Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599078 . G A CCDS5942.1:NM_000193.2:c.474taC>taT_NP_000184.1:p.158Y>Y Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 TYR A:158 G:158 8.0 0.035 H -62.7 -47.6 8.0 0.035 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 TYR B:138 B:158 4.0 0.017 H -79.1 -24.7 4.0 0.017 0.0
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:135 C:158 1.0 0.004 -108.1 -18.5 1.0 0.004 0.0
TYR F:135 F:158 2.0 0.009 -108.1 -18.6 2.0 0.009 0.0
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:135 C:158 2.0 0.009 -108.1 -18.6 2.0 0.009 0.0
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:135 C:158 1.0 0.004 -108.1 -18.5 1.0 0.004 0.0
TYR F:135 F:158 2.0 0.009 -108.1 -18.6 2.0 0.009 0.0
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 TYR C:135 C:158 3.0 0.013 H -57.5 -42.5 3.0 0.013 0.0
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 TYR B:136 C:158 13.0 0.057 H -69.1 -32.1 8.0 0.035 0.022 C:Q13635:0.022
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 TYR B:136 C:158 0.0 0.0 H -86.6 -36.4 0.0 0.0 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 TYR A:136 A:158 2.0 0.009 H -73.9 -31.9 2.0 0.009 0.0 SO4
HOH
 9.981
2.703
 OH
OH
 O1
O
TYR B:136 B:158 3.0 0.013 H -80.3 -30.2 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 TYR B:246 B:158 3.0 0.013 H -49.9 -42.1 1.0 0.004 0.009 A:Q13635+U6GSR1:0.009
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 TYR C:130 H:158 7.0 0.03 H -64.4 -33.5 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 TYR A:130 A:158 6.0 0.026 H -70.6 -36.7 3.0 0.013 0.013 C:None:0.013
 HOH
 2.714
 OH
 O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 TYR A:130 A:158 4.0 0.017 H -70.4 -36.6 4.0 0.017 0.0 GOL
HOH
 5.525
1.919
 N
HH
 H12
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 TYR A:138 A:159 4.0 0.017 H -67.8 -34.7 0.0 0.0 0.017 D:Q4KMG0:0.017
 HOH
 2.663
 OH
 O
TYR B:138 B:159 5.0 0.022 H -68.0 -33.5 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 TYR B:134 H:159 1.0 0.004 H -56.8 -38.1 1.0 0.004 0.0 SO4
 5.324
 OH
 O3
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 TYR A:126 A:159 1.0 0.004 H -64.7 -34.4 1.0 0.004 0.0 SO4
HOH
 4.119
1.692
 HH
HH
 O1
O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 TYR A:148 B:163 4.0 0.017 H -70.9 -30.6 4.0 0.017 0.0 HOH
 3.541
 N
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:122 A:159 5.0 0.022 H -67.1 -33.0 5.0 0.022 0.0 ASG
ACT
HOH
 8.188
4.912
2.731
 OH
OH
OH
 OSB
O
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:122 A:159 0.0 0.0 H -69.8 -33.4 0.0 0.0 0.0 SGN
IDS
SGN
IDS
SGN
HOH
 8.034
9.141
8.126
7.415
9.298
3.753
 CE2
OH
OH
OH
OH
N
 O5S
O1S
O4
O2S
O2S
O
TYR B:122 B:159 5.0 0.022 H -71.7 -31.2 5.0 0.022 0.0 SGN
IDS
SGN
IDS
HOH
 9.663
7.236
5.801
9.631
9.325
 OH
OH
OH
CE2
O
 O1S
O6A
O4S
O5
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 TYR A:124 A:159 4.0 0.017 H -58.7 -46.6 4.0 0.017 0.0 HOH
 3.411
 OH
 O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 TYR A:148 B:163 4.0 0.017 H -66.7 -36.0 4.0 0.017 0.0 SO4
HOH
 8.646
2.817
 OH
OH
 O1
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:148 B:163 3.0 0.013 H -72.6 -30.6 3.0 0.013 0.0 HOH
 3.488
 N
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:148 B:163 4.0 0.017 H -73.8 -32.0 4.0 0.017 0.0 SO4
HOH
 4.591
2.726
 OH
OH
 O1
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 TYR A:120 A:159 5.0 0.022 H -48.8 -40.4 2.0 0.009 0.013 B:Q96QV1:0.013
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 TYR A:120 A:159 6.0 0.026 H -51.9 -25.6 2.0 0.009 0.017 B:Q96QV1:0.017
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:139 A:163 5.0 0.022 H -76.5 -29.3 0.0 0.0 0.022 D:Q4KMG0:0.022
 HOH
 2.194
 HH
 O
TYR B:139 B:163 1.0 0.004 H -73.7 -26.8 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:139 B:163 3.0 0.013 H -73.7 -34.0 0.0 0.0 0.013 B:Q9BWV1:0.013
 HOH
 2.420
 HH
 O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:139 A:163 4.0 0.017 H -54.8 -37.3 4.0 0.017 0.0 HOH
 2.548
 OH
 O
TYR B:139 B:163 5.0 0.022 H -56.5 -37.0 NA NA NA
TYR C:139 C:163 2.0 0.009 H -63.9 -32.6 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:139 B:163 3.0 0.013 H -69.0 -38.4 0.0 0.0 0.013 B:Q9BWV1:0.013

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 TYR A:158 A:158 7.0 0.03 H -65.8 -37.3