Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599129 . G A CCDS5942.1:NM_000193.2:c.423taC>taT_NP_000184.1:p.141Y>Y Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 TYR A:141 G:141 19.0 0.083 H -66.0 -24.9 19.0 0.083 0.0 ZN
 8.558
 N
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 TYR B:121 B:141 19.0 0.083 G -86.3 15.3 19.0 0.083 0.0 ZN
CA
 8.787
7.426
 N
CE1
 ZN
CA
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:118 C:141 24.0 0.104 G -77.2 -10.0 24.0 0.104 0.0 ZN
CA
 8.472
7.771
 N
CE1
 ZN
CA
TYR F:118 F:141 23.0 0.1 G -77.2 -10.0 23.0 0.1 0.0 ZN
CA
 8.472
7.771
 N
CE1
 ZN
CA
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:118 C:141 23.0 0.1 G -77.3 -10.0 23.0 0.1 0.0 ZN
CA
 8.472
7.771
 N
CE1
 ZN
CA
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 TYR C:118 C:141 24.0 0.104 G -77.2 -10.0 24.0 0.104 0.0 ZN
CA
 8.472
7.771
 N
CE1
 ZN
CA
TYR F:118 F:141 23.0 0.1 G -77.2 -10.0 23.0 0.1 0.0 ZN
CA
 8.472
7.771
 N
CE1
 ZN
CA
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 TYR C:118 C:141 9.0 0.039 G -68.3 -25.0 9.0 0.039 0.0 ZN
CA
 8.756
7.465
 N
CE1
 ZN
CA
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 TYR B:119 C:141 20.0 0.087 G -66.1 -19.7 20.0 0.087 0.0 ZN
 9.283
 N
 ZN
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 TYR B:119 C:141 5.0 0.022 T -56.8 -59.3 5.0 0.022 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 TYR A:119 A:141 9.0 0.039 G -78.7 -5.4 9.0 0.039 0.0 ZN
HOH
 8.661
6.648
 N
OH
 ZN
O
TYR B:119 B:141 5.0 0.022 G -80.5 -3.4 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 TYR B:229 B:141 13.0 0.057 H -72.8 -37.6 13.0 0.057 0.0 ZN
 8.344
 H
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 TYR C:113 H:141 18.0 0.078 T -68.3 -17.1 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 TYR A:113 A:141 15.0 0.065 G -73.1 -12.8 15.0 0.065 0.0 ZN
CA
SO4
HOH
 8.522
7.480
6.776
3.326
 N
CE1
OH
CE1
 ZN
CA
O1
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 TYR A:113 A:141 15.0 0.065 G -88.0 1.6 15.0 0.065 0.0 DMS
MG
ZN
MG
HOH
 8.456
8.456
8.862
8.874
2.610
 H
HE1
H
H
HE1
 H23
MG
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 TYR A:121 A:142 4.0 0.017 G -76.5 -4.6 4.0 0.017 0.0 ZN
CA
HOH
 8.743
7.570
3.297
 N
CE1
OH
 ZN
CA
O
TYR B:121 B:142 5.0 0.022 G -72.0 -11.4 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 TYR B:117 H:142 12.0 0.052 G -76.2 -9.6 12.0 0.052 0.0 CA
ZN
 7.842
8.531
 CE1
N
 CA
ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 TYR A:109 A:142 10.0 0.043 G -67.6 -16.1 10.0 0.043 0.0 ZN
HOH
 8.255
3.202
 H
O
 ZN
H2
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 TYR A:131 B:146 7.0 0.03 G -74.9 -13.0 7.0 0.03 0.0 ZN
SO4
GOL
HOH
 8.615
4.894
9.357
2.796
 N
CD2
O
OH
 ZN
O4
O1
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:105 A:142 5.0 0.022 G -76.2 -12.3 5.0 0.022 0.0 ZN
CA
HOH
 8.602
7.625
2.675
 N
CE1
OH
 ZN
CA
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TYR A:105 A:142 14.0 0.061 G -73.6 -6.6 14.0 0.061 0.0 ZN
CA
HOH
 8.617
7.443
6.555
 N
CE1
N
 ZN
CA
O
TYR B:105 B:142 16.0 0.07 G -73.7 -7.4 16.0 0.07 0.0 ZN
CA
HOH
 8.536
7.505
6.814
 N
CE1
O
 ZN
CA
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 TYR A:107 A:142 11.0 0.048 G -65.9 -16.9 11.0 0.048 0.0 ZN
HOH
 8.640
4.018
 N
CE2
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 TYR A:131 B:146 5.0 0.022 G -71.8 -16.5 5.0 0.022 0.0 ZN
SO4
CO3
HOH
 8.571
5.609
6.767
3.458
 N
CD2
CZ
CD1
 ZN
O2
O3
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:131 B:146 6.0 0.026 G -73.1 -13.5 6.0 0.026 0.0 ZN
SO4
HOH
 8.596
4.954
2.798
 N
CD2
OH
 ZN
O4
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TYR A:131 B:146 6.0 0.026 G -72.4 -15.2 6.0 0.026 0.0 ZN
HOH
 8.607
3.238
 N
OH
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 TYR A:103 A:142 12.0 0.052 G -76.7 -11.4 12.0 0.052 0.0 ZN
 8.642
 N
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 TYR A:103 A:142 4.0 0.017 T -71.3 -13.6 4.0 0.017 0.0 ZN
CA
 8.612
8.579
 N
CE1
 ZN
CA
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:122 A:146 10.0 0.043 G -72.7 -10.5 10.0 0.043 0.0 ZN
CA
HOH
 8.267
6.604
2.761
 H
HE1
OH
 ZN
CA
O
TYR B:122 B:146 7.0 0.03 G -72.9 -8.3 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:122 B:146 0.0 0.0 G -71.0 -12.0 0.0 0.0 0.0 ZN
CA
HOH
 8.265
6.947
2.628
 H
HE1
HH
 ZN
CA
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:122 A:146 13.0 0.057 G -78.4 -10.4 13.0 0.057 0.0 ZN
HOH
 8.696
6.434
 N
N
 ZN
O
TYR B:122 B:146 6.0 0.026 G -82.4 -3.6 NA NA NA
TYR C:122 C:146 7.0 0.03 G -74.3 -7.4 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TYR A:122 B:146 9.0 0.039 T -71.9 -8.1 9.0 0.039 0.0 ZN
CA
HOH
 8.973
7.471
8.506
 N
CE1
N
 ZN
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 TYR A:141 A:141 12.0 0.052 G -64.3 -10.6