Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599148 . G A CCDS5942.1:NM_000193.2:c.404tCa>tTa_NP_000184.1:p.135S>L Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 SER A:135 G:135 57.0 0.496 -63.4 160.6 57.0 0.496 0.0 ZN
 8.186
 N
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 SER B:115 B:135 79.0 0.687 -68.6 166.9 58.0 0.504 0.183 A:Q13635:0.183
 ZN
 8.002
 N
 ZN
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:112 C:135 78.0 0.678 -68.5 166.8 57.0 0.496 0.182 A:Q13635:0.183
 ZN
 7.593
 OG
 ZN
SER F:112 F:135 80.0 0.696 -68.5 166.8 60.0 0.522 0.174 D:Q13635:0.174
 ZN
 7.592
 OG
 ZN
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:112 C:135 78.0 0.678 -68.6 166.8 58.0 0.504 0.174 A:Q13635:0.174
 ZN
 7.592
 OG
 ZN
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 SER C:112 C:135 78.0 0.678 -68.5 166.8 57.0 0.496 0.182 A:Q13635:0.183
 ZN
 7.593
 OG
 ZN
SER F:112 F:135 80.0 0.696 -68.5 166.8 60.0 0.522 0.174 D:Q13635:0.174
 ZN
 7.592
 OG
 ZN
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 SER C:112 C:135 67.0 0.583 -70.5 170.4 57.0 0.496 0.087 B:Q13635:0.087
 ZN
 8.294
 N
 ZN
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 SER B:113 C:135 65.0 0.565 -162.4 -176.1 50.0 0.435 0.13 C:Q13635:0.13
 ZN
 8.057
 N
 ZN
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 SER B:113 C:135 57.0 0.496 -175.2 160.9 57.0 0.496 0.0 ZN
 6.038
 OG
 ZN
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 SER A:113 A:135 73.0 0.635 81.0 -162.3 73.0 0.635 0.0 ZN
HOH
 9.613
2.810
 N
OG
 ZN
O
SER B:113 B:135 67.0 0.583 76.8 -168.3 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 SER B:223 B:135 54.0 0.47 -171.5 -171.6 51.0 0.443 0.027 A:Q13635+U6GSR1:0.026
 ZN
 8.779
 H
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 SER C:107 H:135 70.0 0.609 -70.1 157.2 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 SER A:107 A:135 77.0 0.67 -64.5 162.7 45.0 0.391 0.279 B:None:0.278
 ZN
SO4
HOH
 7.679
2.656
3.401
 N
OG
N
 ZN
O1
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 SER A:107 A:135 99.0 0.861 -61.5 154.3 99.0 0.861 0.0 DMS
DMS
ZN
MG
HOH
 5.243
9.663
8.508
8.509
2.146
 HB2
HG
H
H
H
 H11
H13
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 SER A:115 A:136 87.0 0.757 -59.3 150.3 87.0 0.757 0.0 ZN
HOH
 8.264
2.673
 N
N
 ZN
O
SER B:115 B:136 82.0 0.713 -63.0 159.4 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 SER B:111 H:136 62.0 0.539 -167.8 170.7 62.0 0.539 0.0 ZN
 8.572
 N
 ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 SER A:103 A:136 100.0 0.87 -61.3 160.2 100.0 0.87 0.0 ZN
HOH
 7.602
4.692
 H
HG
 ZN
H1
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 SER A:125 B:140 84.0 0.73 -69.6 170.6 84.0 0.73 0.0 ZN
SO4
HOH
 8.498
7.135
2.862
 N
O
OG
 ZN
O4
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 SER A:99 A:136 70.0 0.609 -61.6 158.1 70.0 0.609 0.0 ZN
HOH
 7.992
2.940
 N
OG
 ZN
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 SER A:99 A:136 81.0 0.704 -57.6 145.1 81.0 0.704 0.0 ZN
HOH
 7.737
3.473
 OG
OG
 ZN
O
SER B:99 B:136 83.0 0.722 -58.7 146.6 83.0 0.722 0.0 ZN
HOH
 7.821
6.357
 OG
N
 ZN
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 SER A:101 A:136 112.0 0.974 -43.2 145.4 112.0 0.974 0.0 ZN
HOH
 9.010
4.902
 N
O
 ZN
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 SER A:125 B:140 80.0 0.696 -69.9 170.7 80.0 0.696 0.0 ZN
SO4
CO3
HOH
 8.302
7.705
3.481
4.612
 OG
O
OG
N
 ZN
O2
O3
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 SER A:125 B:140 87.0 0.757 -61.4 166.8 87.0 0.757 0.0 ZN
SO4
HOH
 8.508
6.909
2.765
 N
O
OG
 ZN
O4
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 SER A:125 B:140 84.0 0.73 -66.8 174.7 84.0 0.73 0.0 ZN
HOH
 8.559
2.638
 N
OG
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 SER A:97 A:136 94.0 0.817 -74.4 152.7 76.0 0.661 0.156 B:Q96QV1:0.157
 ZN
 9.591
 N
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 SER A:97 A:136 109.0 0.948 -60.8 122.7 94.0 0.817 0.131 B:Q96QV1:0.13
 ZN
 8.048
 N
 ZN
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:116 A:140 77.0 0.67 -55.3 152.9 77.0 0.67 0.0 ZN
HOH
 6.730
2.094
 H
HG
 ZN
O
SER B:116 B:140 67.0 0.583 -65.3 162.5 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:116 B:140 92.0 0.8 -56.7 150.3 92.0 0.8 0.0 ZN
HOH
 7.708
2.110
 H
H
 ZN
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:116 A:140 96.0 0.835 -72.6 -155.3 96.0 0.835 0.0 ZN
HOH
 8.564
5.045
 N
N
 ZN
O
SER B:116 B:140 108.0 0.939 S -58.2 -162.6 NA NA NA
SER C:116 C:140 91.0 0.791 -47.8 159.5 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 SER A:116 B:140 97.0 0.843 -52.9 133.8 97.0 0.843 0.0 ZN
 8.038
 OG
 ZN

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 SER A:135 A:135 85.0 0.739 -55.8 149.0