025:0.09
 HOH
 3.860
 CA
 O
6bft 3 P15692 99.02 1e-70 X-RAY
 2018-10-31 LYS E:94 G:101 113.0 0.565 E -143.2 144.2 113.0 0.565 0.0
LYS F:94 C:101 122.0 0.61 E -141.1 140.6 122.0 0.61 0.0
6d3o 1 P15692 97.06 3e-70 X-RAY
 2019-04-24 LYS A:94 A:101 146.0 0.73 E -134.5 147.9 146.0 0.73 0.0
4zff 3 P15692 100.0 1e-69 X-RAY
 2015-07-01 LYS C:91 C:101 114.0 0.57 E -144.1 138.8 114.0 0.57 0.0 HOH
 7.823
 CE
 O
LYS D:91 D:101 115.0 0.575 E -142.8 138.9 115.0 0.575 0.0 HOH
 3.545
 CA
 O
4kzn 1 P15692 98.02 2e-69 X-RAY
 2014-06-04 LYS A:96 A:101 107.0 0.535 E -142.5 147.1 107.0 0.535 0.0 HOH
 3.503
 CA
 O
1flt 1 P15692 100.0 1e-68 X-RAY
 1999-01-13 LYS A:90 V:101 110.0 0.55 E -139.4 147.3 110.0 0.55 0.0 HOH
 3.545
 CA
 O
LYS B:90 W:101 117.0 0.585 E -152.9 143.4 117.0 0.585 0.0 HOH
 3.473
 CG
 O
2qr0 3 P15692 100.0 1e-67 X-RAY
 2007-08-14 LYS C:89 C:101 126.0 0.63 E -149.3 135.7 126.0 0.63 0.0
LYS D:89 D:101 128.0 0.64 E -149.3 134.7 128.0 0.64 0.0
LYS I:89 I:101 127.0 0.635 E -148.7 134.8 NA NA NA
LYS J:89 J:101 127.0 0.635 E -149.6 135.2 NA NA NA
LYS O:89 O:101 127.0 0.635 E -149.3 135.1 NA NA NA
LYS P:89 P:101 127.0 0.635 E -149.2 135.3 NA NA NA
LYS U:89 U:101 128.0 0.64 E -149.4 135.4 NA NA NA
LYS V:89 V:101 129.0 0.645 E -149.3 135.5 NA NA NA
3s1b 1 P15692 100.0 5e-67 X-RAY
 2011-08-17 LYS A:90 V:101 118.0 0.59 E -143.1 138.6 118.0 0.59 0.0
6zfl 1 P15692 100.0 3e-66 X-RAY
 2021-06-30 LYS A:90 V:101 120.0 0.6 E -147.0 149.5 120.0 0.6 0.0 MPD
HOH
 8.983
2.159
 H
HZ2
 H52
O
LYS B:90 W:101 122.0 0.61 E -148.2 145.6 122.0 0.61 0.0 MPD
HOH
 9.077
2.480
 H
HZ2
 H52
O
5o4e 4 P15692 100.0 4e-66 X-RAY
 2017-08-30 LYS E:89 E:101 102.0 0.51 E -145.0 142.5 102.0 0.51 0.0 MPD
HOH
 8.156
2.572
 HA
HA
 H4
O
LYS F:89 F:101 111.0 0.555 E -133.4 145.8 111.0 0.555 0.0 CAC
MPD
 7.314
7.050
 HZ1
HA
 H21
HM2
6z13 2 P15692 100.0 6e-66 X-RAY
 2021-05-26 LYS B:89 V:101 119.0 0.595 E -144.3 140.9 119.0 0.595 0.0 HOH
 2.736
 HA
 O
LYS C:89 W:101 98.0 0.49 E -147.6 144.4 98.0 0.49 0.0 HOH
 5.293
 N
 O
6z3f 2 P15692 100.0 6e-66 X-RAY
 2021-06-02 LYS B:89 V:101 120.0 0.6 E -144.7 146.4 120.0 0.6 0.0 HOH
 2.931
 HA
 O
LYS C:89 W:101 116.0 0.58 E -148.9 150.4 116.0 0.58 0.0 HOH
 2.742
 HG2
 O
6zbr 2 P15692 100.0 6e-66 X-RAY
 2021-06-23 LYS B:89 V:101 108.0 0.54 E -149.6 142.3 108.0 0.54 0.0 HOH
 2.821
 HA
 O
LYS C:89 W:101 121.0 0.605 E -148.9 142.7 121.0 0.605 0.0 HOH
 2.699
 HA
 O
6zcd 2 P15692 100.0 6e-66 X-RAY
 2021-06-23 LYS B:89 V:101 116.0 0.58 E -144.1 148.5 116.0 0.58 0.0 HOH
 2.676
 HA
 O
LYS C:89 W:101 124.0 0.62 E -149.5 145.8 124.0 0.62 0.0 HOH
 2.780
 HA
 O
1cz8 1 P15692 100.0 2e-65 X-RAY
 2000-03-20 LYS A:88 V:101 102.0 0.51 E -138.9 137.6 102.0 0.51 0.0 HOH
 2.516
 CA
 O
LYS B:88 W:101 104.0 0.52 E -135.3 138.5 104.0 0.52 0.0 HOH
 3.505
 C
 O
4gls 1 ? 96.08 5e-65 X-RAY
 2012-09-05 DLY A:94 A:94 NA NA NA NA NA NA NA NA
DLY B:94 B:94 NA NA NA NA NA NA NA NA
4glu 1 ? 96.08 5e-65 X-RAY
 2012-09-05 DLY A:94 A:94 NA NA NA NA NA NA NA NA
DLY B:94 D:94 NA NA NA NA NA NA NA NA
DLY C:94 B:94 NA NA NA NA NA NA NA NA
DLY D:94 C:94 NA NA NA NA NA NA NA NA
DLY E:94 E:94 NA NA NA NA NA NA NA NA
DLY F:94 F:94 NA NA NA NA NA NA NA NA
5hhd 3 ? 96.08 5e-65 X-RAY
 2016-03-09 DLY E:94 E:94 NA NA NA NA NA NA NA NA
DLY F:94 F:94 NA NA NA NA NA NA NA NA
1mkg 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 LYS A:89 A:101 119.0 0.595 E -140.3 142.0 119.0 0.595 0.0 HOH
 3.234
 CA
 O
LYS B:89 B:101 101.0 0.505 E -146.6 136.6 101.0 0.505 0.0
LYS C:89 C:101 123.0 0.615 E -141.6 153.5 NA NA NA
LYS D:89 D:101 121.0 0.605 E -150.0 155.0 NA NA NA
1mjv 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 LYS A:89 A:101 100.0 0.5 E -144.4 141.9 100.0 0.5 0.0 HOH
 3.346
 CD
 O
LYS B:89 B:101 100.0 0.5 E -149.4 136.7 100.0 0.5 0.0 HOH
 2.853
 NZ
 O
1mkk 1 P15692 97.89 4e-64 X-RAY
 2002-12-11 LYS A:89 A:101 111.0 0.555 E -147.2 148.7 111.0 0.555 0.0 HOH
 3.465
 CA
 O
LYS B:89 B:101 124.0 0.62 E -146.3 151.7 124.0 0.62 0.0 HOH
 3.510
 CA
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p15692-f1 1 P15692 100.0 3e-178 LYS A:127 A:127 116.0 0.58 E -139.0 144.2