Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599113 . C A CCDS5942.1:NM_000193.2:c.439Gac>Tac_NP_000184.1:p.147D>Y Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ASP A:147 G:147 3.0 0.02 E -93.6 131.1 3.0 0.02 0.0 ZN
 2.074
 OD1
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ASP B:127 B:147 3.0 0.02 E -99.5 135.4 3.0 0.02 0.0 ZN
CA
CA
 2.084
8.341
7.370
 OD2
OD2
O
 ZN
CA
CA
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:124 C:147 4.0 0.027 E -111.8 114.2 4.0 0.027 0.0 ZN
CA
CA
 2.125
8.529
6.985
 OD2
OD2
O
 ZN
CA
CA
ASP F:124 F:147 5.0 0.033 E -111.8 114.2 4.0 0.027 0.006 D:Q13635:0.007
 ZN
CA
CA
 2.125
8.530
6.985
 OD2
OD2
O
 ZN
CA
CA
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:124 C:147 4.0 0.027 E -111.7 114.2 4.0 0.027 0.0 ZN
CA
CA
 2.125
8.530
6.985
 OD2
OD2
O
 ZN
CA
CA
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASP C:124 C:147 4.0 0.027 E -111.8 114.2 4.0 0.027 0.0 ZN
CA
CA
 2.125
8.529
6.985
 OD2
OD2
O
 ZN
CA
CA
ASP F:124 F:147 5.0 0.033 E -111.8 114.2 4.0 0.027 0.006 D:Q13635:0.007
 ZN
CA
CA
 2.125
8.530
6.985
 OD2
OD2
O
 ZN
CA
CA
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ASP C:124 C:147 4.0 0.027 E -104.4 118.2 3.0 0.02 0.007 B:Q13635:0.007
 ZN
CA
CA
 1.970
8.569
7.637
 OD1
OD2
O
 ZN
CA
CA
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ASP B:125 C:147 0.0 0.0 E -117.3 117.5 0.0 0.0 0.0 ZN
CA
CA
 2.342
7.291
7.856
 OD1
O
OD2
 ZN
CA
CA
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ASP B:125 C:147 1.0 0.007 E -91.9 133.4 1.0 0.007 0.0 ZN
 4.870
 OD1
 ZN
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ASP A:125 A:147 3.0 0.02 E -102.3 134.8 3.0 0.02 0.0 ZN
HOH
 1.876
4.201
 OD1
CB
 ZN
O
ASP B:125 B:147 8.0 0.053 E -106.5 136.4 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ASP B:235 B:147 4.0 0.027 E -110.9 108.9 4.0 0.027 0.0 ZN
 2.088
 OD1
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ASP C:119 H:147 7.0 0.047 E -108.9 114.2 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ASP A:119 A:147 7.0 0.047 E -106.0 130.8 0.0 0.0 0.047 C:None:0.047
 ZN
CA
CA
SO4
HOH
 1.971
7.675
7.829
4.998
3.149
 OD1
O
OD2
OD2
OD2
 ZN
CA
CA
O3
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ASP A:119 A:147 14.0 0.093 E -99.6 134.4 14.0 0.093 0.0 DMS
MG
ZN
MG
HOH
 6.494
7.679
2.086
2.087
2.618
 OD1
HB2
OD1
OD1
OD2
 H21
MG
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ASP A:127 A:148 8.0 0.053 E -98.6 137.2 8.0 0.053 0.0 ZN
CA
CA
HOH
 2.074
7.649
8.119
2.561
 OD1
O
OD2
OD2
 ZN
CA
CA
O
ASP B:127 B:148 9.0 0.06 E -103.9 134.8 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ASP B:123 H:148 3.0 0.02 E -104.4 128.1 3.0 0.02 0.0 CA
CA
ZN
SO4
 7.648
7.336
1.695
7.910
 O
OD2
OD1
O
 CA
CA
ZN
O1
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ASP A:115 A:148 4.0 0.027 E -108.4 126.0 4.0 0.027 0.0 ZN
SO4
HOH
 1.965
7.432
2.579
 OD1
CB
OD2
 ZN
O3
O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ASP A:137 B:152 10.0 0.067 E -98.0 128.7 10.0 0.067 0.0 ZN
HOH
 2.003
3.400
 OD1
OD1
 ZN
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASP A:111 A:148 6.0 0.04 E -105.1 130.8 6.0 0.04 0.0 ZN
CA
CA
ACT
HOH
 1.958
8.011
7.774
8.109
2.465
 OD1
OD2
O
CB
OD2
 ZN
CA
CA
CH3
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASP A:111 A:148 5.0 0.033 E -103.1 132.2 5.0 0.033 0.0 IDS
ZN
CA
CA
HOH
 8.477
1.773
8.054
7.609
4.973
 CB
OD1
OD2
O
OD2
 O2S
ZN
CA
CA
O
ASP B:111 B:148 6.0 0.04 E -103.0 131.7 6.0 0.04 0.0 SGN
IDS
ZN
CA
CA
HOH
 6.972
8.292
1.749
7.839
8.131
3.448
 CB
OD2
OD1
O
OD2
OD1
 O5S
O1S
ZN
CA
CA
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ASP A:113 A:148 8.0 0.053 E -107.8 131.0 8.0 0.053 0.0 ZN
CA
HOH
 2.117
7.750
6.407
 OD1
O
OD2
 ZN
CA
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ASP A:137 B:152 6.0 0.04 E -99.5 133.3 6.0 0.04 0.0 ZN
SO4
CO3
HOH
 2.077
9.017
5.255
2.597
 OD1
OD2
OD1
OD2
 ZN
O1
O2
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASP A:137 B:152 12.0 0.08 E -95.8 131.0 12.0 0.08 0.0 ZN
HOH
 1.965
2.697
 OD1
OD2
 ZN
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASP A:137 B:152 11.0 0.073 E -102.1 133.2 11.0 0.073 0.0 ZN
SO4
HOH
 1.975
7.490
2.809
 OD1
O
OD2
 ZN
O3
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ASP A:109 A:148 11.0 0.073 E -105.7 124.6 0.0 0.0 0.073 B:Q96QV1:0.073
 ZN
 2.046
 OD1
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ASP A:109 A:148 10.0 0.067 E -97.5 115.5 0.0 0.0 0.067 B:Q96QV1:0.067
 ZN
CA
CA
 2.032
7.419
7.978
 OD1
OD2
OD2
 ZN
CA
CA
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:128 A:152 6.0 0.04 E -102.4 134.8 6.0 0.04 0.0 ZN
CA
CA
HOH
 1.948
6.990
7.920
2.723
 OD1
HB2
OD2
OD2
 ZN
CA
CA
O
ASP B:128 B:152 5.0 0.033 E -104.5 133.0 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:128 B:152 7.0 0.047 E -109.1 131.9 7.0 0.047 0.0 ZN
CA
CA
HOH
 1.910
7.073
8.144
2.641
 OD1
HB2
OD2
OD2
 ZN
CA
CA
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:128 A:152 7.0 0.047 E -111.0 121.4 7.0 0.047 0.0 ZN
HOH
 2.082
6.423
 OD1
OD1
 ZN
O
ASP B:128 B:152 5.0 0.033 E -106.0 134.0 NA NA NA
ASP C:128 C:152 6.0 0.04 E -105.2 125.7 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASP A:128 B:152 6.0 0.04 E -98.3 120.4 6.0 0.04 0.0 ZN
CA
CA
HOH
 2.341
7.642
8.147
8.463
 OD1
O
OD2
OD2
 ZN
CA
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ASP A:147 A:147 11.0 0.073 E -101.2 132.3