Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599031 . T A CCDS5942.1:NM_000193.2:c.521tAc>tTc_NP_000184.1:p.174Y>F Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 TYR A:174 G:174 49.0 0.213 E -124.2 137.6 49.0 0.213 0.0 ZN
 6.764
 O
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 TYR B:154 B:174 59.0 0.257 E -112.6 118.7 56.0 0.243 0.014 A:Q13635:0.013
 ZN
 7.644
 O
 ZN
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:151 C:174 47.0 0.204 E -129.3 123.1 46.0 0.2 0.004 A:Q13635:0.004
 ZN
 7.103
 CD2
 ZN
TYR F:151 F:174 48.0 0.209 E -129.3 123.1 47.0 0.204 0.005 D:Q13635:0.004
 ZN
 7.102
 CD2
 ZN
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:151 C:174 48.0 0.209 E -129.3 123.1 47.0 0.204 0.005 A:Q13635:0.004
 ZN
 7.103
 CD2
 ZN
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:151 C:174 47.0 0.204 E -129.3 123.1 46.0 0.2 0.004 A:Q13635:0.004
 ZN
 7.103
 CD2
 ZN
TYR F:151 F:174 48.0 0.209 E -129.3 123.1 47.0 0.204 0.005 D:Q13635:0.004
 ZN
 7.102
 CD2
 ZN
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 TYR C:151 C:174 45.0 0.196 E -136.9 115.9 40.0 0.174 0.022 B:Q13635:0.022
 ZN
 6.629
 O
 ZN
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 TYR B:152 C:174 44.0 0.191 E -162.7 115.2 44.0 0.191 0.0 ZN
 6.885
 CD2
 ZN
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 TYR B:152 C:174 62.0 0.27 E -149.5 104.7 62.0 0.27 0.0 ZN
 3.748
 CD2
 ZN
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 TYR A:152 A:174 50.0 0.217 E -137.7 119.1 50.0 0.217 0.0 ZN
HOH
 7.053
5.996
 O
CE1
 ZN
O
TYR B:152 B:174 48.0 0.209 E -138.0 122.5 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 TYR B:262 B:174 48.0 0.209 E -156.7 122.2 47.0 0.204 0.005 A:Q13635+U6GSR1:0.004
 ZN
 6.576
 HD2
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 TYR C:146 H:174 44.0 0.191 E -136.6 120.5 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 TYR A:146 A:174 50.0 0.217 E -140.0 126.0 27.0 0.117 0.1 B:None:0.1
 ZN
SO4
HOH
 7.035
5.235
2.760
 CD2
CD2
OH
 ZN
O2
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 TYR A:146 A:174 50.0 0.217 E -140.9 127.2 50.0 0.217 0.0 DMS
DMS
ZN
MG
HOH
 3.150
3.808
5.706
5.698
1.820
 HD2
CZ
HD2
HD2
HH
 H22
O
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 TYR A:154 A:175 44.0 0.191 E -137.9 123.6 44.0 0.191 0.0 ZN
HOH
 6.676
3.302
 CD2
OH
 ZN
O
TYR B:154 B:175 44.0 0.191 E -136.8 121.6 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 TYR B:150 H:175 47.0 0.204 E -136.6 128.6 47.0 0.204 0.0 ZN
 7.265
 CD2
 ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 TYR A:142 A:175 50.0 0.217 E -136.7 118.6 50.0 0.217 0.0 ZN
HOH
 6.866
3.281
 CD2
HH
 ZN
H1
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 TYR A:164 B:179 46.0 0.2 E -140.8 117.1 46.0 0.2 0.0 ZN
SO4
HOH
 6.831
9.827
2.926
 CD2
N
OH
 ZN
O1
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:138 A:175 46.0 0.2 E -134.3 121.2 46.0 0.2 0.0 ZN
HOH
 7.059
3.968
 CD2
OH
 ZN
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:138 A:175 46.0 0.2 E -133.4 123.8 46.0 0.2 0.0 ZN
HOH
 7.127
6.599
 CD2
CD2
 ZN
O
TYR B:138 B:175 46.0 0.2 E -134.3 122.0 46.0 0.2 0.0 IDS
ZN
HOH
 9.766
7.216
6.052
 OH
CD2
OH
 C3
ZN
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 TYR A:140 A:175 45.0 0.196 E -145.4 124.0 45.0 0.196 0.0 ZN
HOH
 7.112
7.155
 CD2
N
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 TYR A:164 B:179 49.0 0.213 E -131.3 112.6 49.0 0.213 0.0 ZN
SO4
CO3
HOH
 7.081
9.480
5.874
2.642
 CD2
N
CE2
OH
 ZN
O4
O1
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:164 B:179 48.0 0.209 E -136.9 116.4 48.0 0.209 0.0 ZN
SO4
HOH
 6.952
9.890
2.693
 CD2
N
OH
 ZN
O1
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:164 B:179 47.0 0.204 E -140.8 117.7 47.0 0.204 0.0 ZN
HOH
 6.970
3.161
 CD2
OH
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 TYR A:136 A:175 46.0 0.2 E -149.0 120.2 46.0 0.2 0.0 ZN
 7.459
 CD2
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 TYR A:136 A:175 47.0 0.204 E -133.2 125.1 47.0 0.204 0.0 ZN
 7.271
 CD2
 ZN
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:155 A:179 43.0 0.187 E -135.6 116.0 43.0 0.187 0.0 ZN
HOH
 6.146
2.494
 HD2
HE2
 ZN
O
TYR B:155 B:179 47.0 0.204 E -142.7 116.8 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:155 B:179 44.0 0.191 E -138.1 123.5 44.0 0.191 0.0 ZN
HOH
 6.387
3.874
 HD2
HD2
 ZN
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:155 A:179 48.0 0.209 E -140.6 116.7 48.0 0.209 0.0 ZN
HOH
 6.868
6.192
 CD2
CD1
 ZN
O
TYR B:155 B:179 52.0 0.226 E -146.0 119.1 NA NA NA
TYR C:155 C:179 48.0 0.209 E -130.8 115.3 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:155 B:179 45.0 0.196 E -146.6 109.9 45.0 0.196 0.0 ZN
 6.624
 CD2
 ZN

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 TYR A:174 A:174 40.0 0.174 E -131.7 124.9