Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 107545826 . T A CCDS5749.1:NM_000108.3:c.459taT>taA_NP_000099.2:p.153Y>* Homo sapiens dihydrolipoamide dehydrogenase (DLD), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3rnm 1 P09622 99.37 0.0 X-RAY
 2011-05-04 TYR A:139 A:118 74.0 0.322 E -78.2 117.9 74.0 0.322 0.0 FAD
HOH
 3.228
2.890
 CE1
OH
 N6A
O
TYR B:139 B:118 62.0 0.27 E -68.3 115.0 62.0 0.27 0.0 FAD
 3.402
 CE1
 N6A
TYR C:139 C:118 72.0 0.313 E -91.2 107.5 NA NA NA
TYR D:139 D:118 64.0 0.278 E -73.0 117.9 NA NA NA
1zy8 1 P09622 100.0 0.0 X-RAY
 2005-11-15 TYR A:118 A:118 65.0 0.283 E -91.6 96.2 65.0 0.283 0.0 FAD
HOH
 3.315
6.638
 CE1
OH
 N6A
O
TYR B:118 B:118 74.0 0.322 E -91.0 122.9 74.0 0.322 0.0 FAD
HOH
 3.454
4.379
 CE1
CE1
 N6A
O
TYR C:118 C:118 70.0 0.304 E -84.1 110.5 NA NA NA
TYR D:118 D:118 72.0 0.313 E -81.6 110.7 NA NA NA
TYR E:118 E:118 77.0 0.335 E -91.8 121.6 NA NA NA
TYR F:118 F:118 61.0 0.265 E -108.3 113.0 NA NA NA
TYR G:118 G:118 62.0 0.27 -84.4 97.6 NA NA NA
TYR H:118 H:118 70.0 0.304 E -94.2 109.7 NA NA NA
TYR I:118 I:118 84.0 0.365 E -73.5 114.1 NA NA NA
TYR J:118 J:118 80.0 0.348 B -78.5 112.7 NA NA NA
6i4q 1 P09622 100.0 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 75.0 0.326 E -89.0 110.7 75.0 0.326 0.0 FAD
BTB
SO4
HOH
 2.749
5.897
7.077
2.877
 HE1
HE2
HH
HB2
 H61A
H61
O3
O
TYR B:140 B:118 71.0 0.309 E -92.6 112.1 71.0 0.309 0.0 FAD
BTB
SO4
HOH
 2.848
5.911
6.899
3.224
 HE1
HE2
HH
O
 H61A
H81
O3
O
6i4t 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 70.0 0.304 E -88.3 112.0 70.0 0.304 0.0 FAD
SO4
HOH
 2.832
6.972
3.179
 HE1
HH
HD1
 H62A
O2
O
TYR B:140 B:118 69.0 0.3 E -90.5 112.9 69.0 0.3 0.0 FAD
SO4
HOH
 2.735
7.027
3.337
 HE1
HH
HB2
 H62A
O2
O
1zmc 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:118 A:118 68.0 0.296 E -95.4 118.7 68.0 0.296 0.0 SO4
FAD
HOH
 7.494
3.491
4.144
 OH
CE1
OH
 O4
N6A
O
TYR B:118 B:118 65.0 0.283 E -87.1 104.1 65.0 0.283 0.0 FAD
HOH
 3.642
6.933
 CE1
CE2
 N6A
O
TYR C:118 C:118 77.0 0.335 E -103.0 93.1 NA NA NA
TYR D:118 D:118 70.0 0.304 E -92.9 113.8 NA NA NA
TYR E:118 E:118 81.0 0.352 E -78.0 134.2 NA NA NA
TYR F:118 F:118 76.0 0.33 E -93.0 118.3 NA NA NA
TYR G:118 G:118 71.0 0.309 E -91.6 122.1 NA NA NA
TYR H:118 H:118 82.0 0.357 E -77.1 133.1 NA NA NA
1zmd 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:118 A:118 74.0 0.322 E -85.3 118.2 74.0 0.322 0.0 SO4
FAD
HOH
 7.441
3.223
3.207
 OH
CE1
O
 O4
N6A
O
TYR B:118 B:118 62.0 0.27 E -87.1 109.2 62.0 0.27 0.0 SO4
FAD
HOH
 7.647
3.498
6.709
 OH
CE1
CE2
 O1
N6A
O
TYR C:118 C:118 72.0 0.313 E -83.8 105.3 NA NA NA
TYR D:118 D:118 75.0 0.326 E -92.3 117.0 NA NA NA
TYR E:118 E:118 73.0 0.317 E -77.0 117.6 NA NA NA
TYR F:118 F:118 72.0 0.313 E -90.7 115.8 NA NA NA
TYR G:118 G:118 74.0 0.322 E -90.6 118.8 NA NA NA
TYR H:118 H:118 78.0 0.339 E -82.9 119.2 NA NA NA
2f5z 1 P09622 99.79 0.0 X-RAY
 2006-01-17 TYR A:118 A:118 73.0 0.317 B -85.7 118.8 73.0 0.317 0.0 SO4
FAD
HOH
 7.837
3.069
6.825
 CE1
CE1
OH
 O2
N6A
O
TYR B:118 B:118 75.0 0.326 E -81.1 114.8 75.0 0.326 0.0 SO4
FAD
 6.989
3.115
 OH
CE1
 O2
N6A
TYR C:118 C:118 67.0 0.291 E -87.8 111.8 NA NA NA
TYR D:118 D:118 65.0 0.283 E -89.2 115.4 NA NA NA
TYR E:118 E:118 58.0 0.252 E -83.9 118.6 NA NA NA
TYR F:118 F:118 74.0 0.322 E -83.1 111.2 NA NA NA
TYR G:118 G:118 75.0 0.326 E -83.6 116.2 NA NA NA
TYR H:118 H:118 75.0 0.326 E -85.8 120.8 NA NA NA
TYR I:118 I:118 77.0 0.335 -89.8 115.1 NA NA NA
TYR J:118 J:118 67.0 0.291 E -86.2 113.4 NA NA NA
5nhg 1 P09622 100.0 0.0 X-RAY
 2018-05-16 TYR A:139 A:118 65.0 0.283 E -88.9 123.3 65.0 0.283 0.0 FAD
TRS
HOH
 2.739
6.313
6.183
 HE1
HE2
HH
 H61A
O3
O
TYR B:139 B:118 69.0 0.3 E -88.6 123.1 69.0 0.3 0.0 FAD
HOH
 2.677
3.513
 HE1
HH
 H61A
O
TYR C:139 C:118 60.0 0.261 E -89.3 121.9 NA NA NA
TYR D:139 D:118 57.0 0.248 E -86.7 120.8 NA NA NA
TYR E:139 E:118 72.0 0.313 E -87.1 123.9 NA NA NA
TYR F:139 F:118 68.0 0.296 E -90.4 121.0 NA NA NA
TYR G:139 G:118 68.0 0.296 E -87.9 122.1 NA NA NA
TYR H:139 H:118 51.0 0.222 E -90.9 121.6 NA NA NA
6i4u 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 72.0 0.313 E -91.4 113.9 72.0 0.313 0.0 FAD
SO4
HOH
 2.791
7.081
3.109
 HE1
HH
HB3
 H62A
O1
O
TYR B:140 B:118 70.0 0.304 E -94.0 114.5 70.0 0.304 0.0 FAD
SO4
HOH
 2.743
7.251
3.070
 HE1
HH
O
 H61A
O1
O
5j5z 1 P09622 99.79 0.0 X-RAY
 2017-11-15 TYR A:140 A:118 71.0 0.309 E -88.2 118.5 71.0 0.309 0.0 FAD
GOL
HOH
 3.368
7.182
3.180
 CE1
OH
O
 N6A
O2
O
TYR B:140 B:118 69.0 0.3 E -101.3 119.5 69.0 0.3 0.0 FAD
HOH
 3.222
3.019
 CE1
O
 N6A
O
6hg8 1 P09622 99.79 0.0 X-RAY
 2019-09-04 TYR A:140 A:118 73.0 0.317 E -90.4 114.0 73.0 0.317 0.0 FAD
SO4
HOH
 3.293
7.589
3.297
 CE1
OH
O
 N6A
O1
O
TYR B:140 B:118 73.0 0.317 E -91.8 118.1 73.0 0.317 0.0 FAD
SO4
HOH
 3.229
7.845
3.297
 CE1
OH
O
 N6A
O3
O
6i4r 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 75.0 0.326 E -90.7 114.6 75.0 0.326 0.0 FAD
SO4
BTB
HOH
 2.964
6.925
5.822
2.577
 HE1
HH
HE2
OH
 H62A
O2
HO8
O
TYR B:140 B:118 74.0 0.322 E -92.9 114.9 74.0 0.322 0.0 FAD
SO4
BTB
HOH
 2.557
7.059
5.974
3.027
 HE1
HH
HE2
HD1
 H61A
O2
H81
O
6i4p 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 74.0 0.322 E -91.0 112.8 74.0 0.322 0.0 FAD
SO4
BTB
HOH
 2.932
7.027
5.627
2.788
 HE1
HH
HE2
OH
 H62A
O2
HO8
O
TYR B:140 B:118 74.0 0.322 E -92.3 113.7 74.0 0.322 0.0 FAD
SO4
BTB
HOH
 2.837
7.125
5.925
2.980
 HE1
HH
HE2
HD2
 H62A
O1
H81
O
6i4s 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 72.0 0.313 E -87.6 114.7 72.0 0.313 0.0 FAD
SO4
HOH
 2.920
7.103
3.069
 HE1
HH
HB3
 H61A
O2
O
TYR B:140 B:118 75.0 0.326 E -92.8 113.5 75.0 0.326 0.0 FAD
SO4
SO4
HOH
 2.571
7.205
9.633
3.282
 HE1
HH
HE2
O
 H61A
O2
O1
O
6i4z 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:140 A:118 76.0 0.33 E -89.1 115.6 76.0 0.33 0.0 FAD
SO4
HOH
 2.834
6.930
3.109
 HE1
HH
HH
 H62A
O2
O
TYR B:140 B:118 73.0 0.317 E -91.4 119.4 73.0 0.317 0.0 FAD
HOH
 2.483
9.920
 HE1
N
 H62A
O
TYR C:140 C:118 73.0 0.317 E -89.0 116.1 NA NA NA
TYR D:140 D:118 68.0 0.296 E -91.6 117.2 NA NA NA
TYR E:140 E:118 72.0 0.313 E -90.0 115.8 NA NA NA
TYR F:140 F:118 67.0 0.291 E -89.9 116.0 NA NA NA
TYR G:140 G:118 72.0 0.313 E -90.2 114.1 NA NA NA
TYR H:140 H:118 67.0 0.291 E -90.1 116.8 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09622-f1 1 P09622 100.0 0.0 TYR A:153 A:153 67.0 0.291 E -80.7 107.6