Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599164 . C A CCDS5942.1:NM_000193.2:c.388Gaa>Taa_NP_000184.1:p.130E>* Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 GLU A:130 G:130 70.0 0.368 S -122.3 -27.4 70.0 0.368 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 GLU B:110 B:130 73.0 0.384 S -115.3 -13.3 73.0 0.384 0.0 CA
CA
 4.460
8.128
 N
N
 CA
CA
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 GLU C:107 C:130 66.0 0.347 S -115.3 -13.3 66.0 0.347 0.0 CA
CA
 4.460
8.128
 N
N
 CA
CA
GLU F:107 F:130 66.0 0.347 S -115.3 -13.2 66.0 0.347 0.0 CA
CA
 4.460
8.129
 N
N
 CA
CA
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 GLU C:107 C:130 64.0 0.337 S -115.3 -13.3 64.0 0.337 0.0 CA
CA
 4.460
8.128
 N
N
 CA
CA
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 GLU C:107 C:130 66.0 0.347 S -115.3 -13.3 66.0 0.347 0.0 CA
CA
 4.460
8.128
 N
N
 CA
CA
GLU F:107 F:130 66.0 0.347 S -115.3 -13.2 66.0 0.347 0.0 CA
CA
 4.460
8.129
 N
N
 CA
CA
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 GLU C:107 C:130 71.0 0.374 S -111.3 -2.8 71.0 0.374 0.0 CA
CA
 4.638
8.228
 N
N
 CA
CA
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 GLU B:108 C:130 40.0 0.211 S -68.8 -49.4 40.0 0.211 0.0 CA
CA
 9.239
7.046
 OE1
OE1
 CA
CA
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 GLU B:108 C:130 57.0 0.3 S -69.9 -48.6 57.0 0.3 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 GLU A:108 A:130 67.0 0.353 S -90.8 -5.7 67.0 0.353 0.0 HOH
 2.590
 OE1
 O
GLU B:108 B:130 56.0 0.295 S -97.6 -2.5 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 GLU B:218 B:130 59.0 0.311 -139.1 -2.7 59.0 0.311 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 GLU C:102 H:130 81.0 0.426 S -120.4 -8.7 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 GLU A:102 A:130 76.0 0.4 -120.9 5.4 76.0 0.4 0.0 CA
CA
HOH
 8.509
4.937
2.636
 N
N
OE2
 CA
CA
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 GLU A:102 A:130 66.0 0.347 S -101.5 -1.6 66.0 0.347 0.0 DMS
MG
HOH
 8.029
5.577
2.157
 OE2
H
H
 H12
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 GLU A:110 A:131 79.0 0.416 -122.5 2.8 72.0 0.379 0.037 D:Q4KMG0:0.037
 CA
CA
HOH
 8.350
4.781
2.669
 N
N
OE2
 CA
CA
O
GLU B:110 B:131 80.0 0.421 -122.7 0.2 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 GLU B:106 H:131 63.0 0.332 S -98.5 -3.0 63.0 0.332 0.0 CA
CA
 7.808
5.176
 N
N
 CA
CA
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 GLU A:98 A:131 57.0 0.3 S -92.6 -18.0 57.0 0.3 0.0 HOH
 1.830
 H
 O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 GLU A:120 B:135 73.0 0.384 S -89.3 -3.9 73.0 0.384 0.0 HOH
 2.576
 OE1
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 GLU A:94 A:131 81.0 0.426 S -111.4 0.9 81.0 0.426 0.0 CA
CA
HOH
 4.889
8.501
2.603
 N
N
OE2
 CA
CA
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 GLU A:94 A:131 62.0 0.326 S -116.3 -0.5 62.0 0.326 0.0 CA
CA
HOH
 4.911
8.748
4.573
 N
N
N
 CA
CA
O
GLU B:94 B:131 67.0 0.353 S -119.4 -0.0 67.0 0.353 0.0 CA
CA
CL
HOH
 8.507
4.812
5.580
2.408
 N
N
OE2
OE2
 CA
CA
CL
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 GLU A:96 A:131 84.0 0.442 S -103.9 -26.2 84.0 0.442 0.0 CA
HOH
 9.605
3.534
 N
OE1
 CA
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 GLU A:120 B:135 82.0 0.432 S -94.2 3.0 82.0 0.432 0.0 SO4
HOH
 9.642
2.868
 O
N
 O2
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 GLU A:120 B:135 64.0 0.337 S -89.4 -2.0 64.0 0.337 0.0 HOH
 2.648
 OE2
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 GLU A:120 B:135 64.0 0.337 S -83.5 -7.6 64.0 0.337 0.0 HOH
 2.635
 OE2
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 GLU A:92 A:131 75.0 0.395 S -66.8 -20.6 75.0 0.395 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 GLU A:92 A:131 67.0 0.353 S -111.2 43.4 67.0 0.353 0.0 CA
CA
 9.293
5.577
 N
N
 CA
CA
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 GLU A:111 A:135 85.0 0.447 -122.8 4.1 82.0 0.432 0.015 D:Q4KMG0:0.016
 CA
CA
HOH
 7.582
4.151
2.113
 H
H
H
 CA
CA
O
GLU B:111 B:135 86.0 0.453 -117.0 0.8 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 GLU A:111 B:135 78.0 0.411 -126.4 5.7 67.0 0.353 0.058 B:Q9BWV1:0.058
 CA
CA
HOH
 7.577
4.114
2.078
 H
H
H
 CA
CA
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 GLU A:111 A:135 56.0 0.295 S -100.2 -12.3 56.0 0.295 0.0 HOH
 4.156
 N
 O
GLU B:111 B:135 67.0 0.353 S -96.6 -2.5 NA NA NA
GLU C:111 C:135 71.0 0.374 S -97.6 11.5 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 GLU A:111 B:135 82.0 0.432 -137.7 13.9 69.0 0.363 0.069 B:Q9BWV1:0.068
 CA
CA
HOH
 8.421
4.778
5.144
 N
N
N
 CA
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 GLU A:130 A:130 48.0 0.253 S -97.6 -22.2