Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599049 . G A CCDS5942.1:NM_000193.2:c.503gCc>gTc_NP_000184.1:p.168A>V Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
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label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ALA A:168 G:168 23.0 0.2 T -62.4 -14.7 23.0 0.2 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ALA B:148 B:168 25.0 0.217 T -111.7 -30.9 25.0 0.217 0.0
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ALA C:145 C:168 24.0 0.209 T -69.5 -10.3 13.0 0.113 0.096 B:Q13635:0.096
ALA F:145 F:168 25.0 0.217 T -69.5 -10.3 14.0 0.122 0.095 E:Q13635:0.096
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ALA C:145 C:168 25.0 0.217 T -69.5 -10.3 15.0 0.13 0.087 B:Q13635:0.087
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ALA C:145 C:168 24.0 0.209 T -69.5 -10.3 13.0 0.113 0.096 B:Q13635:0.096
ALA F:145 F:168 25.0 0.217 T -69.5 -10.3 14.0 0.122 0.095 E:Q13635:0.096
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ALA C:145 C:168 10.0 0.087 T -86.6 -5.4 8.0 0.07 0.017 A:Q13635:0.017
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ALA B:146 C:168 13.0 0.113 H -69.7 -25.8 11.0 0.096 0.017 A:Q13635:0.017
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ALA B:146 C:168 16.0 0.139 H -74.7 -35.0 15.0 0.13 0.009 A:Q13635:0.009
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ALA A:146 A:168 19.0 0.165 T -69.9 -11.6 19.0 0.165 0.0 SO4
SO4
HOH
 9.515
6.205
3.747
 N
O
CA
 O2
O3
O
ALA B:146 B:168 14.0 0.122 T -74.9 -3.4 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ALA B:256 B:168 15.0 0.13 H -73.1 -47.1 15.0 0.13 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ALA C:140 H:168 18.0 0.157 H -60.0 -27.1 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ALA A:140 A:168 17.0 0.148 T -74.7 -10.6 17.0 0.148 0.0 SO4
HOH
 6.278
2.586
 O
O
 O2
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ALA A:140 A:168 18.0 0.157 T -76.4 -8.5 18.0 0.157 0.0 HOH
 2.581
 HA
 O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ALA A:148 A:169 19.0 0.165 T -73.8 -9.6 19.0 0.165 0.0 HOH
 2.628
 O
 O
ALA B:148 B:169 17.0 0.148 T -74.9 -12.8 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ALA B:144 H:169 17.0 0.148 H -66.1 -19.5 17.0 0.148 0.0
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ALA A:136 A:169 16.0 0.139 T -80.4 -12.4 16.0 0.139 0.0 HOH
 2.533
 H
 H2
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ALA A:158 B:173 4.0 0.035 T -77.1 -8.8 4.0 0.035 0.0 HOH
 3.417
 CA
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ALA A:132 A:169 16.0 0.139 T -77.5 -9.2 16.0 0.139 0.0 HOH
 3.483
 CA
 O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ALA A:132 A:169 19.0 0.165 T -73.0 -8.5 19.0 0.165 0.0 HOH
 2.700
 O
 O
ALA B:132 B:169 19.0 0.165 T -73.6 -8.1 19.0 0.165 0.0 HOH
 3.740
 N
 O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ALA A:134 A:169 15.0 0.13 T -71.7 -10.8 15.0 0.13 0.0 HOH
 3.449
 N
 O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ALA A:158 B:173 9.0 0.078 T -78.3 -4.7 9.0 0.078 0.0 HOH
 3.345
 CB
 O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ALA A:158 B:173 4.0 0.035 T -76.5 -9.6 4.0 0.035 0.0 HOH
 3.377
 CA
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ALA A:158 B:173 9.0 0.078 T -77.3 -7.9 9.0 0.078 0.0 HOH
 2.738
 O
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ALA A:130 A:169 21.0 0.183 T -67.5 -17.8 21.0 0.183 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ALA A:130 A:169 18.0 0.157 H -75.6 -22.9 18.0 0.157 0.0
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ALA A:149 A:173 18.0 0.157 T -73.5 -9.1 18.0 0.157 0.0 HOH
 2.622
 HA
 O
ALA B:149 B:173 19.0 0.165 T -79.2 -10.5 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ALA A:149 B:173 17.0 0.148 T -78.3 -10.2 17.0 0.148 0.0 HOH
 2.518
 HA
 O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ALA A:149 A:173 19.0 0.165 T -73.7 -8.3 19.0 0.165 0.0 HOH
 3.469
 N
 O
ALA B:149 B:173 14.0 0.122 T -83.8 -10.5 NA NA NA
ALA C:149 C:173 19.0 0.165 T -72.9 -8.9 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ALA A:149 B:173 17.0 0.148 T -84.9 -8.5 17.0 0.148 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ALA A:168 A:168 13.0 0.113 H -69.1 -13.9