Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155598998 . A C CCDS5942.1:NM_000193.2:c.554gTg>gGg_NP_000184.1:p.185V>G Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 VAL A:185 G:185 0.0 0.0 -118.1 159.5 0.0 0.0 0.0 ZN
 9.958
 N
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 VAL B:165 B:185 0.0 0.0 -114.9 170.1 0.0 0.0 0.0 SER
 8.426
 C
 OG
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 VAL C:162 C:185 0.0 0.0 -148.8 152.6 0.0 0.0 0.0
VAL F:162 F:185 0.0 0.0 -148.8 152.6 0.0 0.0 0.0
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 VAL C:162 C:185 0.0 0.0 -148.8 152.7 0.0 0.0 0.0
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 VAL C:162 C:185 0.0 0.0 -148.8 152.6 0.0 0.0 0.0
VAL F:162 F:185 0.0 0.0 -148.8 152.6 0.0 0.0 0.0
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 VAL C:162 C:185 0.0 0.0 -115.9 172.4 0.0 0.0 0.0
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 VAL B:163 C:185 0.0 0.0 -134.1 153.4 0.0 0.0 0.0
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 VAL B:163 C:185 1.0 0.006 -124.3 170.1 1.0 0.006 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 VAL A:163 A:185 0.0 0.0 -136.1 151.7 0.0 0.0 0.0 ZN
SO4
HOH
 9.994
8.329
6.967
 N
CG1
O
 ZN
O1
O
VAL B:163 B:185 0.0 0.0 -131.8 156.7 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 VAL B:273 B:185 0.0 0.0 -132.8 179.4 0.0 0.0 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 VAL C:157 H:185 0.0 0.0 -129.0 168.9 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 VAL A:157 A:185 0.0 0.0 -136.3 155.4 0.0 0.0 0.0 ZN
SO4
HOH
 9.817
8.234
3.666
 N
CG1
CG2
 ZN
O2
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 VAL A:157 A:185 0.0 0.0 -129.5 155.3 0.0 0.0 0.0 DMS
HOH
 9.339
3.191
 H
HG23
 H22
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 VAL A:165 A:186 0.0 0.0 -132.1 159.4 0.0 0.0 0.0 HOH
 3.705
 CG2
 O
VAL B:165 B:186 0.0 0.0 -129.9 162.6 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 VAL B:161 H:186 0.0 0.0 -132.1 156.9 0.0 0.0 0.0
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 VAL A:153 A:186 0.0 0.0 -130.7 162.4 0.0 0.0 0.0 ZN
HOH
 9.489
3.733
 H
CG2
 ZN
H1
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 VAL A:175 B:190 0.0 0.0 -130.4 156.9 0.0 0.0 0.0 HOH
 3.722
 CG2
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 VAL A:149 A:186 0.0 0.0 -130.7 160.3 0.0 0.0 0.0 HOH
 3.964
 CG2
 O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 VAL A:149 A:186 0.0 0.0 -131.9 156.4 0.0 0.0 0.0 HOH
 3.812
 CG2
 O
VAL B:149 B:186 0.0 0.0 -129.8 156.4 0.0 0.0 0.0 HOH
 7.123
 CB
 O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 VAL A:151 A:186 0.0 0.0 -131.8 153.2 0.0 0.0 0.0 ZN
HOH
 9.992
3.959
 N
CG2
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 VAL A:175 B:190 0.0 0.0 -136.4 158.4 0.0 0.0 0.0 HOH
 3.756
 CG2
 O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 VAL A:175 B:190 0.0 0.0 -129.6 156.5 0.0 0.0 0.0 HOH
 3.811
 CG2
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 VAL A:175 B:190 0.0 0.0 -132.2 157.1 0.0 0.0 0.0 HOH
 3.931
 CG2
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 VAL A:147 A:186 0.0 0.0 -131.6 176.6 0.0 0.0 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 VAL A:147 A:186 0.0 0.0 -123.0 176.5 0.0 0.0 0.0
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 VAL A:166 A:190 0.0 0.0 -135.9 157.4 0.0 0.0 0.0 ZN
HOH
 9.545
3.141
 H
HG23
 ZN
O
VAL B:166 B:190 0.0 0.0 -132.9 155.2 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 VAL A:166 B:190 0.0 0.0 -132.8 159.8 0.0 0.0 0.0 ZN
HOH
 9.499
3.084
 H
HG23
 ZN
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 VAL A:166 A:190 0.0 0.0 -137.3 160.7 0.0 0.0 0.0 HOH
 3.924
 CG2
 O
VAL B:166 B:190 0.0 0.0 -133.3 161.8 NA NA NA
VAL C:166 C:190 0.0 0.0 -132.6 157.6 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 VAL A:166 B:190 0.0 0.0 -136.2 159.8 0.0 0.0 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 VAL A:185 A:185 0.0 0.0 -126.7 157.8