Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 107557853 . C A CCDS5749.1:NM_000108.3:c.1182taC>taA_NP_000099.2:p.394Y>* Homo sapiens dihydrolipoamide dehydrogenase (DLD), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3rnm 1 P09622 99.37 0.0 X-RAY
 2011-05-04 TYR A:380 A:359 94.0 0.409 -90.9 28.6 18.0 0.078 0.331 B:P09622:0.33
 FAD
HOH
 3.551
2.626
 CE1
O
 O4
O
TYR B:380 B:359 93.0 0.404 -100.1 26.7 19.0 0.083 0.321 A:P09622:0.322
 FAD
HOH
 3.539
2.498
 CE1
O
 O4
O
TYR C:380 C:359 90.0 0.391 -98.9 32.2 NA NA NA
TYR D:380 D:359 90.0 0.391 -96.9 29.4 NA NA NA
1zy8 1 P09622 100.0 0.0 X-RAY
 2005-11-15 TYR A:359 A:359 89.0 0.387 -92.8 36.7 14.0 0.061 0.326 B:P09622:0.326
 FAD
HOH
 3.342
3.782
 CE1
CD1
 O4
O
TYR B:359 B:359 87.0 0.378 -85.3 33.1 17.0 0.074 0.304 A:P09622:0.304
 FAD
HOH
 3.101
2.764
 CE1
O
 O4
O
TYR C:359 C:359 90.0 0.391 -88.3 35.2 NA NA NA
TYR D:359 D:359 101.0 0.439 -92.4 28.4 NA NA NA
TYR E:359 E:359 93.0 0.404 -87.0 21.3 NA NA NA
TYR F:359 F:359 92.0 0.4 -81.6 35.2 NA NA NA
TYR G:359 G:359 88.0 0.383 -89.4 30.7 NA NA NA
TYR H:359 H:359 93.0 0.404 -97.3 50.8 NA NA NA
TYR I:359 I:359 97.0 0.422 -77.9 36.2 NA NA NA
TYR J:359 J:359 94.0 0.409 -91.5 47.5 NA NA NA
6i4q 1 P09622 100.0 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 93.0 0.404 -94.0 29.4 17.0 0.074 0.33 B:P09622:0.33
 FAD
HOH
 3.056
2.680
 HE1
HD1
 O4
O
TYR B:381 B:359 89.0 0.387 -94.7 30.2 16.0 0.07 0.317 A:P09622:0.317
 FAD
HOH
 3.013
2.732
 HE1
HD1
 O4
O
6i4t 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 87.0 0.378 -93.4 28.5 16.0 0.07 0.308 B:P09622:0.309
 FAD
HOH
 2.950
2.815
 HE1
HD1
 O4
O
TYR B:381 B:359 86.0 0.374 -93.5 28.6 16.0 0.07 0.304 A:P09622:0.304
 FAD
HOH
 2.879
2.708
 HE1
OH
 O4
O
1zmc 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:359 A:359 89.0 0.387 -81.2 24.4 17.0 0.074 0.313 B:P09622:0.313
 FAD
HOH
 3.444
2.711
 CE1
O
 O4
O
TYR B:359 B:359 88.0 0.383 -87.2 22.6 17.0 0.074 0.309 A:P09622:0.309
 FAD
HOH
 3.536
2.619
 CE1
O
 O4
O
TYR C:359 C:359 85.0 0.37 -85.9 29.7 NA NA NA
TYR D:359 D:359 90.0 0.391 -83.9 31.5 NA NA NA
TYR E:359 E:359 93.0 0.404 -82.5 33.4 NA NA NA
TYR F:359 F:359 82.0 0.357 -80.8 30.2 NA NA NA
TYR G:359 G:359 87.0 0.378 -91.0 33.1 NA NA NA
TYR H:359 H:359 92.0 0.4 -83.4 31.0 NA NA NA
1zmd 1 P09622 99.79 0.0 X-RAY
 2005-06-28 TYR A:359 A:359 89.0 0.387 -86.7 32.0 19.0 0.083 0.304 B:P09622:0.304
 FAD
NAI
HOH
 3.659
3.374
2.614
 CE1
CD1
OH
 O4
N7N
O
TYR B:359 B:359 88.0 0.383 -89.5 30.1 17.0 0.074 0.309 A:P09622:0.309
 FAD
NAI
HOH
 3.583
3.366
2.687
 CE1
CD1
O
 O4
N7N
O
TYR C:359 C:359 89.0 0.387 -89.5 35.4 NA NA NA
TYR D:359 D:359 86.0 0.374 -84.3 32.2 NA NA NA
TYR E:359 E:359 90.0 0.391 -87.8 29.8 NA NA NA
TYR F:359 F:359 81.0 0.352 -87.0 31.8 NA NA NA
TYR G:359 G:359 89.0 0.387 -90.5 30.8 NA NA NA
TYR H:359 H:359 89.0 0.387 -87.9 28.9 NA NA NA
2f5z 1 P09622 99.79 0.0 X-RAY
 2006-01-17 TYR A:359 A:359 91.0 0.396 -86.6 31.0 17.0 0.074 0.322 B:P09622:0.322
 FAD
HOH
 3.457
2.738
 CE1
O
 O4
O
TYR B:359 B:359 91.0 0.396 -81.2 29.7 18.0 0.078 0.318 A:P09622:0.317
 FAD
HOH
 3.406
2.707
 CE1
OH
 O4
O
TYR C:359 C:359 90.0 0.391 -86.0 31.5 NA NA NA
TYR D:359 D:359 92.0 0.4 -89.3 27.8 NA NA NA
TYR E:359 E:359 88.0 0.383 -87.6 29.9 NA NA NA
TYR F:359 F:359 90.0 0.391 -87.8 30.4 NA NA NA
TYR G:359 G:359 88.0 0.383 -86.2 30.2 NA NA NA
TYR H:359 H:359 92.0 0.4 -89.7 29.1 NA NA NA
TYR I:359 I:359 86.0 0.374 -85.2 25.9 NA NA NA
TYR J:359 J:359 89.0 0.387 -90.7 31.2 NA NA NA
5nhg 1 P09622 100.0 0.0 X-RAY
 2018-05-16 TYR A:380 A:359 85.0 0.37 -93.2 33.6 15.0 0.065 0.305 B:P09622:0.304
 FAD
HOH
 2.868
2.395
 HE1
HD1
 O4
O
TYR B:380 B:359 84.0 0.365 -93.3 33.2 14.0 0.061 0.304 A:P09622:0.304
 FAD
HOH
 3.102
2.577
 HE1
O
 O4
O
TYR C:380 C:359 88.0 0.383 -91.3 32.7 NA NA NA
TYR D:380 D:359 89.0 0.387 -92.0 32.7 NA NA NA
TYR E:380 E:359 87.0 0.378 -92.9 32.7 NA NA NA
TYR F:380 F:359 87.0 0.378 -91.3 31.3 NA NA NA
TYR G:380 G:359 86.0 0.374 -92.1 32.9 NA NA NA
TYR H:380 H:359 84.0 0.365 -91.6 35.4 NA NA NA
6i4u 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 81.0 0.352 -92.6 29.4 12.0 0.052 0.3 B:P09622:0.3
 FAD
HOH
 2.832
2.681
 HE1
HD1
 O4
O
TYR B:381 B:359 68.0 0.296 -91.3 29.0 14.0 0.061 0.235 A:P09622:0.235
 FAD
HOH
 2.970
2.768
 HE1
OH
 O4
O
5j5z 1 P09622 99.79 0.0 X-RAY
 2017-11-15 TYR A:381 A:359 92.0 0.4 -90.2 31.1 16.0 0.07 0.33 B:P09622:0.33
 FAD
HOH
 3.448
2.803
 CE1
O
 O4
O
TYR B:381 B:359 91.0 0.396 -89.9 35.2 18.0 0.078 0.318 A:P09622:0.317
 FAD
HOH
 3.519
2.771
 CE1
O
 O4
O
6hg8 1 P09622 99.79 0.0 X-RAY
 2019-09-04 TYR A:381 A:359 88.0 0.383 -95.6 28.6 17.0 0.074 0.309 B:P09622:0.309
 FAD
SO4
HOH
 3.542
7.033
2.714
 CE1
CE2
O
 O4
O2
O
TYR B:381 B:359 90.0 0.391 -99.4 31.6 19.0 0.083 0.308 A:P09622:0.309
 FAD
HOH
 3.441
2.743
 CE1
O
 O4
O
6i4r 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 93.0 0.404 -96.5 30.1 17.0 0.074 0.33 B:P09622:0.33
 FAD
HOH
 2.932
2.790
 HE1
HD1
 O4
O
TYR B:381 B:359 90.0 0.391 -96.2 30.7 17.0 0.074 0.317 A:P09622:0.317
 FAD
HOH
 2.914
2.861
 HE1
O
 O4
O
6i4p 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 91.0 0.396 -97.6 32.0 16.0 0.07 0.326 B:P09622:0.326
 FAD
HOH
 3.069
2.785
 HE1
HD1
 O4
O
TYR B:381 B:359 89.0 0.387 -98.0 32.1 16.0 0.07 0.317 A:P09622:0.317
 FAD
HOH
 2.947
2.784
 HE1
O
 O4
O
6i4s 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 89.0 0.387 -94.0 29.4 17.0 0.074 0.313 B:P09622:0.313
 FAD
HOH
 2.891
2.698
 HE1
HD1
 O4
O
TYR B:381 B:359 84.0 0.365 -93.8 30.8 15.0 0.065 0.3 A:P09622:0.3
 FAD
HOH
 2.859
2.718
 HE1
OH
 O4
O
6i4z 1 P09622 99.79 0.0 X-RAY
 2019-11-20 TYR A:381 A:359 99.0 0.43 -92.8 31.7 23.0 0.1 0.33 B:P09622:0.33
 FAD
HOH
 3.357
2.664
 HE2
O
 O4
O
TYR B:381 B:359 94.0 0.409 -95.1 31.2 21.0 0.091 0.318 A:P09622:0.317
 FAD
HOH
 3.374
5.845
 HE2
O
 O4
O
TYR C:381 C:359 101.0 0.439 -94.1 31.2 NA NA NA
TYR D:381 D:359 95.0 0.413 -94.8 33.0 NA NA NA
TYR E:381 E:359 98.0 0.426 -93.9 32.7 NA NA NA
TYR F:381 F:359 97.0 0.422 -95.9 34.3 NA NA NA
TYR G:381 G:359 99.0 0.43 -94.6 32.6 NA NA NA
TYR H:381 H:359 97.0 0.422 -96.3 33.3 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p09622-f1 1 P09622 100.0 0.0 TYR A:394 A:394 87.0 0.378 -91.7 34.2