Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr7 | 100771762 | . | T | A | CCDS5711.1:NM_000602.4:c.88Tac>Aac_NP_000593.1:p.30Y>N | Homo sapiens serpin family E member 1 (SERPINE1), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1c5g | 1 | P05121 | 100.0 | 0.0 |
X-RAY |
1999-12-17 | TYR | A:30 | A:30 | 116.0 | 0.504 | H | -59.9 | -48.3 | 116.0 | 0.504 | 0.0 | ||||||
| 1dvn | 1 | P05121 | 100.0 | 0.0 |
X-RAY |
2000-09-13 | TYR | A:7 | A:7 | 113.0 | 0.491 | H | -58.3 | -58.4 | 113.0 | 0.491 | 0.0 |
HOH |
3.914 |
OH |
O |
||
| 1lj5 | 1 | P05121 | 100.0 | 0.0 |
X-RAY |
2002-05-08 | TYR | A:7 | A:7 | 122.0 | 0.53 | H | -68.4 | -52.5 | 122.0 | 0.53 | 0.0 |
DMS HOH |
7.103 2.842 |
N OH |
O O |
||
| 4aqh | 1 | P05121 | 100.0 | 0.0 |
X-RAY |
2012-11-28 | TYR | A:11 | A:7 | 50.0 | 0.217 | G | -115.8 | 10.3 | 50.0 | 0.217 | 0.0 |
TB7 HOH |
7.820 4.568 |
C CB |
C1 O |
||
| TYR | B:11 | B:7 | 44.0 | 0.191 | G | -124.6 | 17.0 | NA | NA | NA | |||||||||||||
| TYR | C:11 | C:7 | 46.0 | 0.2 | G | -110.9 | 8.4 | NA | NA | NA | |||||||||||||
| 1a7c | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
1999-03-23 | TYR | A:7 | A:7 | 110.0 | 0.478 | H | -60.1 | -45.1 | 110.0 | 0.478 | 0.0 |
HOH |
3.085 |
OH |
O |
||
| 3q02 | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
2011-06-22 | TYR | A:7 | A:7 | 158.0 | 0.687 | H | -54.4 | -52.3 | 158.0 | 0.687 | 0.0 |
HOH |
3.516 |
CB |
O |
||
| TYR | B:7 | B:7 | 157.0 | 0.683 | H | -65.3 | -45.9 | NA | NA | NA | |||||||||||||
| 3q03 | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
2011-06-22 | TYR | A:7 | A:7 | 163.0 | 0.709 | H | -50.6 | -47.3 | 163.0 | 0.709 | 0.0 |
HOH |
6.907 |
N |
O |
||
| TYR | B:7 | B:7 | 136.0 | 0.591 | H | -62.1 | -51.1 | NA | NA | NA | |||||||||||||
| 6gwn | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
2020-01-01 | TYR | A:7 | A:7 | 99.0 | 0.43 | H | -64.7 | -56.5 | 99.0 | 0.43 | 0.0 |
HOH |
4.256 |
OH |
O |
||
| 6zrv | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
2020-08-26 | TYR | A:7 | A:7 | 113.0 | NA | 360.0 | 152.5 | 113.0 | NA | NA |
HOH |
5.429 |
N |
O |
|||
| 7aqg | 1 | P05121 | 99.74 | 0.0 |
X-RAY |
2021-02-24 | TYR | A:7 | A:7 | 122.0 | 0.53 | H | -75.4 | -32.2 | 122.0 | 0.53 | 0.0 |
HOH |
7.581 |
O |
O |
||
| 3r4l | 1 | P05121 | 99.47 | 0.0 |
X-RAY |
2011-11-02 | TYR | A:7 | A:30 | 112.0 | 0.487 | H | -48.0 | -51.8 | 112.0 | 0.487 | 0.0 |
HOH |
3.262 |
CD2 |
O |
||
| 3cvm | 1 | P05121 | 98.69 | 0.0 |
X-RAY |
2008-08-19 | TYR | A:20 | A:7 | 83.0 | 0.361 | H | -64.0 | -57.8 | 83.0 | 0.361 | 0.0 |
HOH |
2.501 |
OH |
O |
||
| TYR | B:20 | B:7 | 100.0 | 0.435 | H | -57.9 | -54.7 | NA | NA | NA | |||||||||||||
| 1b3k | 1 | P05121 | 98.94 | 0.0 |
X-RAY |
1999-12-11 | TYR | A:7 | A:7 | 196.0 | 0.852 | 360.0 | -42.4 | 196.0 | 0.852 | 0.0 | |||||||
| TYR | B:7 | B:7 | 185.0 | 0.804 | 360.0 | -17.7 | NA | NA | NA | ||||||||||||||
| TYR | C:7 | C:7 | 177.0 | 0.77 | 360.0 | -18.9 | NA | NA | NA | ||||||||||||||
| TYR | D:7 | D:7 | 184.0 | 0.8 | 360.0 | -14.9 | NA | NA | NA | ||||||||||||||
| 1oc0 | 1 | P05121 | 98.94 | 0.0 |
X-RAY |
2003-06-19 | TYR | A:7 | A:7 | 160.0 | 0.696 | H | -60.6 | -36.0 | 160.0 | 0.696 | 0.0 |
HOH |
6.280 |
N |
O |
||
| 5brr | 1 | P05121 | 98.94 | 0.0 |
X-RAY |
2015-09-02 | TYR | A:7 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6i8s | 1 | P05121 | 98.94 | 0.0 |
X-RAY |
2019-02-13 | TYR | A:7 | A:7 | 160.0 | 0.696 | H | -64.9 | -38.1 | 160.0 | 0.696 | 0.0 | ||||||
| TYR | B:7 | B:7 | 157.0 | 0.683 | H | -73.4 | -41.3 | NA | NA | NA | |||||||||||||
| TYR | C:7 | C:7 | 164.0 | 0.713 | H | -66.5 | -52.9 | NA | NA | NA | |||||||||||||
| TYR | D:7 | D:7 | 170.0 | 0.739 | H | -73.9 | -37.9 | NA | NA | NA | |||||||||||||
| 1dvm | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2000-09-06 | TYR | A:7 | A:7 | 135.0 | 0.587 | H | -69.2 | -65.9 | 135.0 | 0.587 | 0.0 |
HOH |
3.600 |
CE2 |
O |
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| TYR | B:7 | B:7 | 113.0 | 0.491 | H | -63.2 | -56.1 | NA | NA | NA | |||||||||||||
| TYR | C:7 | C:7 | 145.0 | 0.63 | H | -63.9 | -54.1 | NA | NA | NA | |||||||||||||
| TYR | D:7 | D:7 | 118.0 | 0.513 | S | -77.5 | -63.0 | NA | NA | NA | |||||||||||||
| 3pb1 | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2010-12-29 | TYR | A:7 | I:7 | 144.0 | 0.626 | H | -66.4 | -58.2 | 144.0 | 0.626 | 0.0 |
HOH |
2.513 |
OH |
O |
||
| 4ic0 | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2013-12-11 | TYR | A:7 | A:7 | 139.0 | 0.604 | H | -67.6 | -40.0 | 139.0 | 0.604 | 0.0 | ||||||
| TYR | B:7 | B:7 | 118.0 | 0.513 | H | -66.5 | -47.2 | NA | NA | NA | |||||||||||||
| TYR | C:7 | C:7 | 124.0 | 0.539 | H | -33.7 | -53.5 | NA | NA | NA | |||||||||||||
| TYR | D:7 | D:7 | 112.0 | 0.487 | H | -63.3 | -55.0 | NA | NA | NA | |||||||||||||
| 3eox | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2009-02-17 | TYR | A:7 | A:7 | 106.0 | 0.461 | H | -66.1 | -55.7 | 106.0 | 0.461 | 0.0 |
HOH |
3.839 |
CE1 |
O |
||
| 6gwp | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2020-01-01 | TYR | A:7 | A:7 | 144.0 | 0.626 | -96.3 | -30.7 | 144.0 | 0.626 | 0.0 | |||||||
| 6gwq | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2020-01-01 | TYR | A:7 | A:7 | 131.0 | 0.57 | H | -49.5 | -62.9 | 131.0 | 0.57 | 0.0 | ||||||
| 7aqf | 1 | P05121 | 98.68 | 0.0 |
X-RAY |
2021-02-17 | TYR | A:7 | A:7 | 140.0 | 0.609 | H | -63.5 | -45.9 | 140.0 | 0.609 | 0.0 |
HOH |
2.303 |
OH |
O |
||
| TYR | B:7 | B:7 | 190.0 | 0.826 | 360.0 | -53.8 | NA | NA | NA | ||||||||||||||
| 1db2 | 1 | P05121 | 98.67 | 0.0 |
X-RAY |
1999-11-10 | TYR | A:5 | A:7 | 97.0 | 0.422 | H | -70.1 | -42.9 | 97.0 | 0.422 | 0.0 | ||||||
| TYR | B:5 | B:7 | 96.0 | 0.417 | H | -58.6 | -42.4 | 96.0 | 0.417 | 0.0 | |||||||||||||
| 4g8o | 1 | P05121 | 98.93 | 0.0 |
X-RAY |
2013-12-25 | TYR | A:4 | A:7 | 121.0 | 0.526 | H | -67.8 | -47.8 | 121.0 | 0.526 | 0.0 |
HOH |
9.015 |
OH |
O |
||
| TYR | B:4 | B:7 | 117.0 | 0.509 | H | -68.4 | -45.8 | NA | NA | NA | |||||||||||||
| TYR | C:4 | C:7 | 132.0 | 0.574 | H | -67.4 | -47.0 | NA | NA | NA | |||||||||||||
| TYR | D:4 | D:7 | 137.0 | 0.596 | H | -69.1 | -44.1 | NA | NA | NA | |||||||||||||
| 4g8r | 1 | P05121 | 98.93 | 0.0 |
X-RAY |
2013-12-25 | TYR | A:4 | A:7 | 140.0 | 0.609 | H | -63.9 | -56.4 | 140.0 | 0.609 | 0.0 |
HOH |
3.472 |
N |
O |
||
| TYR | B:4 | B:7 | 138.0 | 0.6 | H | -67.1 | -47.9 | NA | NA | NA | |||||||||||||
| 3ut3 | 1 | P05121 | 98.93 | 0.0 |
X-RAY |
2013-02-06 | TYR | A:3 | A:7 | 176.0 | 0.765 | 360.0 | -54.7 | 176.0 | 0.765 | 0.0 | |||||||
| TYR | B:3 | B:7 | 125.0 | 0.543 | H | -64.3 | -56.3 | NA | NA | NA | |||||||||||||
| TYR | C:3 | C:7 | 198.0 | 0.861 | 360.0 | -76.9 | NA | NA | NA | ||||||||||||||
| TYR | D:3 | D:7 | 137.0 | 0.596 | H | -56.9 | -58.3 | NA | NA | NA | |||||||||||||
| 5zlz | 1 | P05121 | 98.93 | 0.0 |
X-RAY |
2019-04-03 | TYR | A:2 | I:7 | 170.0 | 0.739 | T | -65.1 | -10.0 | 170.0 | 0.739 | 0.0 | ||||||
| 9pai | 1 | P05121 | 99.71 | 0.0 |
X-RAY |
1999-03-19 | TYR | A:7 | A:25 | 127.0 | 0.552 | H | -81.6 | -48.9 | 127.0 | 0.552 | 0.0 | ||||||
| 3lw2 | 1 | P22777 | 80.75 | 0.0 |
X-RAY |
2010-04-07 | HIS | A:7 | A:7 | 163.0 | 0.836 | 360.0 | -62.0 | 163.0 | 0.836 | 0.0 |
HOH |
3.309 |
ND1 |
O |
|||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p05121-f1 | 1 | P05121 | 100.0 | 0.0 | TYR | A:30 | A:30 | 101.0 | 0.439 | H | -69.6 | -49.1 | |