Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599169 . C A CCDS5942.1:NM_000193.2:c.383tGg>tTg_NP_000184.1:p.128W>L Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 TRP A:128 G:128 1.0 0.004 S -133.1 119.8 1.0 0.004 0.0 ZN
 9.500
 N
 ZN
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 TRP B:108 B:128 4.0 0.016 S -93.6 98.0 4.0 0.016 0.0 ZN
CA
CA
 9.224
4.681
6.582
 N
O
N
 ZN
CA
CA
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 TRP C:105 C:128 1.0 0.004 S -93.6 98.0 1.0 0.004 0.0 ZN
CA
CA
 9.409
4.681
6.581
 N
O
N
 ZN
CA
CA
TRP F:105 F:128 2.0 0.008 S -93.6 98.0 2.0 0.008 0.0 ZN
CA
CA
 9.409
4.681
6.582
 N
O
N
 ZN
CA
CA
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 TRP C:105 C:128 2.0 0.008 S -93.6 98.0 2.0 0.008 0.0 ZN
CA
CA
 9.409
4.681
6.581
 N
O
N
 ZN
CA
CA
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 TRP C:105 C:128 1.0 0.004 S -93.6 98.0 1.0 0.004 0.0 ZN
CA
CA
 9.409
4.681
6.581
 N
O
N
 ZN
CA
CA
TRP F:105 F:128 2.0 0.008 S -93.6 98.0 2.0 0.008 0.0 ZN
CA
CA
 9.409
4.681
6.582
 N
O
N
 ZN
CA
CA
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 TRP C:105 C:128 0.0 0.0 S -65.6 140.7 0.0 0.0 0.0 ZN
CA
CA
 9.628
4.397
6.152
 N
O
O
 ZN
CA
CA
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 TRP B:106 C:128 0.0 0.0 -139.3 103.5 0.0 0.0 0.0 ZN
CA
CA
 9.526
7.194
5.437
 N
N
O
 ZN
CA
CA
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 TRP B:106 C:128 5.0 0.02 -164.8 142.1 5.0 0.02 0.0
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 TRP A:106 A:128 7.0 0.027 S -64.1 122.7 7.0 0.027 0.0 ZN
HOH
 8.931
2.941
 N
N
 ZN
O
TRP B:106 B:128 1.0 0.004 S -66.0 128.4 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 TRP B:216 B:128 1.0 0.004 S -75.3 134.9 1.0 0.004 0.0 ZN
 9.061
 HA
 ZN
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 TRP C:100 H:128 1.0 0.004 S -72.2 142.8 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 TRP A:100 A:128 1.0 0.004 S -60.0 143.5 1.0 0.004 0.0 ZN
CA
CA
HOH
 9.019
6.371
4.649
2.682
 N
O
O
O
 ZN
CA
CA
O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 TRP A:100 A:128 3.0 0.012 S -87.1 112.3 3.0 0.012 0.0 DMS
MG
ZN
MG
HOH
 6.533
5.547
9.406
9.419
2.485
 HE3
O
N
N
H
 H12
MG
ZN
MG
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 TRP A:108 A:129 0.0 0.0 S -68.8 139.5 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.632
6.348
4.732
2.714
 N
O
O
O
 ZN
CA
CA
O
TRP B:108 B:129 1.0 0.004 S -56.0 139.6 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 TRP B:104 H:129 2.0 0.008 S -57.2 138.2 2.0 0.008 0.0 CA
CA
ZN
 6.017
5.231
8.962
 O
O
N
 CA
CA
ZN
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 TRP A:96 A:129 3.0 0.012 S -62.8 124.3 3.0 0.012 0.0 ZN
HOH
 8.764
2.045
 N
H
 ZN
O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 TRP A:118 B:133 3.0 0.012 S -60.3 128.9 3.0 0.012 0.0 ZN
HOH
 8.809
2.841
 N
O
 ZN
O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TRP A:92 A:129 0.0 0.0 S -65.0 141.0 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.031
4.680
6.396
2.546
 N
O
O
O
 ZN
CA
CA
O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 TRP A:92 A:129 0.0 0.0 S -56.4 139.7 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.128
4.710
6.513
2.500
 N
O
O
O
 ZN
CA
CA
O
TRP B:92 B:129 0.0 0.0 S -58.2 140.7 0.0 0.0 0.0 ZN
CA
CA
CL
HOH
 9.053
6.421
4.815
4.801
2.660
 N
O
O
CZ3
O
 ZN
CA
CA
CL
O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 TRP A:94 A:129 1.0 0.004 S -69.6 129.7 1.0 0.004 0.0 ZN
CA
HOH
 8.979
7.112
3.231
 N
O
O
 ZN
CA
O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 TRP A:118 B:133 8.0 0.031 -66.8 125.5 8.0 0.031 0.0 ZN
SO4
HOH
 8.903
8.457
2.787
 N
O
O
 ZN
O1
O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TRP A:118 B:133 1.0 0.004 -63.9 126.0 1.0 0.004 0.0 ZN
HOH
 8.810
2.729
 N
O
 ZN
O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 TRP A:118 B:133 0.0 0.0 S -70.5 127.0 0.0 0.0 0.0 ZN
HOH
 8.948
2.789
 N
O
 ZN
O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 TRP A:90 A:129 7.0 0.027 -83.1 136.3 7.0 0.027 0.0 ZN
 8.904
 N
 ZN
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 TRP A:90 A:129 0.0 0.0 S -86.4 127.3 0.0 0.0 0.0 ZN
CA
CA
 9.047
6.970
5.244
 N
O
O
 ZN
CA
CA
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TRP A:109 A:133 0.0 0.0 S -59.4 142.8 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.020
6.282
4.716
2.655
 HA
O
O
O
 ZN
CA
CA
O
TRP B:109 B:133 1.0 0.004 S -60.6 137.3 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TRP A:109 B:133 0.0 0.0 S -61.1 145.4 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.067
6.350
4.798
2.639
 HA
O
O
HA
 ZN
CA
CA
O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TRP A:109 A:133 8.0 0.031 S -65.8 121.2 8.0 0.031 0.0 ZN
HOH
 8.933
2.827
 N
N
 ZN
O
TRP B:109 B:133 13.0 0.051 -67.5 116.2 NA NA NA
TRP C:109 C:133 1.0 0.004 S -69.1 135.7 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 TRP A:109 B:133 0.0 0.0 S -61.1 147.7 0.0 0.0 0.0 ZN
CA
CA
HOH
 9.771
6.348
4.731
2.582
 N
O
O
O
 ZN
CA
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 TRP A:128 A:128 1.0 0.004 S -77.4 122.3