Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr7 | 55221833 | . | A | C | CCDS5514.1:NM_005228.3:c.877Aag>Cag_NP_005219.2:p.293K>Q | Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 7syd | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:293 | A:269 | 172.0 | 0.86 | S | -81.4 | -24.4 | 172.0 | 0.86 | 0.0 | ||||||
| LYS | C:293 | B:269 | 138.0 | 0.69 | S | -75.7 | -36.9 | 138.0 | 0.69 | 0.0 | |||||||||||||
| 7sye | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:293 | A:269 | 134.0 | 0.67 | S | -80.6 | -19.0 | 134.0 | 0.67 | 0.0 | ||||||
| LYS | B:293 | B:269 | 136.0 | 0.68 | S | -68.9 | -42.3 | 136.0 | 0.68 | 0.0 | |||||||||||||
| 7sz5 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-22 | LYS | A:293 | A:269 | 143.0 | 0.715 | S | -65.4 | -37.6 | 143.0 | 0.715 | 0.0 | ||||||
| LYS | C:293 | B:269 | 110.0 | 0.55 | S | -68.1 | -24.8 | 110.0 | 0.55 | 0.0 | |||||||||||||
| 7sz7 | 1 | P00533 | 99.92 | 0.0 |
EM |
2021-12-15 | LYS | A:293 | A:269 | 124.0 | 0.62 | S | -72.7 | -44.2 | 124.0 | 0.62 | 0.0 | ||||||
| LYS | C:293 | B:269 | 155.0 | 0.775 | S | -91.6 | 1.5 | 155.0 | 0.775 | 0.0 | |||||||||||||
| 7sz0 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | LYS | A:293 | A:269 | 165.0 | 0.825 | S | -66.8 | -49.1 | 165.0 | 0.825 | 0.0 | ||||||
| LYS | C:293 | B:269 | 165.0 | 0.825 | S | -76.7 | -39.6 | 165.0 | 0.825 | 0.0 | |||||||||||||
| 7sz1 | 1 | P00533 | 99.83 | 0.0 |
EM |
2021-12-22 | LYS | A:293 | A:269 | 157.0 | 0.785 | S | -73.5 | -40.0 | 157.0 | 0.785 | 0.0 | ||||||
| LYS | C:293 | B:269 | 130.0 | 0.65 | S | -74.8 | -15.3 | 130.0 | 0.65 | 0.0 | |||||||||||||
| 5xwd | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2018-02-28 | LYS | A:293 | A:269 | 134.0 | 0.67 | S | -61.8 | -41.5 | 134.0 | 0.67 | 0.0 | ||||||
| 3qwq | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2012-02-01 | LYS | A:293 | A:269 | 78.0 | NA | S | -69.8 | -32.6 | 78.0 | NA | NA | ||||||
| 1ivo | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2002-10-16 | LYS | A:269 | A:269 | 169.0 | 0.845 | S | -94.6 | -28.7 | 169.0 | 0.845 | 0.0 |
HOH |
5.152 |
O |
O |
||
| LYS | B:269 | B:269 | 175.0 | 0.875 | S | -84.5 | -19.3 | 175.0 | 0.875 | 0.0 | |||||||||||||
| 4uv7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-10-14 | LYS | A:269 | A:269 | 140.0 | 0.7 | S | -73.9 | -33.5 | 140.0 | 0.7 | 0.0 |
HOH |
2.915 |
N |
O |
||
| 3b2v | 3 | P00533 | 100.0 | 0.0 |
X-RAY |
2008-02-19 | LYS | C:269 | A:269 | 66.0 | NA | S | -175.4 | 139.2 | 66.0 | NA | NA | ||||||
| 4kro | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2013-08-28 | LYS | A:269 | A:269 | 89.0 | NA | S | -61.3 | -38.7 | 89.0 | NA | NA | ||||||
| 1nql | 1 | 4885199 | 99.84 | 0.0 |
X-RAY |
2003-03-11 | LYS | A:269 | A:269 | 177.0 | 0.885 | S | -65.1 | -25.4 | 177.0 | 0.885 | 0.0 | ||||||
| 4krp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2013-08-28 | LYS | A:269 | A:269 | 85.0 | NA | S | -71.7 | -11.9 | 85.0 | NA | NA | ||||||
| 1yy9 | 1 | P00533 | 99.51 | 0.0 |
X-RAY |
2005-04-26 | LYS | A:269 | A:269 | 150.0 | 0.75 | S | -82.9 | -29.3 | 150.0 | 0.75 | 0.0 | ||||||
| 6aru | 1 | P00533 | 99.68 | 0.0 |
X-RAY |
2018-08-29 | LYS | A:269 | A:269 | 171.0 | 0.855 | S | -87.9 | -17.6 | 171.0 | 0.855 | 0.0 | ||||||
| 3njp | 1 | P00533 | 99.84 | 0.0 |
X-RAY |
2010-10-13 | LYS | A:269 | A:269 | 133.0 | 0.665 | S | -87.0 | -31.2 | 133.0 | 0.665 | 0.0 |
HOH |
9.195 |
NZ |
O |
||
| LYS | B:269 | B:269 | 136.0 | 0.68 | S | -80.4 | -29.4 | 136.0 | 0.68 | 0.0 | |||||||||||||
| 4uip | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2015-11-25 | LYS | A:268 | A:269 | 143.0 | 0.715 | S | -65.8 | -43.2 | 143.0 | 0.715 | 0.0 |
HOH |
8.838 |
N |
O |
||
| 5wb7 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | LYS | A:269 | A:269 | 103.0 | NA | S | -70.9 | -26.6 | 103.0 | NA | NA | ||||||
| LYS | B:269 | B:269 | 85.0 | NA | S | -67.4 | -30.9 | NA | NA | NA | |||||||||||||
| LYS | C:269 | C:269 | 62.0 | NA | S | -72.4 | -22.5 | NA | NA | NA | |||||||||||||
| LYS | D:269 | D:269 | 122.0 | 0.61 | S | -69.7 | -43.7 | 122.0 | 0.61 | 0.0 | |||||||||||||
| 5wb8 | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2017-10-18 | LYS | A:269 | A:269 | 120.0 | 0.6 | S | -65.2 | -21.7 | 120.0 | 0.6 | 0.0 |
HOH |
7.082 |
CD |
O |
||
| LYS | D:269 | D:269 | 82.0 | NA | S | -73.1 | -22.4 | NA | NA | NA | |||||||||||||
| 1mox | 1 | P00533 | 100.0 | 0.0 |
X-RAY |
2003-09-10 | LYS | A:269 | A:269 | 125.0 | 0.625 | S | -62.0 | -53.1 | 125.0 | 0.625 | 0.0 | ||||||
| LYS | B:269 | B:269 | 160.0 | 0.8 | S | -74.0 | -18.9 | 160.0 | 0.8 | 0.0 |
HOH |
9.242 |
N |
O |
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| 7len | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:269 | A:269 | 155.0 | 0.775 | S | -76.7 | -17.6 | 155.0 | 0.775 | 0.0 | ||||||
| LYS | B:269 | B:269 | 75.0 | NA | S | -76.4 | -28.4 | NA | NA | NA | |||||||||||||
| 7lfr | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:269 | A:269 | 165.0 | 0.825 | S | -69.2 | -23.5 | 165.0 | 0.825 | 0.0 | ||||||
| LYS | B:269 | B:269 | 71.0 | NA | S | -74.0 | -19.7 | 71.0 | NA | NA | |||||||||||||
| 7lfs | 1 | P00533 | 99.8 | 0.0 |
X-RAY |
2021-11-17 | LYS | A:269 | A:269 | 101.0 | NA | S | -82.7 | -36.6 | 101.0 | NA | NA | ||||||
| LYS | B:269 | B:269 | 76.0 | NA | S | -66.3 | -20.6 | NA | NA | NA | |||||||||||||
| LYS | C:269 | C:269 | 71.0 | NA | S | -70.2 | -51.3 | NA | NA | NA | |||||||||||||
| LYS | D:269 | D:269 | 146.0 | 0.73 | S | -64.4 | -41.7 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00533-f1 | 1 | P00533 | 100.0 | 0.0 | LYS | A:293 | A:293 | 124.0 | 0.62 | S | -72.8 | -15.8 | |