Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr7 155599221 . T A CCDS5942.1:NM_000193.2:c.331Atc>Ttc_NP_000184.1:p.111I>F Homo sapiens sonic hedgehog (SHH), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
7e2i 1 Q15465 100.0 0.0 EM
 2021-12-08 ILE A:111 G:111 99.0 0.566 H -67.7 -29.8 99.0 0.566 0.0
6dmy 2 Q15465 100.0 7e-128 EM
 2018-07-11 ILE B:91 B:111 97.0 0.554 H -59.3 -44.3 97.0 0.554 0.0
6n7g 2 Q15465 100.0 7e-128 EM
 2019-05-29 ILE C:88 C:111 70.0 0.4 H -75.1 -39.2 3.0 0.017 0.383 B:Q13635:0.383
 CLR
 7.068
 CD1
 O1
ILE F:88 F:111 68.0 0.389 H -75.1 -39.1 2.0 0.011 0.378 E:Q13635:0.377
 CLR
 7.068
 CD1
 O1
6n7h 2 Q15465 100.0 7e-128 EM
 2019-05-29 ILE C:88 C:111 68.0 0.389 H -75.1 -39.1 3.0 0.017 0.372 B:Q13635:0.371
 CLR
 7.068
 CD1
 O1
6n7k 2 Q15465 100.0 7e-128 EM
 2019-05-29 ILE C:88 C:111 70.0 0.4 H -75.1 -39.2 3.0 0.017 0.383 B:Q13635:0.383
 CLR
 7.068
 CD1
 O1
ILE F:88 F:111 68.0 0.389 H -75.1 -39.1 2.0 0.011 0.378 E:Q13635:0.377
 CLR
 7.068
 CD1
 O1
6rvd 2 Q15465 100.0 7e-128 EM
 2019-10-02 ILE C:88 C:111 65.0 0.371 H -60.4 -45.4 11.0 0.063 0.308 A:Q13635:0.309
 CLR
 6.541
 CD1
 O1
6e1h 2 Q15465 100.0 7e-128 EM
 2018-08-29 ILE B:89 C:111 98.0 0.56 H -63.5 -41.5 22.0 0.126 0.434 A:Q13635:0.434
6oev 2 Q15465 100.0 7e-128 EM
 2019-04-17 ILE B:89 C:111 123.0 0.703 H -61.4 -49.1 66.0 0.377 0.326 A:Q13635:0.326
3m1n 1 Q15465 100.0 2e-126 X-RAY
 2010-03-16 ILE A:89 A:111 101.0 0.577 H -58.2 -51.6 101.0 0.577 0.0 HOH
 3.466
 CG1
 O
ILE B:89 B:111 102.0 0.583 H -63.7 -53.9 NA NA NA
6rmg 2 Q15465 98.31 9e-126 EM
 2019-10-09 ILE B:199 B:111 98.0 0.56 H -64.0 -25.8 98.0 0.56 0.0
3ho5 2 Q15465 100.0 2e-123 X-RAY
 2009-06-23 ILE C:83 H:111 118.0 0.674 H -63.4 -42.9 NA NA NA
3mxw 1 Q15465 100.0 2e-123 X-RAY
 2010-05-26 ILE A:83 A:111 125.0 0.714 H -64.3 -50.6 125.0 0.714 0.0 HOH
 2.922
 O
 O
6pjv 1 Q15465 100.0 2e-123 X-RAY
 2019-11-13 ILE A:83 A:111 114.0 0.651 H -62.8 -44.6 114.0 0.651 0.0 CL
HOH
 8.357
2.645
 HD11
HG22
 CL
O
3d1m 1 Q62226 97.62 9e-120 X-RAY
 2008-09-23 ILE A:91 A:112 100.0 0.571 H -65.1 -48.0 100.0 0.571 0.0 HOH
 2.906
 O
 O
ILE B:91 B:112 119.0 0.68 H -64.7 -46.1 NA NA NA
7rpk 2 Q62226 99.39 1e-119 EM
 2021-10-27 ILE B:87 H:112 106.0 0.606 H -58.3 -45.5 106.0 0.606 0.0
1vhh 1 Q62226 99.38 1e-117 X-RAY
 1996-01-29 ILE A:79 A:112 121.0 0.691 H -71.0 -46.9 121.0 0.691 0.0 HOH
 1.872
 O
 H1
3k7g 1 Q14623 88.07 1e-112 X-RAY
 2011-01-26 ILE A:101 B:116 95.0 0.543 H -68.5 -44.3 95.0 0.543 0.0 HOH
 3.326
 O
 O
4c4m 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ILE A:75 A:112 98.0 0.56 H -68.5 -44.4 98.0 0.56 0.0 HOH
 3.397
 CG1
 O
4c4n 1 Q62226 99.36 1e-112 X-RAY
 2013-10-02 ILE A:75 A:112 99.0 0.566 H -68.5 -50.5 99.0 0.566 0.0 HOH
 3.310
 CG2
 O
ILE B:75 B:112 98.0 0.56 H -67.9 -51.0 98.0 0.56 0.0 HOH
 3.561
 O
 O
3n1r 1 Q62226 99.36 2e-112 X-RAY
 2010-06-02 ILE A:77 A:112 96.0 0.549 H -58.5 -56.5 96.0 0.549 0.0 HOH
 3.171
 CG1
 O
3k7j 1 Q14623 87.5 4e-112 X-RAY
 2011-01-26 ILE A:101 B:116 101.0 0.577 H -66.9 -50.7 101.0 0.577 0.0 HOH
 2.969
 O
 O
3k7i 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ILE A:101 B:116 103.0 0.589 H -66.6 -46.5 103.0 0.589 0.0 HOH
 3.018
 O
 O
3k7h 1 Q14623 87.5 5e-112 X-RAY
 2011-01-26 ILE A:101 B:116 99.0 0.566 H -66.7 -45.8 99.0 0.566 0.0 HOH
 3.567
 CG1
 O
2wg4 1 Q62226 99.35 6e-112 X-RAY
 2009-06-30 ILE A:73 A:112 91.0 0.52 H -68.2 -49.0 91.0 0.52 0.0
2wfx 1 Q62226 99.34 5e-110 X-RAY
 2009-06-30 ILE A:73 A:112 107.0 0.611 H -81.2 -44.2 107.0 0.611 0.0
3n1f 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ILE A:92 A:116 87.0 0.497 H -64.3 -47.1 87.0 0.497 0.0 HOH
 2.654
 HG13
 O
ILE B:92 B:116 90.0 0.514 H -67.9 -45.1 NA NA NA
3n1m 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ILE A:92 B:116 107.0 0.611 H -66.5 -46.7 107.0 0.611 0.0 HOH
 2.507
 HG23
 O
3n1o 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ILE A:92 A:116 120.0 0.686 H -77.2 -35.6 120.0 0.686 0.0 HOH
 4.746
 N
 O
ILE B:92 B:116 119.0 0.68 H -65.8 -52.4 NA NA NA
ILE C:92 C:116 110.0 0.629 H -71.7 -42.8 NA NA NA
3n1p 1 Q14623 88.17 7e-107 X-RAY
 2010-06-02 ILE A:92 B:116 117.0 0.669 H -75.2 -39.5 117.0 0.669 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q15465-f1 1 Q15465 100.0 0.0 ILE A:111 A:111 94.0 0.537 H -59.5 -44.9