Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599001 . G A CCDS5942.1:NM_000193.2:c.551tCg>tTg_NP_000184.1:p.184S>L Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 SER A:184 G:184 1.0 0.009 E -134.6 138.1 1.0 0.009 0.0 ZN
 7.177
 CB
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 SER B:164 B:184 0.0 0.0 E -162.7 151.8 0.0 0.0 0.0 ZN
 8.428
 N
 ZN
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:161 C:184 0.0 0.0 E -122.7 172.2 0.0 0.0 0.0 ZN
 7.682
 CB
 ZN
SER F:161 F:184 0.0 0.0 E -122.6 172.2 0.0 0.0 0.0 ZN
 7.682
 CB
 ZN
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:161 C:184 1.0 0.009 E -122.6 172.2 1.0 0.009 0.0 ZN
 7.682
 CB
 ZN
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:161 C:184 0.0 0.0 E -122.7 172.2 0.0 0.0 0.0 ZN
 7.682
 CB
 ZN
SER F:161 F:184 0.0 0.0 E -122.6 172.2 0.0 0.0 0.0 ZN
 7.682
 CB
 ZN
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 SER C:161 C:184 0.0 0.0 E -126.8 152.3 0.0 0.0 0.0 ZN
 7.559
 N
 ZN
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 SER B:162 C:184 0.0 0.0 E -113.0 150.5 0.0 0.0 0.0 ZN
 8.345
 N
 ZN
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 SER B:162 C:184 0.0 0.0 E -130.3 145.4 0.0 0.0 0.0 ZN
 7.100
 OG
 ZN
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 SER A:162 A:184 0.0 0.0 E -140.5 172.9 0.0 0.0 0.0 ZN
HOH
 7.428
5.613
 N
CB
 ZN
O
SER B:162 B:184 0.0 0.0 E -141.2 169.5 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 SER B:272 B:184 1.0 0.009 E -161.9 160.0 1.0 0.009 0.0 ZN
 7.037
 HB3
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 SER C:156 H:184 0.0 0.0 E -147.7 160.9 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 SER A:156 A:184 0.0 0.0 E -143.1 169.5 0.0 0.0 0.0 ZN
SO4
SO4
HOH
 7.227
9.601
7.287
5.655
 CB
O
CB
CB
 ZN
O2
O4
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 SER A:156 A:184 0.0 0.0 E -139.3 165.4 0.0 0.0 0.0 DMS
DMS
ZN
MG
HOH
 5.537
9.273
7.023
7.031
4.972
 HG
HG
HB3
HB3
HB3
 H22
H23
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 SER A:164 A:185 0.0 0.0 E -134.1 167.3 0.0 0.0 0.0 ZN
HOH
 7.898
5.652
 N
CB
 ZN
O
SER B:164 B:185 0.0 0.0 E -140.3 165.8 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 SER B:160 H:185 0.0 0.0 E -149.1 167.3 0.0 0.0 0.0 ZN
 7.498
 CB
 ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 SER A:152 A:185 0.0 0.0 E -135.0 162.9 0.0 0.0 0.0 ZN
HOH
 7.311
4.564
 N
CB
 ZN
H1
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 SER A:174 B:189 0.0 0.0 E -138.4 166.4 0.0 0.0 0.0 ZN
HOH
 7.453
5.452
 CB
CB
 ZN
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 SER A:148 A:185 0.0 0.0 E -139.3 167.0 0.0 0.0 0.0 ZN
HOH
 7.475
5.635
 N
CB
 ZN
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 SER A:148 A:185 0.0 0.0 E -134.1 166.0 0.0 0.0 0.0 ZN
HOH
 7.553
6.131
 N
CB
 ZN
O
SER B:148 B:185 0.0 0.0 E -132.7 166.3 0.0 0.0 0.0 ZN
HOH
 7.435
7.441
 N
O
 ZN
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 SER A:150 A:185 0.0 0.0 E -146.1 164.4 0.0 0.0 0.0 ZN
HOH
 7.348
6.429
 CB
O
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 SER A:174 B:189 0.0 0.0 E -139.6 167.3 0.0 0.0 0.0 ZN
CO3
HOH
 7.398
7.889
5.539
 CB
CB
CB
 ZN
O3
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 SER A:174 B:189 0.0 0.0 E -138.4 166.2 0.0 0.0 0.0 ZN
HOH
 7.464
6.564
 CB
O
 ZN
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 SER A:174 B:189 0.0 0.0 E -139.4 167.8 0.0 0.0 0.0 ZN
HOH
 7.518
5.394
 N
CB
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 SER A:146 A:185 0.0 0.0 E -154.6 159.2 0.0 0.0 0.0 ZN
 7.358
 CB
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 SER A:146 A:185 0.0 0.0 E -155.8 153.2 0.0 0.0 0.0 ZN
 7.585
 CB
 ZN
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:165 A:189 0.0 0.0 E -140.6 170.4 0.0 0.0 0.0 ZN
HOH
 6.378
4.989
 HB3
HB3
 ZN
O
SER B:165 B:189 0.0 0.0 E -141.3 169.9 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:165 B:189 0.0 0.0 E -142.3 170.1 0.0 0.0 0.0 ZN
HOH
 6.315
4.708
 HB3
HB3
 ZN
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:165 A:189 0.0 0.0 E -142.3 168.5 0.0 0.0 0.0 ZN
HOH
 7.510
5.730
 N
CB
 ZN
O
SER B:165 B:189 0.0 0.0 E -145.4 169.0 NA NA NA
SER C:165 C:189 0.0 0.0 E -148.0 166.2 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:165 B:189 0.0 0.0 E -152.1 165.3 0.0 0.0 0.0 ZN
 8.252
 CB
 ZN

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 SER A:184 A:184 0.0 0.0 E -143.3 162.9