Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599121 . C A CCDS5942.1:NM_000193.2:c.431cGc>cTc_NP_000184.1:p.144R>L Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ARG A:144 G:144 15.0 0.067 S -84.6 20.7 15.0 0.067 0.0 ZN
 9.250
 C
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ARG B:124 B:144 6.0 0.027 -107.5 7.4 6.0 0.027 0.0 SER
ZN
 7.841
9.414
 NH2
C
 OG
ZN
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ARG C:121 C:144 5.0 0.022 -108.8 3.2 5.0 0.022 0.0 ZN
 8.689
 C
 ZN
ARG F:121 F:144 5.0 0.022 -108.8 3.2 5.0 0.022 0.0 ZN
 8.689
 C
 ZN
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ARG C:121 C:144 5.0 0.022 -108.8 3.2 5.0 0.022 0.0 ZN
 8.689
 C
 ZN
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ARG C:121 C:144 5.0 0.022 -108.8 3.2 5.0 0.022 0.0 ZN
 8.689
 C
 ZN
ARG F:121 F:144 5.0 0.022 -108.8 3.2 5.0 0.022 0.0 ZN
 8.689
 C
 ZN
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ARG C:121 C:144 7.0 0.031 -118.8 1.8 7.0 0.031 0.0 ZN
 9.010
 C
 ZN
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ARG B:122 C:144 22.0 0.098 -91.7 -62.6 22.0 0.098 0.0 ZN
 9.785
 C
 ZN
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ARG B:122 C:144 38.0 0.169 -80.8 -49.4 38.0 0.169 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ARG A:122 A:144 4.0 0.018 -113.0 8.5 4.0 0.018 0.0 ZN
HOH
 8.276
3.926
 C
NH1
 ZN
O
ARG B:122 B:144 3.0 0.013 -115.9 10.4 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ARG B:232 B:144 9.0 0.04 -108.4 36.7 9.0 0.04 0.0 ZN
 8.823
 C
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ARG C:116 H:144 1.0 0.004 -103.9 -13.9 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ARG A:116 A:144 2.0 0.009 -106.6 8.7 2.0 0.009 0.0 ZN
SO4
HOH
 8.031
8.212
3.416
 C
C
NH2
 ZN
O4
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ARG A:116 A:144 4.0 0.018 -115.0 0.3 4.0 0.018 0.0 DMS
ZN
MG
HOH
 8.922
8.941
8.953
2.814
 O
C
C
H
 H22
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ARG A:124 A:145 4.0 0.018 -110.9 3.1 4.0 0.018 0.0 ZN
HOH
 8.744
3.106
 C
N
 ZN
O
ARG B:124 B:145 3.0 0.013 -107.9 7.3 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ARG B:120 H:145 3.0 0.013 -101.0 11.9 3.0 0.013 0.0 ZN
 8.417
 C
 ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ARG A:112 A:145 0.0 0.0 -112.7 12.4 0.0 0.0 0.0 ZN
HOH
 8.126
2.349
 C
HE
 ZN
O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ARG A:134 B:149 3.0 0.013 -119.2 11.0 3.0 0.013 0.0 ZN
SO4
HOH
 8.230
9.023
3.409
 C
NH2
NE
 ZN
O2
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ARG A:108 A:145 6.0 0.027 -111.2 10.0 6.0 0.027 0.0 ZN
HOH
 8.186
3.436
 C
NH2
 ZN
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ARG A:108 A:145 3.0 0.013 -104.8 12.6 3.0 0.013 0.0 ZN
HOH
 8.426
3.848
 C
CG
 ZN
O
ARG B:108 B:145 2.0 0.009 -106.7 13.1 2.0 0.009 0.0 ZN
 8.320
 C
 ZN
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ARG A:110 A:145 4.0 0.018 -112.9 0.7 4.0 0.018 0.0 ZN
HOH
 8.258
3.087
 C
N
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ARG A:134 B:149 2.0 0.009 -119.9 15.5 2.0 0.009 0.0 ZN
SO4
SO4
CO3
HOH
 8.185
9.996
9.196
8.963
3.581
 C
NH2
NH2
O
CD
 ZN
O3
O2
O3
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ARG A:134 B:149 2.0 0.009 -117.3 10.4 2.0 0.009 0.0 ZN
SO4
HOH
 8.201
9.020
3.228
 C
NH2
NH1
 ZN
O2
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ARG A:134 B:149 2.0 0.009 -119.6 11.5 2.0 0.009 0.0 ZN
HOH
 8.243
3.328
 C
NE
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ARG A:106 A:145 6.0 0.027 -103.5 0.8 6.0 0.027 0.0 ZN
 8.218
 C
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ARG A:106 A:145 4.0 0.018 -103.2 -6.0 4.0 0.018 0.0 ZN
 8.438
 C
 ZN
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ARG A:125 A:149 2.0 0.009 -105.3 11.0 2.0 0.009 0.0 ZN
HOH
 8.131
3.041
 C
HG2
 ZN
O
ARG B:125 B:149 3.0 0.013 -110.1 8.9 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ARG A:125 B:149 5.0 0.022 -103.4 8.7 5.0 0.022 0.0 ZN
HOH
 8.143
2.934
 C
HG2
 ZN
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ARG A:125 A:149 1.0 0.004 -108.1 2.3 1.0 0.004 0.0 ZN
HOH
 8.380
3.825
 C
N
 ZN
O
ARG B:125 B:149 3.0 0.013 -114.1 6.0 NA NA NA
ARG C:125 C:149 3.0 0.013 -120.3 13.8 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ARG A:125 B:149 4.0 0.018 -107.3 5.9 4.0 0.018 0.0 ZN
 9.134
 C
 ZN

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ARG A:144 A:144 3.0 0.013 -112.5 -1.2