Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599207 . G A CCDS5942.1:NM_000193.2:c.345aaC>aaT_NP_000184.1:p.115N>N Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ASN A:115 G:115 136.0 0.85 H -65.7 -60.7 136.0 0.85 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ASN B:95 B:115 125.0 0.781 T -78.4 0.9 125.0 0.781 0.0
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASN C:92 C:115 122.0 0.762 H -87.8 -23.3 4.0 0.025 0.737 B:Q13635:0.738
 CLR
 8.506
 ND2
 C6
ASN F:92 F:115 120.0 0.75 H -87.8 -23.3 4.0 0.025 0.725 E:Q13635:0.725
 CLR
 8.507
 ND2
 C6
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASN C:92 C:115 121.0 0.756 H -87.8 -23.3 5.0 0.031 0.725 B:Q13635:0.725
 CLR
 8.506
 ND2
 C6
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ASN C:92 C:115 122.0 0.762 H -87.8 -23.3 4.0 0.025 0.737 B:Q13635:0.738
 CLR
 8.506
 ND2
 C6
ASN F:92 F:115 120.0 0.75 H -87.8 -23.3 4.0 0.025 0.725 E:Q13635:0.725
 CLR
 8.507
 ND2
 C6
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ASN C:92 C:115 126.0 0.787 H -79.1 -16.7 5.0 0.031 0.756 A:Q13635:0.756
 CLR
 7.595
 ND2
 C2
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ASN B:93 C:115 121.0 0.756 H -65.3 -48.1 0.0 0.0 0.756 A:Q13635:0.756
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ASN B:93 C:115 128.0 0.8 H -94.4 -35.2 12.0 0.075 0.725 A:Q13635:0.725
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ASN A:93 A:115 128.0 0.8 H -66.5 -38.4 128.0 0.8 0.0 HOH
 2.428
 ND2
 O
ASN B:93 B:115 133.0 0.831 H -72.6 -32.0 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ASN B:203 B:115 124.0 0.775 T -66.5 -55.7 124.0 0.775 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ASN C:87 H:115 132.0 0.825 H -82.0 -39.4 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ASN A:87 A:115 131.0 0.819 H -72.0 -40.6 131.0 0.819 0.0 HOH
 5.637
 O
 O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ASN A:87 A:115 127.0 0.794 H -73.9 -41.2 127.0 0.794 0.0 GOL
HOH
 8.256
2.244
 O
HD21
 O3
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ASN A:95 A:116 127.0 0.794 H -68.4 -37.6 127.0 0.794 0.0 HOH
 2.737
 ND2
 O
ASN B:95 B:116 127.0 0.794 H -64.2 -45.7 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ASN B:91 H:116 134.0 0.838 H -70.8 -37.4 134.0 0.838 0.0
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ASN A:83 A:116 130.0 0.812 H -70.8 -37.5 130.0 0.812 0.0 HOH
 1.878
 HD22
 O
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ASN A:105 B:120 122.0 0.762 H -64.8 -43.3 122.0 0.762 0.0 HOH
 2.596
 O
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASN A:79 A:116 127.0 0.794 H -78.7 -30.4 127.0 0.794 0.0 HOH
 2.915
 ND2
 O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ASN A:79 A:116 126.0 0.787 H -73.7 -31.6 126.0 0.787 0.0 HOH
 3.338
 ND2
 O
ASN B:79 B:116 127.0 0.794 H -71.2 -34.3 127.0 0.794 0.0 HOH
 2.929
 OD1
 O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ASN A:81 A:116 125.0 0.781 H -45.7 -40.8 125.0 0.781 0.0 HOH
 2.651
 OD1
 O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ASN A:105 B:120 118.0 0.738 H -68.7 -50.7 118.0 0.738 0.0 HOH
 2.661
 O
 O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASN A:105 B:120 122.0 0.762 H -66.4 -43.7 122.0 0.762 0.0 HOH
 2.531
 O
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ASN A:105 B:120 124.0 0.775 H -62.3 -44.2 124.0 0.775 0.0 HOH
 2.622
 O
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ASN A:77 A:116 128.0 0.8 H -73.8 -26.2 128.0 0.8 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ASN A:77 A:116 134.0 0.838 H -73.4 -34.7 134.0 0.838 0.0
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASN A:96 A:120 127.0 0.794 H -68.2 -31.5 127.0 0.794 0.0 HOH
 2.045
 HD22
 O
ASN B:96 B:120 125.0 0.781 H -71.5 -35.9 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASN A:96 B:120 60.0 0.375 H -73.6 -29.3 60.0 0.375 0.0 HOH
 1.904
 HD22
 O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASN A:96 A:120 126.0 0.787 H -70.0 -40.3 126.0 0.787 0.0 HOH
 2.771
 ND2
 O
ASN B:96 B:120 125.0 0.781 H -75.2 -34.2 NA NA NA
ASN C:96 C:120 131.0 0.819 H -68.7 -38.2 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ASN A:96 B:120 68.0 0.425 H -75.0 -27.8 68.0 0.425 0.0 HOH
 7.689
 O
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ASN A:115 A:115 128.0 0.8 H -70.2 -35.3